Brian K Rutt

Summary

Affiliation: Robarts Research Institute
Country: Canada

Publications

  1. ncbi request reprint Atherosclerotic plaque characterization by MR imaging
    Brian K Rutt
    Imaging Research Laboratories, Robarts Research Institute, 100 Perth Drive, London, Ontario, Canada N6A 5K8
    Curr Drug Targets Cardiovasc Haematol Disord 4:147-59. 2004
  2. pmc Comparison of gadofluorine-M and Gd-DTPA for noninvasive staging of atherosclerotic plaque stability using MRI
    John A Ronald
    Robarts Research Institute, Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Circ Cardiovasc Imaging 2:226-34. 2009
  3. doi request reprint Imaging iron-loaded mouse glioma tumors with bSSFP at 3 T
    Lisa M Bernas
    Imaging Research Laboratories, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
    Magn Reson Med 64:23-31. 2010
  4. ncbi request reprint Variation in the carotid bifurcation geometry of young versus older adults: implications for geometric risk of atherosclerosis
    Jonathan B Thomas
    Imaging Research Laboratories, Robarts Research Institute, P O Box 5015, London, Ontario, Canada
    Stroke 36:2450-6. 2005
  5. ncbi request reprint Validation of automatically classified magnetic resonance images for carotid plaque compositional analysis
    Sharon E Clarke
    Imaging Research Laboratories, Robarts Research Institute, PO Box 5015, London, Ontario, Canada
    Stroke 37:93-7. 2006
  6. doi request reprint Three-dimensional imaging and quantification of both solitary cells and metastases in whole mouse liver by magnetic resonance imaging
    Jason L Townson
    University of Western Ontario, London, Ontario, Canada
    Cancer Res 69:8326-31. 2009
  7. ncbi request reprint Carotid plaque classification: defining the certainty with which plaque components can be differentiated
    Raphael R Ronen
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Magn Reson Med 57:874-80. 2007
  8. ncbi request reprint In vivo MRI of cancer cell fate at the single-cell level in a mouse model of breast cancer metastasis to the brain
    Chris Heyn
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    Magn Reson Med 56:1001-10. 2006
  9. doi request reprint Ex-vivo cellular MRI with b-SSFP: quantitative benefits of 3T over 1.5 T
    Soha Said Ramadan
    Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada
    MAGMA 21:251-9. 2008
  10. pmc In vivo single scan detection of both iron-labeled cells and breast cancer metastases in the mouse brain using balanced steady-state free precession imaging at 1.5 T
    Emeline J Ribot
    Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada
    J Magn Reson Imaging 34:231-8. 2011

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Atherosclerotic plaque characterization by MR imaging
    Brian K Rutt
    Imaging Research Laboratories, Robarts Research Institute, 100 Perth Drive, London, Ontario, Canada N6A 5K8
    Curr Drug Targets Cardiovasc Haematol Disord 4:147-59. 2004
    ..With these developments in place or soon to be available, MR imaging of the diseased carotid artery and aortic wall may prove to be even more important than MR angiography or other current clinical tests...
  2. pmc Comparison of gadofluorine-M and Gd-DTPA for noninvasive staging of atherosclerotic plaque stability using MRI
    John A Ronald
    Robarts Research Institute, Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Circ Cardiovasc Imaging 2:226-34. 2009
    ..In this report, we determined the utility of the MR contrast agent gadofluorine-M (GdF) for staging plaque stability and compared this to the conventional agent Gd-DTPA...
  3. doi request reprint Imaging iron-loaded mouse glioma tumors with bSSFP at 3 T
    Lisa M Bernas
    Imaging Research Laboratories, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
    Magn Reson Med 64:23-31. 2010
    ..Quantitative histologic analysis validated that the strong signal loss seen in balanced steady state free precession pulse sequence images of iron-loaded tumors correlated well with the presence of iron...
