Tiffany W Chow

Summary

Affiliation: Rotman Research Institute
Country: Canada

Publications

  1. pmc MMSE scores decline at a greater rate in frontotemporal degeneration than in AD
    Tiffany W Chow
    Rotman Research Institute of Baycrest, University of Toronto Department of Medicine, Division of Neurology, Toronto, Canada
    Dement Geriatr Cogn Disord 22:194-9. 2006
  2. doi Magnetic resonance imaging in frontotemporal dementia shows subcortical atrophy
    Tiffany W Chow
    Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ont, Canada
    Dement Geriatr Cogn Disord 26:79-88. 2008
  3. pmc Potential cognitive enhancing and disease modification effects of SSRIs for Alzheimer's disease
    Tiffany W Chow
    The Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada
    Neuropsychiatr Dis Treat 3:627-36. 2007
  4. pmc Open-label study of the short-term effects of memantine on FDG-PET in frontotemporal dementia
    Tiffany W Chow
    Division of Neurology, Baycrest
    Neuropsychiatr Dis Treat 7:415-24. 2011
  5. pmc Fluorodeoxyglucose positron emission tomography in semantic dementia after 6 months of memantine: an open-label pilot study
    Tiffany W Chow
    Division of Neurology, Baycrest, Toronto, Canada
    Int J Geriatr Psychiatry 28:319-25. 2013
  6. pmc A case of semantic variant primary progressive aphasia with severe insular atrophy
    T W Chow
    Baycrest Rotman Research Institute, Brain Health Complex, Toronto, ON, Canada
    Neurocase 18:450-6. 2012
  7. pmc Apathy symptom profile and behavioral associations in frontotemporal dementia vs dementia of Alzheimer type
    Tiffany W Chow
    Baycrest Rotman Research Institute, University of Toronto, Toronto, Ontario M6A 2E1, Canada
    Arch Neurol 66:888-93. 2009
  8. pmc Alzheimer's disease neuropathologic changes in semantic dementia
    Tiffany W Chow
    Rotman Research Institute and Division of Neurology, Baycrest, Toronto, ON, Canada
    Neurocase 16:15-22. 2010
  9. ncbi Overlap in frontotemporal atrophy between normal aging and patients with frontotemporal dementias
    Tiffany W Chow
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada
    Alzheimer Dis Assoc Disord 22:327-35. 2008
  10. doi What are the different initial presentations of frontotemporal dementia?
    Tiffany W Chow
    Department of Medicine, Division of Neurology, University of Toronto, Rotman Research Institute, 3560 Bathurst St, Toronto, ON, M6A 2E1, Canada
    J Mol Neurosci 45:710-2. 2011

