C L Grady

Summary

Affiliation: Rotman Research Institute
Country: Canada

Publications

  1. pmc Neural correlates of the episodic encoding of pictures and words
    C L Grady
    Rotman Research Institute of Baycrest Centre and Department of Psychology, University of Toronto, 3560 Bathurst Street, Toronto, Ontario, Canada, M6A 2E1
    Proc Natl Acad Sci U S A 95:2703-8. 1998
  2. pmc Age differences in FMRI adaptation for sound identity and location
    Cheryl L Grady
    Rotman Research Institute, Baycrest Toronto, ON, Canada
    Front Hum Neurosci 5:24. 2011
  3. doi Acute pharmacologically induced shifts in serotonin availability abolish emotion-selective responses to negative face emotions in distinct brain networks
    Cheryl L Grady
    Rotman Research Institute at Baycrest, University of Toronto, Toronto, Canada
    Eur Neuropsychopharmacol 23:368-78. 2013
  4. pmc Age differences in default and reward networks during processing of personally relevant information
    Cheryl L Grady
    Rotman Research Institute at Baycrest, Toronto, Ontario, Canada
    Neuropsychologia 50:1682-97. 2012
  5. pmc The cognitive neuroscience of ageing
    Cheryl Grady
    The Rotman Research Institute at Baycrest, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada
    Nat Rev Neurosci 13:491-505. 2012
  6. ncbi Age-related differences in the functional connectivity of the hippocampus during memory encoding
    Cheryl L Grady
    Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
    Hippocampus 13:572-86. 2003
  7. ncbi Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer's disease
    Cheryl L Grady
    Rotman Research Institute, Baycrest Center for Geriatric Care, Toronto, Ontario, Canada M6A 2E1
    J Neurosci 23:986-93. 2003
  8. ncbi Age-related differences in brain activity underlying working memory for spatial and nonspatial auditory information
    Cheryl L Grady
    Rotman Research Institute at Baycrest, University of Toronto, Toronto, Ontario, Canada
    Cereb Cortex 18:189-99. 2008
  9. ncbi Comment on Greenwood (2007): solving the puzzle of structure/function relations in the aging brain?
    Cheryl L Grady
    Rotman Research Institute at Baycrest, University of Toronto, Ontario, Canada
    Neuropsychology 21:674-5; discussion 680-3. 2007
  10. pmc A multivariate analysis of age-related differences in default mode and task-positive networks across multiple cognitive domains
    Cheryl L Grady
    Rotman Research Institute at Baycrest, Toronto, Ontario, Canada
    Cereb Cortex 20:1432-47. 2010

Detail Information

Publications60

  1. pmc Neural correlates of the episodic encoding of pictures and words
    C L Grady
    Rotman Research Institute of Baycrest Centre and Department of Psychology, University of Toronto, 3560 Bathurst Street, Toronto, Ontario, Canada, M6A 2E1
    Proc Natl Acad Sci U S A 95:2703-8. 1998
    ....
  2. pmc Age differences in FMRI adaptation for sound identity and location
    Cheryl L Grady
    Rotman Research Institute, Baycrest Toronto, ON, Canada
    Front Hum Neurosci 5:24. 2011
    ....
  3. doi Acute pharmacologically induced shifts in serotonin availability abolish emotion-selective responses to negative face emotions in distinct brain networks
    Cheryl L Grady
    Rotman Research Institute at Baycrest, University of Toronto, Toronto, Canada
    Eur Neuropsychopharmacol 23:368-78. 2013
    ..Lower serotonin leads to a broadening of a normally fear-specific response to anger, and higher levels reduce the differentiated brain response to aversive face emotions...
  4. pmc Age differences in default and reward networks during processing of personally relevant information
    Cheryl L Grady
    Rotman Research Institute at Baycrest, Toronto, Ontario, Canada
    Neuropsychologia 50:1682-97. 2012
    ..The finding that older adults had more positive judgments, but weaker engagement and less consistent functional connectivity in these networks, suggests potential brain mechanisms for the "positivity bias" with aging...
  5. pmc The cognitive neuroscience of ageing
    Cheryl Grady
    The Rotman Research Institute at Baycrest, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada
    Nat Rev Neurosci 13:491-505. 2012
    ..In this Review, current trends and unresolved issues in the cognitive neuroscience of ageing are discussed...
  6. ncbi Age-related differences in the functional connectivity of the hippocampus during memory encoding
    Cheryl L Grady
    Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
    Hippocampus 13:572-86. 2003
    ....