  4. ncbi request reprint Variation in the carotid bifurcation geometry of young versus older adults: implications for geometric risk of atherosclerosis
    Jonathan B Thomas
    Imaging Research Laboratories, Robarts Research Institute, P O Box 5015, London, Ontario, Canada
    Stroke 36:2450-6. 2005
    ..On the other hand, anecdotal evidence suggests that vessel geometry is more homogenous in youth, which would tend to undermine this geometric risk hypothesis. The purpose of our study was to test whether the latter is indeed the case...
  5. ncbi request reprint Validation of automatically classified magnetic resonance images for carotid plaque compositional analysis
    Sharon E Clarke
    Imaging Research Laboratories, Robarts Research Institute, PO Box 5015, London, Ontario, Canada
    Stroke 37:93-7. 2006
    ....
  6. doi request reprint Three-dimensional imaging and quantification of both solitary cells and metastases in whole mouse liver by magnetic resonance imaging
    Jason L Townson
    University of Western Ontario, London, Ontario, Canada
    Cancer Res 69:8326-31. 2009
    ....
  7. ncbi request reprint Carotid plaque classification: defining the certainty with which plaque components can be differentiated
    Raphael R Ronen
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Magn Reson Med 57:874-80. 2007
    ..quot; A two-way interaction between contrast weightings and components demonstrated that the value of a contrast can be exploited or marginalized depending on the choice of contrast weightings used...
  8. ncbi request reprint In vivo MRI of cancer cell fate at the single-cell level in a mouse model of breast cancer metastasis to the brain
    Chris Heyn
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    Magn Reson Med 56:1001-10. 2006
    ....
  9. doi request reprint Ex-vivo cellular MRI with b-SSFP: quantitative benefits of 3T over 1.5 T
    Soha Said Ramadan
    Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada
    MAGMA 21:251-9. 2008
    ..We have recently reported that single iron-labeled cells could be detected, as signal voids, in vivo in mouse brains using a balanced steady-state free precession imaging sequence (b-SSFP) and a customized microimaging system at 1.5 T...
  10. pmc In vivo single scan detection of both iron-labeled cells and breast cancer metastases in the mouse brain using balanced steady-state free precession imaging at 1.5 T
    Emeline J Ribot
    Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada
    J Magn Reson Imaging 34:231-8. 2011
    ..5 T on mice developing brain metastases subsequent to the injection of micron-sized iron oxide particle-labeled human breast cancer cells...
  11. doi request reprint Scan-rescan and intra-observer variability of magnetic resonance imaging of carotid atherosclerosis at 1.5 T and 3.0 T
    Arvin Vidal
    Imaging Research Laboratories, Robarts Research Institute, 100 Perth Drive, London, N6A 5K8 Canada
    Phys Med Biol 53:6821-35. 2008
    ..5 T have lower SNR and CNR VWV, measurement variability was not significantly different from 3.0 T VWV and that VWV is field-strength dependent which may be an important consideration for longitudinal studies...
  12. pmc Clinical field-strength MRI of amyloid plaques induced by low-level cholesterol feeding in rabbits
    John A Ronald
    Robarts Research Institute, University of Western Ontario, 100 Perth Drive, 1st Floor, London, ON, Canada N6A 5K8
    Brain 132:1346-54. 2009
    ..We believe extension of these technologies to an in vivo setting in rabbits is feasible and that our results support future work exploring the role of MRI as a leading imaging tool for this debilitating and life-threatening disease...
  13. ncbi request reprint Resolution and SNR effects on carotid plaque classification
    Raphael R Ronen
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Magn Reson Med 56:290-5. 2006
    ..The robustness of automatic classifiers makes them applicable to a wide range of imaging conditions, including standard in vivo carotid imaging scenarios...
  14. ncbi request reprint In vivo magnetic resonance imaging of single cells in mouse brain with optical validation
    Chris Heyn
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    Magn Reson Med 55:23-9. 2006
    ..This work demonstrates the sensitivity of MRI for detecting single cells in small animals for a wide range of application from stem cell to cancer cell tracking...
