J David Spence

Summary

Affiliation: Robarts Research Institute
Country: Canada

Publications

  1. ncbi request reprint Nutrition and stroke prevention
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, 1400 Western Rd, London, Ontario, Canada N6G 2V2
    Stroke 37:2430-5. 2006
  2. ncbi request reprint Stroke prevention in the high-risk patient
    J David Spence
    Robarts Research Institute, Stroke Prevention and Atherosclerosis Research Centre, London, ON, Canada
    Expert Opin Pharmacother 8:1851-9. 2007
  3. doi request reprint Egg yolk consumption and carotid plaque
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, 1400 Western Road, London, ON N6G 2V2, Canada
    Atherosclerosis 224:469-73. 2012
  4. doi request reprint Ezetimibe and regression of carotid atherosclerosis: importance of measuring plaque burden
    Chrysi Bogiatzi
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, University of Western Ontario, 1400 Western Road, London, Ontario, Canada N6G 2V2
    Stroke 43:1153-5. 2012
  5. ncbi request reprint The effect of flax seed cultivars with differing content of alpha-linolenic acid and lignans on responses to mental stress
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, Siebens Drake Robarts Research Institute, 1400 Western Road, London, Ontario N6G 2V2, Canada
    J Am Coll Nutr 22:494-501. 2003
  6. ncbi request reprint Non-invasive assessment of atherosclerosis risk
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, 1400 Western Rd, London, ON, Canada N6G 2V2
    Curr Drug Targets Cardiovasc Haematol Disord 4:125-8. 2004
  7. doi request reprint Measurement of intima-media thickness vs. carotid plaque: uses in patient care, genetic research and evaluation of new therapies
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, 1400 Western Road, London, ON, Canada N6G 2V2
    Int J Stroke 1:216-21. 2006
  8. doi request reprint Polypill: for Pollyanna
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, London, ON, Canada
    Int J Stroke 3:92-7. 2008
  9. ncbi request reprint Perspective on the efficacy analysis of the Vitamin Intervention for Stroke Prevention trial
    J David Spence
    Robarts Research Institute, University of Western Ontario, London, Canada
    Clin Chem Lab Med 45:1582-5. 2007
  10. ncbi request reprint Intensive management of risk factors for accelerated atherosclerosis: the role of multiple interventions
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, London, ON, Canada
    Curr Neurol Neurosci Rep 7:42-8. 2007

Collaborators

Detail Information

Publications83

  1. ncbi request reprint Nutrition and stroke prevention
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, 1400 Western Rd, London, Ontario, Canada N6G 2V2
    Stroke 37:2430-5. 2006
    ..This may be related to the broad combination of antioxidants included in a healthy diet. A Cretan Mediterranean diet is probably more effective because it provides a wide range of antioxidants from fruits and vegetables of all colors...
  2. ncbi request reprint Stroke prevention in the high-risk patient
    J David Spence
    Robarts Research Institute, Stroke Prevention and Atherosclerosis Research Centre, London, ON, Canada
    Expert Opin Pharmacother 8:1851-9. 2007
    ..This review, therefore, places pharmacotherapy in perspective as part of, but not all of, stroke prevention...
  3. doi request reprint Egg yolk consumption and carotid plaque
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, 1400 Western Road, London, ON N6G 2V2, Canada
    Atherosclerosis 224:469-73. 2012
    ..To provide perspective on the magnitude of the effect, we also analysed the effect of smoking (pack-years)...
  4. doi request reprint Ezetimibe and regression of carotid atherosclerosis: importance of measuring plaque burden
    Chrysi Bogiatzi
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, University of Western Ontario, 1400 Western Road, London, Ontario, Canada N6G 2V2
    Stroke 43:1153-5. 2012
    ..There has been recent controversy over failure of ezetimibe to reduce carotid intima-media thickness. Much of this is based on failure to understand important differences among ultrasound phenotypes of atherosclerosis...
  5. ncbi request reprint The effect of flax seed cultivars with differing content of alpha-linolenic acid and lignans on responses to mental stress
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, Siebens Drake Robarts Research Institute, 1400 Western Road, London, Ontario N6G 2V2, Canada
    J Am Coll Nutr 22:494-501. 2003
    ..We have previously shown that the rise in blood pressure during mental stress is a strong predictor of atherosclerosis progression...
