Bruce G Pollock

Summary

Affiliation: Rotman Research Institute
Country: Canada

Publications

  1. ncbi request reprint A double-blind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia
    Bruce G Pollock
    Rotman Research Institute at Baycrest, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 15:942-52. 2007
  2. doi request reprint D2 receptor blockade by risperidone correlates with attention deficits in late-life schizophrenia
    Hiroyuki Uchida
    PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    J Clin Psychopharmacol 29:571-5. 2009
  3. doi request reprint Cholinergic pathways and cognition in patients with schizophrenia: a pilot study
    Tarek K Rajji
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 139:46-52. 2012
  4. doi request reprint Age and sex impact clozapine plasma concentrations in inpatients and outpatients with schizophrenia
    Zahinoor Ismail
    Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 20:53-60. 2012
  5. doi request reprint Clozapine and global cognition in schizophrenia
    Tarek K Rajji
    Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Toronto, Canada
    J Clin Psychopharmacol 30:431-6. 2010
  6. pmc The ZNF804A gene: characterization of a novel neural risk mechanism for the major psychoses
    Aristotle N Voineskos
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Neuropsychopharmacology 36:1871-8. 2011
  7. pmc Age-related decline in white matter tract integrity and cognitive performance: a DTI tractography and structural equation modeling study
    Aristotle N Voineskos
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Neurobiol Aging 33:21-34. 2012
  8. doi request reprint Transient insight induction with electroconvulsive therapy in a patient with refractory schizophrenia: a case report and systematic literature review
    Philip Gerretsen
    Multimodal Imaging Group, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    J ECT 27:247-50. 2011
  9. doi request reprint Neuroimaging evidence for the deficit subtype of schizophrenia
    Aristotle N Voineskos
    Department of Psychiatry, Centre for Addiction and Mental Health, Toronto, Canada
    JAMA Psychiatry 70:472-80. 2013
  10. doi request reprint Effects of aging on 5-HT(2A) R binding: a HRRT PET study with and without partial volume corrections
    Hiroyuki Uchida
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Int J Geriatr Psychiatry 26:1300-8. 2011

Detail Information

Publications82

  1. ncbi request reprint A double-blind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia
    Bruce G Pollock
    Rotman Research Institute at Baycrest, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 15:942-52. 2007
    ..To compare citalopram and risperidone for the treatment of psychotic symptoms and agitation associated with dementia, with a priori hypotheses that risperidone would be more efficacious for psychosis and citalopram for agitation...
  2. doi request reprint D2 receptor blockade by risperidone correlates with attention deficits in late-life schizophrenia
    Hiroyuki Uchida
    PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    J Clin Psychopharmacol 29:571-5. 2009
    ....
  3. doi request reprint Cholinergic pathways and cognition in patients with schizophrenia: a pilot study
    Tarek K Rajji
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 139:46-52. 2012
    ..The objective of this study was to evaluate the impact of compromised cholinergic pathways on executive versus non-executive cognitive functions of patients with schizophrenia...
  4. doi request reprint Age and sex impact clozapine plasma concentrations in inpatients and outpatients with schizophrenia
    Zahinoor Ismail
    Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 20:53-60. 2012
    ..The objective of this study was to assess the magnitude and variability of plasma concentrations of clozapine and norclozapine across the lifespan in a real-world clinical setting...
  5. doi request reprint Clozapine and global cognition in schizophrenia
    Tarek K Rajji
    Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Toronto, Canada
    J Clin Psychopharmacol 30:431-6. 2010
    ..The relative effect and exposure to CLZ and its major metabolite-N-desmethylclozapine (NDMC)-could explain these discrepancies...
  6. pmc The ZNF804A gene: characterization of a novel neural risk mechanism for the major psychoses
    Aristotle N Voineskos
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Neuropsychopharmacology 36:1871-8. 2011
    ..Our findings link genetic, imaging, and cognitive susceptibility relevant to both schizophrenia and bipolar disorder...
  7. pmc Age-related decline in white matter tract integrity and cognitive performance: a DTI tractography and structural equation modeling study
    Aristotle N Voineskos
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Neurobiol Aging 33:21-34. 2012
    ..e., splenium) of the corpus callosum with memory and executive function. Our findings suggest that decline in the microstructural integrity of white matter fibers can account for cognitive decline in normal aging...
