I Caniggia

Summary

Affiliation: Samuel Lunenfeld Research Institute
Country: Canada

Publications

  1. ncbi request reprint Integrin-linked kinase (ILK) is highly expressed in first trimester human chorionic villi and regulates migration of a human cytotrophoblast-derived cell line
    P A Elustondo
    Division of Basic Medical Sciences, Health Sciences Centre, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada A1B 3V6
    Biol Reprod 74:959-68. 2006
  2. ncbi request reprint Endoglin regulates trophoblast differentiation along the invasive pathway in human placental villous explants
    I Caniggia
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Department of Obstetrics and Gynecology, University of Toronto, Ontario, Canada
    Endocrinology 138:4977-88. 1997
  3. pmc Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies
    I Caniggia
    Program in Fetal Health and Development, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Clin Invest 103:1641-50. 1999
  4. pmc Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)
    I Caniggia
    Department of Pediatrics, The Hospital for Sick Children Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 105:577-87. 2000
  5. ncbi request reprint Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsia
    I Caniggia
    Samuel Lunenfeld Research Institute, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Placenta 21:S25-30. 2000
  6. ncbi request reprint Adriana and Luisa Castellucci Award lecture 2001. Hypoxia inducible factor-1: oxygen regulation of trophoblast differentiation in normal and pre-eclamptic pregnancies--a review
    I Caniggia
    Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Placenta 23:S47-57. 2002
  7. ncbi request reprint Mechanisms of oxygen sensing in human trophoblast cells
    C S De Marco
    Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Placenta 23:S58-68. 2002
  8. ncbi request reprint Focal adhesion kinase is a key mediator of human trophoblast development
    D J Macphee
    Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Program in Lung Biology, Department of Obstetrics and Gynecology and Physiology, University of Toronto, Mt. Sinai Hospital, Hospital for Sick Children, Toronto, Ontario, Canada
    Lab Invest 81:1469-83. 2001
  9. doi request reprint Mtd/Bok takes a swing: proapoptotic Mtd/Bok regulates trophoblast cell proliferation during human placental development and in preeclampsia
    J E Ray
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Canada
    Cell Death Differ 17:846-59. 2010
  10. ncbi request reprint A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia
    N Soleymanlou
    Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Cell Death Differ 12:441-52. 2005

