Oksana Shynlova

Summary

Affiliation: Samuel Lunenfeld Research Institute
Country: Canada

Publications

  1. doi request reprint Integration of endocrine and mechanical signals in the regulation of myometrial functions during pregnancy and labour
    Oksana Shynlova
    Centre for Women s and Infant s Health Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto M5G1X5, Canada
    Eur J Obstet Gynecol Reprod Biol 144:S2-10. 2009
  2. ncbi request reprint Monocyte chemoattractant protein-1 (CCL-2) integrates mechanical and endocrine signals that mediate term and preterm labor
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Immunol 181:1470-9. 2008
  3. ncbi request reprint The expression of transforming growth factor beta in pregnant rat myometrium is hormone and stretch dependent
    Oksana Shynlova
    Samuel Lunenfeld Research Institute at Mount Sinai, Mount Sinai Hospital, 600 University Avenue, Suite 870, Toronto, Ontario, Canada M5G 1X5
    Reproduction 134:503-11. 2007
  4. ncbi request reprint Insulin-like growth factors and their binding proteins define specific phases of myometrial differentiation during pregnancy in the rat
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario, Canada
    Biol Reprod 76:571-8. 2007
  5. doi request reprint Expression of genes encoding smooth muscle contractile proteins in vaginal tissue of women with and without pelvic organ prolapse
    Maria A T Bortolini
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Neurourol Urodyn 31:109-14. 2012
  6. doi request reprint Stretch-induced uterine myocyte differentiation during rat pregnancy: involvement of caspase activation
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 25 Orde Street, Toronto, Ontario, Canada
    Biol Reprod 82:1248-55. 2010
  7. doi request reprint Mechanical stretch regulates hypertrophic phenotype of the myometrium during pregnancy
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 25 Orde Street, Room 6 1019, Toronto, Ontario, Canada
    Reproduction 139:247-53. 2010
  8. ncbi request reprint Progesterone and gravidity differentially regulate expression of extracellular matrix components in the pregnant rat myometrium
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Biol Reprod 70:986-92. 2004
  9. doi request reprint Expression and organization of basement membranes and focal adhesion proteins in pregnant myometrium is regulated by uterine stretch
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, M5T 3H7
    Reprod Sci 16:960-9. 2009
  10. doi request reprint Expression of Bone Morphogenetic Protein-1 in vaginal tissue of women with severe pelvic organ prolapse
    Maria A T Bortolini
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Canada
    Am J Obstet Gynecol 204:544.e1-8. 2011

Collaborators

  • May Alarab
  • Yunqing Li
  • Junwu Mu
  • Daniel J MacPhee
  • Jennifer A Mitchell
  • Maria A T Bortolini
  • Stephen Lye
  • Rodrigo A Castro
  • Harold P Drutz
  • Manoel J B C Girao
  • Xuesen Dong
  • Shabana Jaffer
  • Stephen J Lye
  • Britta Döring
  • John R G Challis
  • Celeste Yu
  • Paul S Rennie
  • Ulrike Janssen-Bienhold
  • Robert Feil
  • Susanne Feil
  • Dominik Eckardt
  • Prudence Tsui
  • Franz Hofmann
  • Klaus Willecke