  8. doi request reprint Transient insight induction with electroconvulsive therapy in a patient with refractory schizophrenia: a case report and systematic literature review
    Philip Gerretsen
    Multimodal Imaging Group, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    J ECT 27:247-50. 2011
    ....
  9. doi request reprint Neuroimaging evidence for the deficit subtype of schizophrenia
    Aristotle N Voineskos
    Department of Psychiatry, Centre for Addiction and Mental Health, Toronto, Canada
    JAMA Psychiatry 70:472-80. 2013
    ..Dividing schizophrenia into "deficit" and "nondeficit" subtypes may reduce heterogeneity and facilitate identification of neurobiological markers of disease...
  10. doi request reprint Effects of aging on 5-HT(2A) R binding: a HRRT PET study with and without partial volume corrections
    Hiroyuki Uchida
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Int J Geriatr Psychiatry 26:1300-8. 2011
    ....
  11. ncbi request reprint Increased antipsychotic sensitivity in elderly patients: evidence and mechanisms
    Hiroyuki Uchida
    Centre for Addiction and Mental Health, Positron Emission Tomography Centre, Ontario, Canada
    J Clin Psychiatry 70:397-405. 2009
    ....
  12. pmc Fluorodeoxyglucose positron emission tomography in semantic dementia after 6 months of memantine: an open-label pilot study
    Tiffany W Chow
    Division of Neurology, Baycrest, Toronto, Canada
    Int J Geriatr Psychiatry 28:319-25. 2013
    ..To follow up on the increases we reported in normalized metabolic activity in salience network hubs from a 2-month open-label study of memantine in frontotemporal dementia (FTD)...
  13. doi request reprint A case of apathy due to frontotemporal dementia responsive to memantine
    Kira A Links
    Baycrest, Rotman Research Institute, Toronto, ON, Canada
    Neurocase 19:256-61. 2013
    ..To study the effect of memantine on apathy, a common symptom of behavioral variant frontotemporal dementia (bvFTD)...
  14. pmc A comparison of the E-BEHAVE-AD, NBRS, and NPI in quantifying clinical improvement in the treatment of agitation and psychosis associated with dementia
    Zahinoor Ismail
    Centre for Addiction and Mental Health, Geriatric Mental Health Program, and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 21:78-87. 2013
    ....
  15. doi request reprint Frontotemporoparietal asymmetry and lack of illness awareness in schizophrenia
    Philip Gerretsen
    Multimodal Imaging Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Brain Mapp 34:1035-43. 2013
    ....
  16. doi request reprint Is desire for social relationships mediated by the serotonergic system in the prefrontal cortex? An [(18)F]setoperone PET study
    Philip Gerretsen
    University of Toronto, Toronto, Canada
    Soc Neurosci 5:375-83. 2010
    ..501, p = .017). These correlations were corroborated by a voxel-wise analysis. These results suggest that the serotonergic system may have a regulatory effect on the OFC and ACC for establishing and maintaining social relationships...
  17. doi request reprint Use of lithium in the treatment of bipolar disorder in late-life
    Ramsey D'Souza
    Division of Geriatric Psychiatry, University of Toronto, and Geriatric Mental Health Program, Centre for Addiction and Mental Health, 1001 Queen Street West, Toronto, Ontario M6J 1H4, Canada
    Curr Psychiatry Rep 13:488-92. 2011
    ..Careful monitoring and adjustment of lithium dosage is especially important in older adults to minimize the risk of toxicity...
  18. doi request reprint Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms
    Hiroyuki Uchida
    Schizophrenia Research Group, PET Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 17:255-63. 2009
    ..The objective of this study was to examine whether this sensitivity is due to a central pharmacokinetic (i.e., higher occupancy for a given plasma level) or pharmacodynamic (i.e., greater functional effects for a given occupancy) effect...
  19. pmc Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adults
    Tiffany W Chow
    The Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada
    BMC Med Imaging 9:12. 2009
    ..Methods: Six healthy subjects (age range = 65-78 years) completed two [18F]-setoperone PET scans on two separate occasions 5-16 weeks apart...
  20. doi request reprint Predicting plasma concentration of risperidone associated with dosage change: a population pharmacokinetic study
    Hiroyuki Uchida
    Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
    Ther Drug Monit 34:182-7. 2012
    ..Using population pharmacokinetic methods, the authors therefore sought to predict plasma concentrations of risperidone (RIS) plus 9-hydroxyrisperidone (9-OH-RIS) before a dosage change...
