Gordon Winocur

Summary

Affiliation: Rotman Research Institute
Country: Canada

Publications

  1. ncbi Neural correlates of memory for object identity and object location: effects of aging
    Alessandra Schiavetto
    Rotman Research Institute, Baycrest Center for Geriatric Care, Toronto, Ont, Canada
    Neuropsychologia 40:1428-42. 2002
  2. ncbi The effects of chemotherapy on cognitive function in a mouse model: a prospective study
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, Ontario, Canada
    Clin Cancer Res 18:3112-21. 2012
  3. ncbi Adult hippocampal neurogenesis and memory interference
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada
    Behav Brain Res 227:464-9. 2012
  4. ncbi Memory impairment in obese Zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity
    Gordon Winocur
    Department of Psychology, Trent University, Peterborough, Ontario, Canada
    Behav Neurosci 119:1389-95. 2005
  5. doi Memory formation and long-term retention in humans and animals: convergence towards a transformation account of hippocampal-neocortical interactions
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, Toronto, Canada
    Neuropsychologia 48:2339-56. 2010
  6. doi An investigation of the effects of hippocampal lesions in rats on pre- and postoperatively acquired spatial memory in a complex environment
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada
    Hippocampus 20:1350-65. 2010
  7. ncbi The effects of the anti-cancer drugs, methotrexate and 5-fluorouracil, on cognitive function in mice
    Gordon Winocur
    Department of Psychology, Trent University, Peterborough, Ontario, Canada
    Pharmacol Biochem Behav 85:66-75. 2006
  8. ncbi Changes in context-specificity during memory reconsolidation: selective effects of hippocampal lesions
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, Toronto, Ontario M6A 2E1, Canada
    Learn Mem 16:722-9. 2009
  9. doi A study of remote spatial memory in aged rats
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada
    Neurobiol Aging 31:143-50. 2010
  10. ncbi Cognitive rehabilitation in the elderly: an evaluation of psychosocial factors
    Gordon Winocur
    Rotman Research Institute, Baycrest, Toronto, Ontario, Canada
    J Int Neuropsychol Soc 13:153-65. 2007

Detail Information

Publications54

  1. ncbi Neural correlates of memory for object identity and object location: effects of aging
    Alessandra Schiavetto
    Rotman Research Institute, Baycrest Center for Geriatric Care, Toronto, Ont, Canada
    Neuropsychologia 40:1428-42. 2002
    ....
  2. ncbi The effects of chemotherapy on cognitive function in a mouse model: a prospective study
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, Ontario, Canada
    Clin Cancer Res 18:3112-21. 2012
    ..The present study used a prospective longitudinal design to assess short- and long-term effects of commonly used anticancer drugs on cognitive performance in a mouse model...
  3. ncbi Adult hippocampal neurogenesis and memory interference
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada
    Behav Brain Res 227:464-9. 2012
    ..The results are consistent with computational models of hippocampal function that specify a central role for neurogenesis in the modulation of interfering influences during learning and memory...
  4. ncbi Memory impairment in obese Zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity
    Gordon Winocur
    Department of Psychology, Trent University, Peterborough, Ontario, Canada
    Behav Neurosci 119:1389-95. 2005
    ..These results parallel those of human studies in pointing to the susceptibility of the hippocampus and related structures to the adverse environment of diabetes mellitus...
  5. doi Memory formation and long-term retention in humans and animals: convergence towards a transformation account of hippocampal-neocortical interactions
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, Toronto, Canada
    Neuropsychologia 48:2339-56. 2010
    ..Evidence is provided in support of the transformation hypothesis, which is advanced as a framework for unifying the seemingly disparate results of studies of anterograde and retrograde memory in the animal and human literatures...
  6. doi An investigation of the effects of hippocampal lesions in rats on pre- and postoperatively acquired spatial memory in a complex environment
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada
    Hippocampus 20:1350-65. 2010
    ....
  7. ncbi The effects of the anti-cancer drugs, methotrexate and 5-fluorouracil, on cognitive function in mice
    Gordon Winocur
    Department of Psychology, Trent University, Peterborough, Ontario, Canada
    Pharmacol Biochem Behav 85:66-75. 2006
    ....
