Arya M Sharma

Summary

Country: Canada

Publications

  1. ncbi Hypertension in lean and obese individuals: an evenly or unevenly dangerous condition
    Gianluca Iacobellis
    Nutr Metab Cardiovasc Dis 17:243-6. 2007
  2. ncbi Review: Peroxisome proliferator-activated receptor gamma and adipose tissue--understanding obesity-related changes in regulation of lipid and glucose metabolism
    Arya M Sharma
    Canada Research Chair for Cardiovascular Obesity Research and Management, McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    J Clin Endocrinol Metab 92:386-95. 2007
  3. ncbi Metabolic profile and exercise capacity outcomes: their relationship to overweight and obesity in a Canadian cardiac rehabilitation setting
    Mamdouh M Shubair
    Department of Medicine, McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada
    J Cardiopulm Rehabil 24:405-13. 2004
  4. ncbi Relation of epicardial fat and alanine aminotransferase in subjects with increased visceral fat
    Gianluca Iacobellis
    Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 16:179-83. 2008
  5. ncbi Relation of subepicardial adipose tissue to carotid intima-media thickness in patients with human immunodeficiency virus
    Gianluca Iacobellis
    Cardiovascular Obesity Research and Management at the Michael G deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Cardiol 99:1470-2. 2007
  6. ncbi Identification and management of cardiometabolic risk in Canada: a position paper by the cardiometabolic risk working group (executive summary)
    Lawrence A Leiter
    St Michael s Hospital, Toronto, Ontario, Canada
    Can J Cardiol 27:124-31. 2011
  7. ncbi Prevention of cardiovascular disease: obesity, diabetes and the metabolic syndrome
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Can J Cardiol 26:18C-20C. 2010
  8. ncbi Substantial changes in epicardial fat thickness after weight loss in severely obese subjects
    Gianluca Iacobellis
    1Department of Medicine, Cardiovascular Obesity Research and Management, McMaster University, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 16:1693-7. 2008
  9. ncbi Health status, quality of life, and satisfaction of patients awaiting multidisciplinary bariatric care
    Raj S Padwal
    Department of Medicine, University of Alberta, 2F1, 26 Walter C, Mackenzie Health Sciences Centre, 8440 112th Street, Edmonton, AB T6G 2B7, Canada
    BMC Health Serv Res 12:139. 2012
  10. ncbi Effect of gastric bypass surgery on azithromycin oral bioavailability
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Antimicrob Chemother 67:2203-6. 2012

Collaborators

Detail Information

Publications83

  1. ncbi Hypertension in lean and obese individuals: an evenly or unevenly dangerous condition
    Gianluca Iacobellis
    Nutr Metab Cardiovasc Dis 17:243-6. 2007
  2. ncbi Review: Peroxisome proliferator-activated receptor gamma and adipose tissue--understanding obesity-related changes in regulation of lipid and glucose metabolism
    Arya M Sharma
    Canada Research Chair for Cardiovascular Obesity Research and Management, McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    J Clin Endocrinol Metab 92:386-95. 2007
    ..e. adipocytes display morphological differences alongside aberrant endocrine and metabolic function and low-grade inflammation)...
  3. ncbi Metabolic profile and exercise capacity outcomes: their relationship to overweight and obesity in a Canadian cardiac rehabilitation setting
    Mamdouh M Shubair
    Department of Medicine, McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada
    J Cardiopulm Rehabil 24:405-13. 2004
    ....
  4. ncbi Relation of epicardial fat and alanine aminotransferase in subjects with increased visceral fat
    Gianluca Iacobellis
    Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 16:179-83. 2008
    ..However, the potential link between cardiac adiposity, emerging index of visceral adiposity, and fatty liver is still unexplored...
  5. ncbi Relation of subepicardial adipose tissue to carotid intima-media thickness in patients with human immunodeficiency virus
    Gianluca Iacobellis
    Cardiovascular Obesity Research and Management at the Michael G deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Cardiol 99:1470-2. 2007
    ..81, p <0.01). In conclusion, this study suggests, for the first time, that epicardial adipose tissue, an index of cardiac adiposity, may be significantly related to subclinical atherosclerosis in HIV-infected patients...