  6. ncbi request reprint Non-invasive assessment of atherosclerosis risk
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, 1400 Western Rd, London, ON, Canada N6G 2V2
    Curr Drug Targets Cardiovasc Haematol Disord 4:125-8. 2004
    ..In evaluating new determinants and novel therapies, it will be important to consider the biology and clinical correlates of a specific measured atherosclerosis phenotype in order to select the most appropriate modality...
  7. doi request reprint Measurement of intima-media thickness vs. carotid plaque: uses in patient care, genetic research and evaluation of new therapies
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, 1400 Western Road, London, ON, Canada N6G 2V2
    Int J Stroke 1:216-21. 2006
    ..IMT should not be called 'atherosclerosis': the phenotype being assessed should be specified...
  8. doi request reprint Polypill: for Pollyanna
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, London, ON, Canada
    Int J Stroke 3:92-7. 2008
    ..A single pill that will succeed in all patients is not only practically, but conceptually, an inappropriate approach for the prevention of cardiovascular disease...
  9. ncbi request reprint Perspective on the efficacy analysis of the Vitamin Intervention for Stroke Prevention trial
    J David Spence
    Robarts Research Institute, University of Western Ontario, London, Canada
    Clin Chem Lab Med 45:1582-5. 2007
    ....
  10. ncbi request reprint Intensive management of risk factors for accelerated atherosclerosis: the role of multiple interventions
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, London, ON, Canada
    Curr Neurol Neurosci Rep 7:42-8. 2007
    ..Measurement of carotid plaque may be useful by providing feedback on the success of therapy...
  11. ncbi request reprint Point: uses of carotid plaque measurement as a predictor of cardiovascular events
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, London, Ontario, Canada
    Prev Cardiol 8:118-21; discussion 126. 2005
    ..Trying to treat arteries without measuring plaque is like trying to treat hypertension without measuring the pressure, or hyperlipidemia without measuring the lipids...
  12. ncbi request reprint Technology Insight: ultrasound measurement of carotid plaque--patient management, genetic research, and therapy evaluation
    J David Spence
    University of Western Ontario, Canada
    Nat Clin Pract Neurol 2:611-9. 2006
    ..Measurement of carotid plaque is, therefore, an important tool for patient management, genetic research and evaluation of new therapies for stroke prevention...
  13. ncbi request reprint Vitamin Intervention For Stroke Prevention trial: an efficacy analysis
    J David Spence
    The Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, London, Ontario, Canada
    Stroke 36:2404-9. 2005
    ..The criteria for this subgroup were defined before any data analysis...
  14. ncbi request reprint Absence of microemboli on transcranial Doppler identifies low-risk patients with asymptomatic carotid stenosis
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, University of Western Ontario, London, Canada
    Stroke 36:2373-8. 2005
    ..We studied transcranial Doppler (TCD) embolus detection as a method for identifying patients at higher risk who would have a lower number needed to treat...
  15. doi request reprint Homocysteine and stroke prevention: have the trials settled the issue?
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, 1400 Western Road, London, ON, Canada N6G 2V2
    Int J Stroke 1:242-4. 2006
    ..It remains likely that effective lowering of total homocysteine will reduce stroke and other vascular events...
  16. ncbi request reprint Lipoprotein lipase (LPL) gene variation and progression of carotid artery plaque
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, London, Ontario, Canada
    Stroke 34:1176-80. 2003
    ..We studied the association between LPL cSNPs and a novel noninvasive measure of disease, namely, cross-sectional carotid plaque area (CPA) on B-mode ultrasound...
  17. ncbi request reprint Infection, inflammation, and atherosclerosis
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, London, Ontario, Canada
    Stroke 34:333-4. 2003
  18. ncbi request reprint Carotid plaque area: a tool for targeting and evaluating vascular preventive therapy
    J David Spence
    Robarts Research Institute and University of Western Ontario, London
    Stroke 33:2916-22. 2002
    ..Carotid plaque area measured by ultrasound (cross-sectional area of longitudinal views of all plaques seen) was studied as a way of identifying patients at increased risk of stroke, myocardial infarction, and vascular death...
  19. pmc Dietary cholesterol and egg yolks: not for patients at risk of vascular disease
    J David Spence
    Stroke Prevention and Atheroschlerosis Research Centre, Robarts Research Institute, London, Ontario
    Can J Cardiol 26:e336-9. 2010
    ....
