J Thomas Sanderson
- Antiproliferative, antiandrogenic and cytotoxic effects of novel caffeic acid derivatives in LNCaP human androgen-dependent prostate cancer cellsJ Thomas Sanderson
INRS Institut Armand Frappier, 531, boulevard des Prairies, Laval, QC H7V 1B7, Canada Electronic address
Bioorg Med Chem 21:7182-93. 2013....
- The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicalsJ Thomas Sanderson
INRS Institut Armand Frappier, Universite du Quebec, 245 Hymus Boulevard Pointe Claire, Montreal, Quebec, Canada H9R 1G6
Toxicol Sci 94:3-21. 2006..Considerably more detailed and systematic research in this area of (endocrine) toxicology is required for a better understanding of risks to humans and wildlife...
- Effects of lactone derivatives on aromatase (CYP19) activity in H295R human adrenocortical and (anti)androgenicity in transfected LNCaP human prostate cancer cellsThomas Sanderson
INRS Institut Armand Frappier, 531 Boulevard des Prairies, Laval, QC, Canada
Eur J Pharmacol 593:92-8. 2008..Lactone moiety-containing molecules may form the structural basis for the development of potent drugs effective against hormone-dependent cancers...
- Antiandrogenic and growth inhibitory effects of ring-substituted analogs of 3,3'-diindolylmethane (ring-DIMs) in hormone-responsive LNCaP human prostate cancer cellsKhalil Abdelbaqi
INRS Institut Armand Frappier, Universite du Quebec, Laval, QC, Canada
Prostate 71:1401-12. 2011..Indole-3-carbinol (I3C) and its major metabolite 3,3'-diindolylmethane (DIM), exhibit antitumor activities in vitro and in vivo. Several synthetic ring-substituted dihaloDIMs (ring-DIMs) appear to have increased anticancer activity...
- Evaluation of a bioluminescent mouse model expressing aromatase PII-promoter-controlled luciferase as a tool for the study of endocrine disrupting chemicalsPatricia Rivest
INRS Institut Armand Frappier, Universite du Quebec, 531 blv des Prairies, Laval, QC, Canada H7V 1B7
Toxicol Appl Pharmacol 249:33-40. 2010..In conclusion, certain individual Cyp19-luc mice are highly responsive to aromatase inducers, suggesting this model, with further optimization, may have potential as an in vivo screening tool for environmental contaminants...
- Proliferative and androgenic effects of indirubin derivatives in LNCaP human prostate cancer cells at sub-apoptotic concentrationsPatricia Rivest
INRS Institut Armand Frappier, Universite du Quebec, Laval, QC, Canada
Chem Biol Interact 189:177-85. 2011....
- Antiandrogenic mechanisms of pesticides in human LNCaP prostate and H295R adrenocortical carcinoma cellsChristina N Robitaille
INRS Institut Armand Frappier, Universite du Quebec, 531 Boulevard des Prairies, Laval, Quebec, Canada H7V 1B7
Toxicol Sci 143:126-35. 2015....
- Placental and fetal steroidogenesisJ Thomas Sanderson
Institut National de la Recherche Scientifique INRS Institut Armand Frappier, Universite du Quebec, Laval, Quebec, Canada
Methods Mol Biol 550:127-36. 2009....
- Inhibition and induction of aromatase (CYP19) activity by brominated flame retardants in H295R human adrenocortical carcinoma cellsRocío F Cantón
Institute for Risk Assessment Sciences, IRAS Utrecht University, The Netherlands
Toxicol Sci 88:447-55. 2005..These in vitro results provide a basis for studies of more detailed structure-activity relationships between these brominated compounds and the modulation of aromatase activity...
- A comparison of human H295R and rat R2C cell lines as in vitro screening tools for effects on aromataseMarjoke Heneweer
Institute for Risk Assessment Sciences, Nieuw Gildestein, P O Box 80176, 3508 TD Utrecht, The Netherlands
Toxicol Lett 146:183-94. 2004..The R2C cell line, although not suitable for studying induction, appears to be a more sensitive cell line for studying inhibitory effects of xenobiotics on aromatase activity...
- Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cellsJ Thomas Sanderson
Institute for Risk Assessment Sciences IRAS, University of Utrecht, P O Box 80176, 3508 TD, Utrecht, The Netherlands
Toxicol Appl Pharmacol 182:44-54. 2002....
- Cytochrome P450 1A1 and 1B1 in human blood lymphocytes are not suitable as biomarkers of exposure to dioxin-like compounds: polymorphisms and interindividual variation in expression and inducibilityMajorie B M van Duursen
Institute for Risk Assessment Sciences IRAS, Utrecht University, Yalelaan 2, PO Box 80176, 3508 TD, Utrecht, The Netherlands
Toxicol Sci 85:703-12. 2005....
- In vitro effects of brominated flame retardants and metabolites on CYP17 catalytic activity: a novel mechanism of action?Rocío F Cantón
Institute for Risk Assessment Sciences IRAS, University of Utrecht, Yalelaan 2, 3508 TD, Utrecht, The Netherlands
Toxicol Appl Pharmacol 216:274-81. 2006..These in vitro results indicate that OH and CH(3)O-PBDEs have potential to interfere with CYP17 activity for which the in vivo relevance still has to be adequately determined...
- Co-culture of primary human mammary fibroblasts and MCF-7 cells as an in vitro breast cancer modelMarjoke Heneweer
Institute for Risk Assessment Sciences, Utrecht University, PO Box 80176, 3508 TD Utrecht, The Netherlands
Toxicol Sci 83:257-63. 2005..This co-culture provides a more sophisticated and sensitive system to detect direct and indirect estrogenic effects of compounds and their possible effects on breast tumor promotion...
- Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cellsJ Thomas Sanderson
Institute for Risk Assessment Sciences IRAS, Utrecht University, 3508 TD Utrecht, The Netherlands
Toxicol Sci 82:70-9. 2004..3 promoter-specific aromatase transcripts. These results shed light on the structure-activity relationships for aromatase inhibition as well as mechanisms of induction in human H295R cells...
- Phytochemicals inhibit catechol-O-methyltransferase activity in cytosolic fractions from healthy human mammary tissues: implications for catechol estrogen-induced DNA damageMajorie B M van Duursen
Institute for Risk Assessment Sciences IRAS, Universiteit Utrecht, Utrecht, The Netherlands
Toxicol Sci 81:316-24. 2004....
- Effects of bisphenol A-related diphenylalkanes on vitellogenin production in male carp (Cyprinus carpio) hepatocytes and aromatase (CYP19) activity in human H295R adrenocortical carcinoma cellsRobert J Letcher
National Wildlife Research Centre, Canadian Wildlife Service, Environment Canada, Ottawa, Ontario, Canada K1A 0H3
Toxicol Appl Pharmacol 209:95-104. 2005..Environmental exposure of fish to BPA and related diphenylalkanes, depending on the structure, may pose anti-estrogenic, and to a lesser extent estrogenic, risks to development and reproduction...
- Inhibition of aromatase activity by methyl sulfonyl PCB metabolites in primary culture of human mammary fibroblastsMarjoke Heneweer
Institute for Risk Assessment Sciences, Utrecht University, 3508 TD Utrecht, The Netherlands
Toxicol Appl Pharmacol 202:50-8. 2005..We conclude that in primary human mammary fibroblasts as well as in H295R cells, aromatase inhibition by MeSO(2)-PCBs is likely to be due to catalytic inhibition...