  15. doi request reprint The use of cellular magnetic resonance imaging to track the fate of iron-labeled multipotent stromal cells after direct transplantation in a mouse model of spinal cord injury
    Laura E Gonzalez-Lara
    Department of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada
    Mol Imaging Biol 13:702-11. 2011
    ..The objective of this study was to track the fate of iron-labeled, multipotent stromal cells (MSC) after their direct transplantation into mice with spinal cord injuries using magnetic resonance imaging (MRI)...
  16. ncbi request reprint Rapid T2 estimation with phase-cycled variable nutation steady-state free precession
    Sean C L Deoni
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    Magn Reson Med 52:435-9. 2004
    ..The method is demonstrated in vivo with the acquisition of a 0.34 mm3 isotropic resolution T2 map of the brain with high precision and accuracy and significantly reduced artifact...
  17. ncbi request reprint Magnetic resonance imaging of in vitro glioma cell invasion
    Lisa M Bernas
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    J Neurosurg 106:306-13. 2007
    ..5 tesla and to assess the uptake of micron-sized particles of iron oxide (MPIO) and the consequent effects on cell function...
  18. ncbi request reprint Thematic review series: Adipocyte Biology. Lipodystrophies: windows on adipose biology and metabolism
    Robert A Hegele
    Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Lipid Res 48:1433-44. 2007
    ....
  19. ncbi request reprint Visualization of thalamic nuclei on high resolution, multi-averaged T1 and T2 maps acquired at 1.5 T
    Sean C L Deoni
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    Hum Brain Mapp 25:353-9. 2005
    ..These results confirm our hypothesis and demonstrate the potential high-resolution quantitative imaging for nucleus visualization and surgical planning...
  20. ncbi request reprint High-resolution T1 and T2 mapping of the brain in a clinically acceptable time with DESPOT1 and DESPOT2
    Sean C L Deoni
    Imaging Research Laboratories, Robarts Research Institute, 100 Perth Drive, London, Ontario, Canada N6A 5K8
    Magn Reson Med 53:237-41. 2005
    ..7 ms and 6.7 ms. These results demonstrate the clinical feasibility of the methods in the study of neurologic disease...
  21. ncbi request reprint Imaging single mammalian cells with a 1.5 T clinical MRI scanner
    Paula Foster-Gareau
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    Magn Reson Med 49:968-71. 2003
    ..This work provides the first evidence that single-cell tracking will be possible using clinical MRI scanners, opening up new possibilities for cell tracking and monitoring of cellular therapeutics in vivo in humans...
  22. pmc Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques
    John A Ronald
    Robarts Research Institute, London, Ontario, Canada
    Circulation 120:592-9. 2009
    ..We report here that a unique functional in vivo magnetic resonance agent can visualize myeloperoxidase activity in atherosclerotic plaques in a rabbit model...
  23. pmc Quantitative and qualitative differences in subcutaneous adipose tissue stores across lipodystrophy types shown by magnetic resonance imaging
    Salam A Al-Attar
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, N6A 5K8, Canada
    BMC Med Imaging 7:3. 2007
    ..We now extend the MRI analysis across the whole body of patients with different forms of lipodystrophy...
  24. ncbi request reprint Quantitative assessment of carotid plaque composition using multicontrast MRI and registered histology
    Sharon E Clarke
    Imaging Research Laboratories, Robarts Research Institute, London, Canada
    Magn Reson Med 50:1199-208. 2003
    ..Furthermore, this methodology will provide a framework for comparing different classification algorithms, and determining which combination of MR contrasts will be most valuable for in vivo plaque imaging...
  25. ncbi request reprint Comparison of B-mode ultrasound, 3-dimensional ultrasound, and magnetic resonance imaging measurements of carotid atherosclerosis
    Micaela Egger
    Imaging Research Laboratories, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
    J Ultrasound Med 27:1321-34. 2008
    ..We also evaluated the associations of these measurements and sample sizes required to detect specific changes in patients with moderate atherosclerosis...