  6. ncbi Identification and management of cardiometabolic risk in Canada: a position paper by the cardiometabolic risk working group (executive summary)
    Lawrence A Leiter
    St Michael s Hospital, Toronto, Ontario, Canada
    Can J Cardiol 27:124-31. 2011
    ..Health care professionals must also consider ethnicity-related risk factors in order to appropriately evaluate all individuals in their diverse patient populations...
  7. ncbi Prevention of cardiovascular disease: obesity, diabetes and the metabolic syndrome
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Can J Cardiol 26:18C-20C. 2010
    ..Future efforts will need to focus on these factors and pansocietal solutions will be required if&nbsp;success in reversing the population-wide weight increases that have occurred over the past several decades is to be achieved...
  8. ncbi Substantial changes in epicardial fat thickness after weight loss in severely obese subjects
    Gianluca Iacobellis
    1Department of Medicine, Cardiovascular Obesity Research and Management, McMaster University, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 16:1693-7. 2008
    ..Measurement of echocardiographic epicardial fat thickness may provide an additional tool in understanding the metabolic risk associated with variation in fat distribution...
  9. ncbi Health status, quality of life, and satisfaction of patients awaiting multidisciplinary bariatric care
    Raj S Padwal
    Department of Medicine, University of Alberta, 2F1, 26 Walter C, Mackenzie Health Sciences Centre, 8440 112th Street, Edmonton, AB T6G 2B7, Canada
    BMC Health Serv Res 12:139. 2012
    ..Our objective was to examine wait-listed patients' health status and perceptions regarding the consequences of prolonged wait times using a cross-sectional study design nested within a prospective cohort...
  10. ncbi Effect of gastric bypass surgery on azithromycin oral bioavailability
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Antimicrob Chemother 67:2203-6. 2012
    ..Gastric bypass, a procedure that circumvents the upper gut, may compromise azithromycin plasma levels. We hypothesized that azithromycin concentrations would be reduced following gastric bypass...
  11. ncbi The value of current interventions for obesity
    Arya M Sharma
    Cardiovascular Obesity Research and Management in Michael deGroote School of Medicine, McMaster University, Hamilton, ON, Canada
    Nat Clin Pract Cardiovasc Med 5:S3-9. 2008
    ..If this effect can be demonstrated in humans, this type of agent might become the treatment of choice for obese or overweight people at risk of type 2 diabetes...
  12. ncbi Threshold values of high-risk echocardiographic epicardial fat thickness
    Gianluca Iacobellis
    Department of Medicine, Cardiovascular Obesity Research and Management, McMaster University, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 16:887-92. 2008
    ..In this study, we sought to provide threshold values of echocardiographic epicardial fat thickness associated with metabolic and anthropometric risk factors...
  13. ncbi Urinary sodium and potassium excretion and risk of cardiovascular events
    MARTIN J O'DONNELL
    Population Health Research Institute, Hamilton General Hospital, McMaster University, 237 Barton St E, Third Floor, Hamilton, ON, L8L 2X2, Canada
    JAMA 306:2229-38. 2011
    ..The precise relationship between sodium and potassium intake and cardiovascular (CV) risk remains uncertain, especially in patients with CV disease...
  14. ncbi Adipocyte hypertrophy, fatty liver and metabolic risk factors in South Asians: the Molecular Study of Health and Risk in Ethnic Groups (mol-SHARE)
    Sonia S Anand
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 6:e22112. 2011
    ..We sought to determine if differences in the distribution and characteristics of adipose tissue between South Asians and white Caucasians account for differences in risk factors for cardiovascular disease...
  15. ncbi Epicardial adipose tissue as new cardio-metabolic risk marker and potential therapeutic target in the metabolic syndrome
    Gianluca Iacobellis
    Department of Medicine, Cardiovascular Obesity Research and Management, McMaster University Hamilton, Ontario, Canada
    Curr Pharm Des 13:2180-4. 2007
    ..In this article, epicardial adipose tissue's structure, function, method of assessment and reliability as a diagnostic tool and potential therapeutic target is reviewed...
  16. ncbi Telmisartan/hydrochlorothiazide versus valsartan/hydrochlorothiazide in obese hypertensive patients with type 2 diabetes: the SMOOTH study
    Arya M Sharma
    McMaster University, Hamilton, ON, Canada
    Cardiovasc Diabetol 6:28. 2007
    ....
