H S Mayberg
Affiliation: Rotman Research Institute
- The functional neuroanatomy of the placebo effectHelen S Mayberg
Department of Psychiatry, University of Texas at San Antonio, USA
Am J Psychiatry 159:728-37. 2002..Administration of placebo can result in a clinical response indistinguishable from that seen with active antidepressant treatment. Functional brain correlates of this phenomenon have not been fully characterized...
- Personality influences limbic-cortical interactions during sad mood inductionMichelle L Keightley
Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
Neuroimage 20:2031-9. 2003....
- Positron emission tomography imaging in depression: a neural systems perspectiveHelen S Mayberg
Department of Psychiatry and Medicine Neurology, Rotman Research Institute, Baycrest Centre, University of Toronto, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada
Neuroimaging Clin N Am 13:805-15. 2003..An additional goal is the development of routine, brain-based clinical algorithms that optimize diagnosis and treatment of individual depressed patients...
- Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadnessH S Mayberg
Research Imaging Center, University of Texas Health Science Center at San Antonio, USA
Am J Psychiatry 156:675-82. 1999..Expanding on this theory, this study examined functional interactions between specific limbic and neocortical regions accompanying normal and disease-associated shifts in negative mood state...
- The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging studyJ H Meyer
Clarke Division, Centre for Addictions and Mental Health, Department ofPsychiatry, University of Toronto, Ontario, Canada
Am J Psychiatry 158:78-85. 2001..The objective of this study was to evaluate the effect of 6 weeks of paroxetine treatment on 5-HT(2A) receptors in depressed patients...
- Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depressionS H Kennedy
Mood and Anxiety Disorders Program, Centre for Addiction and Mental Health, Clarke Site, 250 College St, Toronto, Ontario M5T 1R8, Canada
Am J Psychiatry 158:899-905. 2001..The aim of the present study was to assess the effects of successful paroxetine treatment on regional glucose metabolism in patients with major depression...
- The role of functional neuroimaging in the neuropsychology of depressionM Liotti
Research Imaging Center, and Department of Radiology, Psychiatry and Medicine Neurology, University of Texas Health Science Center, San Antonio, TX, USA
J Clin Exp Neuropsychol 23:121-36. 2001....
- Xenon effects on regional cerebral blood flow assessed by 15O-H2O positron emission tomography: implications for hyperpolarized xenon MRIM Liotti
Research Imaging Center, University of Texas Health Science Center at San Antonio 78284 6240, USA
J Magn Reson Imaging 7:761-4. 1997..No such decreases were found in other sensory or motor regions...
- Modulating limbic-cortical circuits in depression: targets of antidepressant treatmentsHelen S Mayberg
Department of Psychiatry, University of Toronto, Ontario, Canada
Semin Clin Neuropsychiatry 7:255-68. 2002....
- Differences in brain glucose metabolism between responders to CBT and venlafaxine in a 16-week randomized controlled trialSidney H Kennedy
University Health Network, Institute of Medical Science, University of Toronto, Department of Psychiatry, and Toronto General Hospital, 200 Elizabeth St, Eaton North Wing 8 222, Toronto, Ontario M5G 2C4, Canada
Am J Psychiatry 164:778-88. 2007..In this study, the authors report changes in fluorine-18-fluorodeoxyglucose PET in responders to CBT or venlafaxine during a randomized controlled trial...
- Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for obsessive compulsive disorderS L Rauch
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 50:659-67. 2001..Further research, utilizing a prospective design, is indicated to determine the validity and reliability of this finding. If confirmed, an index for noninvasively predicting response to cingulotomy for OCD would be of great value...
- Limbic-frontal circuitry in major depression: a path modeling metanalysisD A Seminowicz
Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
Neuroimage 22:409-18. 2004....
- An ERP study of the temporal course of the Stroop color-word interference effectM Liotti
University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284 6240, USA
Neuropsychologia 38:701-11. 2000....
- Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depressionAndres M Lozano
Division of Neurosurgery, University of Toronto, Toronto, Canada
Biol Psychiatry 64:461-7. 2008..We now report the results of these and an additional 14 patients with extended follow-up...
- Treatment resistant depression as a failure of brain homeostatic mechanisms: implications for deep brain stimulationPeter Giacobbe
Department of Psychiatry, University Health Network, University of Toronto, Canada
Exp Neurol 219:44-52. 2009....
- Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for treatment of major depressionDarin D Dougherty
Department of Psychiatry, Radiology, Neurosurgery, and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
J Neurosurg 99:1010-7. 2003..If confirmed, the availability of an index for noninvasively predicting a patient's response to cingulotomy for the treatment of major depression would be of great clinical value...
- Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatmentHelen S Mayberg
Department of Psychiatry and the Rotman Research Institute, University of Toronto, Ontario, Canada
Br Med Bull 65:193-207. 2003....
- Risk and resilience markers in bipolar disorder: brain responses to emotional challenge in bipolar patients and their healthy siblingsStephanie Krüger
Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
Am J Psychiatry 163:257-64. 2006..In this study, potential markers of bipolar risk and resilience were examined in a new cohort of lithium-responsive bipolar patients and their healthy siblings...
- Neural stimulation successfully treats depression in patients with prior ablative cingulotomyJoseph S Neimat
Toronto Western Hospital, 399 Bathurst St, WW4-425, Toronto, Ontario M5T 2S8, Canada
Am J Psychiatry 165:687-93. 2008
- Relationship between regional brain metabolism, illness severity and age in depressed subjectsJakub Z Konarski
Institute of Medical Science, University of Toronto, Toronto, ON, Canada
Psychiatry Res 155:203-10. 2007..The age-dependent changes documented herein may influence the distinct clinical presentation and treatment response described in older-age depression...
- An fMRI study investigating cognitive modulation of brain regions associated with emotional processing of visual stimuliMichelle L Keightley
Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ont, M6A 2E1 Canada
Neuropsychologia 41:585-96. 2003....
- Changes in regional cerebral blood flow following mood challenge in drug-free, remitted patients with unipolar depressionMichael C Gemar
Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
Depress Anxiety 24:597-601. 2007..Previously reported mediofrontal changes in remitted patients are unlikely to be a consequence of maintenance medication and more likely are evidence of relapse vulnerability...
- Neurobiological mechanisms of the placebo effectFabrizio Benedetti
Department of Neuroscience, University of Turin Medical School, 10125 Turin, Italy
J Neurosci 25:10390-402. 2005
- Persistent auditory hallucinations that are unresponsive to antipsychotic drugsStephen E Nicolson
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA
Am J Psychiatry 163:1153-9. 2006
- Posttraumatic stress disorder: a state-of-the-science reviewCharles B Nemeroff
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322 4990, USA
J Psychiatr Res 40:1-21. 2006....
- Is late-life depression a predictor of Alzheimer's disease? Results from a historical cohort studyRobert van Reekum
Int J Geriatr Psychiatry 20:80-2. 2005
- Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinicKerry J Ressler
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Drive, Atlanta, Georgia 30329, USA
Nat Neurosci 10:1116-24. 2007..Although many of these approaches are experimental, the rapidly developing understanding of emotional circuit regulation is likely to provide exciting and powerful future treatments for debilitating mood and anxiety disorders...
- Neuropsychological impact of Cg25 deep brain stimulation for treatment-resistant depression: preliminary results over 12 monthsHeather E McNeely
Schizophrenia Services, Neuropsychology Service, St Joseph s Healthcare, Hamilton, Ontario, Canada
J Nerv Ment Dis 196:405-10. 2008..Though the sample size is small, these results support cognitive safety of Cg25 DBS for TRD...
- State and trait influences on mood regulation in bipolar disorder: blood flow differences with an acute mood challengeStephanie Krüger
Department of Psychiatry SK, University of Dresden, Dresden, Germany
Biol Psychiatry 54:1274-83. 2003..Imitating such stressors by the controlled transient exposure to an emotional stimulus may help to identify brain regions modulating this sensitivity...
- Unmasking disease-specific cerebral blood flow abnormalities: mood challenge in patients with remitted unipolar depressionMario Liotti
Division of Psychiatry, Faculty of Medicine, University of Nottingham, A Floor, South Block, Queens Medical Centre, Nottingham NG7 2UH, UK
Am J Psychiatry 159:1830-40. 2002....
- Defining the neural circuitry of depression: toward a new nosology with therapeutic implicationsHelen S Mayberg
Biol Psychiatry 61:729-30. 2007