  21. doi request reprint Clozapine exposure and the impact of smoking and gender: a population pharmacokinetic study
    Wenzie Ng
    Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, Ontario M5T 1R8, Canada
    Ther Drug Monit 31:360-6. 2009
    ..These findings may account for some of the variability in clozapine exposure and have important implications for individualized drug dosing and therapeutic drug monitoring...
  22. doi request reprint The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease
    Aristotle N Voineskos
    Department of Psychiatry, Geriatric Mental Health Program, Centre for Addiction and Mental Health, 250 College St, Toronto, Ontario, Canada M5T 1R8
    Arch Gen Psychiatry 68:198-206. 2011
    ..Imaging-genetics strategies may clarify the manner in which BDNF gene variation predicts the risk of AD via characterization of its effects on at-risk structures or neural networks susceptible in this disorder...
  23. doi request reprint Abnormal network connectivity in frontotemporal dementia: evidence for prefrontal isolation
    Norman A S Farb
    Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada
    Cortex 49:1856-73. 2013
    ..Recent neuroimaging research also associates FTD with alterations in the brain's intrinsic connectivity networks. The present study explored the relationship between neural network connectivity and specific behavioral symptoms in FTD...
  24. doi request reprint An improved radiosynthesis of the muscarinic M2 radiopharmaceutical, [18F]FP-TZTP
    Erik M van Oosten
    Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario, Canada M5S 3H6
    Appl Radiat Isot 67:611-6. 2009
    ..This methodology offers higher yields, faster synthesis times, an optimized precursor, and simpler automation than previously reported...
  25. pmc Adherence to escitalopram treatment in depression: a study of electronically compiled dosing histories in the 'Depression: the search for phenotypes' study
    Alette M Wessels
    Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Int Clin Psychopharmacol 27:291-7. 2012
    ..IPT+escitalopram. Early discontinuation of treatment and suboptimal daily execution of the prescribed regimen are the most common facets of poor adherence in this study population...
  26. ncbi request reprint Outcomes of late-life anxiety disorders during 32 weeks of citalopram treatment
    Stephen Blank
    Intervention Research Center for Late Life Mood Disorders, The Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 67:468-72. 2006
    ..Anxiety disorders are common in later life, but little is known about the long-term benefits and risks of pharmacotherapy...
  27. ncbi request reprint Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study
    Carmen Andreescu
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Room E 823, Pittsburgh, PA15213, USA
    Br J Psychiatry 190:344-9. 2007
    ..Comorbid anxiety is common in depressive disorders in both middle and late life, and it affects response to antidepressant treatment...
  28. ncbi request reprint Population pharmacokinetics as a method to detect variable risperidone exposure in patients suffering from dementia with behavioral disturbances
    Robert R Bies
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Geriatr Pharmacother 3:87-91. 2005
    ..This study was intended to compare the consistency of risperidone exposure in patients who have dementia and behavioral disturbances treated in a psychiatric hospital versus a community care setting...
  29. ncbi request reprint Effects of nortriptyline and paroxetine on postural sway in depressed elderly patients
    David C Mamo
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Geriatr Psychiatry 10:199-205. 2002
    ..Further studies with other SSRIs are needed...
  30. pmc Elderly patients with dementia-related symptoms of severe agitation and aggression: consensus statement on treatment options, clinical trials methodology, and policy
    Carl Salzman
    Department of Psychiatry, Harvard Medical School, Boston, Mass 02115, USA
    J Clin Psychiatry 69:889-98. 2008
    ..In 2005, the FDA issued a black box warning regarding increased risk of mortality associated with the use of atypical antipsychotic drugs in this patient population...
  31. ncbi request reprint Correlates of anticholinergic activity in patients with dementia and psychosis treated with risperidone or olanzapine
    Benoit H Mulsant
    Western Psychiatric Institute and Clinic, Department of Psychiatry, Division of Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 65:1708-14. 2004
    ..Older individuals with dementia are highly sensitive to the effects of muscarinic receptor blockade...
  32. ncbi request reprint Antidepressant pharmacotherapy in the treatment of depression in the very old: a randomized, placebo-controlled trial
    Steven P Roose
    New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Psychiatry 161:2050-9. 2004
    ..This study determined the efficacy of antidepressant medication for the treatment of depression in the "old-old."..