  20. doi request reprint Secondary stroke prevention
    J David Spence
    Stroke Prevention and Atherosclerosis Research Center, 1400 Western Road, London, ON N6G 2V2, Canada
    Nat Rev Neurol 6:477-86. 2010
    ..Most patients with asymptomatic stenosis, however, should be treated with medical therapy, unless indicators of high stroke risk are present. In this narrative Review, I discuss recent advances in secondary stroke prevention...
  21. ncbi request reprint Measurement of carotid plaque and effect of vitamin therapy for total homocysteine
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, London, ON, Canada
    Clin Chem Lab Med 41:1498-504. 2003
    ..Measurement of the effect of vitamin therapy on atherosclerosis has therefore been used as an example of this approach...
  22. ncbi request reprint Homocysteine-lowering therapy: a role in stroke prevention?
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, London, ON, Canada
    Lancet Neurol 6:830-8. 2007
    ..Thus, therapy to lower homocysteine could still help to prevent stroke, if not other vascular outcomes...
  23. doi request reprint Treating arteries instead of risk factors: a paradigm change in management of atherosclerosis
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, 1400 Western Road, London, ON Canada N6G 2V2
    Stroke 41:1193-9. 2010
    ..We studied the proportion of patients with plaque progression vs regression before and after this change in paradigm...
  24. ncbi request reprint The role of lipoprotein(a) in the formation of arterial plaques, stenoses and occlusions
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, London, Ontario, Canada
    Can J Cardiol 26:37A-40A. 2010
    ..Future imaging studies of therapy to lower Lp(a) should not use intermediate end points such as intima-media thickness or plaque volume, but should assess development of stenosis and occlusion...
  25. ncbi request reprint Noninvasive phenotypes of atherosclerosis: similar windows but different views
    J David Spence
    Robarts Research Institute, 1400 Western Rd, London, Ontario, Canada N6G 2V2
    Stroke 35:649-53. 2004
    ..For instance, total carotid plaque area may reflect atherosclerotic lesion size more closely than carotid stenosis, which instead may reflect hemodynamic compromise within the arterial lumen...
  26. doi request reprint Effects of intensive medical therapy on microemboli and cardiovascular risk in asymptomatic carotid stenosis
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, 1400 Western Road, London, Ontario, Canada
    Arch Neurol 67:180-6. 2010
    ..To assess the effect of more intensive medical therapy on the rate of transcranial Doppler (TCD) microemboli and cardiovascular events in patients with asymptomatic carotid stenosis (ACS)...
  27. ncbi request reprint Association of obesity and central fat distribution with carotid artery wall thickening in middle-aged women
    Mario De Michele
    Departments of Clinical and Experimental Medicine, Federico II, University, Naples, Italy
    Stroke 33:2923-8. 2002
    ..In the present analysis, we evaluated whether common carotid intima-media thickness (IMT) and area, 2 markers of preclinical atherosclerosis, were increased in obese subjects...
  28. ncbi request reprint Disparate associations of a functional promoter polymorphism in PCK1 with carotid wall ultrasound traits
    Robert A Hegele
    Robarts Research Institute, London, Ontario, Canada
    Stroke 36:2566-70. 2005
    ..We hypothesized that this polymorphism would be associated with carotid atherosclerosis in a sample of 150 aboriginal Canadians...
  29. doi request reprint Longitudinal ultrasound evaluation of carotid atherosclerosis in one, two and three dimensions
    Christiane Mallett
    Imaging Research Laboratories, Robarts Research Institute, London, Canada
    Ultrasound Med Biol 35:367-75. 2009
    ....
  30. ncbi request reprint Differences between carotid wall morphological phenotypes measured by ultrasound in one, two and three dimensions
    Khalid Al-Shali
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, 406 100 Perth Drive, London, Ont, Canada N6A 5K8
    Atherosclerosis 178:319-25. 2005
    ..Because the measurements have different implications and determinants, investigators might need to be selective about the particular measurements they choose for specific applications...
  31. pmc Relationship of the metabolic syndrome to carotid ultrasound traits
    Rebecca L Pollex
    Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Ultrasound 4:28. 2006
    ..We evaluated two carotid ultrasound measurements, namely intima media thickness and total plaque volume, in a Canadian Oji-Cree population with a high metabolic syndrome prevalence rate...