  8. ncbi Changes in context-specificity during memory reconsolidation: selective effects of hippocampal lesions
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, Toronto, Ontario M6A 2E1, Canada
    Learn Mem 16:722-9. 2009
    ..These findings, which relate loss of reactivated memories after hippocampal destruction (or inactivation) to changes in memory representation, are interpreted as consistent with the transformation hypothesis of memory processing...
  9. doi A study of remote spatial memory in aged rats
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada
    Neurobiol Aging 31:143-50. 2010
    ..The potential contribution of the hippocampus to the pattern of lost and spared learning and memory observed in the aged rats was discussed...
  10. ncbi Cognitive rehabilitation in the elderly: an evaluation of psychosocial factors
    Gordon Winocur
    Rotman Research Institute, Baycrest, Toronto, Ontario, Canada
    J Int Neuropsychol Soc 13:153-65. 2007
    ..The results, which show that the benefits of our rehabilitation program extend into the psychosocial domain, underscore the potentially important relationship between psychosocial factors and cognitive performance in older adults...
  11. ncbi Cognitive rehabilitation in the elderly: overview and future directions
    Gordon Winocur
    Rotman Research Institute, Baycrest, Toronto, Ontario, Canada
    J Int Neuropsychol Soc 13:166-71. 2007
    ..The benefits were attributed to several factors, including the program's emphasis on techniques that promoted efficient strategic processing. Limitations of the program and directions for future research are discussed...
  12. ncbi Inhibition of neurogenesis interferes with hippocampus-dependent memory function
    Gordon Winocur
    Department of Psychology, Trent University, Peterborough, Ontario
    Hippocampus 16:296-304. 2006
    ....
  13. ncbi Memory consolidation or transformation: context manipulation and hippocampal representations of memory
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario, M6A 2E1, Canada
    Nat Neurosci 10:555-7. 2007
    ..By manipulating context in two protocols that are widely used to investigate hippocampal-neocortical interactions in memory, we find evidence for the transformation view...
  14. ncbi Age and time-of-day effects on learning and memory in a non-matching-to-sample test
    Gordon Winocur
    Department of Psychology, Trent University, Peterborough, Ont, Canada
    Neurobiol Aging 25:1107-15. 2004
    ....
  15. doi Donepezil reduces cognitive impairment associated with anti-cancer drugs in a mouse model
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, 3560 Bathurst Street, Toronto, ON M6A 2E1, Canada
    Neuropharmacology 61:1222-8. 2011
    ..g., Alzheimer's disease)...
  16. ncbi Preserved spatial memory after hippocampal lesions: effects of extensive experience in a complex environment
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario M6A 2E1, Canada
    Nat Neurosci 8:273-5. 2005
    ..These results, which ruled out dependency on single cues, landmarks or specific routes, suggest that extensive premorbid experience leads to spatial representations that are independent of the hippocampus...
  17. doi Memory transformation and systems consolidation
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, Toronto, Canada
    J Int Neuropsychol Soc 17:766-80. 2011
    ..The transformation hypothesis emphasizes the dynamic nature of memory, as well as the underlying functional and neural interactions that must be taken into account in a comprehensive theory of memory...
  18. ncbi Retrograde amnesia in rats with lesions to the hippocampus on a test of spatial memory
    Gordon Winocur
    Department of Psychology, Trent University, Ontario, Canada
    Neuropsychologia 43:1580-90. 2005
    ....
  19. ncbi Studies of the effects of high fat diets on cognitive function in a rat model
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ont, Canada
    Neurobiol Aging 26:46-9. 2005
    ....
  20. ncbi Cognitive rehabilitation in the elderly: a randomized trial to evaluate a new protocol
    Donald T Stuss
    Rotman Research Institute, Baycrest, Toronto, Ontario, Canada
    J Int Neuropsychol Soc 13:120-31. 2007
    ..The results for each functional domain are reported in separate papers in this series...