  33. ncbi request reprint Efficacy and tolerability of citalopram in the treatment of late-life anxiety disorders: results from an 8-week randomized, placebo-controlled trial
    Eric J Lenze
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine and VA Healthcare System, PA, USA
    Am J Psychiatry 162:146-50. 2005
    ..Anxiety disorders are highly prevalent in elderly persons. However, to date, the efficacy of selective serotonin reuptake inhibitors (SSRIs) for the treatment of anxiety disorders in this age group has not been established...
  34. ncbi request reprint Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients
    Bruce G Pollock
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 159:460-5. 2002
    ....
  35. doi request reprint Desvenlafaxine succinate for major depressive disorder
    Beth A Sproule
    The Centre for Addiction and Mental Health, University of Toronto, Canada
    Drugs Today (Barc) 44:475-87. 2008
    ..The only identified potential advantage of desvenlafaxine over venlafaxine or other antidepressant agents at this time is the apparently reduced risk for pharmacokinetic drug interactions...
  36. ncbi request reprint A model of anticholinergic activity of atypical antipsychotic medications
    Marci L Chew
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Schizophr Res 88:63-72. 2006
    ..However, it is difficult with the available data to predict the likelihood of anticholinergic effects occurring with various doses of an atypical antipsychotic...
  37. ncbi request reprint Emergence, persistence, and resolution of suicidal ideation during treatment of depression in old age
    Katalin Szanto
    University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, Pennsylvania 15213, United States
    J Affect Disord 98:153-61. 2007
    ..To determine the rate and clinical correlates of emergent, persistent, and resolved suicidal ideation during treatment of major depression in the elderly...
  38. ncbi request reprint Cardiovascular changes associated with venlafaxine in the treatment of late-life depression
    Ellyn M Johnson
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:796-802. 2006
    ..Potential cardiovascular side effects from venlafaxine-XR must be considered when prescribing this medication, especially in geriatric patients, who often present with comorbid medical conditions...
  39. ncbi request reprint Paroxetine treatment of primary insomnia in older adults
    Charles F Reynolds
    Advanced Center for Interventions and Services Research for Late Life Mood Disorders ACISR LLMD and the John A Hartford Center of Excellence in Geriatric Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:803-7. 2006
    ..The goal of this study was to test the efficacy of paroxetine for primary insomnia in older adults...
  40. ncbi request reprint Evaluating the consistency of pharmacotherapy exposure by use of state-of-the-art techniques
    Robert R Bies
    Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 10:696-705. 2002
    ..Therefore, it is important to measure adherence patterns in clinical trials evaluating these treatments and to incorporate this information into the research findings...
  41. ncbi request reprint Lower central serotonergic responsivity is associated with preclinical carotid artery atherosclerosis
    Matthew F Muldoon
    Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Stroke 38:2228-33. 2007
    ..This investigation tested a hypothesized association between central serotonergic functioning and preclinical atherosclerosis...
  42. ncbi request reprint Maintenance treatment for old-age depression preserves health-related quality of life: a randomized, controlled trial of paroxetine and interpersonal psychotherapy
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 55:1325-32. 2007
    ..To determine whether maintenance antidepressant pharmacotherapy and interpersonal psychotherapy sustain gains in health-related quality of life (HR-QOL) achieved during short-term treatment in older patients with depression...
  43. doi request reprint Sex, race, and smoking impact olanzapine exposure
    Kristin L Bigos
    Department of Pharmaceutical Sciences, University of Pittsburgh, School of Pharmacy, 805 Salk Hall, 3501 Terrace St, Pittsburgh, PA 15261, USA
    J Clin Pharmacol 48:157-65. 2008
    ..0001). Differences in olanzapine exposure due to sex, race, and smoking may account for some of the variability in response to olanzapine...
  44. pmc Serotonin transporter genotype interacts with paroxetine plasma levels to influence depression treatment response in geriatric patients
    Francis E Lotrich
    NIMH Advanced Center in Interventions and Services Research for Late Life Mood Disorders and the John A Hartford Foundation Center of Excellence in Geriatric Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Psychiatry Neurosci 33:123-30. 2008
    ..To investigate whether variable antidepressant response may be influenced by an interaction between the serotonin transporter promoter polymorphism (5-HTTLPR) and antidepressant concentration...