  32. ncbi request reprint Variation in the carotid bifurcation geometry of young versus older adults: implications for geometric risk of atherosclerosis
    Jonathan B Thomas
    Imaging Research Laboratories, Robarts Research Institute, P O Box 5015, London, Ontario, Canada
    Stroke 36:2450-6. 2005
    ..On the other hand, anecdotal evidence suggests that vessel geometry is more homogenous in youth, which would tend to undermine this geometric risk hypothesis. The purpose of our study was to test whether the latter is indeed the case...
  33. doi request reprint Three-dimensional ultrasound quantification of intensive statin treatment of carotid atherosclerosis
    Adam Krasinski
    Imaging Research Laboratories, Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5K8
    Ultrasound Med Biol 35:1763-72. 2009
    ..Quantitative VWV thickness difference maps provide visual evidence of the spatial and temporal dynamics of carotid artery changes...
  34. ncbi request reprint Complications of Type 2 Diabetes Among Aboriginal Canadians: prevalence and associated risk factors
    Anthony J G Hanley
    Leadership Sinai Centre for Diabetes, Lebovic Building, Room 5 210, Mt Sinai Hospital, 600 University Ave, Toronto, Ontario, M5G 1X5, Canada
    Diabetes Care 28:2054-7. 2005
  35. doi request reprint Mesna for the treatment of hyperhomocysteinemia in hemodialysis patients
    Murray J Cutler
    Division of Clinical Pharmacology, University of Western Ontario, London, Ont, Canada
    Blood Purif 27:306-10. 2009
    ..We hypothesized that 12 mg/kg intravenous mesna administered predialysis would cause a significant decrease in plasma tHcy compared to placebo...
  36. doi request reprint Three-dimensional carotid ultrasound segmentation variability dependence on signal difference and boundary orientation
    Bernard Chiu
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    Ultrasound Med Biol 36:95-110. 2010
    ..This information provides a target value of local signal difference on the arterial boundaries that should be achieved to obtain an accurate prediction of local segmentation SD. (E-mail: bcychiu@alumni.uwo.ca)...
  37. ncbi request reprint Genetic variation in PPARG encoding peroxisome proliferator-activated receptor gamma associated with carotid atherosclerosis
    Khalid Z Al-Shali
    Robarts Research Institute, London, Ontario, Canada
    Stroke 35:2036-40. 2004
    ..Genetic variation in PPARG has been associated with metabolic and cardiovascular end points...
  38. ncbi request reprint 3D ultrasound measurement of change in carotid plaque volume: a tool for rapid evaluation of new therapies
    Craig D Ainsworth
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, 1400 Western Rd, London, ON, N6G 2V2, Canada
    Stroke 36:1904-9. 2005
    ..To study such treatments, it will be necessary to directly measure changes in atherosclerosis. The study was designed to determine sample sizes needed to detect effects of treatment using 3D ultrasound (US) measurement of carotid plaque...
  39. pmc A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes
    Rebecca L Pollex
    Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Ultrasound 3:15. 2005
    ..Thus, the objective of this study was to compare the traditional intima-media thickness measurement against the novel total plaque volume measurement in analyzing carotid atherosclerosis development in individuals with type 2 diabetes...
  40. ncbi request reprint Nonrigid registration of three-dimensional ultrasound and magnetic resonance images of the carotid arteries
    Nuwan D Nanayakkara
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A 5K8, Canada
    Med Phys 36:373-85. 2009
    ..Visual inspection of segmented vessel surfaces also showed a substantial improvement of alignment with this nonrigid registration technique compared to rigid registration...
  41. doi request reprint A "twisting and bending" model-based nonrigid image registration technique for 3-D ultrasound carotid images
    Nuwan D Nanayakkara
    Imaging Research Laboratories, Robarts Research Institute and Graduate Program in Biomedical Engineering, The University of Western Ontario, London, ON N6A5K8, Canada
    IEEE Trans Med Imaging 27:1378-88. 2008
    ..80 +/-0.26 mm using our nonrigid registration technique, which was a significant improvement in registration accuracy over rigid registration, even with reduced degrees-of-freedom compared to the other nonrigid registration algorithms...
  42. doi request reprint Angiotensin inhibition in renovascular disease: a population-based cohort study
    Daniel G Hackam
    Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada
    Am Heart J 156:549-55. 2008
    ....