Detail Information

Publications22

  1. doi request reprint Integration of endocrine and mechanical signals in the regulation of myometrial functions during pregnancy and labour
    Oksana Shynlova
    Centre for Women s and Infant s Health Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto M5G1X5, Canada
    Eur J Obstet Gynecol Reprod Biol 144:S2-10. 2009
    ..Our data are obtained mostly from the rat, but we believe that they are generally applicable across species...
  2. ncbi request reprint Monocyte chemoattractant protein-1 (CCL-2) integrates mechanical and endocrine signals that mediate term and preterm labor
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Immunol 181:1470-9. 2008
    ....
  3. ncbi request reprint The expression of transforming growth factor beta in pregnant rat myometrium is hormone and stretch dependent
    Oksana Shynlova
    Samuel Lunenfeld Research Institute at Mount Sinai, Mount Sinai Hospital, 600 University Avenue, Suite 870, Toronto, Ontario, Canada M5G 1X5
    Reproduction 134:503-11. 2007
    ..Collectively, these data indicate that the TGFbeta family contributes in the regulation of myometrial activation at term integrating mechanical and endocrine signals for successful labor contraction...
  4. ncbi request reprint Insulin-like growth factors and their binding proteins define specific phases of myometrial differentiation during pregnancy in the rat
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario, Canada
    Biol Reprod 76:571-8. 2007
    ..Igfbp5 gene was induced during postpartum involution. Our results suggest the importance of the IGF system in phenotypic and functional changes of myometrial SMCs throughout gestation in preparation for labor...
  5. doi request reprint Expression of genes encoding smooth muscle contractile proteins in vaginal tissue of women with and without pelvic organ prolapse
    Maria A T Bortolini
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Neurourol Urodyn 31:109-14. 2012
    ..We aim to analyze the expression of SM-myosin heavy chain (MHY11), caldesmon (CALD1), SM gamma-actin (ACTG2), and tropomyosin (TPM1), in premenopausal and postmenopausal women with advanced POP and asymptomatic controls...
  6. doi request reprint Stretch-induced uterine myocyte differentiation during rat pregnancy: involvement of caspase activation
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 25 Orde Street, Toronto, Ontario, Canada
    Biol Reprod 82:1248-55. 2010
    ..We speculate that hypoxia resulting from mechanical stretch may activate caspase 3 within the pregnant myometrium only in the context of a specific endocrine environment...
  7. doi request reprint Mechanical stretch regulates hypertrophic phenotype of the myometrium during pregnancy
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 25 Orde Street, Room 6 1019, Toronto, Ontario, Canada
    Reproduction 139:247-53. 2010
    ..The restriction of the hypertrophy to cells within the gravid horn suggests that it may be a response to the biological mechanical stretch of uterine walls by the growing fetus(es) and placenta(s)...
  8. ncbi request reprint Progesterone and gravidity differentially regulate expression of extracellular matrix components in the pregnant rat myometrium
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Biol Reprod 70:986-92. 2004
    ..These ECM changes contribute to myometrial growth and remodeling during late pregnancy and the preparation for the synchronized contractions of labor...
  9. doi request reprint Expression and organization of basement membranes and focal adhesion proteins in pregnant myometrium is regulated by uterine stretch
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, M5T 3H7
    Reprod Sci 16:960-9. 2009
    ..We suggest that these stretch-induced changes facilitate formation of stable cell-matrix adhesions and provide the molecular basis for optimal force transduction during labor contractions...
  10. doi request reprint Expression of Bone Morphogenetic Protein-1 in vaginal tissue of women with severe pelvic organ prolapse
    Maria A T Bortolini
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Canada
    Am J Obstet Gynecol 204:544.e1-8. 2011
    ..To analyze the differential gene and protein expression of Bone Morphogenetic Protein-1 in vaginal tissue of women with advanced pelvic organ prolapse and controls...
  11. doi request reprint Mammalian target of rapamycin is activated in association with myometrial proliferation during pregnancy
    Shabana Jaffer
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Endocrinology 150:4672-80. 2009
    ..Our in vivo data demonstrate that estradiol was able to activate the PI3K/mTOR signaling pathway in uterine myocytes and suggest that this activation is responsible for the induction of myometrial hyperplasia during early gestation...
  12. ncbi request reprint Expression and localization of alpha-smooth muscle and gamma-actins in the pregnant rat myometrium
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Biol Reprod 73:773-80. 2005
    ....
  13. ncbi request reprint Myometrial apoptosis: activation of the caspase cascade in the pregnant rat myometrium at midgestation
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Biol Reprod 74:839-49. 2006
    ..The transition between these phases was associated with transient activation of the caspase cascade that triggered the differentiation of uterine smooth muscle...
  14. ncbi request reprint Mechanical stretch and progesterone differentially regulate activator protein-1 transcription factors in primary rat myometrial smooth muscle cells
    Jennifer A Mitchell
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Am J Physiol Endocrinol Metab 287:E439-45. 2004
    ....
  15. doi request reprint Infiltration of myeloid cells into decidua is a critical early event in the labour cascade and post-partum uterine remodelling
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    J Cell Mol Med 17:311-24. 2013
    ....
  16. ncbi request reprint Uterine stretch regulates temporal and spatial expression of fibronectin protein and its alpha 5 integrin receptor in myometrium of unilaterally pregnant rats
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Biol Reprod 77:880-8. 2007
    ....
  17. doi request reprint p54nrb is a transcriptional corepressor of the progesterone receptor that modulates transcription of the labor-associated gene, connexin 43 (Gja1)
    Xuesen Dong
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5
    Mol Endocrinol 23:1147-60. 2009
    ..We conclude that p54nrb is a transcriptional corepressor of PR. Decreased expression of p54nrb at the time of labor may act to derepress PR-mediated inhibition on connexin 43 expression and contribute to the initiation of labor...
  18. doi request reprint Myometrial immune cells contribute to term parturition, preterm labour and post-partum involution in mice
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    J Cell Mol Med 17:90-102. 2013
    ..We concluded that leucocytes infiltrate myometrium around the time of parturition implicating their potential role in labour activation (both term and preterm) and major role in PP uterine involution...
  19. doi request reprint Genes responsible for vaginal extracellular matrix metabolism are modulated by women's reproductive cycle and menopause
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Int Braz J Urol 39:257-67. 2013
    ....
  20. doi request reprint Physiologic uterine inflammation and labor onset: integration of endocrine and mechanical signals
    Oksana Shynlova
    Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto, Canada
    Reprod Sci 20:154-67. 2013
    ....
  21. doi request reprint LOX family enzymes expression in vaginal tissue of premenopausal women with severe pelvic organ prolapse
    May Alarab
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, 700 University Avenue, Suite 3083, Toronto, ON M5G 1Z5, Canada
    Int Urogynecol J 21:1397-404. 2010
    ..All women were in the proliferative phase of menstrual cycle...
  22. ncbi request reprint Ablation of connexin43 in uterine smooth muscle cells of the mouse causes delayed parturition
    Britta Döring
    Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Römerstr 164, 53117 Bonn, Germany
    J Cell Sci 119:1715-22. 2006
    ..Our results indicate the important function of Cx43 during parturition in the living animal and suggest further strategies to investigate the role of connexins in uterine contractility in transgenic mice...