Research Grants

  1. Serotonergic Function in Dementia
    Tiffany Chow; Fiscal Year: 2005

Detail Information

Publications37

  1. pmc MMSE scores decline at a greater rate in frontotemporal degeneration than in AD
    Tiffany W Chow
    Rotman Research Institute of Baycrest, University of Toronto Department of Medicine, Division of Neurology, Toronto, Canada
    Dement Geriatr Cogn Disord 22:194-9. 2006
    ..018). Changes in MMSE subscores paralleled the clinical diagnostic criteria for FTD. The more rapid progression on the language subscore was observed in both language and behavioral variants of FTD...
  2. doi Magnetic resonance imaging in frontotemporal dementia shows subcortical atrophy
    Tiffany W Chow
    Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ont, Canada
    Dement Geriatr Cogn Disord 26:79-88. 2008
    ..We explored the extent to which subcortical atrophy on structural magnetic resonance imaging may indicate a subcortical contribution to the progression of FTD...
  3. pmc Potential cognitive enhancing and disease modification effects of SSRIs for Alzheimer's disease
    Tiffany W Chow
    The Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada
    Neuropsychiatr Dis Treat 3:627-36. 2007
    ..We performed a systematic review for preclinical and human clinical trial evidence to support the use of SSRIs specifically for the management of cognitive decline in AD...
  4. pmc Open-label study of the short-term effects of memantine on FDG-PET in frontotemporal dementia
    Tiffany W Chow
    Division of Neurology, Baycrest
    Neuropsychiatr Dis Treat 7:415-24. 2011
    ..We hypothesized that participants with frontotemporal dementia taking memantine would show an increased cortical metabolic activity in frontal regions, temporal regions, or in salience network hubs...
  5. pmc Fluorodeoxyglucose positron emission tomography in semantic dementia after 6 months of memantine: an open-label pilot study
    Tiffany W Chow
    Division of Neurology, Baycrest, Toronto, Canada
    Int J Geriatr Psychiatry 28:319-25. 2013
    ..To follow up on the increases we reported in normalized metabolic activity in salience network hubs from a 2-month open-label study of memantine in frontotemporal dementia (FTD)...
  6. pmc A case of semantic variant primary progressive aphasia with severe insular atrophy
    T W Chow
    Baycrest Rotman Research Institute, Brain Health Complex, Toronto, ON, Canada
    Neurocase 18:450-6. 2012
    ..s (2007 , Alzheimer Disease & Associated Disorders, 21, S50) hypothesis that von Economo neurons and fork cell-rich brain regions, particularly in the insula, are targeted in additional subtypes of FTD beyond the behavioral variant...
  7. pmc Apathy symptom profile and behavioral associations in frontotemporal dementia vs dementia of Alzheimer type
    Tiffany W Chow
    Baycrest Rotman Research Institute, University of Toronto, Toronto, Ontario M6A 2E1, Canada
    Arch Neurol 66:888-93. 2009
    ..Apathy is a common and significant problem in patients with dementia, regardless of its cause. Observations about frontosubcortical circuit syndromes indicate that apathy may have affective, behavioral, or cognitive manifestations...
  8. pmc Alzheimer's disease neuropathologic changes in semantic dementia
    Tiffany W Chow
    Rotman Research Institute and Division of Neurology, Baycrest, Toronto, ON, Canada
    Neurocase 16:15-22. 2010
    ..This case series examines retrospectively which clinical parameters might have pointed to the neuropathological diagnosis of AD...
  9. ncbi Overlap in frontotemporal atrophy between normal aging and patients with frontotemporal dementias
    Tiffany W Chow
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada
    Alzheimer Dis Assoc Disord 22:327-35. 2008
    ..While volumetry identified left-sided atrophy as useful for identifying FTD cases, future studies should determine whether clinicians could make these distinctions on viewing routine diagnostic magnetic resonance imaging scans...
  10. doi What are the different initial presentations of frontotemporal dementia?
    Tiffany W Chow
    Department of Medicine, Division of Neurology, University of Toronto, Rotman Research Institute, 3560 Bathurst St, Toronto, ON, M6A 2E1, Canada
    J Mol Neurosci 45:710-2. 2011
    ....
  11. pmc Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adults
    Tiffany W Chow
    The Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada
    BMC Med Imaging 9:12. 2009
    ..The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring 5HT2AR availability in subjects greater than 60 years old...
  12. ncbi Treatment approaches to symptoms associated with frontotemporal degeneration
    Tiffany W Chow
    The Rotman Research Institute, 3560 Bathurst Street, 8th Floor, Posluns Building, Toronto, Ontario M6A 2E1, Canada
    Curr Psychiatry Rep 7:376-80. 2005
    ..There is Class II evidence for use of rivastigmine in FTD behavioral disturbances, although there is no consistent evidence of cholinergic deficit in this illness...