  43. pmc Mesna for treatment of hyperhomocysteinemia in hemodialysis patients: a placebo-controlled, double-blind, randomized trial
    Bradley L Urquhart
    Department of Physiology and Pharmacology, University of Western Ontario, London Health Sciences Centre, London, Ontario, Canada
    Clin J Am Soc Nephrol 3:1041-7. 2008
    ..It was hypothesized 5 mg/kg intravenous mesna administered thrice weekly, before dialysis, for 8 wk would cause a significant decrease in plasma total homocysteine compared with placebo...
  44. ncbi request reprint Mapping spatial and temporal changes in carotid atherosclerosis from three-dimensional ultrasound images
    Micaela Egger
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    Ultrasound Med Biol 34:64-72. 2008
    ..Carotid atherosclerosis thickness difference maps generated from 3DUS images provide evidence of vessel wall and plaque thickness changes for all subjects assessed...
  45. doi request reprint Lipoprotein(a) is associated differentially with carotid stenosis, occlusion, and total plaque area
    Jonathan H Klein
    Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada
    Arterioscler Thromb Vasc Biol 28:1851-6. 2008
    ..We studied relationships of Lp(a) with carotid stenosis, occlusion, and total plaque area, distinct phenotypes of atherosclerosis that may be differentially affected by cardiovascular risk factors...
  46. doi request reprint Effect of B-vitamin therapy on progression of diabetic nephropathy: a randomized controlled trial
    Andrew A House
    Division of Nephrology, University of Western Ontario, London, Ontario, Canada
    JAMA 303:1603-9. 2010
    ..Hyperhomocysteinemia is frequently observed in patients with diabetic nephropathy. B-vitamin therapy (folic acid, vitamin B(6), and vitamin B(12)) has been shown to lower the plasma concentration of homocysteine...
  47. ncbi request reprint Quantification of carotid vessel wall and plaque thickness change using 3D ultrasound images
    Bernard Chiu
    Imaging Research Laboratories and Graduate Program in Biomedical Engineering, University of Western Ontario, London, Ontario, Canada
    Med Phys 35:3691-710. 2008
    ....
  48. ncbi request reprint Validation of 3D ultrasound vessel wall volume: an imaging phenotype of carotid atherosclerosis
    Micaela Egger
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    Ultrasound Med Biol 33:905-14. 2007
    ..7% ICC = 0.85, rescan COV = 21.1% ICC = 0.88 and interscan variability, COV = 31.1%, ICC = 0.83), although absolute variances for both phenotypes were very similar (VWV = 90 mm3, TPV = 80 mm3)...
  49. doi request reprint Analysis of carotid lumen surface morphology using three-dimensional ultrasound imaging
    Bernard Chiu
    Robarts Research Institute, London, Ontario, Canada
    Phys Med Biol 54:1149-67. 2009
    ..Finally, we demonstrated the application of the proposed method for detecting ulcers on luminal surfaces, which were segmented from the 3D US images acquired for two human subjects...
  50. doi request reprint Geometry of the carotid bifurcation predicts its exposure to disturbed flow
    Sang Wook Lee
    Biomedical Simulation Laboratory, University of Toronto, Ontario, Canada
    Stroke 39:2341-7. 2008
    ..In testing these often-implicit assumptions, the present study aimed to determine whether investigations of local risk factors in atherosclerosis can indeed rely on surrogate geometric markers of disturbed flow...
  51. doi request reprint Progression of carotid plaque volume predicts cardiovascular events
    Thapat Wannarong
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Canada
    Stroke 44:1859-65. 2013
    ..We compared progression/regression of IMT, total plaque area (TPA), and total plaque volume (TPV) as predictors of cardiovascular outcomes...
  52. doi request reprint Scan-rescan and intra-observer variability of magnetic resonance imaging of carotid atherosclerosis at 1.5 T and 3.0 T
    Arvin Vidal
    Imaging Research Laboratories, Robarts Research Institute, 100 Perth Drive, London, N6A 5K8 Canada
    Phys Med Biol 53:6821-35. 2008
    ..5 T have lower SNR and CNR VWV, measurement variability was not significantly different from 3.0 T VWV and that VWV is field-strength dependent which may be an important consideration for longitudinal studies...
  53. ncbi request reprint Quantification of carotid plaque volume measurements using 3D ultrasound imaging
    Anthony Landry
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    Ultrasound Med Biol 31:751-62. 2005
    ..7%. Thus, our results support the clinical utility of measuring carotid plaque volume by manual planimetry noninvasively using 3D US...
