Marc J Servant
Khan K, DÃ´ F, Marineau A, Doyon P, ClÃ©ment J, Woodgett J, et al
. Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/Î²-Catenin Pathway. Mol Cell Biol. 2015;35:3029-43 pubmed publisher
..This study identifies the role of a GSK-3/Î²-catenin axis in antiviral innate immunity. ..
Clément J, Bibeau Poirier A, Gravel S, Grandvaux N, Bonneil E, Thibault P, et al
. Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association. J Virol. 2008;82:3984-96 pubmed publisher
..Importantly, our study establishes a molecular link between the role of serine 339 in IRF-3 homodimerization, CBP association, and its destabilization. ..