  17. ncbi Epicardial adipose tissue is related to carotid intima-media thickness and visceral adiposity in HIV-infected patients with highly active antiretroviral therapy-associated metabolic syndrome
    Gianluca Iacobellis
    Cardiovascular Obesity Research and Management at the Michael G deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr HIV Res 5:275-9. 2007
    ..Detection of epicardial fat thickness, new index of visceral adiposity in non HIV-infected patients, might be important as diagnostic tool in HIV-infected patients on HAART...
  18. ncbi Can PPARgamma agonists have a role in the management of obesity-related hypertension?
    Vasudhevan T Chetty
    Michael deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Vascul Pharmacol 45:46-53. 2006
    ..This review will highlight the role of TZDs in various models of hypertension and discuss their potential role in the management of obesity-related hypertension...
  19. ncbi Glycemic index predicts individual glucose responses after self-selected breakfasts in free-living, abdominally obese adults
    Angela M Kochan
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    J Nutr 142:27-32. 2012
    ..In this study, GI was a more important determinant of glycemic response than carbohydrate intake...
  20. ncbi Treatment of obesity: a challenging task
    Arya M Sharma
    Department of Medicine, Cardiovascular Obesity Research and Management at the Michael G deGroote School of Medicine, Hamilton, Canada
    Contrib Nephrol 151:212-20. 2006
    ..Successful obesity treatment should be defined as long-term weight loss maintenance. In this chapter, we briefly review the current evidences regarding the treatment of obesity...
  21. ncbi Bariatric surgery: a systematic review of the clinical and economic evidence
    Raj Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Gen Intern Med 26:1183-94. 2011
    ..Use of bariatric surgery for severe obesity has increased dramatically...
  22. ncbi Effect of gastric bypass surgery on the absorption and bioavailability of metformin
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Diabetes Care 34:1295-300. 2011
    ..Metformin, the first-line drug for diabetes, has low bioavailability and slow, incomplete gastrointestinal absorption. We hypothesized that gastric bypass would further reduce the absorption and bioavailability of metformin...
  23. ncbi Emergency department equipment for obese patients: perceptions of adequacy
    Navneet Singh
    Honours Program Cardiovascular Obesity Research and Management, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Adv Nurs 59:140-5. 2007
    ....
  24. ncbi The relationship of body mass index to outcomes after percutaneous coronary intervention
    Mamdouh M Shubair
    Department of Medicine, McMaster University, Hamilton Health Sciences (General Site, Hamilton, Ontario, Canada
    J Interv Cardiol 19:388-95. 2006
    ..CONCLUSIONS: Obesity is not associated with increased risk of adverse postprocedural in-hospital outcomes. These findings, however, do not discount the need for sustained efforts in secondary prevention of obesity and its consequences...
  25. ncbi The role of renin-angiotensin system blockade in the management of hypertension associated with the cardiometabolic syndrome
    Arya M Sharma
    Michael G deGroote Medical School, McMaster University, Hamilton, Ontario, Canada
    J Cardiometab Syndr 1:29-35. 2006
    ..Randomized, controlled trials conducted specifically in patients with obesity and hypertension are needed to determine the optimal therapeutic approach for these patients...
  26. ncbi The Alberta population-based prospective evaluation of the quality of life outcomes and economic impact of bariatric surgery (APPLES) study: background, design and rationale
    Raj S Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    BMC Health Serv Res 10:284. 2010
    ..We hypothesize that lower indirect, out of pocket and productivity costs will offset increased direct health-care costs resulting in lower total costs for bariatric surgery...
  27. ncbi Do cardiac and perivascular adipose tissue play a role in atherosclerosis?
    Gianluca Iacobellis
    Department of Medicine, St Joseph s Hospital, 50 Charlton Avenue East, 5th Fontbonne Building, Hamilton, Ontario, L8N 4A6, Canada
    Curr Diab Rep 8:20-4. 2008
    ..The double role of epicardial and perivascular adipose tissue in the development of cardiovascular pathology and/or in protecting the heart and arteries warrants further studies...