  21. doi Brain regions involved in the retrieval of spatial and episodic details associated with a familiar environment: an fMRI study
    Marnie Hirshhorn
    Department of Psychology, University of Toronto, Toronto, Canada
    Neuropsychologia 50:3094-106. 2012
    ..Episodic judgments recruited the posterior cingulate and medial frontal lobes as well as the angular gyrus. These results are discussed in terms of their implications for theories of hippocampal function and spatial and episodic memory...
  22. doi The hippocampus is involved in mental navigation for a recently learned, but not a highly familiar environment: a longitudinal fMRI study
    Marnie Hirshhorn
    Department of Psychology, University of Toronto, Toronto, Ontario, Canada
    Hippocampus 22:842-52. 2012
    ..These findings suggest that the right hippocampus is required for the acquisition of new spatial information but is not needed to represent this information when the environment is highly familiar...
  23. ncbi Cognitive rehabilitation in the elderly: effects on strategic behavior in relation to goal management
    Brian Levine
    Rotman Research Institute, Baycrest, Toronto, Ontario, Canada
    J Int Neuropsychol Soc 13:143-52. 2007
    ..These gains were maintained at long-term follow-up. Future research will assess the specificity of these effects in patient groups...
  24. doi Right frontal lobe mediation of recollection- and familiarity-based verbal recognition memory: evidence from patients with tumor resections
    Nicole D Anderson
    Rotman Research Institute, Baycrest, 3560 Bathurst Street, Toronto, ON M6A 2E1 Canada
    J Cogn Neurosci 23:3804-16. 2011
    ..These results are discussed in terms of prior work linking this area to an overextended sense of familiarity...
  25. ncbi Memory for familiar environments learned in the remote past: fMRI studies of healthy people and an amnesic person with extensive bilateral hippocampal lesions
    R Shayna Rosenbaum
    Department of Psychology, York University, Toronto, Ontario, Canada
    Hippocampus 17:1241-51. 2007
    ..The distinction between recent and remote memory, therefore, may apply as much to spatial theories of hippocampal function as it does to theories emphasizing the role of the hippocampus in other types of explicit memory...
  26. ncbi Cognitive rehabilitation in the elderly: effects on memory
    Fergus I M Craik
    Rotman Research Institute, Baycrest, Toronto, Ontario, Canada
    J Int Neuropsychol Soc 13:132-42. 2007
    ..The results need to be treated with caution, but are promising for the rehabilitation of memory functioning in older adults...
  27. ncbi The cognitive neuroscience of remote episodic, semantic and spatial memory
    Morris Moscovitch
    Department of Psychology, University of Toronto, 100 Saint George Street, Toronto, ON Canada, M5S 3G3
    Curr Opin Neurobiol 16:179-90. 2006
    ....
  28. doi Hippocampal lesions produce both nongraded and temporally graded retrograde amnesia in the same rat
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, Toronto, Canada
    Hippocampus 23:330-41. 2013
    ..2010a) Neuropsychologia 48:2339-2356; Winocur and Moscovitch (2011) J Int Neuropsychol Soc 17:766-780) and at variance with standard consolidation theory and other theoretical models of memory...
  29. ncbi Environmental complexity affects contextual fear conditioning following hippocampal lesions in rats
    Sandra N Moses
    Rotman Research Institute, Baycrest Centre, Toronto, Canada
    Hippocampus 17:333-7. 2007
    ..The results were interpreted as consistent with theories of hippocampal function that emphasize its role in integrating multiple stimulus elements in a memory trace...
  30. ncbi Age effects on social cognition: faces tell a different story
    Michelle L Keightley
    Department of Occupational Science and Occupational Therapy, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Psychol Aging 21:558-72. 2006
    ..Nevertheless, with age there appears to be increasing reliance on a common resource to perform social tasks, but one that is not shared with other cognitive domains...
  31. pmc Functional neuroanatomy of remote episodic, semantic and spatial memory: a unified account based on multiple trace theory
    Morris Moscovitch
    Department of Psychology, University of Toronto and Rotman Research Institute Baycrest Centre, Ontario, Canada
    J Anat 207:35-66. 2005
    ....
  32. ncbi Remembering our past: functional neuroanatomy of recollection of recent and very remote personal events
    Asaf Gilboa
    Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst St, Toronto, Ontario, M6A 2E1, Canada
    Cereb Cortex 14:1214-25. 2004
    ..These findings are incompatible with theories of long-term memory consolidation, and are more easily accommodated by multiple-trace theory, which posits that detailed memories are always dependent on the hippocampus...