  54. ncbi request reprint Dimercaptosuccinic acid for the treatment of hyperhomocysteinemia in hemodialysis patients: a placebo-controlled, double-blind, randomized trial
    Andrew A House
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Am J Kidney Dis 44:689-94. 2004
    ..We designed a randomized, double-blind, placebo-controlled trial to determine the effect of prolonged administration of oral dimercaptosuccinic acid (DMSA) on plasma tHcy levels in vitamin-replete hemodialysis patients...
  55. pmc Carotid ultrasound phenotypes in vulnerable populations
    Silvia A Riccio
    Imaging Research Laboratories, Robarts Research Institute, 100 Perth Drive, London, Ontario, N6A 5K8, Canada
    Cardiovasc Ultrasound 4:44. 2006
    ..In this study we measured and compared intima media thickness (IMT), total plaque volume (TPV) and total plaque area (TPA) in two separate populations, both vulnerable to carotid atherosclerosis...
  56. ncbi request reprint Mesna as a nonvitamin intervention to lower plasma total homocysteine concentration: implications for assessment of the homocysteine theory of atherosclerosis
    Bradley L Urquhart
    Division of Clinical Pharmacology, Department of Medicine and Physiology, University of Western Ontario and Lawson Health Research Institute, London, Ontario, Canada
    J Clin Pharmacol 47:991-7. 2007
    ..9 +/- 2.4 mumol) compared to vehicle (0.4 +/- 0.1 mumol), P < .01. Oral mesna decreases plasma total homocysteine and is a potential nonvitamin treatment for assessing the homocysteine theory of atherosclerosis...
  57. ncbi request reprint The effect of mesna on plasma total homocysteine concentration in hemodialysis patients
    Bradley L Urquhart
    Department of Medicine, University of Western Ontario, Canada
    Am J Kidney Dis 49:109-17. 2007
    ..The objective of this study is to determine whether a single intravenous dose of mesna, a thiol-containing drug analogue of taurine, facilitates tHcy clearance during hemodialysis...
  58. ncbi request reprint Manual planimetric measurement of carotid plaque volume using three-dimensional ultrasound imaging
    Anthony Landry
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A 5K8, Canada
    Med Phys 34:1496-505. 2007
    ..Furthermore, we demonstrated the utility of M3 to quantify regional plaque burden and to quantify change in plaque volume...
  59. ncbi request reprint Thiol exchange: an in vitro assay that predicts the efficacy of novel homocysteine lowering therapies
    Bradley L Urquhart
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada
    J Pharm Sci 95:1742-50. 2006
    ..001. Our in vitro results indicate that mesna, captopril, and NAC effectively exchange with covalently bound Hcy. This assay can act as screening tool for novel tHcy lowering therapies and should spare the expense of negative trials...
  60. ncbi request reprint Measurement of carotid plaque volume by 3-dimensional ultrasound
    Anthony Landry
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    Stroke 35:864-9. 2004
    ..Measurement precision was unchanged for ISDs <3.0 mm, whereas measurement variability increased with ISD. Repeated 3D US scans did not affect plaque volume measurement variability...
  61. ncbi request reprint Nutritional and metabolic aspects of stroke prevention
    J David Spence
    Department of Clinical Neurological Sciences, University of Western Ontario, Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, London, Ontario, Canada
    Adv Neurol 92:173-8. 2003
    ..Such a diet can therefore be confidently recommended as a source not only of natural proportions of vitamins and antioxidants but also for benefits that we are only beginning to define...
  62. pmc Unstable carotid plaque
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, The John P Robarts Research Institute, London, Ont
    CMAJ 166:1189. 2002
  63. ncbi request reprint Anthropometric data for magnetic resonance imaging of the carotid bifurcation
    Jonathan B Thomas
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    J Magn Reson Imaging 21:845-9. 2005
    ....
  64. ncbi request reprint Role of renin-angiotensin system blockade in atherosclerotic renal artery stenosis and renovascular hypertension
    Daniel G Hackam
    Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada
    Hypertension 50:998-1003. 2007
  65. ncbi request reprint 3D ultrasound imaging of the carotid arteries
    Aaron Fenster
    Robarts Research Institute, London, Ontario, Canada
    Curr Drug Targets Cardiovasc Haematol Disord 4:161-75. 2004
    ..This paper describes 3D ultrasound imaging techniques used to image the carotid arteries and summarizes some of the developments aimed at quantifying plaque volume and morphology...
