Research Topics
| Caroline Schild-PoulterSummaryAffiliation: Robarts Research Institute Country: Canada Publications
| Collaborators
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Detail Information
Publications
RanBPM has proapoptotic activities that regulate cell death pathways in response to DNA damageElnaz Atabakhsh
Robarts Research Institute, London, Ontario, Canada N6A 5K8
Mol Cancer Res 7:1962-72. 2009..Overall, our results reveal a novel proapoptotic function for RanBPM in DNA damage-induced apoptosis through the regulation of factors involved in the mitochondrial apoptotic pathway...- Association of autoantibodies with Ku and DNA repair proteins in connective tissue diseasesC Schild-Poulter
Department of Medicine, University of Ottawa, The Ottawa Health Research Institute, Ontario, Canada
Rheumatology (Oxford) 47:165-71. 2008..To analyse the autoimmune response to DNA damage response factors in systemic autoimmune rheumatic disease (SARD) patients and to determine their association with autoantibodies to Ku antigen... 
DNA-PK phosphorylation sites on Oct-1 promote cell survival following DNA damageC Schild-Poulter
Department of Medicine, The Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
Oncogene 26:3980-8. 2007..These results implicate Oct-1 as a primary effector in a DNA-PK-dependent cell survival pathway that is activated by double-stranded DNA breaks...- Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1Caroline Schild-Poulter
Department of Medicine, University of Ottawa, The Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ontario K1Y 4E9, Canada
Cancer Res 63:7197-205. 2003..These results suggest a mechanism for the regulation of Oct-1 in response to DNA damage through specific phosphorylation within the NH(2)-terminal transcriptional regulatory domain... - Structured DNA promotes phosphorylation of p53 by DNA-dependent protein kinase at serine 9 and threonine 18Sebastien Soubeyrand
Department of Medicine, University of Ottawa, The Ottawa Health Research Institute, Ottawa, Ontario, Canada
Eur J Biochem 271:3776-84. 2004..Our results suggest a role for DNA-PK in the modulation of p53 activity resultant from the convergence of p53 and DNA-PK on structured DNA... 
Ku regulates signaling to DNA damage response pathways through the Ku70 von Willebrand A domainVictoria L Fell
Robarts Research Institute and Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
Mol Cell Biol 32:76-87. 2012..Thus, these findings infer that Ku links signals from the DNA repair machinery to DNA damage signaling regulators that control apoptotic pathways...- Differential DNA binding of Ku antigen determines its involvement in DNA replicationCaroline Schild-Poulter
Department of Medicine, The Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
DNA Cell Biol 22:65-78. 2003..Our results establish A3/4 as a new class of Ku DNA binding site. Classification of Ku DNA binding into eight categories of interaction based on recognition and DNA crosslinking experiments is discussed... - The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinaseC Schild-Poulter
Department of Medicine, The Loeb Health Research Institute at the Ottawa Hospital, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
J Biol Chem 276:16848-56. 2001..These results suggest that Ku functions as a substrate docking protein for signaling by DNA-PK to homeodomain proteins from DNA ends... - Evidence implicating Ku antigen as a structural factor in RNA polymerase II-mediated transcriptionJesse Bertinato
Graduate Program in Biochemistry, University of Ottawa, The Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ont. K1Y 4E9, Canada
Gene 302:53-64. 2003..These results suggest a preferential targeting of Ku to transcriptionally active chromatin that indicate a possible function for Ku within the RNA polymerase II holoenzyme... - Stimulation of preadipocyte differentiation by steroid through targeting of an HDAC1 complexNadine Wiper-Bergeron
The Ottawa Health Research Institute, University of Ottawa, 725 Parkdale Avenue, Ottawa, Ontario, Canada K1Y 4E9
EMBO J 22:2135-45. 2003..Recapitulation of the glucocorticoid effect by progestin treatment in the presence of the progesterone receptor ligand-binding domain suggests a conserved mechanism relevant to many aspects of steroid-mediated differentiation... - Nuclear localization of Ku antigen is promoted independently by basic motifs in the Ku70 and Ku80 subunitsJ Bertinato
Graduate Program in Biochemistry, Department of Medicine, University of Ottawa, Ontario, Canada, K1Y 4K9
J Cell Sci 114:89-99. 2001..Lastly, our results indicate that mutations in Ku previously proposed to abrogate Ku70/Ku80 heterodimerization, markedly reduced the accumulation of Ku70 without affecting heterodimer formation in mammalian cells... - Activation and autoregulation of DNA-PK from structured single-stranded DNA and coding end hairpinsS Soubeyrand
Department of Medicine, University of Ottawa, Ottawa Health Research Institute, ON, Canada
Proc Natl Acad Sci U S A 98:9605-10. 2001.... - Recruitment of octamer transcription factors to DNA by glucocorticoid receptorG G Préfontaine
Department of Biochemistry, Ottawa Civic Hospital Loeb Research Institute, University of Ottawa, Ottawa, Ontario, Canada K1Y 4E9
Mol Cell Biol 18:3416-30. 1998....