  28. ncbi Characteristics of the population eligible for and receiving publicly funded bariatric surgery in Canada
    Raj S Padwal
    Department of Medicine, 2F1, 26 Walter C, Mackenzie Health Sciences Centre, University of Alberta, 8440 112th Street, Edmonton, T6G 2B7, Alberta, Canada
    Int J Equity Health 11:54. 2012
    ..The purpose of this study was to quantify and characterize the bariatric surgery-eligible population in Canada in comparison to surgery-ineligible subjects and surgical recipients...
  29. ncbi Feasibility of an interdisciplinary program for obesity management in Canada
    Sean Wharton
    Wharton Medical Clinic, Hamilton, Ont, Canada
    Can Fam Physician 58:e32-8. 2012
    ..To assess the feasibility of a medically supervised, publicly funded interdisciplinary program for obesity management in a Canadian setting...
  30. ncbi Perivascular adipose tissue promotes vasoconstriction: the role of superoxide anion
    Yu Jing Gao
    Smooth Muscle Research Program and Department of Anaesthesia, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    Cardiovasc Res 71:363-73. 2006
    ..In this study, we examined if PVAT releases other vasoactive factors in response to perivascular nerve activation by electrical field stimulation (EFS)...
  31. ncbi Different "weight" of cardiac and general adiposity in predicting left ventricle morphology
    Gianluca Iacobellis
    Department of Medicine, Cardiovascular Obesity Research and Management, Michael G DeGroote School of Medicine, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 14:1679-84. 2006
    ..Nevertheless, the close anatomical and functional relationship of epicardial adipose tissue to the adjacent myocardium should readily allow local, paracrine interactions between these tissues...
  32. ncbi Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance
    Andrew Mente
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 33:1629-34. 2010
    ..To investigate ethnic differences in adiponectin and leptin concentration and to determine whether these adipokines and a high-glycemic index diet account for ethnic variation in insulin resistance...
  33. ncbi Barriers to obesity treatment
    Marina Mauro
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Eur J Intern Med 19:173-80. 2008
    ..Failure to do so may further undermine the sense of failure, low self esteem and self efficacy already common among obese individuals. Addressing treatment barriers can save resources and increase the prospect of long-term success...
  34. ncbi Income status and approval for bariatric surgery in a publicly funded regional obesity program
    Kieran Halloran
    Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Obes Surg 21:373-8. 2011
    ..Whether this relationship is also present in a universally accessible, publicly funded health care system is not currently known...
  35. ncbi The obese patient with diabetes mellitus: from research targets to treatment options
    Arya M Sharma
    Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Med 119:S17-23. 2006
    ..Clinical trials with telmisartan are currently investigating the effects of RAS blockade on insulin sensitivity in humans...
  36. ncbi Obesity and cardiovascular disease: pathogenic mechanisms and potential benefits of weight reduction
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Semin Vasc Med 5:25-33. 2005
    ....
  37. ncbi Management of hypertension in overweight and obese patients: a practical guide for clinicians
    Francesco Dentali
    St. Joseph's Hospital, Room F-541, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Curr Hypertens Rep 7:330-6. 2005
    ..Additional studies to further clarify the management of these patients are warranted...
  38. ncbi Metabolic syndrome and acute hyperglycemia are associated with endoplasmic reticulum stress in human mononuclear cells
    Andrew T Sage
    Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 20:748-55. 2012
    ..These findings suggest that there is an association between both acute and chronic dysglycemia and ER stress in humans...
  39. ncbi Health status, hospitalizations, day procedures, and physician costs associated with body mass index (BMI) levels in Ontario, Canada
    Jean Eric Tarride
    Programs for Assessment of Technology in Health PATH Research Institute, St Joseph s Healthcare Hamilton, Hamilton, Ontario, Canada
    Clinicoecon Outcomes Res 4:21-30. 2012
    ..Obesity is today's principal neglected public health problem, as a rising proportion of adults will succumb to the medical complications of obesity. However, little is known about the burden of obesity in adults living in Ontario...
  40. ncbi Cardiometabolic risk in Canada: a detailed analysis and position paper by the cardiometabolic risk working group
    Lawrence A Leiter
    Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Can J Cardiol 27:e1-e33. 2011
    ..Health care professionals must also consider risk factors related to ethnicity in order to appropriately evaluate everyone in their diverse patient populations...
