Research Topics
Genomes and Genes
| Laurent BriollaisSummaryAffiliation: Samuel Lunenfeld Research Institute Country: Canada Publications
| Collaborators
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Detail Information
Publications
Combined effect of CCND1 and COMT polymorphisms and increased breast cancer riskUmmiye V Onay
Fred A, Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
BMC Cancer 8:6. 2008..Several studies have also shown the relationship between estrogen and cell cycle progression through activation of CCND1 transcription...
Discovery of genetic profiles impacting response to chemotherapy: application to gemcitabineHamdi Jarjanazi
Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
Hum Mutat 29:461-7. 2008..The results obtained using this novel methodology can be used to better design the clinical trials for effective study of the chemotherapeutic agents and thus provide a basis for individualized chemotherapy...- Methodological issues in detecting gene-gene interactions in breast cancer susceptibility: a population-based study in OntarioLaurent Briollais
Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, M5T 3L9, Canada
BMC Med 5:22. 2007.... 
Regressive threshold model for familial analysis of complex diseases with variable age of onsetL Briollais
Inserm Emi 00 06, Evry, France
Genet Epidemiol 23:375-97. 2002..This new model may thus prove helpful in contributing to identification of genes underlying complex diseases, since it can easily include linked marker loci and linkage disequilibrium...- Novel approach for genome scan meta-analysis of rheumatoid arthritis: a kernel-based estimation procedureLaurent Briollais
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street, Toronto, Ontario MT5 3L9, Canada
BMC Proc 1:S96. 2007..The method is applied to the rheumatoid arthritis genome scan data (Genetic Analysis Workshop 15 Problem 2)... - Multilevel modeling for the analysis of longitudinal blood pressure data in the Framingham Heart Study pedigreesLaurent Briollais
Division of Epidemiology and Biostatistics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada, M5G 1X5
BMC Genet 4:S19. 2003..The data arising from a longitudinal familial study have a complex correlation structure that cannot be modeled using classical methods for the analysis of familial data at a single time point... - Association of tissue promoter methylation levels of APC, TGFβ2, HOXD3 and RASSF1A with prostate cancer progressionLiyang Liu
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
Int J Cancer 129:2454-62. 2011..017). Our study demonstrated that quantitative increase in promoter methylation levels of APC, HOXD3 and TGFβ2 are associated with PCa progression... - SNP-SNP interactions in breast cancer susceptibilityVenüs Ummiye Onay
Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
BMC Cancer 6:114. 2006..However, polygenic models suggest that multiple commonly occurring low to modestly penetrant SNPs of cancer related genes might have a greater effect on a disease when considered in combination... - Identification of germline alterations of the mad homology 2 domain of SMAD3 and SMAD4 from the Ontario site of the breast cancer family registry (CFR)Eric Tram
Fred A, Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Department of Laboratory Medicine and Pathobiology, University of Toronto, 60 Murray St, Toronto, ON M5T 3L9, Canada
Breast Cancer Res 13:R77. 2011..Thus, it is currently unknown whether germline SMAD3 and SMAD4 mutations are involved in breast cancer predisposition... - A whole-genome SNP association study of NCI60 cell line panel indicates a role of Ca2+ signaling in selenium resistanceSevtap Savas
Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
PLoS ONE 5:e12601. 2010.... - Polymorphisms cMyc-N11S and p27-V109G and breast cancer risk and prognosisJane C Figueiredo
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
BMC Cancer 7:99. 2007..In this study, we focus on a rare non-synonymous polymorphism in cMyc (N11S) and a common polymorphism in p27 (V109G) and determine their role in risk and prognosis using data collected from the Ontario Breast Cancer Family Registry... - Using an age-at-onset phenotype with interval censoring to compare methods of segregation and linkage analysis in a candidate region for elevated systolic blood pressureKaren A Kopciuk
Samuel Lunenfeld Research Institute of Mount Sinai Hospital, 60 Murray Street, 5th Floor, Toronto, Ontario, M5G 1X5, Canada
BMC Genet 4:S84. 2003..Since age-at-onset for diagnosed hypertension can vary substantially between individuals, a phenotype based on long-term follow up in unselected families can yield valuable insights into this disorder for the general population... - Estimating disease risk associated with mutated genes in family-based designsYun Hee Choi
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont, Canada
Hum Hered 66:238-51. 2008..Many clinical decisions require accurate estimates of disease risk associated with inherited gene mutations. While several family-based designs have been proposed, their relative advantages remain unclear... - NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cellsSevtap Savas
Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