  7. ncbi Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer's disease
    Cheryl L Grady
    Rotman Research Institute, Baycrest Center for Geriatric Care, Toronto, Ontario, Canada M6A 2E1
    J Neurosci 23:986-93. 2003
    ....
  8. ncbi Age-related differences in brain activity underlying working memory for spatial and nonspatial auditory information
    Cheryl L Grady
    Rotman Research Institute at Baycrest, University of Toronto, Toronto, Ontario, Canada
    Cereb Cortex 18:189-99. 2008
    ....
  9. ncbi Comment on Greenwood (2007): solving the puzzle of structure/function relations in the aging brain?
    Cheryl L Grady
    Rotman Research Institute at Baycrest, University of Toronto, Ontario, Canada
    Neuropsychology 21:674-5; discussion 680-3. 2007
    ..This hypothesis should stimulate research into these mechanisms and hopefully will ultimately inform researchers' ability to rehabilitate cognitive disorders in the elderly...
  10. pmc A multivariate analysis of age-related differences in default mode and task-positive networks across multiple cognitive domains
    Cheryl L Grady
    Rotman Research Institute at Baycrest, Toronto, Ontario, Canada
    Cereb Cortex 20:1432-47. 2010
    ..Increased use of the TPN may reflect greater demand on cognitive control processes in older individuals that may be partially offset by alterations in prefrontal functional connectivity...
  11. ncbi Age-related changes in brain activity across the adult lifespan
    Cheryl L Grady
    Rotman Research Institute, University of Toronto, Toronto, Ontario, Canada
    J Cogn Neurosci 18:227-41. 2006
    ..Such an alteration in the balance between default-mode and task-related activity could account for increased vulnerability to distraction from irrelevant information, and thereby affect multiple cognitive domains...
  12. ncbi Task-related activity in prefrontal cortex and its relation to recognition memory performance in young and old adults
    Cheryl L Grady
    Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst St, Toronto, Ont, Canada M6A 2E1
    Neuropsychologia 43:1466-81. 2005
    ....
  13. ncbi The effect of age on memory for emotional faces
    Cheryl L Grady
    Rotman Research Institute at Baycrest, University of Toronto, Toronto, ON, Canada
    Neuropsychology 21:371-80. 2007
    ..This enhancement is absent in older adults, but memory for emotional faces is modulated in older adults by personality traits that are relevant to emotional processing...
  14. doi Cognitive neuroscience of aging
    Cheryl L Grady
    Rotman Research Institute at Baycrest, 3560 Bathurst St, Toronto, Ontario M6A 2E1, Canada
    Ann N Y Acad Sci 1124:127-44. 2008
    ....
  15. ncbi Studies of altered social cognition in neuropsychiatric disorders using functional neuroimaging
    Cheryl L Grady
    Rotman Research Institute, Baycrest Centre for Geriatric Care, Department of Psychology, Department of Psychiatry, University of Toronto, Toronto, Ontario
    Can J Psychiatry 47:327-36. 2002
    ..Although there is much work remaining in this area, we are beginning to understand the complex interactions of brain function and behaviour that lead to disruptions of social abilities...
  16. ncbi The effects of encoding task on age-related differences in the functional neuroanatomy of face memory
    Cheryl L Grady
    Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
    Psychol Aging 17:7-23. 2002
    ..Differential correlations of brain activity and behavior were found that suggest older adults use unique neural systems to facilitate face memory...
  17. ncbi Introduction to the special section on aging, cognition, and neuroimaging
    Cheryl L Grady
    Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
    Psychol Aging 17:3-6. 2002
    ..These articles are representative of the field and cover many of the issues faced by researchers in this area. This introduction presents some background into the techniques that are used and provides an overview of the articles...
  18. ncbi Brain imaging and age-related changes in cognition
    C L Grady
    Rotman Research Institute and University of Toronto, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
    Exp Gerontol 33:661-73. 1998
    ..However, data collected to date on this issue are still limited, so although the evidence is intriguing, the definitive interpretation of these findings must await further experiments...
  19. ncbi Functional brain imaging and age-related changes in cognition
    C L Grady
    Rotman Research Institute and University of Toronto, Baycrest Centre for Geriatric Care, 3560 Bathurst St, Toronto, Ont, Canada M6A 2E1
    Biol Psychol 54:259-81. 2000
    ..However, data collected to date on this issue are still limited, so although the evidence is intriguing, the definitive interpretation of these findings must await further experiments...
  20. ncbi Changes in memory processing with age
    C L Grady
    Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
    Curr Opin Neurobiol 10:224-31. 2000
    ..Recent behavioral and neurophysiological experiments are furthering our understanding of the effects of aging on cognition. It appears that some brain changes seen with age may be compensatory...