  13. pmc Referral patterns for syndromes associated with frontotemporal lobar degeneration
    Tiffany W Chow
    The Rotman Research Institute, University of Toronto, Toronto, Ontario
    Alzheimer Dis Assoc Disord 19:17-9. 2005
    ..Clinics specializing in FTD recruit more language presentation cases. There were statistical but not clinically significant differences in ages at onset...
  14. doi A case of apathy due to frontotemporal dementia responsive to memantine
    Kira A Links
    Baycrest, Rotman Research Institute, Toronto, ON, Canada
    Neurocase 19:256-61. 2013
    ..To study the effect of memantine on apathy, a common symptom of behavioral variant frontotemporal dementia (bvFTD)...
  15. pmc Apathy is not associated with basal ganglia atrophy in frontotemporal dementia
    Kira A Links
    Division of Neurology, Rotman Research Institute, Baycrest, Toronto, ON, Canada M6A 2E1
    Am J Geriatr Psychiatry 17:819-21. 2009
    ..To determine whether basal ganglia atrophy, known to be associated with apathy in nondementia populations, was associated with presence of apathy in patients with frontotemporal dementia (FTD)...
  16. doi Trajectories of behavioral disturbance in dementia
    Tiffany W Chow
    Rotman Research Institute of Baycrest, Toronto, ON, Canada
    J Alzheimers Dis 31:143-9. 2012
    ..These results support a crescendo-decrescendo trajectory of behavioral symptoms in bvFTD but do not suggest that there is a similar pattern in AD, and further longitudinal data collection is necessary...
  17. doi Abnormal network connectivity in frontotemporal dementia: evidence for prefrontal isolation
    Norman A S Farb
    Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada
    Cortex 49:1856-73. 2013
    ..Recent neuroimaging research also associates FTD with alterations in the brain's intrinsic connectivity networks. The present study explored the relationship between neural network connectivity and specific behavioral symptoms in FTD...
  18. doi Cholinergic pathways and cognition in patients with schizophrenia: a pilot study
    Tarek K Rajji
    Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 139:46-52. 2012
    ..The objective of this study was to evaluate the impact of compromised cholinergic pathways on executive versus non-executive cognitive functions of patients with schizophrenia...
  19. doi Effects of aging on 5-HT(2A) R binding: a HRRT PET study with and without partial volume corrections
    Hiroyuki Uchida
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Int J Geriatr Psychiatry 26:1300-8. 2011
    ....
  20. pmc Occupation attributes relate to location of atrophy in frontotemporal lobar degeneration
    R Nathan Spreng
    Rotman Research Institute, Baycrest Centre, Toronto, ON, Canada
    Neuropsychologia 48:3634-41. 2010
    ..Alternatively, long-term engagement of activities associated with these occupations contributed to left-lateralized reserve, right-lateralized dysfunction, or both...
  21. doi Whole-brain white matter disruption in semantic and nonfluent variants of primary progressive aphasia
    Graeme C Schwindt
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    Hum Brain Mapp 34:973-84. 2013
    ..Further, they suggest that differences in the relative sensitivity of diffusion metrics may reflect differences in the nature of underlying white matter pathology in these two subtypes...
  22. doi Recollection and familiarity for public events in neurologically intact older adults and two brain-damaged patients
    Raluca Petrican
    Department of Psychology, University of Toronto, 100 St George Street, Toronto, Ontario M5S 3G3, Canada
    Neuropsychologia 48:945-60. 2010
    ..We discuss the present results in the context of neuroanatomical and process-oriented theories of how memories age...
  23. doi Incorporating new diagnostic schemas, genetics, and proteinopathy into the evaluation of frontotemporal degeneration
    Tiffany W Chow
    Baycrest Rotman Research Institute, 3560 Bathurst Street, 8th Floor Brain Health Complex, Toronto, ON M6A 2E1, Canada
    Continuum (Minneap Minn) 19:438-56. 2013
    ..Neurologists, neuropsychologists, and speech pathologists are particularly involved in the diagnosis and recognition of etiologies for patients with deficits in frontal lobe function and language...
  24. doi 100 years after Alzheimer: contemporary neurology practice assessment of referrals for dementia
    Tiffany W Chow
    Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ontario, Canada
    Am J Alzheimers Dis Other Demen 23:516-27. 2008
    ..The prevalence of dementia is placing an increased burden on specialists...
  25. ncbi An international needs assessment of caregivers for frontotemporal dementia
    Tiffany W Chow
    Rotman Research Institute, Baycrest, 3560 Bathurst Street, 8th Floor Brain Health Complex, Toronto, Ontario, M6A 2E1, Canada
    Can J Neurol Sci 38:753-7. 2011
    ..To guide development of public awareness and caregiver support resources for frontotemporal dementia (FTD) syndromes...
  26. doi Development of supportive services for frontotemporal dementias through community engagement