PLoS ONE 6:e18306. 2011..Our results indicated genes involved in the cellular response to these statins and siRNA studies confirmed the role of the EAF2 in response to these drugs in HCT-116 colon cancer cells... - DNA methylation of HOXD3 as a marker of prostate cancer progressionKen J Kron
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
Lab Invest 90:1060-7. 2010..028). The results indicate that HOXD3 methylation distinguishes low-grade prostate cancers from intermediate and high-grade ones and may also have prognostic value when considered together with pathological stage... - Fine mapping by linkage and association in nuclear family and case-control designsShelley B Bull
Samuel Lunenfeld Research Institute of Mount Sinai Hospital and Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
Genet Epidemiol 29:S48-58. 2005.... - Polymorphisms XRCC1-R399Q and XRCC3-T241M and the risk of breast cancer at the Ontario site of the Breast Cancer Family RegistryJane C Figueiredo
Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Cancer Epidemiol Biomarkers Prev 13:583-91. 2004..Our results suggest that these polymorphisms may influence breast cancer risk by modifying the effect of risk factors such as FH. There is a need for further study into the role of these polymorphisms as effect modifiers... - Quantitative DNA methylation analysis of genes coding for kallikrein-related peptidases 6 and 10 as biomarkers for prostate cancerEkaterina Olkhov-Mitsel
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
Epigenetics 7:1037-45. 2012..A similar trend for KLK6 DNA methylation was observed. The results suggest that KLK6 and KLK10 DNA methylation distinguishes organ confined from locally invasive PCa and may have prognostic value... - Comparison of genotype- and haplotype-based approaches for fine-mapping of alcohol dependence using COGA dataDushanthi Pinnaduwage
Division of Epidemiology and Biostatistics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
BMC Genet 6:S65. 2005..However, caution should be taken when generalizing these results to other chromosomal regions or to other populations... - A Bayesian segmentation approach to ascertain copy number variations at the population levelLong Yang Wu
Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada
Bioinformatics 25:1669-79. 2009..This approach has the unique feature of carrying out segmentation and assigning copy number status simultaneously-a desirable property that current segmentation methods do not share... - Heterogeneity in IBD allele sharing among covariate-defined subgroups: issues and findings for affected relativesShelley B Bull
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont, Canada
Hum Hered 56:94-106. 2003..In this report, we highlight issues that arise in studies of families with affected relatives... - Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarraysKen Kron
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
PLoS ONE 4:e4830. 2009..Such occurrences often lead to the silencing of these key genes and thus they may contribute to the development of cancer, including prostate cancer... - Comparison of pathway analysis approaches using lung cancer GWAS data setsGordon Fehringer
Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
PLoS ONE 7:e31816. 2012.... - Tests for covariate-associated heterogeneity in IBD allele sharing of affected relativesLucia Mirea
Prosserman Centre for Studies of Complex Diseases in Human Populations, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
Genet Epidemiol 26:44-60. 2004..Application of these tests for heterogeneity detected significant differences in allele sharing between subgroups of families with inflammatory bowel disease... - Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instabilityVessela Vassileva
Samuel Lunenfeld Research Institute, Toronto, Ontario, M5G 1X5 Canada
Cancer Res 62:4095-9. 2002.... - Apoptotic and growth regulatory genes as mutational targets in mismatch repair deficient endometrioid adenocarcinomas of young patientsVessela Vassileva
Samuel Lunenfeld Research Institute, Toronto, Canada
Oncol Rep 11:931-7. 2004..06) for the overall mutation status for both pathways combined. Our results suggest that genes implicated in apoptosis may serve as targets in the progression of MSI+ EC in young patients... - Longitudinal data analysis in pedigree studiesW James Gauderman
Department of Preventive Medicine, University of Southern California, Los Angeles, 90089, USA
Genet Epidemiol 25:S18-28. 2003..Several areas for future research are discussed... - Alcohol metabolism, alcohol intake, and breast cancer risk: a sister-set analysis using the Breast Cancer Family RegistryMary Beth Terry
Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, Room 724, New York, NY 10032, USA
Breast Cancer Res Treat 106:281-8. 2007..However, only 19% and 42% of sisters were discordant by ADH1B and ADH1C, respectively, and even fewer were discordant by both genotype and alcohol intake, making it difficult to detect differences if they existed... - Linkage analyses of rheumatoid arthritis and related quantitative phenotypes: the GAW15 experienceSaurabh Ghosh
Human Genetics Unit, Indian Statistical Institute, 203 B T Road, Kolkata 700 108, India
Genet Epidemiol 31:S86-95. 2007..In this report, we discuss the different strategies explored by the different investigators with the common goal of improving the power to detect linkage...