  21. ncbi Altered brain functional connectivity and impaired short-term memory in Alzheimer's disease
    C L Grady
    Rotman Research Institute, Baycrest Centre for Geriatric Care, University of Toronto, Toronto, Ontario, Canada
    Brain 124:739-56. 2001
    ..Furthermore, the positive association between amygdala activity and memory performance in the patients suggests a possible compensatory role for an emotion-related network of regions...
  22. ncbi Corticolimbic interactions associated with performance on a short-term memory task are modified by age
    V Della-Maggiore
    Rotman Research Institute of Baycrest Centre, Toronto, Ontario M6A 2E1, Canada
    J Neurosci 20:8410-6. 2000
    ..Recruitment of a distinct corticolimbic network for visual memory in the elderly suggests that age-related neurobiological deterioration not only results in focal changes but also in the modification of large-scale network operations...
  23. doi Top-down and bottom-up attention to memory: a hypothesis (AtoM) on the role of the posterior parietal cortex in memory retrieval
    Elisa Ciaramelli
    Rotman Research Institute, 3560 Bathurst Street, Toronto, ON M6A 2E1, Canada
    Neuropsychologia 46:1828-51. 2008
    ..weak memories, for vividly recollected vs. familiar memories, for memories retrieved with high vs. low confidence. We introduce a model of episodic memory retrieval that characterizes contributions of posterior parietal cortex...
  24. doi Memory networks supporting retrieval effort and retrieval success under conditions of full and divided attention
    Erin I Skinner
    Department of Psychology, University of Waterloo, Ontario, Canada
    Exp Psychol 56:386-96. 2009
    ..Finally, DA conditions that disrupt successful memory performance (DA-word) interfere with recruitment of both retrieval-effort and retrieval-success networks...
  25. ncbi An examination of the effects of stimulus type, encoding task, and functional connectivity on the role of right prefrontal cortex in recognition memory
    C L Grady
    Rotman Research Institute, University of Toronto, Toronto, Ontario M6A 2E1, Canada
    Neuroimage 14:556-71. 2001
    ....
  26. doi Reactivation of context-specific brain regions during retrieval
    Erin I Skinner
    Department of Psychology, University of Waterloo, Waterloo, Ontario, Canada
    Neuropsychologia 48:156-64. 2010
    ....
  27. ncbi Neural correlates of memory for object identity and object location: effects of aging
    Alessandra Schiavetto
    Rotman Research Institute, Baycrest Center for Geriatric Care, Toronto, Ont, Canada
    Neuropsychologia 40:1428-42. 2002
    ....
  28. ncbi Neural correlates of processing facial identity based on features versus their spacing
    D Maurer
    Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ont, Canada
    Neuropsychologia 45:1438-51. 2007
    ....
  29. pmc Altered connectivity among emotion-related brain regions during short-term memory in Alzheimer's disease
    R Shayna Rosenbaum
    Department of Psychology, York University, 4700 Keele Street, Toronto, Ontario, Canada
    Neurobiol Aging 31:780-6. 2010
    ....
  30. doi Aging and emotional memory: cognitive mechanisms underlying the positivity effect
    Julia Spaniol
    Department of Psychology, Ryerson University, Toronto, Ontario, Canada
    Psychol Aging 23:859-72. 2008
    ..Specifically, older adults experienced greater overall familiarity for positive items than younger adults. We interpret this finding in terms of an age-related increase in the accessibility of positive information in long-term memory...
  31. doi Recollection- and familiarity-based memory in healthy aging and amnestic mild cognitive impairment
    Nicole D Anderson
    Kunin Lunenfeld Applied Research Unit, Baycrest, University of Toronto, Toronto, ON, CA
    Neuropsychology 22:177-87. 2008
    ..Hippocampal atrophy associated with aMCI may disrupt this brain network, and thereby interfere with recollection...
  32. ncbi The functional organization of auditory working memory as revealed by fMRI
    Stephen R Arnott
    Baycrest Centre for Geriatric Care, Toronto, Canada
    J Cogn Neurosci 17:819-31. 2005
    ....
  33. ncbi Frontotemporal interactions in face encoding and recognition
    M N Rajah
    Rotman Research Institute of Baycrest Centre, University of Toronto, 3560 Bathurst Street, Toronto, ON, Canada
    Brain Res Cogn Brain Res 8:259-69. 1999
    ..This pattern of interaction was specific to the recognition task and might represent the process whereby the input faces are compared to the internal representation laid down during encoding, thus enabling recognition...