  26. doi request reprint Predicting abdominal adipose tissue among women with familial partial lipodystrophy
    Tisha Joy
    Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5K8
    Metabolism 58:828-34. 2009
    ....
  27. ncbi request reprint Detection threshold of single SPIO-labeled cells with FIESTA
    Chris Heyn
    Imaging Research Laboratories, Robarts Research Institute, London, Canada
    Magn Reson Med 53:312-20. 2005
    ..The results of this work will aid in the design of cellular imaging experiments by defining the lower limit of SPIO labeling required for single cell detection at any given resolution and SNR...
  28. pmc Comparing the MRI appearance of the lymph nodes and spleen in wild-type and immuno-deficient mouse strains
    Vasiliki Economopoulos
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 6:e27508. 2011
    ..This is important to recognize in order to avoid the misinterpretation of MRI findings as abnormal when these strains are used in MRI imaging studies...
  29. ncbi request reprint Quantitative diffusion imaging with steady-state free precession
    Sean C L Deoni
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    Magn Reson Med 51:428-33. 2004
    ..Error within the DESPOD-derived ADC maps was found to be less than 3%, with good precision over a biologically relevant range of ADC values...
  30. ncbi request reprint Anthropometric data for magnetic resonance imaging of the carotid bifurcation
    Jonathan B Thomas
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    J Magn Reson Imaging 21:845-9. 2005
    ....
  31. ncbi request reprint Application of the static dephasing regime theory to superparamagnetic iron-oxide loaded cells
    Chris V Bowen
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Magn Reson Med 48:52-61. 2002
    ..This work is an important first step in quantifying cellular iron content and ultimately mapping the density of a targeted cell population...
  32. ncbi request reprint Reconstruction of carotid bifurcation hemodynamics and wall thickness using computational fluid dynamics and MRI
    David A Steinman
    Imaging Research Labs, John P Robarts Research Institute, London, Ontario, Canada
    Magn Reson Med 47:149-59. 2002
    ..The noninvasive nature of this image-based modeling approach makes it ideal for carrying out future prospective studies of hemodynamics and plaque development or progression in otherwise healthy subjects...
  33. ncbi request reprint Rapid combined T1 and T2 mapping using gradient recalled acquisition in the steady state
    Sean C L Deoni
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    Magn Reson Med 49:515-26. 2003
    ..The method therefore permits real-time clinical acquisition and display of whole brain T(1) and T(2) maps for the first time...
  34. ncbi request reprint Cellular MRI contrast via coexpression of transferrin receptor and ferritin
    Abby E Deans
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Magn Reson Med 56:51-9. 2006
    ..These results indicate that dual expression of proteins at different critical points in the iron metabolism pathway may improve cellular contrast without compromising cell viability...
  35. ncbi request reprint Reproducibility of image-based computational fluid dynamics models of the human carotid bifurcation
    Jonathan B Thomas
    Imaging Research Labs, Robarts Research Institute and Department of Medical Biophysics, University of Western Ontario, London, Ontario N6A 5K8, Canada
    Ann Biomed Eng 31:132-41. 2003
    ....
  36. ncbi request reprint Segmentation of thalamic nuclei using a modified k-means clustering algorithm and high-resolution quantitative magnetic resonance imaging at 1.5 T
    Sean C L Deoni
    Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, PO89, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Neuroimage 34:117-26. 2007
    ....
  37. ncbi request reprint Synthetic T1-weighted brain image generation with incorporated coil intensity correction using DESPOT1
    Sean C L Deoni
    Centre for Neuroimaging Sciences, Institute of Psychiatry, Box P089, London SE5 8AF, UK
    Magn Reson Imaging 24:1241-8. 2006
    ..This technique also provides a robust method for signal normalization, which is useful in multicenter longitudinal MR studies of disease progression, and allows the user to reconstruct T(1)-weighted images with arbitrary T(1) weighting...