B Zinman

Summary

Affiliation: Samuel Lunenfeld Research Institute
Country: Canada

Publications

  1. ncbi Relationship of the metabolic syndrome to carotid ultrasound traits
    Rebecca L Pollex
    Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Ultrasound 4:28. 2006
  2. ncbi A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes
    Rebecca L Pollex
    Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Ultrasound 3:15. 2005
  3. ncbi Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample
    Salam A Al-Attar
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Diabetol 7:5. 2008
  4. ncbi Assessing the association of the HNF1A G319S variant with C-reactive protein in Aboriginal Canadians: a population-based epidemiological study
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Cardiovasc Diabetol 9:39. 2010
  5. ncbi Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes
    Rebecca L Pollex
    Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Diabetol 4:17. 2005
  6. ncbi Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample
    Rebecca L Pollex
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    BMC Med Genet 8:80. 2007
  7. ncbi HNF1A G319S variant, active cigarette smoking and incident type 2 diabetes in Aboriginal Canadians: a population-based epidemiological study
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    BMC Med Genet 12:1. 2011
  8. ncbi Effectiveness of human ultralente versus NPH insulin in providing basal insulin replacement for an insulin lispro multiple daily injection regimen. A double-blind randomized prospective trial. The Canadian Lispro Study Group
    B Zinman
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 22:603-8. 1999
  9. ncbi Circulating tumor necrosis factor-alpha concentrations in a native Canadian population with high rates of type 2 diabetes mellitus
    B Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Banting and Best Diabetes Center, University of Toronto, Ontario, Canada
    J Clin Endocrinol Metab 84:272-8. 1999
  10. ncbi The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and University of Toronto, Toronto, Ontario, Canada
    Ann Intern Med 146:477-85. 2007

Detail Information

Publications133 found, 100 shown here

  1. ncbi Relationship of the metabolic syndrome to carotid ultrasound traits
    Rebecca L Pollex
    Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Ultrasound 4:28. 2006
    ..We evaluated two carotid ultrasound measurements, namely intima media thickness and total plaque volume, in a Canadian Oji-Cree population with a high metabolic syndrome prevalence rate...
  2. ncbi A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes
    Rebecca L Pollex
    Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Ultrasound 3:15. 2005
    ..Thus, the objective of this study was to compare the traditional intima-media thickness measurement against the novel total plaque volume measurement in analyzing carotid atherosclerosis development in individuals with type 2 diabetes...
  3. ncbi Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample
    Salam A Al-Attar
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Diabetol 7:5. 2008
    ..The objective of this study is to examine whether this association extends to metabolic syndrome (MetS) and applies in non-Caucasian samples...
  4. ncbi Assessing the association of the HNF1A G319S variant with C-reactive protein in Aboriginal Canadians: a population-based epidemiological study
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Cardiovasc Diabetol 9:39. 2010
    ..We aimed to investigate whether CRP was mediating the association between HNF1A G319S and type 2 diabetes in an Aboriginal Canadian population with a high prevalence of diabetes...
  5. ncbi Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes
    Rebecca L Pollex
    Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Diabetol 4:17. 2005
    ..The objective of this study was to investigate a possible role for the MTHFR 677C>T gene polymorphism with PAD in subjects with type 2 diabetes from an isolated aboriginal Canadian population...
  6. ncbi Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample
    Rebecca L Pollex
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    BMC Med Genet 8:80. 2007
    ..The objective of this study is to examine the APOC3 -455T>C and the INSIG2 rs7566605 polymorphisms as potential genetic determinants for MetS in a multi-ethnic sample...
  7. ncbi HNF1A G319S variant, active cigarette smoking and incident type 2 diabetes in Aboriginal Canadians: a population-based epidemiological study
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    BMC Med Genet 12:1. 2011
    ..We aimed to investigate the association of the HNF1A G319S polymorphism with incident type 2 diabetes and to assess whether clinical risk variables for type 2 diabetes influence the association in an Aboriginal population...
  8. ncbi Effectiveness of human ultralente versus NPH insulin in providing basal insulin replacement for an insulin lispro multiple daily injection regimen. A double-blind randomized prospective trial. The Canadian Lispro Study Group
    B Zinman
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 22:603-8. 1999
    ..To compare human ultralente (UL) insulin with human NPH insulin as basal insulin replacement in patients who use insulin lispro before meals...
