- A pragmatic, randomized, controlled study evaluating the impact of access to smoking cessation pharmacotherapy coverage on the proportion of successful quitters in a Canadian population of smokers motivated to quit (ACCESSATION)Peter Selby
Addictions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
BMC Public Health 14:433. 2014..Financial coverage for these medications increases utilization of pharmacotherapies. This study assesses whether financial coverage increases the proportion of successful quitters...
- Escalating doses of transdermal nicotine in heavy smokers: effects on smoking behavior and cravingPeter Selby
Nicotine Dependence Clinic, Addictions Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
J Clin Psychopharmacol 33:667-74. 2013..Titrating doses of NRT to effect with brief intervention hold promise as an effective clinical strategy to assist heavily dependent psychiatrically ill smokers to change their smoking behavior. ..
- How pragmatic or explanatory is the randomized, controlled trial? The application and enhancement of the PRECIS tool to the evaluation of a smoking cessation trialPeter Selby
Addictions Program, Centre for Addiction and Mental Health, 100 Stokes St, 33 Russell Street, Toronto, ON M6J 1H4, Canada
BMC Med Res Methodol 12:101. 2012..However, there is no clear method to scale each dimension during the trial design phase to ensure that the design matches the intended purpose of the study...
- Methods for quantification of exposure to cigarette smoking and environmental tobacco smoke: focus on developmental toxicologyAna Florescu
Department of Research, The CAMH Center, University of Toronto, Toronto, Ontario, Canada
Ther Drug Monit 31:14-30. 2009..This review aims at defining the sensitivity, specificity, and clinical utilization of different methods used to estimate exposure to cigarette smoking and environmental tobacco smoke...
- Online social and professional support for smokers trying to quit: an exploration of first time posts from 2562 membersPeter Selby
Centre for Addiction and Mental Health, Toronto, Canada
J Med Internet Res 12:e34. 2010..However, to date there has been little research to guide development of this particular feature of Web-assisted tobacco interventions (WATIs)...
- Reach and effectiveness of mailed nicotine replacement therapy for smokers: 6-month outcomes in a naturalistic exploratory studyLaurie Zawertailo
Addictions Program, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON M5S 2S1, Canada
Tob Control 22:e4. 2013..The objective of this study was to determine the effectiveness of free nicotine replacement therapy (NRT), brief advice and self-help materials on quit attempts and 6-month quit rates in motivated smokers...
- The impact of Ontario smoke-free legislation on secondhand smoke in enclosed public placesBo Zhang
Ontario Tobacco Research Unit, University of Toronto, 33 Russell Street, Toronto, Ontario, Canada
J Occup Environ Hyg 7:133-43. 2010..DSRs did not provide adequate protection from SHS. The Smoke-Free Ontario Act produced a significant and firm reduction in SHS exposure in venues both with and without DSRs...
- Impact of an indoor smoking ban on bar workers' exposure to secondhand smokeSusan J Bondy
Dalla Lana School of Public Health, University of Toronto, Ontario, Canada
J Occup Environ Med 51:612-9. 2009..To evaluate the impact of an indoor smoke-free bylaw in Toronto, Ontario, implemented June 2004...
- Effectiveness of pharmacist counseling combined with nicotine replacement therapy: a pragmatic randomized trial with 6,987 smokersMary Jean Costello
Centre for Addiction and Mental Health, Toronto, ON, Canada
Cancer Causes Control 22:167-80. 2011..Pharmacists may be effective health care practitioners to deliver smoking cessation interventions. This paper examines the short-term outcomes of smokers randomized to one of two models of a pharmacist-led smoking cessation intervention...
- The impact of chronic bupropion on plasma cotinine and on the subjective effects of ad lib smoking: a randomized controlled trial in unmotivated smokersSarwar Hussain
Clinical Neuroscience, Centre for Addiction and Mental Health, 33 Russell St, Toronto, ON, Canada M5S 2S1
Addict Behav 35:164-7. 2010..This study is among the first to systematically investigate the effect of chronic bupropion administration, free from the confounding effect of the smoker's motivation to quit smoking...
- Major depressive disorder and patient satisfaction in relation to methadone pharmacokinetics and pharmacodynamics in stabilized methadone maintenance patientsAlexander K Elkader
Faculty of Pharmacy, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
J Clin Psychopharmacol 29:77-81. 2009..05). Study findings suggest that (S)-methadone may relate to patients' dissatisfaction with methadone treatment. Depressed methadone patients may be more sensitive to negative opioid effects and opioid withdrawal...
- Individualized smoking cessation treatment in an outpatient setting: Predictors of outcome in a sample with psychiatric and addictions co-morbidityPeter Selby
Addictions Program and Nicotine Dependence Clinic, Centre for Addiction and Mental Health, Toronto, ON, Canada M5S 2S1
Addict Behav 35:811-7. 2010..However, few studies have compared patients with schizophrenia or schizoaffective disorders to patients with other psychiatric diagnoses without psychosis, addressing ability to quit and differences in treatment characteristics...
