Research Topics
Genomes and Genes | S E QuagginSummaryAffiliation: Samuel Lunenfeld Research Institute Country: Canada Publications
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Publications
The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesisS E Quaggin
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
Development 126:5771-83. 1999..Defects specific to later specialized cell types where Pod1 is expressed, such as the podocytes, were also observed, suggesting that this transcription factor may play multiple roles in kidney morphogenesis...- A podocentric view of nephrologyJo Ly
The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Curr Opin Nephrol Hypertens 13:299-305. 2004.... 
Uncapping the potential of renal stem cellsSusan E Quaggin
Samuel Lunenfeld Research Institute, 881 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Cell Stem Cell 3:123-4. 2008..six2-expressing mesenchymal cells exhibit hallmark stem cell traits, in that they appear to self-renew and are clonally multipotent for a range of nephron epithelial cell types...- How do mesangial and endothelial cells form the glomerular tuft?Michael R Vaughan
Samuel Lunenfeld Research Institute, Mt Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
J Am Soc Nephrol 19:24-33. 2008..Current concepts of the role of mesangial and endothelial cells in formation of the capillary tuft are reviewed here... - Transcriptional regulation of podocyte specification and differentiationSusan E Quaggin
Division of Nephrology, St Michael s Hospital and Department of Maternal and Fetal Health, The Samuel Lunenfeld Research Inst, Mt Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada
Microsc Res Tech 57:208-11. 2002..This article reviews the present state of knowledge regarding transcriptional regulation of podocyte specification and differentiation... 
Sizing up sialic acid in glomerular diseaseSusan E Quaggin
The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
J Clin Invest 117:1480-3. 2007..Remarkably, the lesion can be reversed through dietary addition of N-acetylmannosamine, a sialic acid precursor, raising the intriguing possibility that this approach might have therapeutic benefit in patients with glomerular disease...- Pod1 is required in stromal cells for glomerulogenesisShiying Cui
The Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
Dev Dyn 226:512-22. 2003..Most strikingly, the glomerulogenesis defect was rescued by the presence of wild-type stromal cells, suggesting a non-cell autonomous role for Pod1 in this cell population... - Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseasesVera Eremina
The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
J Clin Invest 111:707-16. 2003..Our data demonstrate that tight regulation of VEGF-A signaling is critical for establishment and maintenance of the glomerular filtration barrier and strongly supports a pivotal role for VEGF-A in renal disease... - Rapid isolation of glomeruli coupled with gene expression profiling identifies downstream targets in Pod1 knockout miceShiying Cui
The Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Ontario, Canada
J Am Soc Nephrol 16:3247-55. 2005..This procedure may be adapted to any transgenic strain, providing a rapid and efficient method to dissect the function of specific genes in glomerular development... - Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survivalVera Eremina
Department of Maternal and Fetal Health, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Room 855Q, 600 University of Toronto, Ontario, Canada M5G 1X5
J Am Soc Nephrol 17:724-35. 2006..Together, these results demonstrate a key role for VEGF-A production in the podocyte for mesangial cell survival and differentiation... - Conditional gene targeting in the kidneyAlexander Gawlik
The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, ON, Canada
Curr Mol Med 5:527-36. 2005..In addition to reverse genetic approaches, forward genetic techniques like random mutagenesis in mice continue to evolve and will enhance our understanding of disease mechanisms in the kidney... - Deciphering the renal code: advances in conditional gene targetingAlexander Gawlik
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto M5G 1X5, Canada
Physiology (Bethesda) 19:245-52. 2004..Here we discuss the advantages and pitfalls of currently available gene-targeting systems... - Nck proteins maintain the adult glomerular filtration barrierNina Jones
Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Road East, New Science Complex, Guelph, Ontario, Canada
J Am Soc Nephrol 20:1533-43. 2009..These data suggest that Nck is required to maintain adult podocytes and that phosphotyrosine-based interactions with nephrin may occur in foot processes of resting, mature podocytes... - WT1 activates a glomerular-specific enhancer identified from the human nephrin geneGordon Guo
Samuel Lunenfeld Research Institute, Mt Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
J Am Soc Nephrol 15:2851-6. 2004..Taken together, these results suggest that WT1 may be required for regulation of the NPHS1 gene in vivo... - Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout miceShiying Cui
Department of Maternal and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario M5G 1X5, Canada
Development 131:4095-105. 2004..Our results establish that Pod1 is essential for gonadal development, and place it in a transcriptional network that orchestrates cell fate decisions in gonadal progenitors... - Role of the VEGF--a signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrierVera Eremina