  45. ncbi request reprint Persistence of neuropsychologic deficits in the remitted state of late-life depression
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 14:419-27. 2006
    ..Cognitive impairment in late-life depression (LLD) is prevalent, disabling, and persists despite the remission of depressive symptoms. This article characterizes neuropsychologic functioning during remission in LLD...
  46. pmc Paroxetine: population pharmacokinetic analysis in late-life depression using sparse concentration sampling
    Yan Feng
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA 15261, USA, and Rotman Research Institute, Baycrest Hospital, University of Toronto, Canada
    Br J Clin Pharmacol 61:558-69. 2006
    ..To develop a population pharmacokinetic (PK) model using sparse sampling of long-term treatment with paroxetine in elderly depressed subjects, incorporating CYP2D6 genotype as well as other covariates...
  47. ncbi request reprint Treatment considerations for anxiety in the elderly
    Eric J Lenze
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    CNS Spectr 8:6-13. 2003
    ..Overall, the research in late-life anxiety has not caught up to the literature in late-life depression and, for the most part, treatment recommendations must be extrapolated from studies in young adults...
  48. ncbi request reprint Paroxetine-induced hyponatremia in older adults: a 12-week prospective study
    Tanya J Fabian
    Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Arch Intern Med 164:327-32. 2004
    ....
  49. ncbi request reprint Serotonin modulation of cerebral glucose metabolism in normal aging
    Sara Goldberg
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Neurobiol Aging 25:167-74. 2004
    ..These results suggest different compensatory processes in anterior compared to posterior brain regions secondary to the age-related loss of serotonin innervation...
  50. ncbi request reprint Plasma levels of citalopram in depressed patients with hepatitis C
    Ondria C Gleason
    Department of Psychiatry, University of Oklahoma College of Medicine Tulsa, 74135 2512, USA
    Psychosomatics 45:29-33. 2004
    ....
  51. ncbi request reprint alpha1-acid glycoprotein in late-life depression: relationship to medical burden and genetics
    Opeolu M Adeoye
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    J Geriatr Psychiatry Neurol 16:235-9. 2003
    ..Frequency differences in ORM1 allelic variants apparently did not influence increased AAG concentrations in depressed patients...
  52. ncbi request reprint Good treatment outcomes in late-life depression with comorbid anxiety
    Eric J Lenze
    The Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Affect Disord 77:247-54. 2003
    ..This study evaluated the impact of comorbid anxiety on response, dropouts, and side effects, in elderly subjects treated for depression...
  53. ncbi request reprint Paroxetine-induced hyponatremia in the elderly due to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
    Tanya J Fabian
    Intervention Research Center for Late Life Mood Disorders, USA
    J Geriatr Psychiatry Neurol 16:160-4. 2003
    ..Data suggest hyponatremia is a common adverse event in elderly patients prescribed paroxetine and implicates inappropriate secretion of ADH as the potential mechanism...
  54. ncbi request reprint Acute and chronic effects of citalopram on cerebral glucose metabolism in geriatric depression
    Gwenn S Smith
    Department of Psychiatry Research, Hillside Hospital and the Neuroscience Institute of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Am J Geriatr Psychiatry 10:715-23. 2002
    ....
  55. ncbi request reprint Verification of scale sub-domains in elderly patients with dementia: a confirmatory factor-analytic approach
    Kari B Kastango
    Department of Biostatistics, University of Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 10:706-14. 2002
    ....
  56. ncbi request reprint Risk factors for falls during treatment of late-life depression
    Jin H Joo
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 63:936-41. 2002
    ..This study evaluated the time course and potential risk factors for falls in a treatment protocol for late-life depression to identify specific at-risk periods and risk factors for falls in this population...
  57. ncbi request reprint Effect of nortriptyline and paroxetine on CYP2D6 activity in depressed elderly patients
    LalithKumar K Solai
    Mental Health Intervention Research Center for the Study of Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Clin Psychopharmacol 22:481-6. 2002
    ..CYP2D6 inhibition by paroxetine, which effectively converted 59% of patients to phenotypic PMs, may be especially relevant for elderly patients given their generally higher concentration of paroxetine...
  58. ncbi request reprint Response speed and rate of remission in primary and specialty care of elderly patients with depression
    Leslie Thomas
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 10:583-91. 2002
    ....