- Monoamine oxidase A binding in the prefrontal and anterior cingulate cortices during acute withdrawal from heavy cigarette smokingIngrid Bacher
Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, 250 College St, Toronto, ON, Canada
Arch Gen Psychiatry 68:817-26. 2011..Dysphoria during cigarette withdrawal predicts relapse. It is unknown whether MAO-A binding increases during early cigarette withdrawal...
- Enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fMRI studyVladyslav Kushnir
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Int J Neuropsychopharmacol 16:997-1008. 2013..Such enhanced salience of smoking cues, even after smoking a cigarette, may play a critical role both in the maintenance of smoking in depression and in greater levels of nicotine dependence seen in this patient population...
- A perioperative smoking cessation intervention with varenicline: a double-blind, randomized, placebo-controlled trialJean Wong
Department of Anesthesia, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
Anesthesiology 117:755-64. 2012..Our objective was to determine the efficacy and safety of a perioperative smoking cessation intervention with varenicline to reduce smoking in elective surgical patients...
- Heightened D(3) dopamine receptor levels in cocaine dependence and contributions to the addiction behavioral phenotype: a positron emission tomography study with [(11)C]-(+)-PHNODoris E Payer
1 Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, ON, Canada 2 Research Imaging Centre and Vivian M Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
Neuropsychopharmacology 39:311-8. 2014..D3 upregulation is emerging as a biomarker in preclinical models of addiction, and human PET studies of this receptor system can help guide novel pharmacological strategies for treatment. ..
- Do components of current 'hardcore smoker' definitions predict quitting behaviour?David T Ip
Ontario Tobacco Research Unit, Toronto, Canada
Addiction 107:434-40. 2012..To evaluate whether 'hardcore smoker' definition components predict quitting behaviours and which combinations of 'hardcore' components are most predictive...
- The acceptability of physical activity programming within a smoking cessation service for individuals with severe mental illnessGuy Faulkner
Faculty of Physical Education and Health, University of Toronto, Toronto, Canada
Patient Educ Couns 66:123-6. 2007..The current study assessed the acceptability of introducing physical activity, including perceived advantages and disadvantages, as an adjunct to a smoking cessation service within this population...
- Methadone-nicotine interactions in methadone maintenance treatment patientsAlexander K Elkader
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
J Clin Psychopharmacol 29:231-8. 2009..The overall results may help to explain high smoking rates in the MMT population and may account for reports of increased positive effects of methadone when the drugs are taken together...
- Impact of a smoke-free policy in a large psychiatric hospital on staff attitudes and patient behaviorSabrina Voci
Centre for Addiction and Mental Health, Toronto, Canada M5S 2S1
Gen Hosp Psychiatry 32:623-30. 2010....
- Transitions in smoking status over time in a population-based panel study of smokersSusan J Bondy
University of Toronto Dalla Lana School of Public Health, Toronto, Ontario, Canada
Nicotine Tob Res 15:1201-10. 2013..Transitions from daily to occasional smoking are particularly of interest as these may be steps toward cessation...
- Elevation of dopamine induced by cigarette smoking: novel insights from a [(11)C]-(+)-PHNO PET study in humansBernard Le Foll
1 Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada 2 Alcohol Research and Treatment Clinic, Addiction Medicine Services, Ambulatory Care and Structured Treatments, Centre for Addiction and Mental Health, Toronto, ON, Canada 3 Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada 4 Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada 5 Department of Pharmacology, University of Toronto, Toronto, ON, Canada 6 Department of Psychiatry, Division of Brain and Therapeutics, University of Toronto, Toronto, ON, Canada 7 Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
Neuropsychopharmacology 39:415-24. 2014..We propose that due to the robust effect of smoking on [(11)C]-(+)-PHNO binding, this radiotracer represents an ideal translational tool to investigate novel therapeutic strategies targeting DA transmission. ..
- Smoking cessation in women with severe mental illness: exploring the role of exercise as an adjunct treatmentKelly P Arbour-Nicitopoulos
Faculty of Physical Education and Health, University of Toronto, Toronto, ON, Canada
Arch Psychiatr Nurs 25:43-52. 2011..The aim of this study was to investigate the potential role of exercise in smoking cessation in women with severe mental illness (SMI)...
- Reference values for hair cotinine as a biomarker of active and passive smoking in women of reproductive age, pregnant women, children, and neonates: systematic review and meta-analysisAna Florescu
Public Health Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
Ther Drug Monit 29:437-46. 2007..These new values should facilitate clinical diagnosis of active and passive exposure to tobacco smoke. Such diagnosis is critical in pregnancy and in a large number of tobacco-induced medical conditions...
