John F MacDonald

Summary

Affiliation: Robarts Research Institute
Country: Canada

Publications

  1. doi request reprint Nonselective cation channels and links to hippocampal ischemia, aging, and dementia
    John F MacDonald
    Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada
    Adv Exp Med Biol 961:433-47. 2013
  2. pmc Dependence of NMDA/GSK-3β mediated metaplasticity on TRPM2 channels at hippocampal CA3-CA1 synapses
    Yu Feng Xie
    Robarts Research Institute, University of Western Ontario, London, ON, Canada
    Mol Brain 4:44. 2011
  3. pmc Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons
    Jillian C Belrose
    Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, N6A 5 K8, Canada
    Mol Brain 5:11. 2012
  4. doi request reprint Plasticity of synaptic GluN receptors is required for the Src-dependent induction of long-term potentiation at CA3-CA1 synapses
    Hong Bin Li
    Department of Physiology and Pharmacology, Robarts Research Institute, University of Western Ontario, London, Ontario
    Hippocampus 21:1053-61. 2011
  5. pmc Ca2+-dependent induction of TRPM2 currents in hippocampal neurons
    Michelle E Olah
    Robarts Research Institute, Molecular Brain Research Group, University of Western Ontario, 100 Perth Drive, London, ON, Canada, N6A 5K8
    J Physiol 587:965-79. 2009
  6. doi request reprint Fyn, a potential target for Alzheimer's disease
    Kai Yang
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    J Alzheimers Dis 27:243-52. 2011
  7. pmc Elimination of the vesicular acetylcholine transporter in the forebrain causes hyperactivity and deficits in spatial memory and long-term potentiation
    Amanda C Martyn
    Molecular Brain Research Group, Robarts Research Institute, and Department of Anatomy and Cell Biology and Physiology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada N6A 5K8
    Proc Natl Acad Sci U S A 109:17651-6. 2012
  8. doi request reprint Isoflurane regulates atypical type-A γ-aminobutyric acid receptors in alveolar type II epithelial cells
    Yun Yan Xiang
    Department of Physiology and Pharmacology and Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
    Anesthesiology 118:1065-75. 2013
  9. doi request reprint The involvement of PACAP/VIP system in the synaptic transmission in the hippocampus
    Kai Yang
    Department of Physiology, University of Toronto, I King s College Circle, Toronto, ON, Canada
    J Mol Neurosci 42:319-26. 2010
  10. doi request reprint Regulation of NMDA receptors by the tyrosine kinase Fyn
    Catherine H Trepanier
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
    FEBS J 279:12-9. 2012

