J T Henderson

Summary

Affiliation: Samuel Lunenfeld Research Institute
Country: Canada

Publications

  1. ncbi The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function
    J T Henderson
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, Ontario, Canada
    Neuron 32:1041-56. 2001
  2. doi EphB2 and EphA4 receptors regulate formation of the principal inter-hemispheric tracts of the mammalian forebrain
    S K Y Ho
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, Canada
    Neuroscience 160:784-95. 2009
  3. ncbi The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons
    R Sakai
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, Ontario, Canada
    Neuron 28:819-33. 2000
  4. ncbi Excitatory tonus is required for the survival of granule cell precursors during postnatal development within the cerebellum
    A K Kanungo
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3M2
    Neuroscience 158:1364-77. 2009
  5. ncbi Multiple behavioral anomalies in GluR2 mutant mice exhibiting enhanced LTP
    R Gerlai
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont, Canada
    Behav Brain Res 95:37-45. 1998
  6. ncbi Development of a high resolution three-dimensional surgical atlas of the murine head for strains 129S1/SvImJ and C57Bl/6J using magnetic resonance imaging and micro-computed tomography
    E Chan
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
    Neuroscience 144:604-15. 2007
  7. ncbi Differential requirement for caspase 9 in apoptotic pathways in vivo
    R Hakem
    Amgen Institute, Toronto, Ontario, Canada
    Cell 94:339-52. 1998
  8. ncbi Glial overexpression of NGF enhances neuropathic pain and adrenergic sprouting into DRG following chronic sciatic constriction in mice
    M S Ramer
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Neurosci Lett 251:53-6. 1998
  9. ncbi Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS
    M A Lomaga
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada M5S 2S2
    J Neurosci 20:7384-93. 2000
  10. pmc Caspase-3 deficiency reveals a physiologic role for Smac/DIABLO in regulating programmed cell death
    K K W Hui
    Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    Cell Death Differ 18:1780-90. 2011

Collaborators

Detail Information

Publications16

  1. ncbi The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function
    J T Henderson
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, Ontario, Canada
    Neuron 32:1041-56. 2001
    ..Together, these data demonstrate that EphB2 plays an important role in regulating synaptic function...
  2. doi EphB2 and EphA4 receptors regulate formation of the principal inter-hemispheric tracts of the mammalian forebrain
    S K Y Ho
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, Canada
    Neuroscience 160:784-95. 2009
    ....
  3. ncbi The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons
    R Sakai
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, Ontario, Canada
    Neuron 28:819-33. 2000
    ..The results indicate that these Shc family members possess both unique and overlapping functions in regulating neural development and suggest physiological roles for ShcB/ShcC in TrkA signaling...
  4. ncbi Excitatory tonus is required for the survival of granule cell precursors during postnatal development within the cerebellum
    A K Kanungo
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3M2
    Neuroscience 158:1364-77. 2009
    ....
  5. ncbi Multiple behavioral anomalies in GluR2 mutant mice exhibiting enhanced LTP
    R Gerlai
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont, Canada
    Behav Brain Res 95:37-45. 1998
    ..We speculate that GluR2 mutant mice suffer from an overall non-specifically increased excitability that may alter cognitive functions ranging from stimulus processing to motivation and learning...
  6. ncbi Development of a high resolution three-dimensional surgical atlas of the murine head for strains 129S1/SvImJ and C57Bl/6J using magnetic resonance imaging and micro-computed tomography
    E Chan
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
    Neuroscience 144:604-15. 2007
    ..The aim of these studies is to enhance comparative morphometric analyses and stereotactic surgical procedures in mice...
  7. ncbi Differential requirement for caspase 9 in apoptotic pathways in vivo
    R Hakem
    Amgen Institute, Toronto, Ontario, Canada
    Cell 94:339-52. 1998
    ..Comparison of the requirement for Casp9 and Casp3 in different apoptotic settings indicates the existence of at least four different apoptotic pathways in mammalian cells...
  8. ncbi Glial overexpression of NGF enhances neuropathic pain and adrenergic sprouting into DRG following chronic sciatic constriction in mice
    M S Ramer
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Neurosci Lett 251:53-6. 1998
    ..These results demonstrate a connection between the endogenous ectopic overexpression of NGF and (1) neuropathic pain behaviour and (2) sympathetic sprouting in the DRG...
  9. ncbi Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS
    M A Lomaga
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada M5S 2S2
    J Neurosci 20:7384-93. 2000
    ..Our results demonstrate a novel and prominent role for TRAF6 in the regional control of PCD within the developing CNS...
  10. pmc Caspase-3 deficiency reveals a physiologic role for Smac/DIABLO in regulating programmed cell death
    K K W Hui
    Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    Cell Death Differ 18:1780-90. 2011
    ....
  11. ncbi Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPsigma
    M J Wallace
    The Hospital for Sick Children, Programme in Cell Biology, Toronto, Ontario, Canada
    Nat Genet 21:334-8. 1999
    ..By approximately three weeks of age, most remaining Ptprs-/- mice died from a wasting syndrome with atrophic intestinal villi. These results suggest that PTPsigma has a role in neuronal and epithelial development in mice...
  12. ncbi Differential sensitivity of skeletal and fusimotor neurons to Bcl-2-mediated apoptosis during neuromuscular development
    K Hui
    Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    Cell Death Differ 15:691-9. 2008
    ..These results demonstrate, for the first time, the connection between Bcl-2 expression, motor neuron survival, and the establishment of different motor populations...
  13. ncbi Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP
    Y M Lu
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Neurosci 17:5196-205. 1997
    ..This is consistent with the hypothesis that LTP in the CA1 region may underlie spatial learning and memory...
  14. ncbi Nuk controls pathfinding of commissural axons in the mammalian central nervous system
    M Henkemeyer
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cell 86:35-46. 1996
    ..These results indicate that Nuk, a receptor that binds transmembrane ligands, plays a critical and unique role in the pathfinding of specific axons in the mammalian central nervous system...
  15. ncbi A three-dimensional MRI atlas of the mouse brain with estimates of the average and variability
    N Kovacevic
    Mouse Imaging Centre, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Cereb Cortex 15:639-45. 2005
    ..Our results indicate that variational atlases of inbred strains represent a well-defined basis against which mutant outliers can be readily compared...
  16. ncbi The NMDA receptor subunit 2B locus (Nmdar2b) maps to the distal end of murine chromosome 6
    A R Madarnas
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Division of Neurobiology and Molecular Immunology, Toronto, Ontario, Canada
    Mamm Genome 5:115-6. 1994