Caroline Schild-Poulter

Summary

Affiliation: Robarts Research Institute
Country: Canada

Publications

  1. doi request reprint RanBPM has proapoptotic activities that regulate cell death pathways in response to DNA damage
    Elnaz Atabakhsh
    Robarts Research Institute, London, Ontario, Canada N6A 5K8
    Mol Cancer Res 7:1962-72. 2009
  2. pmc RanBPM is an inhibitor of ERK signaling
    Elnaz Atabakhsh
    Robarts Research Institute and Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    PLoS ONE 7:e47803. 2012
  3. ncbi request reprint DNA-PK phosphorylation sites on Oct-1 promote cell survival following DNA damage
    C Schild-Poulter
    Department of Medicine, The Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Oncogene 26:3980-8. 2007
  4. ncbi request reprint Association of autoantibodies with Ku and DNA repair proteins in connective tissue diseases
    C Schild-Poulter
    Department of Medicine, University of Ottawa, The Ottawa Health Research Institute, Ontario, Canada
    Rheumatology (Oxford) 47:165-71. 2008
  5. ncbi request reprint Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1
    Caroline Schild-Poulter
    Department of Medicine, University of Ottawa, The Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ontario K1Y 4E9, Canada
    Cancer Res 63:7197-205. 2003
  6. ncbi request reprint Structured DNA promotes phosphorylation of p53 by DNA-dependent protein kinase at serine 9 and threonine 18
    Sebastien Soubeyrand
    Department of Medicine, University of Ottawa, The Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Eur J Biochem 271:3776-84. 2004
  7. ncbi request reprint Differential DNA binding of Ku antigen determines its involvement in DNA replication
    Caroline Schild-Poulter
    Department of Medicine, The Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    DNA Cell Biol 22:65-78. 2003
  8. pmc Ku regulates signaling to DNA damage response pathways through the Ku70 von Willebrand A domain
    Victoria L Fell
    Robarts Research Institute and Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    Mol Cell Biol 32:76-87. 2012
  9. ncbi request reprint The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase
    C Schild-Poulter
    Department of Medicine, The Loeb Health Research Institute at the Ottawa Hospital, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
    J Biol Chem 276:16848-56. 2001
  10. ncbi request reprint MegaTevs: single-chain dual nucleases for efficient gene disruption
    Jason M Wolfs
    Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A 5C1, Canada
    Nucleic Acids Res 42:8816-29. 2014