  9. ncbi Circulating tumor necrosis factor-alpha concentrations in a native Canadian population with high rates of type 2 diabetes mellitus
    B Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Banting and Best Diabetes Center, University of Toronto, Ontario, Canada
    J Clin Endocrinol Metab 84:272-8. 1999
    ..The data suggest a possible role for TNF alpha in the pathophysiology of insulin resistance...
  10. ncbi The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and University of Toronto, Toronto, Ontario, Canada
    Ann Intern Med 146:477-85. 2007
    ..Exenatide therapy is effective in combination with metformin or sulfonylureas for treating type 2 diabetes. Thiazolidinediones (TZDs) also are commonly used, but the efficacy of exenatide with a TZD has not been reported...
  11. ncbi Type 2 diabetes mellitus: magnitude of the problem and failure to achieve glycemic control
    Bernard Zinman
    Leadership Sinai Centre for Diabetes, University of Toronto, Toronto, Ontario, Canada
    Endocrinol Metab Clin North Am 35:3-5; discussion 17-19. 2006
  12. ncbi Preventing type 2 diabetes using combination therapy: design and methods of the CAnadian Normoglycaemia Outcomes Evaluation (CANOE) trial
    B Zinman
    Leadership Sinai Centre for Diabetes, Department of Medicine, Mount Sinai Hospital and the University of Toronto, Toronto, Ontario, Canada
    Diabetes Obes Metab 8:531-7. 2006
    ..In conclusion, the CANOE study will determine whether combination pharmacological therapy combined with a lifestyle intervention programme can significantly modify the development of diabetes in high-risk Canadians...
  13. ncbi Common genomic variation in the APOC3 promoter associated with variation in plasma lipoproteins
    R A Hegele
    Department of Medicine, St Michael s Hospital, London, Canada
    Arterioscler Thromb Vasc Biol 17:2753-8. 1997
    ..However, the associations could also have resulted from linkage disequilibrium with other functional variants in APOC3 or the closely linked APOA1 and/or APOA4 genes...
  14. ncbi Common genomic variants associated with variation in plasma lipoproteins in young aboriginal Canadians
    R A Hegele
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 17:1060-6. 1997
    ..045, and P = .047, respectively). The average young age and relative absence of age-dependent secondary environmental factors could have eased the identification of small genetic effects on lipoprotein phenotypes in this study sample...
  15. ncbi Absence of association between genetic variation of the beta 3-adrenergic receptor and metabolic phenotypes in Oji-Cree
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, London, Ontario, Canada
    Diabetes Care 21:851-4. 1998
    ..To assess the association between the common missense variant, Y64R, in the gene encoding the beta 3-adrenergic receptor, ADRB3, and intermediate phenotypes related to obesity and NIDDM in Canadian Oji-Cree...
  16. ncbi Prevalence and determinants of microalbuminuria in high-risk diabetic and nondiabetic patients in the Heart Outcomes Prevention Evaluation Study. The HOPE Study Investigators
    H C Gerstein
    McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 23:B35-9. 2000
    ....
  17. ncbi Gender, obesity, hepatic nuclear factor-1alpha G319S and the age-of-onset of type 2 diabetes in Canadian Oji-Cree
    R A Hegele
    John P Robarts Research Institute, London, Ontario, Canada
    Int J Obes Relat Metab Disord 24:1062-4. 2000
    ..One factor that might account for the gender difference in the onset of HNF1A S319-associated type 2 diabetes is the greater prevalence and severity, and earlier onset of, obesity among female Oji-Cree...
  18. ncbi Maternal pregravid weight is the primary determinant of serum leptin and its metabolic associations in pregnancy, irrespective of gestational glucose tolerance status
    L Maple-Brown
    Leadership Sinai Centre for Diabetes, 60 Murray Street, Suite L5 025, Mailbox 21, Toronto, Ontario, Canada M5T 3L9
    J Clin Endocrinol Metab 97:4148-55. 2012
    ..However, these studies have yielded markedly conflicting results, including increased, decreased, and unchanged leptin levels in women with GDM as compared with their peers...
  19. ncbi Increased plasma apolipoprotein B-containing lipoproteins associated with increased urinary albumin within the microalbuminuria range in type 2 diabetes
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, John P Robarts Research Institute, London, Ontario, Canada
    Clin Biochem 32:143-8. 1999
    ....
  20. ncbi Adiponectin and beta cell dysfunction in gestational diabetes: pathophysiological implications
    R Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabetologia 48:993-1001. 2005
    ..We conducted the current investigation to determine whether adiponectin is associated with beta cell dysfunction in GDM...