  34. ncbi Recruitment of unique neural systems to support visual memory in normal aging
    A R McIntosh
    Rotman Research Institute of Baycrest Centre, Toronto, Ontario, Canada
    Curr Biol 9:1275-8. 1999
    ..These unique areas were strongly interactive and their activity was related to performance only in old participants. Therefore, these areas may have acted to compensate for reduced interactions between the other brain areas...
  35. ncbi Age effects on social cognition: faces tell a different story
    Michelle L Keightley
    Department of Occupational Science and Occupational Therapy, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Psychol Aging 21:558-72. 2006
    ..Nevertheless, with age there appears to be increasing reliance on a common resource to perform social tasks, but one that is not shared with other cognitive domains...
  36. doi Patterns of brain activity supporting autobiographical memory, prospection, and theory of mind, and their relationship to the default mode network
    R Nathan Spreng
    Rotman Research Institute at Baycrest, Toronto, Ontario, Canada
    J Cogn Neurosci 22:1112-23. 2010
    ..We conclude that the DMN supports common aspects of these cognitive behaviors involved in simulating an internalized experience...
  37. ncbi An fMRI study investigating cognitive modulation of brain regions associated with emotional processing of visual stimuli
    Michelle L Keightley
    Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ont, M6A 2E1 Canada
    Neuropsychologia 41:585-96. 2003
    ....
  38. pmc Functional reorganisation of memory after traumatic brain injury: a study with H(2)(15)0 positron emission tomography
    B Levine
    Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Canada
    J Neurol Neurosurg Psychiatry 73:173-81. 2002
    ..To study the effects of moderate to severe traumatic brain injury (TBI) on the functional neuroanatomy supporting memory retrieval...
  39. doi Event-related fMRI studies of episodic encoding and retrieval: meta-analyses using activation likelihood estimation
    Julia Spaniol
    Department of Psychology, Ryerson University, 350 Victoria Street, Toronto, Ontario, Canada
    Neuropsychologia 47:1765-79. 2009
    ..In summary, these results identify broadly consistent activation patterns associated with episodic encoding and retrieval, and subjective and objective recollection, but also subtle differences among these processes...
  40. ncbi The effect of encoding strategy on the neural correlates of memory for faces
    Lori J Bernstein
    Rotman Research Institute, Baycrest Centre for Geriatric Care, University of Toronto, 3560 Bathurst Street, Ont, M6A 2EI, Toronto, Canada
    Neuropsychologia 40:86-98. 2002
    ....
  41. ncbi Dissecting the effect of aging on the neural substrates of memory: deterioration, preservation or functional reorganization?
    Valeria Della-Maggiore
    Rotman Research Institute of Baycrest Centre, Department of Psychology, University of Toronto, Ontario, Canada
    Rev Neurosci 13:167-81. 2002
    ....
  42. pmc Biological changes associated with healthy versus pathological aging: a symposium review
    M N Rajah
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada
    Ageing Res Rev 8:140-6. 2009
    ....
  43. ncbi Memory for familiar environments learned in the remote past: fMRI studies of healthy people and an amnesic person with extensive bilateral hippocampal lesions
    R Shayna Rosenbaum
    Department of Psychology, York University, Toronto, Ontario, Canada
    Hippocampus 17:1241-51. 2007
    ..The distinction between recent and remote memory, therefore, may apply as much to spatial theories of hippocampal function as it does to theories emphasizing the role of the hippocampus in other types of explicit memory...
  44. ncbi Age-related differences in face processing: a meta-analysis of three functional neuroimaging experiments
    Cheryl L Grady
    Rotman Research Institute, Departments of Psychiatry and Psychology, University of Toronto
    Can J Exp Psychol 56:208-20. 2002
    ....
  45. pmc Task-related effects on the temporal and spatial dynamics of resting-state functional connectivity in the default network
    Omer Grigg
    Rotman Research Institute at Baycrest, Toronto, Ontario, Canada
    PLoS ONE 5:e13311. 2010
    ....
  46. pmc The default network and processing of personally relevant information: converging evidence from task-related modulations and functional connectivity
    Omer Grigg
    Rotman Research Institute at Baycrest, Toronto, Ontario, Canada
    Neuropsychologia 48:3815-23. 2010
    ..They also suggest that the DN may be somewhat more extensive than currently thought...
  47. ncbi Common and unique neural activations in autobiographical, episodic, and semantic retrieval
    Hana Burianova
    University of Toronto, Toronto, Canada
    J Cogn Neurosci 19:1520-34. 2007
    ..These findings suggest a common neural network underlying all declarative memory retrieval, as well as unique neural contributions reflecting the specific properties of retrieved memories...