Collaborators

Detail Information

Publications18

  1. doi request reprint RanBPM has proapoptotic activities that regulate cell death pathways in response to DNA damage
    Elnaz Atabakhsh
    Robarts Research Institute, London, Ontario, Canada N6A 5K8
    Mol Cancer Res 7:1962-72. 2009
    ..Overall, our results reveal a novel proapoptotic function for RanBPM in DNA damage-induced apoptosis through the regulation of factors involved in the mitochondrial apoptotic pathway...
  2. pmc RanBPM is an inhibitor of ERK signaling
    Elnaz Atabakhsh
    Robarts Research Institute and Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    PLoS ONE 7:e47803. 2012
    ....
  3. ncbi request reprint DNA-PK phosphorylation sites on Oct-1 promote cell survival following DNA damage
    C Schild-Poulter
    Department of Medicine, The Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Oncogene 26:3980-8. 2007
    ..These results implicate Oct-1 as a primary effector in a DNA-PK-dependent cell survival pathway that is activated by double-stranded DNA breaks...
  4. ncbi request reprint Association of autoantibodies with Ku and DNA repair proteins in connective tissue diseases
    C Schild-Poulter
    Department of Medicine, University of Ottawa, The Ottawa Health Research Institute, Ontario, Canada
    Rheumatology (Oxford) 47:165-71. 2008
    ..To analyse the autoimmune response to DNA damage response factors in systemic autoimmune rheumatic disease (SARD) patients and to determine their association with autoantibodies to Ku antigen...
  5. ncbi request reprint Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1
    Caroline Schild-Poulter
    Department of Medicine, University of Ottawa, The Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ontario K1Y 4E9, Canada
    Cancer Res 63:7197-205. 2003
    ..These results suggest a mechanism for the regulation of Oct-1 in response to DNA damage through specific phosphorylation within the NH(2)-terminal transcriptional regulatory domain...
  6. ncbi request reprint Structured DNA promotes phosphorylation of p53 by DNA-dependent protein kinase at serine 9 and threonine 18
    Sebastien Soubeyrand
    Department of Medicine, University of Ottawa, The Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Eur J Biochem 271:3776-84. 2004
    ..Our results suggest a role for DNA-PK in the modulation of p53 activity resultant from the convergence of p53 and DNA-PK on structured DNA...
  7. ncbi request reprint Differential DNA binding of Ku antigen determines its involvement in DNA replication
    Caroline Schild-Poulter
    Department of Medicine, The Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    DNA Cell Biol 22:65-78. 2003
    ..Our results establish A3/4 as a new class of Ku DNA binding site. Classification of Ku DNA binding into eight categories of interaction based on recognition and DNA crosslinking experiments is discussed...
  8. pmc Ku regulates signaling to DNA damage response pathways through the Ku70 von Willebrand A domain
    Victoria L Fell
    Robarts Research Institute and Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    Mol Cell Biol 32:76-87. 2012
    ..Thus, these findings infer that Ku links signals from the DNA repair machinery to DNA damage signaling regulators that control apoptotic pathways...
  9. ncbi request reprint The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase
    C Schild-Poulter
    Department of Medicine, The Loeb Health Research Institute at the Ottawa Hospital, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
    J Biol Chem 276:16848-56. 2001
    ..These results suggest that Ku functions as a substrate docking protein for signaling by DNA-PK to homeodomain proteins from DNA ends...
  10. ncbi request reprint MegaTevs: single-chain dual nucleases for efficient gene disruption
    Jason M Wolfs
    Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A 5C1, Canada
    Nucleic Acids Res 42:8816-29. 2014
    ..The MegaTev enzyme represents a small, programmable nuclease platform for extremely specific genome-engineering applications. ..
  11. ncbi request reprint Evidence implicating Ku antigen as a structural factor in RNA polymerase II-mediated transcription
    Jesse Bertinato
    Graduate Program in Biochemistry, University of Ottawa, The Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, Ont K1Y 4E9, Canada
    Gene 302:53-64. 2003
    ..These results suggest a preferential targeting of Ku to transcriptionally active chromatin that indicate a possible function for Ku within the RNA polymerase II holoenzyme...
  12. pmc Stimulation of preadipocyte differentiation by steroid through targeting of an HDAC1 complex
    Nadine Wiper-Bergeron
    The Ottawa Health Research Institute, University of Ottawa, 725 Parkdale Avenue, Ottawa, Ontario, Canada K1Y 4E9
    EMBO J 22:2135-45. 2003
    ..Recapitulation of the glucocorticoid effect by progestin treatment in the presence of the progesterone receptor ligand-binding domain suggests a conserved mechanism relevant to many aspects of steroid-mediated differentiation...
  13. ncbi request reprint Nuclear localization of Ku antigen is promoted independently by basic motifs in the Ku70 and Ku80 subunits
    J Bertinato
    Graduate Program in Biochemistry, Department of Medicine, University of Ottawa, Ontario, Canada, K1Y 4K9
    J Cell Sci 114:89-99. 2001
    ..Lastly, our results indicate that mutations in Ku previously proposed to abrogate Ku70/Ku80 heterodimerization, markedly reduced the accumulation of Ku70 without affecting heterodimer formation in mammalian cells...
  14. pmc Regulation of stress-inducible phosphoprotein 1 nuclear retention by protein inhibitor of activated STAT PIAS1
    Iaci N Soares
    Robarts Research Institute, The University of Western Ontario, London, ON, Canada
    Mol Cell Proteomics 12:3253-70. 2013
    ..These experiments provide evidence that direct interaction between STI1 and PIAS1 is involved in the accumulation of nuclear STI1. This retention mechanism could facilitate nuclear chaperone activity. ..
  15. pmc The I-TevI nuclease and linker domains contribute to the specificity of monomeric TALENs
    Benjamin P Kleinstiver
    Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada N6A 5C1
    G3 (Bethesda) 4:1155-65. 2014
    ..Our data substantiate the applicability of Tev-mTALENs as genome-editing tools but highlight DNA spacer and cleavage site nucleotide preferences that, while enhancing specificity, do confer moderate targeting constraints...
  16. pmc RanBPM expression regulates transcriptional pathways involved in development and tumorigenesis
    Elnaz Atabakhsh
    Robarts Research Institute and Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University London, Ontario, N6A 5K8, Canada
    Am J Cancer Res 2:549-65. 2012
    ..Altogether, these results suggest that RanBPM does indeed function to regulate many genomic events that regulate embryonic, tissue, and cellular development as well as those involved in cancer development and progression...
  17. pmc Activation and autoregulation of DNA-PK from structured single-stranded DNA and coding end hairpins
    S Soubeyrand
    Department of Medicine, University of Ottawa, Ottawa Health Research Institute, ON, Canada
    Proc Natl Acad Sci U S A 98:9605-10. 2001
    ....
  18. pmc Recruitment of octamer transcription factors to DNA by glucocorticoid receptor
    G G Préfontaine
    Department of Biochemistry, Ottawa Civic Hospital Loeb Research Institute, University of Ottawa, Ottawa, Ontario, Canada K1Y 4E9
    Mol Cell Biol 18:3416-30. 1998
    ....