  21. ncbi G protein beta3 subunit gene variant and blood pressure variation in Canadian Oji-Cree
    R A Hegele
    Robarts Research Institute and Department of Medicine, Thames Valley Family Practice Research Unit, University of Western Ontario, London, Ontario, Canada
    Hypertension 32:688-92. 1998
    ..571 versus 0.496; P=NS), although this young sample had relatively few subjects with hypertension. The findings support an association of variation in this gene with variation in blood pressure...
  22. ncbi NAT2 polymorphism associated with plasma glucose concentration in Canadian Oji-Cree
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, London, Ontario, Canada
    Pharmacogenetics 10:233-8. 2000
    ..However, NAT2 might be a 'modifier gene' affecting the level of glycaemia in non-diabetic subjects...
  23. ncbi -6A promoter variant of angiotensinogen and blood pressure variation in Canadian Oji-Cree
    R A Hegele
    St Michael s Hospital, Toronto, Ontario, Canada
    J Hum Genet 43:37-41. 1998
    ..Our findings are consistent with a marginally deleterious effect of the AGT -6A allele on blood pressure, but linkage disequilibrium with another causative variant cannot be ruled out in this sample of aboriginal Canadians...
  24. ncbi Association between AGT codon 235 polymorphism and variation in serum concentrations of creatinine and urea in Canadian Oji-Cree
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, London, Ontario, Canada
    Clin Genet 55:438-43. 1999
    ..The findings suggest that the AGT T235 allele is a determinant of intermediate traits related to renal function in these aboriginal Canadians...
  25. ncbi The postpartum cardiovascular risk factor profile of women with isolated hyperglycemia at 1-hour on the oral glucose tolerance test in pregnancy
    R Retnakaran
    Leadership Sinai Centre for Diabetes, 60 Murray Street, Toronto, Ontario, Canada
    Nutr Metab Cardiovasc Dis 21:706-12. 2011
    ....
  26. ncbi Low adiponectin concentration during pregnancy predicts postpartum insulin resistance, beta cell dysfunction and fasting glycaemia
    R Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, 60 Murray Street, Suite L5 039, Mailbox 21, Toronto, ON, Canada
    Diabetologia 53:268-76. 2010
    ..Thus, we sought to determine whether adiponectin, leptin and CRP levels during pregnancy relate to the postpartum metabolic defects linking GDM with type 2 diabetes...
  27. ncbi Variable association between genetic variation in the CYP7 gene promoter and plasma lipoproteins in three Canadian populations
    R A Hegele
    Department of Medicine, Blackburn Cardiovascular Genetics Laboratory, John P Robarts Research Institute, University of Western Ontario, 406 100 Perth Drive, Ont, N6A 5K8, London, Canada
    Atherosclerosis 154:579-87. 2001
    ..The inconsistencies could be due to differences in genetic background or to unspecified environmental or genetic factors...
  28. ncbi Cross-sectional and prospective associations between proinsulin and cardiovascular disease risk factors in a population experiencing rapid cultural transition
    A J Hanley
    Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 24:1240-7. 2001
    ..CONCLUSIONS: These results confirm previously reported cross-sectional associations between proinsulin and lipid concentrations. In addition, an unexpected association between baseline lipids and proinsulin change was documented...
  29. ncbi Angiotensinogen gene variation associated with variation in blood pressure in aboriginal Canadians
    R A Hegele
    St Michael s Hospital Health Sciences Research Centre, Toronto, Ontario, Canada
    Hypertension 29:1073-7. 1997
    ..The high frequency of the angiotensinogen T235 variant suggests that subjects in this young, essentially normotensive population might be predisposed to hypertension, which may become more apparent in the presence of secondary factors...
  30. ncbi Absence of association between genetic variation in the LIPC gene promoter and plasma lipoproteins in three Canadian populations
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, Department of Medicine, London, Ont, Canada
    Atherosclerosis 146:153-60. 1999
    ....
  31. ncbi Elevated C-reactive protein in Native Canadian children: an ominous early complication of childhood obesity
    R Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabetes Obes Metab 8:483-91. 2006
    ..CONCLUSION: Subclinical inflammation is an early complication of childhood obesity in Native children and may foreshadow an increased burden of CVD and type 2 diabetes in the future...
  32. ncbi Relation of waist circumference and glycemic status to C-reactive protein in the Sandy Lake Oji-Cree
    P W Connelly
    Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada
    Int J Obes Relat Metab Disord 27:347-54. 2003
    ....
