D B Donoviel

Summary

Affiliation: Samuel Lunenfeld Research Institute
Country: Canada

Publications

  1. ncbi Cloning and characterization of Sel-1l, a murine homolog of the C. elegans sel-1 gene
    D B Donoviel
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Mech Dev 78:203-7. 1998
  2. ncbi SEL-1L maps to human chromosome 14, near the insulin-dependent diabetes mellitus locus 11
    D B Donoviel
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Genomics 56:232-3. 1999
  3. pmc Mice lacking both presenilin genes exhibit early embryonic patterning defects
    D B Donoviel
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Genes Dev 13:2801-10. 1999
  4. ncbi Functional characterization of novel presenilin-2 variants identified in human breast cancers
    M D To
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Oncogene 25:3557-64. 2006
  5. ncbi Embryonic and adult expression patterns of the Tec tyrosine kinase gene suggest a role in megakaryocytopoiesis, blood vessel development, and melanogenesis
    M Kluppel
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto Ontario, Canada
    Cell Growth Differ 8:1249-56. 1997
  6. pmc Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN
    D B Donoviel
    Pharmaceutical Biology, Lexicon Genetics, Inc, The Woodlands, Texas 77381, USA
    Mol Cell Biol 21:4829-36. 2001

Collaborators

Detail Information

Publications6

  1. ncbi Cloning and characterization of Sel-1l, a murine homolog of the C. elegans sel-1 gene
    D B Donoviel
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Mech Dev 78:203-7. 1998
    ..5 and E17.5 in the acini of the pancreas, and moderate in the epithelial cells of the gut villi. We localized the SEL-1L protein to the cytosol, possibly in intracellular vesicles, in a beta-islet-derived tumor cell line (RinM)...
  2. ncbi SEL-1L maps to human chromosome 14, near the insulin-dependent diabetes mellitus locus 11
    D B Donoviel
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Genomics 56:232-3. 1999
  3. pmc Mice lacking both presenilin genes exhibit early embryonic patterning defects
    D B Donoviel
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Genes Dev 13:2801-10. 1999
    ....
  4. ncbi Functional characterization of novel presenilin-2 variants identified in human breast cancers
    M D To
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Oncogene 25:3557-64. 2006
    ..Nonetheless, these results collectively suggest that the novel PS-2 alleles described here, especially R71W, affect PS-2 function and may potentially confer a moderate risk of susceptibility to breast cancer...
  5. ncbi Embryonic and adult expression patterns of the Tec tyrosine kinase gene suggest a role in megakaryocytopoiesis, blood vessel development, and melanogenesis
    M Kluppel
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto Ontario, Canada
    Cell Growth Differ 8:1249-56. 1997
    ..The observed developmental expression pattern of Tec suggests a role for this gene in several aspects of hematopoiesis and/or blood vessel development as well as in late stages of melanogenesis...
  6. pmc Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN
    D B Donoviel
    Pharmaceutical Biology, Lexicon Genetics, Inc, The Woodlands, Texas 77381, USA
    Mol Cell Biol 21:4829-36. 2001
    ..These findings suggest that NEPH1, like NEPHRIN, may play an important role in maintaining the structure of the filtration barrier that prevents proteins from freely entering the glomerular urinary space...