J Thomas Sanderson

Summary

Country: Canada

Publications

  1. doi request reprint Effects of lactone derivatives on aromatase (CYP19) activity in H295R human adrenocortical and (anti)androgenicity in transfected LNCaP human prostate cancer cells
    Thomas Sanderson
    INRS Institut Armand Frappier, 531 Boulevard des Prairies, Laval, QC, Canada
    Eur J Pharmacol 593:92-8. 2008
  2. ncbi request reprint The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals
    J Thomas Sanderson
    INRS Institut Armand Frappier, Universite du Quebec, 245 Hymus Boulevard Pointe Claire, Montreal, Quebec, Canada H9R 1G6
    Toxicol Sci 94:3-21. 2006
  3. doi request reprint Evaluation of a bioluminescent mouse model expressing aromatase PII-promoter-controlled luciferase as a tool for the study of endocrine disrupting chemicals
    Patricia Rivest
    INRS Institut Armand Frappier, Universite du Quebec, 531 blv des Prairies, Laval, QC, Canada H7V 1B7
    Toxicol Appl Pharmacol 249:33-40. 2010
  4. doi request reprint Antiandrogenic and growth inhibitory effects of ring-substituted analogs of 3,3'-diindolylmethane (ring-DIMs) in hormone-responsive LNCaP human prostate cancer cells
    Khalil Abdelbaqi
    INRS Institut Armand Frappier, Universite du Quebec, Laval, QC, Canada
    Prostate 71:1401-12. 2011
  5. doi request reprint Proliferative and androgenic effects of indirubin derivatives in LNCaP human prostate cancer cells at sub-apoptotic concentrations
    Patricia Rivest
    INRS Institut Armand Frappier, Universite du Quebec, Laval, QC, Canada
    Chem Biol Interact 189:177-85. 2011
  6. doi request reprint Placental and fetal steroidogenesis
    J Thomas Sanderson
    Institut National de la Recherche Scientifique INRS Institut Armand Frappier, Universite du Quebec, Laval, Quebec, Canada
    Methods Mol Biol 550:127-36. 2009
  7. ncbi request reprint Inhibition and induction of aromatase (CYP19) activity by brominated flame retardants in H295R human adrenocortical carcinoma cells
    Rocío F Cantón
    Institute for Risk Assessment Sciences, IRAS Utrecht University, The Netherlands
    Toxicol Sci 88:447-55. 2005
  8. ncbi request reprint A comparison of human H295R and rat R2C cell lines as in vitro screening tools for effects on aromatase
    Marjoke Heneweer
    Institute for Risk Assessment Sciences, Nieuw Gildestein, P O Box 80176, 3508 TD Utrecht, The Netherlands
    Toxicol Lett 146:183-94. 2004
  9. ncbi request reprint Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells
    J Thomas Sanderson
    Institute for Risk Assessment Sciences IRAS, University of Utrecht, P O Box 80176, 3508 TD, Utrecht, The Netherlands
    Toxicol Appl Pharmacol 182:44-54. 2002
  10. ncbi request reprint Effects of bisphenol A-related diphenylalkanes on vitellogenin production in male carp (Cyprinus carpio) hepatocytes and aromatase (CYP19) activity in human H295R adrenocortical carcinoma cells
    Robert J Letcher
    National Wildlife Research Centre, Canadian Wildlife Service, Environment Canada, Ottawa, Ontario, Canada K1A 0H3
    Toxicol Appl Pharmacol 209:95-104. 2005

Collaborators

  • R J Letcher
  • Patricia Rivest
  • Marjoke Heneweer
  • Martin van den Berg
  • Rocío F Cantón
  • Majorie B M van Duursen
  • Khalil Abdelbaqi
  • Thomas Sanderson
  • Sandra Nijmeijer
  • Ake Bergman
  • Nathan Lack
  • Stephen Safe
  • Leela Kotha
  • Emma Tomlinson Guns
  • Colleen Nelson
  • Somsak Ruchirawat
  • Simon Cowell
  • Martin Renaud
  • Thumnoon Mutarapat
  • Deborah Scholten
  • Emma Guns
  • Paul C de Jong
  • Marlies Kraaij