  33. ncbi Characteristics and prevalence of the metabolic syndrome among three ethnic groups in Canada
    J Liu
    Department of Public Health Science, University of Toronto, Toronto, Ontario, Canada
    Int J Obes (Lond) 30:669-76. 2006
    ..Given the diverse nature of these populations, careful consideration should be given to developing culturally appropriate community-based prevention strategies aimed at reducing the frequency of this syndrome...
  34. ncbi Discordant effects on central obesity, hepatic insulin resistance, and alanine aminotransferase of low-dose metformin and thiazolidinedione combination therapy in patients with impaired glucose tolerance
    R Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Obes Metab 14:91-3. 2012
    ..In contrast, Rosi/Met lowered ALT in year 1 and maintained this effect throughout the trial. Thus, low-dose Rosi/Met had no effect on central obesity, a transient effect on hepatic insulin sensitivity, and a sustained effect on ALT...
  35. ncbi Association between AGT T235 variant and microalbuminuria in Canadian Oji-Cree with type 2 diabetes mellitus
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, London, Ontario, Canada
    Clin Biochem 32:201-5. 1999
    ..To assess the association between the common variation in the gene encoding angiotensinogen, AGT, and the presence of microalbuminuria in Canadian Oji-Cree with type 2 diabetes mellitus...
  36. ncbi Disparity between association and linkage analysis for HNF1A G319S in type 2 diabetes in Canadian Oji-Cree
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, John P Roberts Research Institute, London, Ontario, Canada
    J Hum Genet 45:184-7. 2000
    ..Furthermore, our experience confirms the value of using several complementary strategies to identify susceptibility genes for a complex disease...
  37. ncbi Decreased high-molecular-weight adiponectin in gestational diabetes: implications for the pathophysiology of Type 2 diabetes
    R Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Canada
    Diabet Med 24:245-52. 2007
    ..e. representing an early stage in the natural history of the disease), we sought to determine if decreased HMW adiponectin is a feature of GDM...
  38. ncbi Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in noninsulin-dependent diabetes mellitus
    R A Hegele
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 82:3373-7. 1997
    ....
  39. ncbi Clinical and genetic associations with hypertriglyceridemic waist in a Canadian aboriginal population
    R L Pollex
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute and University of Western Ontario, London, Ontario, Canada
    Int J Obes (Lond) 30:484-91. 2006
    ....
  40. ncbi Hypoadiponectinaemia in South Asian women during pregnancy: evidence of ethnic variation in adiponectin concentration
    R Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabet Med 21:388-92. 2004
    ..This observation raises the possibility of hypoadiponectinaemia as a potential factor contributing to the increased risk of diabetes and cardiovascular disease in South Asians...
  41. ncbi Low dietary fiber and high protein intakes associated with newly diagnosed diabetes in a remote aboriginal community
    T M Wolever
    Department of Nutritional Sciences and Medicine, University of Toronto, Ontario, Canada
    Am J Clin Nutr 66:1470-4. 1997
    ..These data support Trowell's original dietary-fiber hypothesis that "... dietary fiber depleted starchy foods are conducive to the development of diabetes mellitus in susceptible human genotypes."..
  42. ncbi Initial short-term intensive insulin therapy as a strategy for evaluating the preservation of beta-cell function with oral antidiabetic medications: a pilot study with sitagliptin
    R Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Obes Metab 12:909-15. 2010
    ..We applied this strategy to assess the effect of sitagliptin on beta-cell function...
  43. ncbi Rationale and design of a large study to evaluate the renal and cardiovascular effects of an ACE inhibitor and vitamin E in high-risk patients with diabetes. The MICRO-HOPE Study. Microalbuminuria, cardiovascular, and renal outcomes. Heart Outcomes Preven
    H C Gerstein
    McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 19:1225-8. 1996
    ....
  44. ncbi Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia
    A Giacca
    Department of Medicine, University of Toronto, Canada
    Diabetes 47:1763-70. 1998
    ....
  45. ncbi Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 32:1224-30. 2009
    ..To determine the efficacy and safety of liraglutide (a glucagon-like peptide-1 receptor agonist) when added to metformin and rosiglitazone in type 2 diabetes...
  46. ncbi Ethnicity modifies the effect of obesity on insulin resistance in pregnancy: a comparison of Asian, South Asian, and Caucasian women
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada M5G 1L5
    J Clin Endocrinol Metab 91:93-7. 2006
    ..Prepregnancy BMI has a much greater effect on insulin resistance in pregnancy in Asian women than in Caucasians. Ethnicity thus emerges as a factor that modulates the effect of obesity on insulin resistance in pregnancy...