  33. doi Amnesia as an impairment of detail generation and binding: evidence from personal, fictional, and semantic narratives in K.C
    R Shayna Rosenbaum
    Department of Psychology, York University, 4700 Keele St, Toronto, Ontario, Canada
    Neuropsychologia 47:2181-7. 2009
    ..Thus, retrograde AM impairment may be viewed as both a loss of information as well as a deficit in reconstructive processes that hamper or prevent the binding of information to generate a cohesive, detail-rich memory...
  34. ncbi "I have often walked down this street before": fMRI studies on the hippocampus and other structures during mental navigation of an old environment
    R Shayna Rosenbaum
    Department of Psychology, University of Toronto, Toronto, Ontario, Canada
    Hippocampus 14:826-35. 2004
    ..Importantly, right medial temporal lobe activity was observed, its magnitude equivalent across all tasks, though the core of the activated region was in the parahippocampal gyrus, barely touching the hippocampus proper...
  35. pmc Age-related differences in brain activity underlying identification of emotional expressions in faces
    Michelle L Keightley
    Department of Occupational Science and Occupational Therapy, University of Toronto, Ontario, Canada
    Soc Cogn Affect Neurosci 2:292-302. 2007
    ....
  36. ncbi Age-related changes in brain activity across the adult lifespan
    Cheryl L Grady
    Rotman Research Institute, University of Toronto, Toronto, Ontario, Canada
    J Cogn Neurosci 18:227-41. 2006
    ..Such an alteration in the balance between default-mode and task-related activity could account for increased vulnerability to distraction from irrelevant information, and thereby affect multiple cognitive domains...
  37. doi The effects of high- and low-risk environments on cognitive function in rats following 2-vessel occlusion of the carotid arteries: a behavioral study
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario, M6A 2E1, Canada
    Behav Brain Res 252:144-56. 2013
    ..The results underscore the importance of lifestyle factors with respect to the impact of stroke on cognition and in assessing prospects for recovery of function. ..
  38. ncbi Verbal fluency, trail making, and Wisconsin Card Sorting Test performance following right frontal lobe tumor resection
    Patrick S R Davidson
    Rotman Research Institute, Baycrest, Ontario, Canada
    J Clin Exp Neuropsychol 30:18-32. 2008
    ..We discuss the importance of etiology in examining brain-behavior relations...
  39. doi The effects of running and of inhibiting adult neurogenesis on learning and memory in rats
    J Martin Wojtowicz
    Department of Physiology, University of Toronto, Toronto, ON, M5S 1A8, Canada
    Eur J Neurosci 27:1494-502. 2008
    ..Performance on the fear conditioning task was weakly related to enhanced neurogenesis or running. The results improve our understanding of the functional role of adult neurogenesis in behaving animals...
  40. ncbi High-fat diets, insulin resistance and declining cognitive function
    Carol E Greenwood
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ont, Canada
    Neurobiol Aging 26:42-5. 2005
    ..Collectively, the human and rodent data point to a role of diet-induced endocrine abnormalities, including the development of insulin resistance, as mediating the cognitive deficits associated with high fat consumption...
  41. ncbi The relation between brain activity during memory tasks and years of education in young and older adults
    Mellanie V Springer
    Rotman Research Institute, Baycrest Centre for Geriatric Care, University of Toronto, Toronto, ON, Canada
    Neuropsychology 19:181-92. 2005
    ..This suggests that the frontal cortex is engaged by older adults, particularly by the highly educated, as an alternative network that may be engaged to aid cognitive function...
  42. ncbi Return to productivity following traumatic brain injury: cognitive, psychological, physical, spiritual, and environmental correlates
    Deirdre R Dawson
    Kunin Lunenfeld Applied Research Unit Baycrest, Toronto, Ontario, Canada
    Disabil Rehabil 29:301-13. 2007
    ..The purpose of this study was to investigate the determinants and correlates of return to productivity (RTP) defined here as return to paid employment and/or school four years following traumatic brain injury (TBI)...