  59. ncbi request reprint Glucose metabolic response to total sleep deprivation, recovery sleep, and acute antidepressant treatment as functional neuroanatomic correlates of treatment outcome in geriatric depression
    Gwenn S Smith
    Department of Psychiatry Research, Hillside Hospital of the North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Am J Geriatr Psychiatry 10:561-7. 2002
    ....
  60. ncbi request reprint Serotonin modulation of cerebral glucose metabolism measured with positron emission tomography (PET) in human subjects
    Gwenn S Smith
    Department of Psychiatry Research, Hillside Hospital, Neuroscience Institute of the North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Synapse 45:105-12. 2002
    ..Future studies will evaluate how the acute metabolic response to citalopram relates to the metabolic response after chronic treatment in patients with geriatric depression...
  61. ncbi request reprint Risperidone and 9-hydroxyrisperidone concentrations are not dependent on age or creatinine clearance among elderly subjects
    Rae Ann Maxwell
    Pharmacy Department, Western Psychiatric Institute and Clinic, VA Pittsburgh Health System, Pennsylvania, USA
    J Geriatr Psychiatry Neurol 15:77-81. 2002
    ..These results were unchanged when concentrations were corrected for total daily risperidone dose. Among elderly subjects, risperidone and 9-OH clearance do not decline with increasing age or declining CrCl...
  62. ncbi request reprint A randomized, placebo-controlled trial of paroxetine in nursing home residents with non-major depression
    Adam B Burrows
    Geriatrics Section, Boston University School of Medicine, 74 Fenwood Road, Boston, MA 02115, USA
    Depress Anxiety 15:102-10. 2002
    ..The study also illustrates the discordance between patient and caregiver ratings, and the difficulties in studying very elderly patients with mood disorders...
  63. ncbi request reprint The nature and determinants of neuropsychological functioning in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 61:587-95. 2004
    ..Cognitive impairment in late-life depression (LLD) is highly prevalent, disabling, poorly understood, and likely related to long-term outcome...
  64. ncbi request reprint Executive functioning, illness course, and relapse/recurrence in continuation and maintenance treatment of late-life depression: is there a relationship?
    Meryl A Butters
    Intervention Research Center for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh Medical Center, USA
    Am J Geriatr Psychiatry 12:387-94. 2004
    ..The authors tested the hypothesis that impaired executive functioning leads to high rates of relapse and recurrence in late-life depression...
  65. ncbi request reprint Effects of serotonin transporter promoter polymorphisms on serotonin function
    Gwenn S Smith
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 29:2226-34. 2004
    ....
  66. ncbi request reprint Decreasing pain and anxiety associated with patient-activated atrial shock: a placebo-controlled study of adjunctive sedation with oral triazolam
    Tanya J Fabian
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
    J Cardiovasc Electrophysiol 17:391-5. 2006
    ..The main objective of the present study was to determine whether triazolam improved patient perception of the shock experience or altered patient memory of shock discomfort relative to placebo...
  67. ncbi request reprint What is the optimal duration of a short-term antidepressant trial when treating geriatric depression?
    Benoit H Mulsant
    Advanced Center in Intervention and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychopharmacol 26:113-20. 2006
    ..To determine the optimal duration of an antidepressant trial in elderly patients, the authors examined the probability of eventually responding to treatment based on early improvement...
  68. ncbi request reprint A genetic algorithm-based, hybrid machine learning approach to model selection
    Robert R Bies
    Department of Pharmaceutical Sciences and Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    J Pharmacokinet Pharmacodyn 33:195-221. 2006
    ..This includes structural, inter-individual random effects, covariate effects and residual error models using machine learning. This method is based on combinatorial optimization using genetic algorithm...
  69. ncbi request reprint Maintenance treatment of major depression in old age
    Charles F Reynolds
    Advanced Center for Intervention and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    N Engl J Med 354:1130-8. 2006
    ..Elderly patients with major depression, including those having a first episode, are at high risk for recurrence of depression, disability, and death...
  70. ncbi request reprint The metabolic syndrome is associated with reduced central serotonergic responsivity in healthy community volunteers
    Matthew F Muldoon
    Division of Clinical Pharmacology, Departments of Medicine and Epidemiology, University of Pittsburgh, 4015 O Hara Street, Pittsburgh, PA 15260, USA
    J Clin Endocrinol Metab 91:718-21. 2006
    ..The pathobiology of the metabolic syndrome remains unclear. The central nervous system is likely to be involved via regulation of eating, physical activity, blood pressure, and metabolism...