  47. ncbi Nontraditional cardiovascular risk factors in pediatric metabolic syndrome
    Ravi Retnakaran
    Division of Endocrinology, The Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Pediatr 148:176-82. 2006
    ..Furthermore, inclusion of these factors in factor analysis suggests that 5 core traits underlie the early development of an enhanced CV risk factor profile in Native children...
  48. ncbi Utility of non-high-density lipoprotein cholesterol in assessing incident type 2 diabetes risk
    S H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    Diabetes Obes Metab 14:821-5. 2012
    ....
  49. ncbi Genome-wide scanning for type 2 diabetes susceptibility in Canadian Oji-Cree, using 190 microsatellite markers
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, John P Robarts Research Institute, London, Ontario, Canada
    J Hum Genet 44:10-4. 1999
    ..Thus, different marker sets will likely be required for different ethnic groups in order to maximize their information content for linkage calculations...
  50. ncbi Common and rare ABCA1 variants affecting plasma HDL cholesterol
    J Wang
    John P Robarts Research Institute, London, Ontario, Canada
    Arterioscler Thromb Vasc Biol 20:1983-9. 2000
    ....
  51. ncbi The impact of insulin resistance on proinsulin secretion in pregnancy: hyperproinsulinemia is not a feature of gestational diabetes
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 28:2710-5. 2005
    ..These data suggest that relative proinsulin secretion in late pregnancy is primarily related to insulin resistance and does not necessarily reflect beta-cell function...
  52. ncbi Lifestyle variables, non-traditional cardiovascular risk factors, and the metabolic syndrome in an Aboriginal Canadian population
    Juan Liu
    Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
    Obesity (Silver Spring) 14:500-8. 2006
    ....
  53. ncbi Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Obesity (Silver Spring) 16:1901-7. 2008
    ..Based on these findings, the product of these two indices emerges as a potential OGTT-based measure of beta-cell function...
  54. ncbi Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Ont
    CMAJ 180:617-24. 2009
    ..We aimed to determine the incidence of type 2 diabetes in an Aboriginal community and to evaluate prospective associations with metabolic syndrome and its components...
  55. ncbi Free fatty acid-mediated impairment of glucose-stimulated insulin secretion in nondiabetic Oji-Cree individuals from the Sandy Lake community of Ontario, Canada: a population at very high risk for developing type 2 diabetes
    Andre Carpentier
    Department of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Diabetes 52:1485-95. 2003
    ..Whether this reflects an inherent resistance to lipotoxicity or an already-present lipotoxic effect in this population will require further study...
  56. ncbi Low-dose combination therapy with rosiglitazone and metformin to prevent type 2 diabetes mellitus (CANOE trial): a double-blind randomised controlled study
    Bernard Zinman
    Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada
    Lancet 376:103-11. 2010
    ..The CANOE (CAnadian Normoglycemia Outcomes Evaluation) trial investigated whether low-dose combination therapy would affect development of type 2 diabetes...
  57. ncbi Effect of Rosiglitazone and Ramipril on {beta}-cell function in people with impaired glucose tolerance or impaired fasting glucose: the DREAM trial
    Anthony J Hanley
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Diabetes Care 33:608-13. 2010
    ....
  58. ncbi Short-term intensified insulin treatment in type 2 diabetes: long-term effects on β-cell function
    R Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Obes Metab 14:161-6. 2012
    ..In this report, we will review the rationale and evidence underlying this interesting therapeutic option, and its implications for both clinical research and the management of patients with T2DM...
  59. ncbi Intensive insulin therapy with insulin lispro: a randomized trial of continuous subcutaneous insulin infusion versus multiple daily insulin injection
    E Tsui
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 24:1722-7. 2001
    ..5% HbA(1c) between the two regimens can be confidently ruled out. We conclude that the choice of intensive insulin therapy should be a matter of patient preference, consistent with lifestyle...
  60. ncbi The response to short-term intensive insulin therapy in type 2 diabetes
    R Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada
    Diabetes Obes Metab 12:65-71. 2010
    ..Thus, we sought to evaluate the effect of short-term IIT in patients with established T2DM...
  61. ncbi Effect of rosiglitazone, metformin, and glyburide on bone biomarkers in patients with type 2 diabetes
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital and University of Toronto, Ontario, Canada
    J Clin Endocrinol Metab 95:134-42. 2010
    ..An increase in bone fractures has been observed in women taking thiazolidinediones...