  43. ncbi An fMRI study investigating cognitive modulation of brain regions associated with emotional processing of visual stimuli
    Michelle L Keightley
    Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ont, M6A 2E1 Canada
    Neuropsychologia 41:585-96. 2003
    ....
  44. ncbi Factors affecting graded and ungraded memory loss following hippocampal lesions
    Gordon Winocur
    Rotman Research Institute, Baycrest Centre, Toronto, Canada Department of Psychology, Trent University, Peterborough, Canada Departments of Psychology and Psychiatry, University of Toronto, Toronto, Canada Electronic address
    Neurobiol Learn Mem 106:351-64. 2013
    ..Research strategies aimed at characterizing the neural basis of long-term consolidation/transformation, as well as other outstanding issues are discussed...
  45. doi Differential contributions of executive and episodic memory functions to problem solving in younger and older adults
    Susan Vandermorris
    1 Rotman Research Institute, Baycrest, Toronto, Canada
    J Int Neuropsychol Soc 19:1087-96. 2013
    ..Implications for the development of intervention strategies that target preservation of functional independence in older adults are discussed...
  46. ncbi Aging and autobiographical memory: dissociating episodic from semantic retrieval
    Brian Levine
    Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
    Psychol Aging 17:677-89. 2002
    ..This pattern persisted after additional structured probing for contextual details. The Autobiographical Interview is a useful instrument for quantifying episodic and semantic contributions to personal remote memory...
  47. pmc Remote spatial memory in aging: all is not lost
    R Shayna Rosenbaum
    Neuroscience Graduate Diploma Program, Department of Psychology, York University Toronto, ON, Canada Rotman Research Institute, Baycrest Toronto, ON, Canada
    Front Aging Neurosci 4:25. 2012
    ..The results are seen as analogous to the pattern of better semantic than episodic memory that has been found to accompany healthy aging...
  48. doi Memory rescue and enhanced neurogenesis following electrical stimulation of the anterior thalamus in rats treated with corticosterone
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada
    Exp Neurol 232:100-4. 2011
    ....
  49. ncbi Physical exercise prevents suppression of hippocampal neurogenesis and reduces cognitive impairment in chemotherapy-treated rats
    Gordon Winocur
    Baycrest Centre, Rotman Research Institute, 3560 Bathurst St, Toronto, Ontario, Canada, M6A 2E1
    Psychopharmacology (Berl) 231:2311-20. 2014
    ..It is unknown whether exercise similarly protects against chemotherapy-induced cognitive impairment and whether recovery of neurogenesis is a critical factor...
  50. pmc Divided attention improves delayed, but not immediate retrieval of a consolidated memory
    Yoav Kessler
    Rotman Research Institute, Baycrest Centre and University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 9:e91309. 2014
    ..The results are consistent with other findings showing long-term benefits of retrieval difficulty. Implications for theories of reconsolidation in human episodic memory are discussed. ..
  51. ncbi An occupation-based strategy training approach to managing age-related executive changes: a pilot randomized controlled trial
    Deirdre Dawson
    1Rotman Research Institute, Baycrest Centre, Toronto, ON, Canada
    Clin Rehabil 28:118-27. 2014
    ..Conclusions: These data support the feasibility of a larger trial where a sample of 72 (36 participants in each arm) would be required to confirm or refute these findings. ..
  52. doi How we forget may depend on how we remember
    Talya Sadeh
    Rotman Research Institute, Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1 Electronic address
    Trends Cogn Sci 18:26-36. 2014
    ..This review provides comprehensive evidence for this hypothesis. ..
  53. ncbi Hippocampal contributions to recollection in retrograde and anterograde amnesia
    Asaf Gilboa
    Department of Psychology, University of Haifa, Mount Carmel, Israel
    Hippocampus 16:966-80. 2006
    ..These data suggest that the extended hippocampal system is required to support recollection for both anterograde and retrograde memories, regardless of their age...
  54. ncbi Anterograde and retrograde amnesia in a person with bilateral fornix lesions following removal of a colloid cyst
    Amir Poreh
    Cleveland State University, Department of Psychology, Cleveland, OH 44115, USA
    Neuropsychologia 44:2241-8. 2006
    ....