  48. ncbi Assessing the auditory dual-pathway model in humans
    Stephen R Arnott
    Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
    Neuroimage 22:401-8. 2004
    ..g., sound identity) is processed primarily along the ventral stream whereas sound location is processed along the dorsal stream and areas posterior to primary auditory cortex...
  49. doi A common functional brain network for autobiographical, episodic, and semantic memory retrieval
    Hana Burianova
    Department of Psychology, University of Toronto, 100 St George Street, Toronto, Ontario, Canada
    Neuroimage 49:865-74. 2010
    ..This proposed network consists of increased activity in regions that represent internal processes of memory retrieval and decreased activity in regions that mediate attention to external stimuli...
  50. ncbi Remembering our past: functional neuroanatomy of recollection of recent and very remote personal events
    Asaf Gilboa
    Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst St, Toronto, Ontario, M6A 2E1, Canada
    Cereb Cortex 14:1214-25. 2004
    ..These findings are incompatible with theories of long-term memory consolidation, and are more easily accommodated by multiple-trace theory, which posits that detailed memories are always dependent on the hippocampus...
  51. ncbi "I have often walked down this street before": fMRI studies on the hippocampus and other structures during mental navigation of an old environment
    R Shayna Rosenbaum
    Department of Psychology, University of Toronto, Toronto, Ontario, Canada
    Hippocampus 14:826-35. 2004
    ..Importantly, right medial temporal lobe activity was observed, its magnitude equivalent across all tasks, though the core of the activated region was in the parahippocampal gyrus, barely touching the hippocampus proper...
  52. ncbi Acute effects of alcohol on neural correlates of episodic memory encoding
    Hedvig Söderlund
    The Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, ON, Canada M6A 2E1
    Neuroimage 35:928-39. 2007
    ..These results suggest that alcohol impairs episodic memory by interfering with activity of regions involved in encoding, and further indicate which regions are critical for human memory...
  53. doi Everyday memory compensation: the impact of cognitive reserve, subjective memory, and stress
    Douglas D Garrett
    Rotman Research Institute, Baycrest, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada
    Psychol Aging 25:74-83. 2010
    ..These results suggest boundary conditions for the concept of cognitive reserve, and highlight the importance of subjective memory and life stress for defining contexts in which compensation may occur...
  54. ncbi The relation between brain activity during memory tasks and years of education in young and older adults
    Mellanie V Springer
    Rotman Research Institute, Baycrest Centre for Geriatric Care, University of Toronto, Toronto, ON, Canada
    Neuropsychology 19:181-92. 2005
    ..This suggests that the frontal cortex is engaged by older adults, particularly by the highly educated, as an alternative network that may be engaged to aid cognitive function...
  55. ncbi fMRI studies of remote spatial memory in an amnesic person
    R S Rosenbaum
    Rotman Research Institute, Baycrest Centre for Geriatric Care, University of Toronto, Ont, Canada
    Brain Cogn 54:170-2. 2004
  56. pmc "What" and "where" in the human auditory system
    C Alain
    The Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, ON, Canada M6A 2E1
    Proc Natl Acad Sci U S A 98:12301-6. 2001
    ..These findings are analogous to the "what" and "where" segregation of visual information processing, and suggest that a similar functional organization exists for processing information from the auditory modality...
  57. ncbi Neuroimaging the serial position curve. A test of single-store versus dual-store models
    Deborah Talmi
    University of Toronto, Toronto, Ontario, Canada
    Psychol Sci 16:716-23. 2005
    ..None of these areas was activated for retrieval of late items. These results indicate differential use of LTM retrieval processes, and therefore support dual-store models over single-store models...
  58. ncbi The influence of sex on limbic volume and perfusion in AD
    David J A Callen
    Department of Medical Imaging, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ont, Canada
    Neurobiol Aging 25:761-70. 2004
    ..Women with AD exclusively showed anterior thalamic atrophy. Separating men and women did not substantially improve diagnostic classification...
  59. doi Blood oxygen level-dependent signal variability is more than just noise
    Douglas D Garrett
    Rotman Research Institute, Baycrest, Toronto, Ontario M6A 2E1, Canada
    J Neurosci 30:4914-21. 2010
    ..We suggest that examination of BOLD signal variability may reveal a host of novel brain-related effects not previously considered in neuroimaging research...
  60. ncbi Functional specificity of the visual word form area: general activation for words and symbols but specific network activation for words
    Karen Reinke
    Department of Psychology, Southern Illinois University, Carbondale, IL, USA
    Brain Lang 104:180-9. 2008
    ..e., the broader activity distributed in the brain that is correlated with VWFA, that is specific for visual word representation, not activity in this brain region per se...