  62. ncbi Maternal insulin sensitivity during pregnancy predicts infant weight gain and adiposity at 1 year of age
    Jill K Hamilton
    Hospital for Sick Children, Department of Pediatrics, Toronto, Ontario, Canada
    Obesity (Silver Spring) 18:340-6. 2010
    ..Further longitudinal study to evaluate obesity in this group of children will increase our understanding of the contribution of the intrauterine environment to their long-term health...
  63. ncbi Association of hematological parameters with insulin resistance and beta-cell dysfunction in nondiabetic subjects
    Anthony J G Hanley
    Department of Nutritional Sciences, University of Toronto, Fitzgerald Building, Toronto, Ontario, Canada M5S 3E2
    J Clin Endocrinol Metab 94:3824-32. 2009
    ....
  64. ncbi Isolated hyperglycemia at 1 hour on oral glucose tolerance test in pregnancy resembles gestational diabetes mellitus in predicting postpartum metabolic dysfunction
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Care 31:1275-81. 2008
    ..Thus, we hypothesized that 1-h GIGT would be associated with the same adverse outcomes as GDM, i.e., increased infant birth weight and postpartum metabolic dysfunction...
  65. ncbi C-reactive protein and gestational diabetes: the central role of maternal obesity
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto M5G 1X5, Ontario, Canada
    J Clin Endocrinol Metab 88:3507-12. 2003
    ..These data suggest a model in which obesity mediates a systemic inflammatory response, with possible downstream metabolic sequelae, including insulin resistance and glucose dysregulation...
  66. ncbi Genetic variation of intestinal fatty acid-binding protein associated with variation in body mass in aboriginal Canadians
    R A Hegele
    St Michael s Hospital Health Sciences Research Center, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 81:4334-7. 1996
    ..These findings suggest that the T54 variant of the intestinal fatty acid-binding protein is associated with differences in fat metabolism in this aboriginal population...
  67. ncbi Association of a single nucleotide polymorphism in CPB2 encoding the thrombin-activable fibrinolysis inhibitor (TAF1) with blood pressure
    M L Koschinsky
    Department of a Biochemistry, Queen s University, Kingston, Ontario, Canada
    Clin Genet 60:345-9. 2001
    ..Although the mechanism underlying the association is unclear, the findings are of interest because TAFI may provide a link between coagulation and blood pressure regulation...
  68. ncbi Cross-sectional and prospective associations between abdominal adiposity and proinsulin concentration
    Anthony J G Hanley
    Department of Public Health Sciences, University of Toronto, Ontario M5S 1A8, Canada
    J Clin Endocrinol Metab 87:77-83. 2002
    ..24, P = 0.03, respectively). These data highlight the detrimental effects of abdominal obesity on beta-cell function, and support the hypothesis that beta-cell dysfunction occurs early in the natural history of glucose intolerance...
  69. ncbi Low serum levels of high-molecular weight adiponectin in Indo-Asian women during pregnancy: evidence of ethnic variation in adiponectin isoform distribution
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G1X5
    Diabetes Care 29:1377-9. 2006
  70. ncbi Adiponectin in a native Canadian population experiencing rapid epidemiological transition
    Anthony J G Hanley
    Leadership Sinai Centre for Diabetes, Mt Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 26:3219-25. 2003
    ....
  71. ncbi Association of parity with risk of type 2 diabetes and related metabolic disorders
    Anthony J G Hanley
    Department of Public Health Sciences, University of Toronto, Toronto, Canada
    Diabetes Care 25:690-5. 2002
    ..The objective of this study was to investigate the association between parity and risk of glucose intolerance and related metabolic disorders using data from a population-based study in a Native Canadian community...
  72. ncbi Complications of Type 2 Diabetes Among Aboriginal Canadians: prevalence and associated risk factors
    Anthony J G Hanley
    Leadership Sinai Centre for Diabetes, Lebovic Building, Room 5-210, Mt. Sinai Hospital, 600 University Ave, Toronto, Ontario, M5G 1X5, Canada
    Diabetes Care 28:2054-7. 2005
  73. ncbi Achieving a clinically relevant composite outcome of an HbA1c of <7% without weight gain or hypoglycaemia in type 2 diabetes: a meta-analysis of the liraglutide clinical trial programme
    B Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Diabetes Obes Metab 14:77-82. 2012
    ....
  74. ncbi Cigarette smoking and cardiovascular risk factors among Aboriginal Canadian youths
    Ravi Retnakaran
    Division of Endocrinology, Department of Medicine, University of Toronto, Toronto, Ont
    CMAJ 173:885-9. 2005
    ..The association of cigarette smoking with an enhanced cardiovascular risk profile at an early age may be a factor contributing to the high prevalence of cardiovascular disease in this Aboriginal population...