  66. ncbi request reprint Ultrasound measurement of carotid plaque as a surrogate outcome for coronary artery disease
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, London, Ontario, Canada
    Am J Cardiol 89:10B-15B; discussion 15B-16B. 2002
    ....
  67. ncbi request reprint Quantification of progression and regression of carotid vessel atherosclerosis using 3D ultrasound images
    Bernard Chiu
    Robarts Res Inst, London, Ont
    Conf Proc IEEE Eng Med Biol Soc 1:3819-22. 2006
    ....
  68. ncbi request reprint Quantitative measurement of carotid atherosclerosis in relation to levels of von Willebrand factor and fibrinolytic variables in plasma--a 2-year follow-up study
    Torbjörn K Nilsson
    Dept of Clinical Chemistry, Umea University Hospital, London, Canada
    J Cardiovasc Risk 9:215-21. 2002
    ....
  69. ncbi request reprint Reconstruction of carotid bifurcation hemodynamics and wall thickness using computational fluid dynamics and MRI
    David A Steinman
    Imaging Research Labs, John P Robarts Research Institute, London, Ontario, Canada
    Magn Reson Med 47:149-59. 2002
    ..The noninvasive nature of this image-based modeling approach makes it ideal for carrying out future prospective studies of hemodynamics and plaque development or progression in otherwise healthy subjects...
  70. ncbi request reprint Keloid scarring, but not Dupuytren's contracture, is associated with unexplained carotid atherosclerosis
    Sankalp Bhavsar
    Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada
    Clin Invest Med 32:E95-102. 2009
    ..TGF-beta and associated signaling molecules have been implicated in the pathophysiology of keloid scarring, Dupuytren's Contracture and atherosclerotic plaques in independent studies...
  71. ncbi request reprint Letter by Rundek et al regarding article, "Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis"
    Tatjana Rundek
    Circulation 116:e317; author reply e318. 2007
  72. ncbi request reprint Homocysteine: call off the funeral
    J David Spence
    Stroke 37:282-3. 2006
  73. ncbi request reprint Measuring effects of antiatherosclerotic therapies
    J David Spence
    J Am Coll Cardiol 48:845-6; author reply 846. 2006
  74. ncbi request reprint Carotid intima-media thickness and cognitive decline: what does it mean for prevention of dementia?
    J David Spence
    J Neurol Sci 223:103-5. 2004
  75. ncbi request reprint Sex differences in carotid plaque and stenosis
    Francesco Iemolo
    Department of Neurology, General Hospital R Guzzardi Vittoria Ragusa, A S L 7 Sicilian Region, Italy
    Stroke 35:477-81. 2004
    ..We studied sex differences in carotid plaque and stenosis in relation to survival free of stroke, death, and myocardial infarction...
  76. ncbi request reprint Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial
    James F Toole
    Stroke Research Center, Department of Neurology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    JAMA 291:565-75. 2004
    ..However the utility of homocysteine-lowering therapy to reduce that risk has not been confirmed by randomized trials...
  77. ncbi request reprint Folate supplementation and cardiovascular disease
    J David Spence
    Lancet 367:1238; author reply 1238-9. 2006
  78. ncbi request reprint [Better prognosis for stroke patients]
    J David Spence
    MMW Fortschr Med 148:64. 2006
  79. pmc Vitamin B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products
    Julie Robertson
    Department of Family Medicine, McMaster University, Hamilton, Ont
    CMAJ 172:1569-73. 2005
    ....
  80. ncbi request reprint Effects of non-steroidal anti-inflammatory drugs on blood pressure
    J David Spence
    J Hypertens 25:248; author reply 248-9. 2007
  81. ncbi request reprint Ultrasound measurement of atherosclerosis
    J David Spence
    Stroke 35:e87-8; author reply e87-8. 2004
  82. ncbi request reprint Effects of perindopril on elastic and structural properties of large arteries in essential hypertension
    Yves Lacourciere
    Centre hospitalier de l Universite Laval, Sainte Foy, Quebec
    Can J Cardiol 20:795-9. 2004
    ..It decreases the stiffness of the larger arteries; questions remain as to the mechanisms involved and whether it is blood pressure (BP) control-dependent...
  83. ncbi request reprint Systolic blood pressure in patients with osteoarthritis and rheumatoid arthritis
    J David Spence
    J Rheumatol 31:829. 2004