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Integrin-linked kinase (ILK) is highly expressed in first trimester human chorionic villi and regulates migration of a human cytotrophoblast-derived cell line
    P A Elustondo
    Division of Basic Medical Sciences, Health Sciences Centre, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada A1B 3V6
    Biol Reprod 74:959-68. 2006
    ....
  2. ncbi request reprint Endoglin regulates trophoblast differentiation along the invasive pathway in human placental villous explants
    I Caniggia
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Department of Obstetrics and Gynecology, University of Toronto, Ontario, Canada
    Endocrinology 138:4977-88. 1997
    ....
  3. pmc Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies
    I Caniggia
    Program in Fetal Health and Development, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Clin Invest 103:1641-50. 1999
    ..We speculate that a failure to downregulate expression of TGF-beta 3 at around 9 weeks' gestation results in shallow trophoblast invasion and predisposes the pregnancy to preeclampsia...
  4. pmc Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)
    I Caniggia
    Department of Pediatrics, The Hospital for Sick Children Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 105:577-87. 2000
    ..These data suggest that the oxygen-regulated early events of trophoblast differentiation are in part mediated by TGFbeta(3) through HIF-1 transcription factors...
  5. ncbi request reprint Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsia
    I Caniggia
    Samuel Lunenfeld Research Institute, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Placenta 21:S25-30. 2000
    ..synthesis and degradation of extracellular matrix proteins and their receptors, and changes in the spatial distribution of extracellular matrix proteins, as well as changes in the expression of adhesion molecules (Damsky, Fitzgerald and..
  6. ncbi request reprint Adriana and Luisa Castellucci Award lecture 2001. Hypoxia inducible factor-1: oxygen regulation of trophoblast differentiation in normal and pre-eclamptic pregnancies--a review
    I Caniggia
    Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Placenta 23:S47-57. 2002
    ..This will prevent the normal TGFbeta3 down-regulation and will lead to poor trophoblast invasion predisposing the pregnancy to pre-eclampsia...
  7. ncbi request reprint Mechanisms of oxygen sensing in human trophoblast cells
    C S De Marco
    Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Placenta 23:S58-68. 2002
    ..Thus, this data supports a hypothesis that trophoblast cells may utilize mitochondria and/or hemoproteins as oxygen sensors to detect the critical changes in oxygen tension during pregnancy...
  8. ncbi request reprint Focal adhesion kinase is a key mediator of human trophoblast development
    D J Macphee
    Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Program in Lung Biology, Department of Obstetrics and Gynecology and Physiology, University of Toronto, Mt. Sinai Hospital, Hospital for Sick Children, Toronto, Ontario, Canada
    Lab Invest 81:1469-83. 2001
    ..These data suggest that FAK is a key kinase involved in early trophoblast cell differentiation and plays a role in regulating cell proliferation and motility during early placental development...
  9. doi request reprint Mtd/Bok takes a swing: proapoptotic Mtd/Bok regulates trophoblast cell proliferation during human placental development and in preeclampsia
    J E Ray
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Canada
    Cell Death Differ 17:846-59. 2010
    ....
  10. ncbi request reprint A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia
    N Soleymanlou
    Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Cell Death Differ 12:441-52. 2005
    ..We conclude that under conditions of reduced oxygenation/oxidative stress, Mtd-P causes trophoblast cell death in pre-eclampsia and hence may contribute to the molecular events leading to the clinical manifestations of this disease...
  11. pmc The double life of MULE in preeclamptic and IUGR placentae
    A Rolfo
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cell Death Dis 3:e305. 2012
    ..The different preferential targets of MULE in PE and IUGR placentae classify early-onset PE and IUGR as distinct molecular pathologies...
  12. doi request reprint IFPA Trophoblast Research Award Lecture: the dynamic role of Bcl-2 family members in trophoblast cell fate
    J Ray
    Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada
    Placenta 30:S96-100. 2009
    ..Disruption in Mtd/Mcl-1 expression seen in preeclampsia may contribute to both the increased apoptosis and hyperproliferative nature of this disorder...
  13. ncbi request reprint TGF-beta 3 expression during umbilical cord development and its alteration in pre-eclampsia
    I B Copland
    Programme in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, The Hospital for Sick Children Research Institute and Department of Obstetrics and Gynaecology, University of Toronto, Ontario, Canada
    Placenta 23:311-21. 2002
    ..We speculate that the downregulation of TGF-beta 3 expression found in pre-eclamptic umbilical cord may contribute to the abnormal structure and mechanical properties seen in these pathological umbilical cords...
  14. ncbi request reprint Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation
    B Huppertz
    Department of Anatomy, University Hospital RWTH Aachen, Germany
    Placenta 24:181-90. 2003
    ..Since uteroplacental ischaemia is a significant risk factor for pre-eclampsia, these findings may explain the link between reduced uteroplacental blood flow and the systemic clinical manifestations of this disease...
  15. ncbi request reprint In vitro models to study trophoblast function and dysfunction-- a workshop report
    D W Morrish
    Department of Medicine, University of Alberta, Edmonton, Canada
    Placenta 23:S114-8. 2002
  16. ncbi request reprint Growth factors and trophoblast differentiation--workshop report
    D W Morrish
    Department of Medicine, University of Alberta, 362 Heritage Medical Research Centre, Edmonton, Alberta T6G 2S2, Canada
    Placenta 28:S121-4. 2007
  17. ncbi request reprint Oxygen regulation of placental 11 beta-hydroxysteroid dehydrogenase 2: physiological and pathological implications
    N Alfaidy
    Department of Physiology, Canadian Institutes for Health Research Group in Development and Fetal Health, University of Toronto Toronto, Ontario, Canada M5S 1A8
    J Clin Endocrinol Metab 87:4797-805. 2002
    ..3% O(2). No change in 11 beta-HSD1 expression was observed in early pregnancy or in PE. This is the first report to suggest that 11 beta-HSD2 is O(2) dependent in first and third trimester placenta during human gestation...
  18. ncbi request reprint There are many approaches to the culture of human trophoblast but few that facilitate study of complex interactions between fetal and maternal tissues
    T Poehlmann
    Placenta 25:357-8. 2004
  19. ncbi request reprint Human placental explants in culture: approaches and assessments
    R K Miller
    Department of Obstetrics and Gynecology, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8668, USA
    Placenta 26:439-48. 2005
    ..Optimization of explant methods is examined for first and third trimester human placental tissue and the biological processes under investigation...