  75. ncbi Diabetes care in the U.S. and Canada
    Gillian L Booth
    Department of Medicine, Division of Endocrinology and Metabolism, St Michael s Hospital, Toronto, Ontario, Canada
    Diabetes Care 25:1149-53. 2002
    ..To compare the glycemic control of patients with type 1 diabetes treated in the U.S. and Canada...
  76. ncbi Continuous subcutaneous insulin infusion versus multiple daily injections: the impact of baseline A1c
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 27:2590-6. 2004
    ..Thus, CSII emerges as an important modality for implementing intensive therapy and may be uniquely advantageous in patients with poor glycemic control...
  77. ncbi Adipokines and incident type 2 diabetes in an Aboriginal Canadian [corrected] population: the Sandy Lake Health and Diabetes Project
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 31:1410-5. 2008
    ....
  78. ncbi Reduced adiponectin concentration in women with gestational diabetes: a potential factor in progression to type 2 diabetes
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 27:799-800. 2004
  79. ncbi Comparison of National Diabetes Data Group and American Diabetes Association diagnostic criteria for gestational diabetes in their identification of postpartum risk of glucose intolerance
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Res Clin Pract 85:40-6. 2009
    ....
  80. ncbi Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals
    H C Gerstein
    Department of Medicine, Room 3V38, 1200 Main St W, Hamilton, Ontario, L8N 3Z5
    JAMA 286:421-6. 2001
    ..Microalbuminuria is a risk factor for cardiovascular (CV) events. The relationship between the degree of albuminuria and CV risk is unclear...
  81. ncbi Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy
    Eva Lonn
    Department of Medicine and Population Health Institute, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 25:1919-27. 2002
    ..However, data from randomized clinical trials are limited. Therefore, we evaluated the effects of vitamin E supplementation on major CV outcomes and on the development of nephropathy in people with diabetes...
  82. ncbi Changes in diabetes self-care behaviors make a difference in glycemic control: the Diabetes Stages of Change (DiSC) study
    Helen Jones
    Leadership Sinai Center for Diabetes, Mount Sinai Hospital and University of Toronto, Toronto, Canada
    Diabetes Care 26:732-7. 2003
    ..01). CONCLUSIONS: This study demonstrates that this intervention has the potential of positively impacting the health of broad populations of individuals with diabetes, not just the minority who are ready for change...
  83. ncbi Glucose intolerance in pregnancy and future risk of pre-diabetes or diabetes
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 31:2026-31. 2008
    ....
  84. ncbi Impaired glucose tolerance of pregnancy is a heterogeneous metabolic disorder as defined by the glycemic response to the oral glucose tolerance test
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Ontario, Canada
    Diabetes Care 29:57-62. 2006
    ..The metabolic phenotype associated with 1-h IGT resembles that of GDM, whereas the phenotype associated with 2-h/3-h IGT exhibits similarity to that of NGT...
  85. ncbi Association of the novel cardiovascular risk factors paraoxonase 1 and cystatin C in type 2 diabetes
    Philip W Connelly
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Canada
    J Lipid Res 50:1216-22. 2009
    ..73 m(2). The lower mass of PON1, an anti-inflammatory HDL-associated enzyme, in T2DM with cystatin C-eGFR <60 ml/min per 1.73 m(2) may contribute to their increased risk for cardiovascular disease...
  86. ncbi Pre-gravid physical activity and reduced risk of glucose intolerance in pregnancy: the role of insulin sensitivity
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Clin Endocrinol (Oxf) 70:615-22. 2009
    ..Thus, we sought to study the relationships between types of pre-gravid physical activity and metabolic parameters in pregnancy, including glucose tolerance, insulin sensitivity and beta-cell function...
  87. ncbi Type 2 diabetes and impaired glucose tolerance in aboriginal populations: a global perspective
    Catherine H Y Yu
    Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Ontario, Canada
    Diabetes Res Clin Pract 78:159-70. 2007
    ..To perform a systematic review of the prevalence of type 2 diabetes and impaired glucose tolerance (IGT) in aboriginal populations worldwide...
  88. ncbi The impact of family history of diabetes on risk factors for gestational diabetes
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Clin Endocrinol (Oxf) 67:754-60. 2007
    ..We thus hypothesized that the risk factors for gestational hyperglycaemia in women with FHD may differ from those in women without FHD...