    Adriana Shnall
    Baycrest Health Sciences, Toronto, Ontario, Canada
    Int Rev Psychiatry 25:246-52. 2013
    ..The strength of these interventions is that services were developed with involvement of stakeholders in FTD care from the start, to deal with gaps in services in a sustainable way...
  27. ncbi Exploring the recognition memory deficit in Parkinson's disease: estimates of recollection versus familiarity
    Patrick S R Davidson
    The Rotman Research Institute, Baycrest Centre for Geriatric Care Toronto, Ontario, Canada
    Brain 129:1768-79. 2006
    ..We discuss how this pattern may be related to dysfunction of striatal, prefrontal and/or medial temporal regions in Parkinson's disease...
  28. doi Distraction during relational reasoning: the role of prefrontal cortex in interference control
    Daniel C Krawczyk
    Center for BrainHealth, The University of Texas at Dallas, Dallas, TX 75235, USA
    Neuropsychologia 46:2020-32. 2008
    ..These results demonstrate that intact prefrontal cortex (PFC) is necessary for controlling interference from perceptual and semantic distractors in order to reason from relational structure...
  29. ncbi Frontotemporal dementias: clinical features and management
    Tiffany W Chow
    Department of Neurology, University of Southern California, Downey, CA, USA
    Semin Clin Neuropsychiatry 8:58-70. 2003
    ..Although there is currently no disease-modifying therapeutic agent, symptomatic pharmacotherapy helps to control the marked mood and behavioral disturbances that may distinguish this syndrome from other causes of dementia...
  30. pmc Novel tau polymorphisms, tau haplotypes, and splicing in familial and sporadic frontotemporal dementia
    Maria Jesus Sobrido
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 9095, USA
    Arch Neurol 60:698-702. 2003
    ..A subset of familial cases (FTDP-17) of frontotemporal dementia (FTD) are caused by mutations in the tau gene. The role of tau gene mutations and haplotypes in sporadic FTD and the functional consequences of tau polymorphisms are unknown...
  31. ncbi Randomized controlled trials in long-term care residents with dementia: a systematic review
    Edward J Mills
    The University of Oxford
    J Am Med Dir Assoc 4:302-7. 2003
    ..To evaluate the quality of reporting of randomized controlled trials for pharmacologic interventions in long-term care residents with dementia...
  32. ncbi A neurocomputational model of analogical reasoning and its breakdown in frontotemporal lobar degeneration
    Robert G Morrison
    Department of Psychology, University of California, Los Angelesm 90095 1563, USA
    J Cogn Neurosci 16:260-71. 2004
    ..Using the "Learning and Inference with Schemas and Analogies" model, we provide a specific account of how such deficits may arise within neural networks supporting analogical problem solving...
  33. ncbi Frontotemporal lobar degeneration: demographic characteristics of 353 patients
    Julene K Johnson
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, 94117, USA
    Arch Neurol 62:925-30. 2005
    ..The publication of consensus criteria for FTLD, however, prompted systematic studies. The criteria categorize FTLD into 3 subgroups: frontotemporal dementia, semantic dementia, and progressive nonfluent aphasia...
  34. ncbi The differential diagnosis of pseudobulbar affect (PBA). Distinguishing PBA among disorders of mood and affect. Proceedings of a roundtable meeting
    David B Arciniegas
    Neuropsychiatry Service, Department of Psychiatry, University of Colorado School of Medicine, Denver, Colorado 80211, USA
    CNS Spectr 10:1-14; quiz 15-6. 2005
    ..The material presented in this monograph will help clinicians better recognize, diagnose, and treat PBA, and will form a foundation for understanding and interpreting future studies of this condition...
  35. ncbi Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directions
    Katya Rascovsky
    Memory and Aging Center, University of California, San Francisco, CA 94117, USA
    Alzheimer Dis Assoc Disord 21:S14-8. 2007
    ..In this article, we discuss the limitations of current diagnostic criteria and propose the establishment of an international consortium to revise diagnostic and research criteria for the behavioral variant of frontotemporal dementia...
  36. ncbi Goals in symptomatic pharmacologic management of frontotemporal lobar degeneration
    Tiffany W Chow
    University of Southern California at Los Angeles, USA
    Am J Alzheimers Dis Other Demen 17:267-72. 2002
    ..Behavioral disturbances can be alleviatedpharmacologically, but further research might determine guidelines for management of this non-Alzheimer's dementia syndrome that could decrease the frequency of adverse drug events...

Research Grants1

  1. Serotonergic Function in Dementia
    Tiffany Chow; Fiscal Year: 2005
    ..If changes in serotonergic function in frontal regions of interest correlate with the symptoms, this study will provide the basis for further investigations to identify serotonergic pharmacotherapy for such patients. ..