The Samuel Lunenfeld Research Institute, University of Toronto, Toronto, ON, Canada
Nephron Physiol 106:p32-7. 2007.... - Development of the renal glomerulus: good neighbors and good fencesSusan E Quaggin
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
Development 135:609-20. 2008.... - VEGF inhibition and renal thrombotic microangiopathyVera Eremina
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
N Engl J Med 358:1129-36. 2008..These observations provide evidence that glomerular injury in patients who are treated with bevacizumab is probably due to direct targeting of VEGF by antiangiogenic therapy... - Glomerular-specific gene excision in vivoVera Eremina
The Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada
J Am Soc Nephrol 13:788-93. 2002..This murine founder line represents a powerful new tool for the manipulation of the expression of genes in podocytes and will provide valuable insight into podocyte biology in the whole animal... - Genetic susceptibility to HIV-associated nephropathySusan E Quaggin
St Michael s Hospital, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada
J Clin Invest 119:1085-9. 2009..This report confirms the central role of podocytes in the pathogenesis of HIVAN and demonstrates the power of this combination of genomic analysis techniques in elucidating the pathogenesis of glomerular disease... - Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signalingKaren Sison
The Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
J Am Soc Nephrol 21:1691-701. 2010..VEGF produced by the podocyte regulates the structure and function of the adjacent endothelial cell... - Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in miceMei Ding
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Nat Med 12:1081-7. 2006..Collectively, these results indicate an alternative mechanism for the pathogenesis of RPGN and glomerular disease in an animal model and suggest novel molecular pathways for intervention in this disease... - Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytesNina Jones
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Nature 440:818-23. 2006..Simple and widely expressed SH2/SH3 adaptor proteins can therefore direct the formation of a specialized cellular morphology in vivo... - Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline inductionGusztav Belteki
Samuel Lunenfeld Research Institute, Mount Sinai Hospital 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
Nucleic Acids Res 33:e51. 2005..The presented approach abrogates the need to generate tissue-specific rtTA transgenes for tissues where well-characterized Cre lines already exist... - The role of VEGF-A in glomerular development and functionVera Eremina
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada
Curr Opin Nephrol Hypertens 13:9-15. 2004..This review will summarize some of the recent advances in our understanding of the role(s) of VEGF in these processes... - Deregulated expression of the homeobox gene Cux-1 in transgenic mice results in downregulation of p27(kip1) expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasiaAric W Ledford
Department of Biology, East Carolina University, Greenville, NC 27858, USA
Dev Biol 245:157-71. 2002..Transient transfection experiments revealed that Cux-1 is an inhibitor of p27 promoter activity. These results suggest that Cux-1 regulates cell proliferation during early nephrogenesis by inhibiting expression of p27... - Large-scale identification of genes implicated in kidney glomerulus development and functionMinoru Takemoto
Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
EMBO J 25:1160-74. 2006..We surmise that studies on the other novel glomerulus-enriched transcripts identified in this study will provide new insight into glomerular development and pathomechanisms of disease... - A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary developmentThomas A Natoli
Department of Medicine and Laboratory for Skeletal Disorders and Rehabilitation, Department of Orthopedic Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
J Am Soc Nephrol 13:2058-67. 2002..These results suggest that WT1 controls the expression of growth factors that regulate glomerular capillary development and that abnormal capillary development might lead to glomerular disease... - Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesisTino D Piscione
Program in Developmental Biology, Research Institute, The Hospital for Sick Children, 555 University Ave, Toronto, Ont, Canada M5G 1X8
Gene Expr Patterns 4:707-11. 2004..Consequently, the differential, spatial regulation of Hes1 and Hes5 gene expression by the Notch signaling pathway in developing nephrons may be a mechanism for patterning cell fate decisions during nephron morphogenesis... - Beta1 integrin expression by podocytes is required to maintain glomerular structural integrityAmbra Pozzi
Department of Medicine, Veterans Affairs Hospital, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Dev Biol 316:288-301. 2008..Thus, expression of beta1 containing integrins by the podocyte is critical for maintaining the structural integrity of the glomerulus... - A "molecular toolbox" for the nephrologistSusan E Quaggin
J Am Soc Nephrol 13:1682-5. 2002 - Toward a mouse model of diabetic nephropathy: is endothelial nitric oxide synthase the missing link?Susan E Quaggin
J Am Soc Nephrol 18:364-6. 2007