  89. ncbi Disparate associations of a functional promoter polymorphism in PCK1 with carotid wall ultrasound traits
    Robert A Hegele
    Robarts Research Institute, London, Ontario, Canada
    Stroke 36:2566-70. 2005
    ..We hypothesized that this polymorphism would be associated with carotid atherosclerosis in a sample of 150 aboriginal Canadians...
  90. ncbi Phenotypic characteristics of GAD antibody-positive recently diagnosed patients with type 2 diabetes in North America and Europe
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Diabetes 53:3193-200. 2004
    ..1 vs. 83.7%, P = 0.0009). These phenotypic differences may underlie a potential difference in the natural history of hyperglycemia and its clinical outcomes...
  91. ncbi Association of apolipoprotein B with incident type 2 diabetes in an aboriginal Canadian population
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Clin Chem 56:666-70. 2010
    ..We assessed the association of apo B with incident type 2 diabetes and compared it with traditional lipid variables as a risk predictor in aboriginal Canadians...
  92. ncbi Use of vascular risk-modifying medications for diabetic patients differs between physician specialties
    B R Shah
    Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, ON, Canada
    Diabet Med 23:1117-23. 2006
    ..This study examined whether vascular risk-modifying medication utilization for diabetic patients differed among physician specialties...
  93. ncbi Meta-analysis of the effect of diabetes on restenosis rates among patients receiving coronary angioplasty stenting
    Jeremy Gilbert
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 27:990-4. 2004
    ....
  94. ncbi The graded relationship between glucose tolerance status in pregnancy and postpartum levels of low-density-lipoprotein cholesterol and apolipoprotein B in young women: implications for future cardiovascular risk
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, 60 Murray Street, Suite L5 039, Mailbox 21, Toronto, Ontario, Canada M5T 3L9
    J Clin Endocrinol Metab 95:4345-53. 2010
    ..Because lipid factors can contribute to cardiovascular risk, we sought to characterize the relationship between gestational glucose tolerance status and lipid profile in pregnancy and the postpartum...
  95. ncbi Effect of direct renin inhibition on renal hemodynamic function, arterial stiffness, and endothelial function in humans with uncomplicated type 1 diabetes: a pilot study
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 33:361-5. 2010
    ..The recent development of direct renin inhibitors (DRIs) provides a new approach to block the RAS, but the effects of DRIs on renal and systemic vascular function in uncomplicated type 1 diabetes have not been elucidated...
  96. ncbi Maternal obesity and familial history of diabetes have opposing effects on infant birth weight in women with mild glucose intolerance in pregnancy
    Phillip Segal
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Matern Fetal Neonatal Med 21:73-9. 2008
    ..We thus sought to evaluate the maternal constitutional and biochemical factors that determine infant birth weight in this patient population...
  97. ncbi Risk of development of diabetes mellitus after diagnosis of gestational diabetes
    Denice S Feig
    Department of Medicine, University of Toronto, Toronto, Ont
    CMAJ 179:229-34. 2008
    ..However, the precise relation between these 2 conditions remains unknown. We sought to determine the incidence of diabetes mellitus after diagnosis of gestational diabetes...
  98. ncbi Maternal serum adiponectin and infant birthweight: the role of adiponectin isoform distribution
    Gabie K B Ong
    Faculty of Arts and Sciences, University of Toronto, Toronto, ON, Canada
    Clin Endocrinol (Oxf) 67:108-14. 2007
    ....
  99. ncbi The antepartum glucose values that predict neonatal macrosomia differ from those that predict postpartum prediabetes or diabetes: implications for the diagnostic criteria for gestational diabetes
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada M5T3L9
    J Clin Endocrinol Metab 94:840-5. 2009
    ..Thus, to test this assumption, we sought to evaluate the predictive capacity of each glucose value on antepartum OGTT in relation to LGA and postpartum prediabetes/diabetes...
  100. ncbi Cystatin C is associated with cardiovascular risk factors and metabolic syndrome in Aboriginal youth
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Canada
    Pediatr Nephrol 22:1007-13. 2007
    ..0072). In summary, increased cystatin C is associated with an enhanced CV risk factor profile in Aboriginal youth and may be an early event in the natural history of vascular disease...
  101. ncbi Genetic variation in PPARG encoding peroxisome proliferator-activated receptor gamma associated with carotid atherosclerosis
    Khalid Z Al-Shali
    Robarts Research Institute, London, Ontario, Canada
    Stroke 35:2036-40. 2004
    ..Genetic variation in PPARG has been associated with metabolic and cardiovascular end points...