  41. ncbi Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart
    Gianluca Iacobellis
    Department of Medicine, Cardiovascular Obesity Research and Management, Michael G DeGroote School of Medicine, Hamilton, Ontario, Canada
    Nat Clin Pract Cardiovasc Med 2:536-43. 2005
    ..In this paper, we briefly review the rapidly emerging evidence pointing to a specific role of epicardial adipose tissue both as a cardiac risk marker and as a potentially active player in the development of cardiac pathology...
  42. ncbi A patient with personal control of the adjustable gastric band and bulimia: a psychiatric complication
    Valerie H Taylor
    Mood Disorders Program, Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada
    Obes Surg 16:1386-7. 2006
    ..Self-adjustment of the gastric band for control of intake is a potential problem. Preoperative psychiatric evaluation is desirable to identify and treat eating disorders and depression, and to indicate surveillance...
  43. ncbi Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
    Lancet 366:1640-9. 2005
    ..We aimed to assess whether markers of obesity, especially waist-to-hip ratio, would be stronger indicators of myocardial infarction than body-mass index (BMI), the conventional measure...
  44. ncbi Perivascular adipose tissue modulates vascular function in the human internal thoracic artery
    Yu Jing Gao
    Department of Anaesthesia, McMaster University, Hamilton, Ontario, Canada
    J Thorac Cardiovasc Surg 130:1130-6. 2005
    ..The purpose of the present study was to examine whether this vasodilator is also present in human internal thoracic arteries...
  45. ncbi Managing weighty issues on lean evidence: the challenges of bariatric medicine
    Arya M Sharma
    Cardiovascular Obesity Research and Management, McMaster University, Hamilton, Ont
    CMAJ 172:30-1. 2005
  46. ncbi The management of hypertension in the overweight and obese patient: is weight reduction sufficient?
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Drugs 64:795-803. 2004
    ..Additional studies are needed to determine the long-term (>1 year) efficacy and safety of antihypertensive and anti-obesity management strategies in the overweight and obese hypertensive patient...
  47. ncbi Is there a rationale for angiotensin blockade in the management of obesity hypertension?
    Arya M Sharma
    McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, ON, Canada
    Hypertension 44:12-9. 2004
    ....
  48. ncbi Obesity research in Canada: literature overview of the last 3 decades
    Hanan B Sokar-Todd
    Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    Obes Res 12:1547-53. 2004
    ..To identify research published on obesity in Canada, to explore the range of areas studied, and to identify gaps and areas that merit future research attention...
  49. ncbi Association between adiponectin and mediators of inflammation in obese women
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Diabetes 52:942-7. 2003
    ....
  50. ncbi Adipose tissue metabolism and CD11b expression on monocytes in obese hypertensives
    Michael Boschmann
    Franz Volhard Clinical Research Center, Charite Campus Buch, HELIOS Klinikum, Berlin, Germany
    Hypertension 46:130-6. 2005
    ..These findings may be explained in part by monocyte/macrophage infiltration of adipose tissue, which appears to interfere with insulin responsiveness...
  51. ncbi Activation of the peripheral endocannabinoid system in human obesity
    Stefan Engeli
    Franz Volhard Clinical Research Center, Charite Campus Buch, 13125 Berlin, Germany
    Diabetes 54:2838-43. 2005
    ..Our findings support the presence of a peripheral endocannabinoid system that is upregulated in human obesity...
  52. ncbi A weighty issue: medication as a cornerstone of medical obesity management
    Arya M Sharma
    University of Alberta, Royal Alexandra Hospital, 10240 Kingsway Ave, 406 CSC, Edmonton, AB T5H 3V9
    Can Fam Physician 54:498-9, 500-1. 2008
  53. ncbi The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome?
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Department of Nephrology and Hypertension, Humboldt University of Berlin, Wiltberg Strasse 50, Berlin 13125, Germany
    Int J Biochem Cell Biol 35:807-25. 2003
    ....
  54. ncbi Long-term weight loss and changes in blood pressure
    Arya M Sharma
    Curr Hypertens Rep 4:11-2. 2002
  55. ncbi Effect of forced titration of nebivolol on response rate in obese hypertensive patients
    Tobias Pischon
    Am J Hypertens 16:98-100. 2003
  56. ncbi Managing big issues on lean evidence: treating obesity hypertension
    Arya M Sharma
    Nephrol Dial Transplant 17:353-5. 2002
  57. ncbi Genetics of obesity and obesity-related hypertension
    Andreas Hamann
    Department of Internal Medicine, University of Heidelberg, Germany
    Semin Nephrol 22:100-4. 2002
    ..This knowledge should help develop new strategies for the treatment of obesity and associated risk factors for hypertension and related cardiovascular disorders...