- Relighting cigarettes: how common is it?John A Cunningham
Centre for Addiction and Mental Health and University of Toronto, Ontario, Canada
Nicotine Tob Res 9:621-3. 2007..Smokers contemplating change were less likely to relight cigarettes. Given that previous research has indicated that relighting cigarettes leads to increased harm, the public health implications of this smoking practice are discussed...
- Web-assisted tobacco interventions: empowering change in the global fight for the public's (e)HealthCameron D Norman
Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
J Med Internet Res 10:e48. 2008....
- Association between tobacco industry denormalization beliefs, tobacco control community discontent and smokers' level of nicotine dependenceVladyslav Kushnir
Centre for Addiction and Mental Health, 33 Russell St, Toronto, M5S 2S1 Canada
Addict Behav 38:2273-8. 2013..In addition, it evaluated how these attitudes and beliefs may be associated with smokers' intentions to reduce or quit smoking...
- A tobacco reconceptualization in psychiatry: toward the development of tobacco-free psychiatric facilitiesTaryn G Moss
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Am J Addict 19:293-311. 2010..Finally, questions for further research in this field are delineated. This Tobacco Reconceptualization in Psychiatry is long overdue, given the clear and compelling benefits of tobacco-free environments in psychiatric institutions...
- Higher binding of the dopamine D3 receptor-preferring ligand [11C]-(+)-propyl-hexahydro-naphtho-oxazin in methamphetamine polydrug users: a positron emission tomography studyIsabelle Boileau
Addiction Imaging Research Group, Vivian M Rakoff PET Imaging Centre, Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
J Neurosci 32:1353-9. 2012..Pharmacological studies are needed to establish whether normalization of D3 receptor function could reduce vulnerability to relapse in stimulant abuse...
- The role of ANKK1 and TTC12 genes on drinking behaviour in tobacco dependent subjectsDaniela S S Lobo
Neuroscience Department, Centre for Addiction and Mental Health, Toronto, ON, Canada
World J Biol Psychiatry 13:232-8. 2012....
- Changing practitioner behavior and building capacity in tobacco cessation treatment: the TEACH projectMarilyn Herie
Nicotine Dependence Clinic, Addictions Program, Centre for Addiction and Mental Health, Toronto, Canada
Patient Educ Couns 86:49-56. 2012..To facilitate interprofessional knowledge transfer to practice by increasing treatment capacity of health care practitioners to deliver evidence-informed smoking cessation counseling...
- Psychopharmacology of smoking cessation in patients with mental illnessPeter Selby
Addictions Program, Centre for Addiction and Mental Health, Departments of Family and Community Medicine, Psychiatry and Public Health Sciences, University of Toronto, Toronto, Ont, Canada
J Psychiatry Neurosci 31:360. 2006
- Motivating smoking reductions by framing health information as safer smoking tipsJohn A Cunningham
Centre for Addiction and Mental Health, University of Toronto, 33 Russell Street, Toronto, Ontario, Canada M5S 2S1
Addict Behav 31:1465-8. 2006..This pilot result is encouraging but requires replication before considering the value of including safer smoking tips in health messages for smokers in the general population...
- A randomized, double-blind, placebo-controlled trial of naltrexone in the treatment of concurrent alcohol use disorder and pathological gamblingTony Toneatto
Clinical Research Department, Center for Addiction and Mental Health, Toronto, Ontario, Canada tony
Am J Addict 18:219-25. 2009..However, a strong time effect was found suggesting that treatment, in general, was effective. The use of naltrexone to treat concurrent alcohol use and gambling problems was not supported...
- Methadone: a review of drug-drug and pathophysiological interactionsBhushan M Kapur
Department of Clinical Pathology, Sunnybrook Health Sciences Centre, Toronto, Canada
Crit Rev Clin Lab Sci 48:171-95. 2011....
- Second-hand smoke as a predictor of smoking cessation among lung cancer survivorsLawson Eng
Lawson Eng, Jie Su, Xin Qiu, Prakruthi R Palepu, Henrique Hon, Ehab Fadhel, Luke Harland, Anthony La Delfa, Steven Habbous, Aidin Kashigar, Sinead Cuffe, Frances A Shepherd, Natasha B Leighl, Andrew F Pierre, David P Goldstein, Wei Xu, and Geoffrey Liu, Princess Margaret Hospital Ontario Cancer Institute University Health Network, University of Toronto Peter Selby, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
J Clin Oncol 32:564-70. 2014..We assessed whether SHS is associated with cessation rates in lung cancer survivors...
- I'll txt U if I have a problem: how the Société canadienne du cancer in Quebec applied behavior-change theory, data mining and agile software development to help young adults quit smokingTrevor van Mierlo
Evolution Health Systems Inc, Toronto, Ontario, Canada
PLoS ONE 9:e91832. 2014..The purpose of this study is to analyze the use of Agile software development and outcomes of a three-phase mHealth program designed to help young adult Quebecers quit smoking...