Collaborators

Detail Information

Publications13

  1. doi request reprint Nonselective cation channels and links to hippocampal ischemia, aging, and dementia
    John F MacDonald
    Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada
    Adv Exp Med Biol 961:433-47. 2013
    ..We also discuss the properties of several other nonselective cation channels, transient receptor potential melastatin 2 and 7 channels, and their implications in linking these conditions...
  2. pmc Dependence of NMDA/GSK-3β mediated metaplasticity on TRPM2 channels at hippocampal CA3-CA1 synapses
    Yu Feng Xie
    Robarts Research Institute, University of Western Ontario, London, ON, Canada
    Mol Brain 4:44. 2011
    ..Notably, LTD could be rescued in TRPM2 null mice by recruitment of GSK-3β signaling following dopamine D2 receptor stimulation. We propose that TRPM2 channels play a key role in hippocampal synaptic plasticity...
  3. pmc Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons
    Jillian C Belrose
    Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, N6A 5 K8, Canada
    Mol Brain 5:11. 2012
    ..Herein, we explore the relation between cellular GSH and TRPM2 channel activity in long-term cultures of hippocampal neurons...
  4. doi request reprint Plasticity of synaptic GluN receptors is required for the Src-dependent induction of long-term potentiation at CA3-CA1 synapses
    Hong Bin Li
    Department of Physiology and Pharmacology, Robarts Research Institute, University of Western Ontario, London, Ontario
    Hippocampus 21:1053-61. 2011
    ..Collectively, our findings suggest that GluNR plasticity, although not strictly required for induction, is necessary for the maintenance of a nondecrementing component of LTP...
  5. pmc Ca2+-dependent induction of TRPM2 currents in hippocampal neurons
    Michelle E Olah
    Robarts Research Institute, Molecular Brain Research Group, University of Western Ontario, 100 Perth Drive, London, ON, Canada, N6A 5K8
    J Physiol 587:965-79. 2009
    ..Taken together, these results indicate that hippocampal pyramidal neurons possess functional TRPM2 channels whose activation by ADPR is functionally coupled to VDCCs and NMDARs through a rise in [Ca(2+)](i)...
  6. doi request reprint Fyn, a potential target for Alzheimer's disease
    Kai Yang
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    J Alzheimers Dis 27:243-52. 2011
    ..Novel insights into the role of Fyn in AD may help identify alternative pharmacological approaches for the treatment of AD...
  7. pmc Elimination of the vesicular acetylcholine transporter in the forebrain causes hyperactivity and deficits in spatial memory and long-term potentiation
    Amanda C Martyn
    Molecular Brain Research Group, Robarts Research Institute, and Department of Anatomy and Cell Biology and Physiology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada N6A 5K8
    Proc Natl Acad Sci U S A 109:17651-6. 2012
    ..These data uncover the specific contribution of forebrain cholinergic tone for synaptic plasticity and behavior. Moreover, these experiments define specific cognitive functions that could be targeted by cholinergic replacement therapy...
  8. doi request reprint Isoflurane regulates atypical type-A γ-aminobutyric acid receptors in alveolar type II epithelial cells
    Yun Yan Xiang
    Department of Physiology and Pharmacology and Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
    Anesthesiology 118:1065-75. 2013
    ..The goal of this study was to determine whether human ATII cells also express GABAA receptors and whether volatile anesthetics upregulate GABAA receptor activity, thereby reducing the expression of COX-2 in ATII cells...
  9. doi request reprint The involvement of PACAP/VIP system in the synaptic transmission in the hippocampus
    Kai Yang
    Department of Physiology, University of Toronto, I King s College Circle, Toronto, ON, Canada
    J Mol Neurosci 42:319-26. 2010
    ..Their roles in learning and memory are also demonstrated using transgenic mice and pharmacological methods...
  10. doi request reprint Regulation of NMDA receptors by the tyrosine kinase Fyn
    Catherine H Trepanier
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
    FEBS J 279:12-9. 2012
    ..In addition to its effects on NMDA receptor function, Fyn also modifies the threshold for synaptic plasticity at CA1 synapses, an effect that probably contributes to the effects of Fyn on spatial and contextual fear learning...
  11. pmc Abelson tyrosine kinase links PDGFbeta receptor activation to cytoskeletal regulation of NMDA receptors in CA1 hippocampal neurons
    Michael A Beazely
    Department of Physiology, University of Toronto, ON, Canada
    Mol Brain 1:20. 2008
    ..The mechanism whereby PDGF receptor regulates cytoskeletal dynamics in central neurons remains poorly understood...
  12. ncbi request reprint G protein-coupled receptors control NMDARs and metaplasticity in the hippocampus
    John F MacDonald
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Biochim Biophys Acta 1768:941-51. 2007
    ..We discuss the protein kinase signal cascades stimulated by Galphaq and Galphas coupled GPCRs and describe how control of NMDAR activity shifts the threshold for the induction of LTP...
  13. ncbi request reprint Alpha5GABAA receptors regulate the intrinsic excitability of mouse hippocampal pyramidal neurons
    Robert P Bonin
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    J Neurophysiol 98:2244-54. 2007
    ..We conclude that shunting inhibition mediated by alpha5GABA(A) receptors regulates the firing of action potentials and may synchronize network activity that underlies hippocampal-dependent behavior...