  58. ncbi Norepinephrine transporter function and autonomic control of metabolism
    Michael Boschmann
    German Institute of Human Nutrition, 14558 Potsdam, Germany
    J Clin Endocrinol Metab 87:5130-7. 2002
    ..This effect cannot be explained by increased systemic or adipose tissue norepinephrine concentrations. Instead, NET inhibition may sensitize adipose tissue to beta-adrenergic stimulation...
  59. ncbi Hormonal regulation of the human adipose-tissue renin-angiotensin system: relationship to obesity and hypertension
    Kerstin Gorzelniak
    Helios Klinkum Berlin, , Humboldt University of Berlin, Germany
    J Hypertens 20:965-73. 2002
    ..The role of the adipose-tissue renin-angiotensin system in the development of obesity-associated hypertension or metabolic disease clearly warrants further study...
  60. ncbi Angiotensin blockade prevents type 2 diabetes by formation of fat cells
    Arya M Sharma
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Humboldt University of Berlin, and Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hypertension 40:609-11. 2002
    ..Increased formation of adipocytes would counteract the ectopic deposition of lipids in other tissues (muscle, liver, pancreas), thereby improving insulin sensitivity and preventing the development of type 2 diabetes...
  61. ncbi Periadventitial fat releases a vascular relaxing factor
    Matthias Löhn
    HELIOS Klinikum Berlin, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    FASEB J 16:1057-63. 2002
    ..We suggest that perivascular adventitial adipose tissue releases a transferable adventitium-derived relaxing factor that acts by tyrosine kinase-dependent activation of K+ channels in vascular smooth muscle cells...
  62. ncbi Angiotensin-converting enzyme inhibition but not beta-adrenergic blockade limits transforming growth factor-beta overexpression in acute normotensive anti-thy1 glomerulonephritis
    Harm Peters
    Division of Nephrology, Charite, Campus Mitte, Humboldt University, Berlin, Germany
    J Hypertens 21:771-80. 2003
    ....
  63. ncbi Emerging concepts in the pathophysiology and treatment of obesity-associated hypertension
    Stefan Engeli
    Franz Volhard Clinic, Helios Klinikum Buch-Charit, Medical Faculty of the Humboldt University Berlin, Germany
    Curr Opin Cardiol 17:355-9. 2002
    ....
  64. ncbi Resistin gene expression in human adipocytes is not related to insulin resistance
    Jurgen Janke
    Franz Volhard Clinic Charité, the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Obes Res 10:1-5. 2002
    ..Resistin, therefore, has been suggested to play a role in the pathogenesis of insulin resistance...
  65. ncbi Effects of exercise on plasma lipoproteins
    Arya M Sharma
    N Engl J Med 348:1494-6; author reply 1494-6. 2003
  66. ncbi Obesity prevalence from a European perspective: a systematic review
    Anne Berghöfer
    Institute for Social Medicine, Epidemiology and Health Economics, Charite University Medical Center, Berlin, Germany
    BMC Public Health 8:200. 2008
    ..We therefore aimed to identify and discuss current epidemiological data on the prevalence of obesity in European countries...
  67. ncbi Telmisartan: the ACE of ARBs?
    Arya M Sharma
    Hypertension 47:822-3. 2006
  68. ncbi Hemodynamic and metabolic responses to interstitial angiotensin II in normal weight and obese men
    Michael Boschmann
    Franz Volhard Clinical Research Center, Charite, Universitary Medicine Berlin, Germany
    J Hypertens 24:1165-71. 2006
    ..Therefore, we hypothesized that peripheral tissues of obese subjects are hypersensitive to angiotensin (Ang) II...
  69. ncbi Angiotensin type 1 receptor antagonists induce human in-vitro adipogenesis through peroxisome proliferator-activated receptor-gamma activation
    Jurgen Janke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Berlin, Germany
    J Hypertens 24:1809-16. 2006
    ..In clonal animal cells, certain angiotensin receptor blockers (ARB) activate the peroxisome proliferator-activated receptor-gamma (PPARgamma). The aim of this work was to validate that observation in human cells and humans...