  71. ncbi request reprint Development of a short form of the Severe Impairment Battery
    Judith Saxton
    Univ of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 13:999-1005. 2005
    ..The authors sought to develop a short form of the Severe Impairment Battery (SIB)...
  72. ncbi request reprint Comorbid anxiety disorder in late life depression: association with memory decline over four years
    Alison K DeLuca
    The Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 20:848-54. 2005
    ..The purpose of this study was to determine whether comorbid GAD or PD was associated with poorer long-term outcomes of late-life MDD, in terms of symptoms, functional disability, and cognitive status...
  73. ncbi request reprint Dextromethorphan-induced delirium and possible methadone interaction
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Geriatr Pharmacother 3:17-20. 2005
    ..It is metabolized primarily by the cytochrome P450 (CYP) 2D6 isozyme. Methadone has been found to inhibit CYP2D6, indicating a potential for interaction with dextromethorphan...
  74. ncbi request reprint Late-onset major depression: clinical and treatment-response variability
    Henry C Driscoll
    Intervention Research Center for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 20:661-7. 2005
    ..To explore clinical and treatment-response variability in late-onset vs early-onset non-bipolar, non-psychotic major depression...
  75. ncbi request reprint Serum anticholinergic activity and cognition in patients with moderate-to-severe dementia
    Marci L Chew
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:535-8. 2005
    ..The authors investigated the association between serum anticholinergic activity (SAA) and cognitive performance in a group of patients with moderate-to-severe dementia...
  76. ncbi request reprint Accelerating symptom-reduction in late-life depression: a double-blind, randomized, placebo-controlled trial of sleep deprivation
    Charles F Reynolds
    Intervention Research Center for Late Life Mood Disorders IRC LLMD, Univ of Pittsburgh School of Medicine, 3811 O Hara Street, E 113521, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:353-8. 2005
    ..Authors tested the hypothesis that one night of total sleep deprivation (TSD) would accelerate antidepressant response to paroxetine, as compared with TSD+placebo (PBO) and paroxetine-alone, in late-life major depression...
  77. ncbi request reprint Does education moderate neuropsychological impairment in late-life depression?
    Rishi K Bhalla
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    Int J Geriatr Psychiatry 20:413-7. 2005
    ..This study examined whether educational level influences the degree of neuropsychological impairment associated with late-life depression...
  78. ncbi request reprint Estimating treatment effects from longitudinal clinical trial data with missing values: comparative analyses using different methods
    Patricia R Houck
    Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, UPMC Health System, Thomas Detre Hall, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Psychiatry Res 129:209-15. 2004
    ..No significant treatment differences were found. We conclude that attention to the missing-data mechanism should be an integral part in analysis of clinical trial data...
  79. ncbi request reprint Utility of sparse concentration sampling for citalopram in elderly clinical trial subjects
    Robert R Bies
    Department of Psychiatry and Pharmaceutical Sciences, University of Pittsburgh, 805 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15213, USA
    J Clin Pharmacol 44:1352-9. 2004
    ..This is particularly valuable for populations such as the elderly, who are not typically available for pharmacokinetic studies...
  80. ncbi request reprint Neuroendocrine response to intravenous citalopram in healthy control subjects: pharmacokinetic influences
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    Psychopharmacology (Berl) 178:268-75. 2005
    ..The neuroendocrine response to intravenous citalopram may provide an acute, functional, in vivo measure of the neural serotonin (5-HT) system...
  81. ncbi request reprint Neuropathologic correlates of late-onset major depression
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2242-50. 2004
    ..These preliminary findings suggest that AD is the predominant neuropathologic condition in LLMD subjects with dementia. Further assessment of the role of comorbid cerebrovascular disease and comorbid DLB is needed...
  82. ncbi request reprint Intent-to-treat analysis for clinical trials: use of data collected after termination of treatment protocol
    Sati Mazumdar
    Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Psychiatr Res 36:153-64. 2002
    ..Statistical inference is based on bootstrap sampling procedures. We have illustrated this methodology using data from a drug trial comparing nortriptyline and paroxetine in the treatment of major depression in older patients...