Detail Information

Publications16

  1. doi request reprint Effects of lactone derivatives on aromatase (CYP19) activity in H295R human adrenocortical and (anti)androgenicity in transfected LNCaP human prostate cancer cells
    Thomas Sanderson
    INRS Institut Armand Frappier, 531 Boulevard des Prairies, Laval, QC, Canada
    Eur J Pharmacol 593:92-8. 2008
    ..Lactone moiety-containing molecules may form the structural basis for the development of potent drugs effective against hormone-dependent cancers...
  2. ncbi request reprint The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals
    J Thomas Sanderson
    INRS Institut Armand Frappier, Universite du Quebec, 245 Hymus Boulevard Pointe Claire, Montreal, Quebec, Canada H9R 1G6
    Toxicol Sci 94:3-21. 2006
    ..Considerably more detailed and systematic research in this area of (endocrine) toxicology is required for a better understanding of risks to humans and wildlife...
  3. doi request reprint Evaluation of a bioluminescent mouse model expressing aromatase PII-promoter-controlled luciferase as a tool for the study of endocrine disrupting chemicals
    Patricia Rivest
    INRS Institut Armand Frappier, Universite du Quebec, 531 blv des Prairies, Laval, QC, Canada H7V 1B7
    Toxicol Appl Pharmacol 249:33-40. 2010
    ..In conclusion, certain individual Cyp19-luc mice are highly responsive to aromatase inducers, suggesting this model, with further optimization, may have potential as an in vivo screening tool for environmental contaminants...
  4. doi request reprint Antiandrogenic and growth inhibitory effects of ring-substituted analogs of 3,3'-diindolylmethane (ring-DIMs) in hormone-responsive LNCaP human prostate cancer cells
    Khalil Abdelbaqi
    INRS Institut Armand Frappier, Universite du Quebec, Laval, QC, Canada
    Prostate 71:1401-12. 2011
    ..Indole-3-carbinol (I3C) and its major metabolite 3,3'-diindolylmethane (DIM), exhibit antitumor activities in vitro and in vivo. Several synthetic ring-substituted dihaloDIMs (ring-DIMs) appear to have increased anticancer activity...
  5. doi request reprint Proliferative and androgenic effects of indirubin derivatives in LNCaP human prostate cancer cells at sub-apoptotic concentrations
    Patricia Rivest
    INRS Institut Armand Frappier, Universite du Quebec, Laval, QC, Canada
    Chem Biol Interact 189:177-85. 2011
    ....
  6. doi request reprint Placental and fetal steroidogenesis
    J Thomas Sanderson
    Institut National de la Recherche Scientifique INRS Institut Armand Frappier, Universite du Quebec, Laval, Quebec, Canada
    Methods Mol Biol 550:127-36. 2009
    ....
  7. ncbi request reprint Inhibition and induction of aromatase (CYP19) activity by brominated flame retardants in H295R human adrenocortical carcinoma cells
    Rocío F Cantón
    Institute for Risk Assessment Sciences, IRAS Utrecht University, The Netherlands
    Toxicol Sci 88:447-55. 2005
    ..These in vitro results provide a basis for studies of more detailed structure-activity relationships between these brominated compounds and the modulation of aromatase activity...
  8. ncbi request reprint A comparison of human H295R and rat R2C cell lines as in vitro screening tools for effects on aromatase
    Marjoke Heneweer
    Institute for Risk Assessment Sciences, Nieuw Gildestein, P O Box 80176, 3508 TD Utrecht, The Netherlands
    Toxicol Lett 146:183-94. 2004
    ..The R2C cell line, although not suitable for studying induction, appears to be a more sensitive cell line for studying inhibitory effects of xenobiotics on aromatase activity...
  9. ncbi request reprint Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells
    J Thomas Sanderson
    Institute for Risk Assessment Sciences IRAS, University of Utrecht, P O Box 80176, 3508 TD, Utrecht, The Netherlands
    Toxicol Appl Pharmacol 182:44-54. 2002
    ....
  10. ncbi request reprint Effects of bisphenol A-related diphenylalkanes on vitellogenin production in male carp (Cyprinus carpio) hepatocytes and aromatase (CYP19) activity in human H295R adrenocortical carcinoma cells
    Robert J Letcher
    National Wildlife Research Centre, Canadian Wildlife Service, Environment Canada, Ottawa, Ontario, Canada K1A 0H3
    Toxicol Appl Pharmacol 209:95-104. 2005
    ..Environmental exposure of fish to BPA and related diphenylalkanes, depending on the structure, may pose anti-estrogenic, and to a lesser extent estrogenic, risks to development and reproduction...
  11. ncbi request reprint Cytochrome P450 1A1 and 1B1 in human blood lymphocytes are not suitable as biomarkers of exposure to dioxin-like compounds: polymorphisms and interindividual variation in expression and inducibility
    Majorie B M van Duursen
    Institute for Risk Assessment Sciences IRAS, Utrecht University, Yalelaan 2, PO Box 80176, 3508 TD, Utrecht, The Netherlands
    Toxicol Sci 85:703-12. 2005
    ....
  12. ncbi request reprint Inhibition of aromatase activity by methyl sulfonyl PCB metabolites in primary culture of human mammary fibroblasts
    Marjoke Heneweer
    Institute for Risk Assessment Sciences, Utrecht University, 3508 TD Utrecht, The Netherlands
    Toxicol Appl Pharmacol 202:50-8. 2005
    ..We conclude that in primary human mammary fibroblasts as well as in H295R cells, aromatase inhibition by MeSO(2)-PCBs is likely to be due to catalytic inhibition...
  13. ncbi request reprint In vitro effects of brominated flame retardants and metabolites on CYP17 catalytic activity: a novel mechanism of action?
    Rocío F Cantón
    Institute for Risk Assessment Sciences IRAS, University of Utrecht, Yalelaan 2, 3508 TD, Utrecht, The Netherlands
    Toxicol Appl Pharmacol 216:274-81. 2006
    ..These in vitro results indicate that OH and CH(3)O-PBDEs have potential to interfere with CYP17 activity for which the in vivo relevance still has to be adequately determined...
  14. ncbi request reprint Co-culture of primary human mammary fibroblasts and MCF-7 cells as an in vitro breast cancer model
    Marjoke Heneweer
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80176, 3508 TD Utrecht, The Netherlands
    Toxicol Sci 83:257-63. 2005
    ..This co-culture provides a more sophisticated and sensitive system to detect direct and indirect estrogenic effects of compounds and their possible effects on breast tumor promotion...
  15. ncbi request reprint Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells
    J Thomas Sanderson
    Institute for Risk Assessment Sciences IRAS, Utrecht University, 3508 TD Utrecht, The Netherlands
    Toxicol Sci 82:70-9. 2004
    ..3 promoter-specific aromatase transcripts. These results shed light on the structure-activity relationships for aromatase inhibition as well as mechanisms of induction in human H295R cells...
  16. ncbi request reprint Phytochemicals inhibit catechol-O-methyltransferase activity in cytosolic fractions from healthy human mammary tissues: implications for catechol estrogen-induced DNA damage
    Majorie B M van Duursen
    Institute for Risk Assessment Sciences IRAS, Universiteit Utrecht, Utrecht, The Netherlands
    Toxicol Sci 81:316-24. 2004
    ....