  70. ncbi Influences of AT1 receptor blockade on tissue metabolism in obese men
    Michael Boschmann
    Franz Volhard Clinical Research Center, Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R219-23. 2006
    ..Endogeneous ANG II may slightly increase adipose tissue lipolysis. The mechanism may promote the redistribution of triglycerides from adipose tissue toward other organs...
  71. ncbi Retinol-binding protein 4 in human obesity
    Jurgen Janke
    Franz Volhard Clinical Research Center Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    Diabetes 55:2805-10. 2006
    ..Our findings point to profound differences between rodents and humans in the regulation of adipose or circulating RBP4 and challenge the notion that glucose uptake by adipocytes has a dominant role in the regulation of RBP4...
  72. ncbi Adiposity of the heart
    Gianluca Iacobellis
    Ann Intern Med 145:554-5; author reply 555. 2006
  73. ncbi Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Hypertens 23:2313-8. 2005
    ..Treatment recommendations for lean hypertensives may not be simply extrapolated to obese hypertensive persons...
  74. ncbi Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive patients--sibutramine and blood pressure
    Andreas L Birkenfeld
    Franz-Volhard Clinical Research Center, , Berlin, Germany
    Clin Auton Res 15:200-6. 2005
    ..These paradoxical changes are consistent with previous studies in healthy subjects and suggest a combination of peripheral and central nervous system mechanisms...
  75. ncbi 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]
    David C W Lau
    Department of Medicine, Julia McFarlane Diabetes Research Centre, Diabetes and Endocrine Research Group, University of Calgary, Calgary, Alta
    CMAJ 176:S1-13. 2007
  76. ncbi Weight loss and the renin-angiotensin-aldosterone system
    Stefan Engeli
    Medical Faculty of the Charite, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, HELIOS Klinikum, Berlin, Germany
    Hypertension 45:356-62. 2005
    ..These data suggest that a 5% reduction in body weight can lead to a meaningfully reduced renin-angiotensin-aldosterone system in plasma and adipose tissue, which may contribute to the reduced blood pressure...
  77. ncbi Hypertension in overweight and obese primary care patients is highly prevalent and poorly controlled
    Peter Bramlage
    Institute of Clinical Pharmacology, Institute of Clinical Psychology and Psychotherapy, Technical University, Dresden
    Am J Hypertens 17:904-10. 2004
    ..The objective of this study was to assess the prevalence of hypertension and the diagnosis, treatment status, and control rates of hypertension in obese patients as compared to patients with normal weight...
  78. ncbi Mediastinal fat, insulin resistance, and hypertension
    Arya M Sharma
    Hypertension 44:117-8. 2004
  79. ncbi Regulation of the nitric oxide system in human adipose tissue
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Charite University Medicine in Berlin, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Lipid Res 45:1640-8. 2004
    ..Increased eNOS and iNOS expression in adipocytes and local effects of insulin and Ang II may increase adipose tissue production of NO in obesity...
  80. ncbi Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Obes Res 12:9-17. 2004
    ..The aim of this study was to determine whether up-regulation of human adipose 11beta-HSD1 in obesity can also be found at the gene expression level...
  81. ncbi Bound leptin and sympathetic outflow in nonobese men
    Jens Tank
    HELIOS Kliniken Berlin, Franz Volhard Cardiovascular Research Center, Medical Faculty of the Charite, Humboldt University, 13125 Berlin, Germany
    J Clin Endocrinol Metab 88:4955-9. 2003
    ..This relationship cannot be explained by a direct central nervous effect of protein-bound leptin. Instead, protein-bound leptin may increase sympathetic vasomotor tone indirectly via a baroreflex mechanism...
  82. ncbi Potential for sibutramine-yohimbine interaction?
    Jens Jordan
    Lancet 361:1826. 2003
  83. ncbi Interleukin-6 g.-174G>C promoter polymorphism is associated with obesity in the EPIC-Potsdam Study
    Kerstin Klipstein-Grobusch
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal
    Obesity (Silver Spring) 14:14-8. 2006
    ..044) and was most pronounced in subjects with the CC genotype, suggesting that the IL-6 g.-174G>C promoter polymorphism is a susceptibility or modifying locus for common obesity and weight gain...