Research Topics
Species | Feng BaoSummaryAffiliation: Robarts Research Institute Country: Canada Publications
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Detail Information
Publications
An integrin inhibiting molecule decreases oxidative damage and improves neurological function after spinal cord injuryFeng Bao
Spinal Cord Injury Laboratory, BioTherapeutics Research Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, The University of Western Ontario, PO Box 5015, 100 Perth Drive, London, Ontario Canada
Exp Neurol 214:160-7. 2008..This improved function correlated with decreased lesion size and spared myelin-containing white matter. The neurological improvement offered by this neuroprotective strategy supports the potential for an anti-integrin treatment for SCI...
Anti-CD11d antibody treatment reduces free radical formation and cell death in the injured spinal cord of ratsFeng Bao
Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
J Neurochem 94:1361-73. 2005..These effects likely underlie tissue preservation and improved neurological function that result from the mAb treatment...- Alpha4beta1 integrin blockade after spinal cord injury decreases damage and improves neurological functionJennifer C Fleming
Spinal Cord Injury Laboratory, BioTherapeutics Research Group, Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5K8
Exp Neurol 214:147-59. 2008..The significant neurological improvement offered by this neuroprotective strategy underscores the potential for an anti-integrin treatment for SCI... - Timing and duration of anti-alpha4beta1 integrin treatment after spinal cord injury: effect on therapeutic efficacyJennifer C Fleming
Spinal Cord Injury Laboratory, The University of Western Ontario, London, Ontario, Canada
J Neurosurg Spine 11:575-87. 2009.... - The systemic inflammatory response after spinal cord injury in the rat is decreased by α4β1 integrin blockadeFeng Bao
Spinal Cord Injury Team, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
J Neurotrauma 29:1626-37. 2012..The SIRS after SCI impedes recovery, and attenuation of the SIRS with an anti-integrin treatment is an important, clinically-relevant finding... - CD11d Antibody Treatment Improves Recovery in Spinal Cord-Injured MiceNicole M Geremia
The Spinal Cord Injury Team, Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada
J Neurotrauma 29:539-50. 2012..Our results with the 205C CD11d mAb treatment complement previous work using this anti-integrin treatment in a rat model of SCI... - Early anti-inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in ratsFeng Bao
Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
J Neurochem 88:1335-44. 2004..These effects likely underlie improved tissue preservation and neurological function resulting from the mAb treatment... - A therapeutic time window for anti-CD 11d monoclonal antibody treatment yielding reduced secondary tissue damage and enhanced behavioral recovery following severe spinal cord injuryDavid S Ditor
Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
J Neurosurg Spine 5:343-52. 2006..A more clinically relevant time for the initiation of treatment after SCI, however, is 6 or more hours postinjury... - CD11d integrin blockade reduces the systemic inflammatory response syndrome after spinal cord injuryFeng Bao
Spinal Cord Injury Team, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5K8
Exp Neurol 231:272-83. 2011..Clinical studies show that SIRS, with its associated organ failure, contributes significantly to the morbidity and mortality of SCI patients. This anti-integrin treatment may block the onset of SIRS after SCI... - Anti-alpha4beta1 integrin antibody induces receptor internalization and does not impair the function of circulating neutrophilic leukocytesJennifer C Fleming
Schulich School of Medicine and Dentistry, Robarts Research Institute, The University of Western Ontario, London, ON, Canada
Inflamm Res 59:647-57. 2010..This study assessed the effects of anti-alpha4 mAb binding on neutrophil activation [reactive oxygen species (ROS) production], function (phagocytic activity) and anti-alpha4-mAb/alpha4beta1-integrin-complex internalization... 
A selective phosphodiesterase-4 inhibitor reduces leukocyte infiltration, oxidative processes, and tissue damage after spinal cord injuryFeng Bao
Spinal Cord Injury Team, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
J Neurotrauma 28:1035-49. 2011..Early inhibition of PDE4 is neuroprotective after SCI when given acutely and briefly at sufficient doses...- Increased oxidative activity in human blood neutrophils and monocytes after spinal cord injuryFeng Bao
Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, 100 Perth Drive, London, ON, Canada N6A 5K8
Exp Neurol 215:308-16. 2009..1.9-fold). Spinal cord injury causes a particularly intense systemic inflammatory response. Limiting this response briefly after cord injury should protect the spinal cord and tissues/organs outside the CNS from secondary damage... - Human spinal cord injury causes specific increases in surface expression of β integrins on leukocytesFeng Bao
Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
J Neurotrauma 28:269-80. 2011..Integrins may be excellent targets for anti-inflammatory treatment after human SCI... - Effects of a novel tripeptide on neurological outcomes after spinal cord injurySunil M John
Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
Neuroreport 17:1793-6. 2006..In conclusion, the anti-inflammatory and anti-oxidative actions of feG treatment correlate with improved neurological outcomes after spinal cord injury... - An anti-CD11d integrin antibody reduces cyclooxygenase-2 expression and protein and DNA oxidation after spinal cord injury in ratsFeng Bao
Laboratory of Spinal Cord Injury, BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
J Neurochem 90:1194-204. 2004..These effects likely underlie tissue preservation and improved neurological function resulting from the mAb treatment... - Schwann cell coculture improves the therapeutic effect of bone marrow stromal cells on recovery in spinal cord-injured miceXiaoyun Xu
The Spinal Cord Injury Team, BioTherapeutics Research Laboratories and Molecular Brain Research Group, Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada
Cell Transplant 20:1065-86. 2011.... - A CD11d monoclonal antibody treatment reduces tissue injury and improves neurological outcome after fluid percussion brain injury in ratsFeng Bao
Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
J Neurotrauma 29:2375-92. 2012..These findings suggest that neuroinflammation is associated with behavioral deficits after TBI, and that anti-CD11d antibody treatment is a viable strategy to improve neurological outcomes after TBI... - Repeated mild lateral fluid percussion brain injury in the rat causes cumulative long-term behavioral impairments, neuroinflammation, and cortical loss in an animal model of repeated concussionSandy R Shultz
Department of Medicine, Melbourne Brain Centre, The University of Melbourne, Parkville, Victoria 3010, Australia
J Neurotrauma 29:281-94. 2012.... - Mn (III) tetrakis (4-benzoic acid) porphyrin administered into the intrathecal space reduces oxidative damage and neuron death after spinal cord injury: a comparison with methylprednisoloneJorge E Hachmeister
Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555-0881, USA
J Neurotrauma 23:1766-78. 2006.... - Peroxynitrite generated at the level produced by spinal cord injury induces peroxidation of membrane phospholipids in normal rat cord: reduction by a metalloporphyrinDanxia Liu
Departments of Neurology, Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0881, USA
J Neurotrauma 22:1123-33. 2005.... - Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: reduction by Mn (III) tetrakis (4-benzoic acid) porphyrinFeng Bao
Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555-0653, USA
J Neurosci Res 71:220-7. 2003..7 for DNP and 0.2 for Ntyr). These results further demonstrate peroxynitrite-induced protein oxidation and nitration and the efficiency of MnTBAP in scavenging peroxynitrite... - Exposure to short-lasting impulse noise causes neuronal c-Jun expression and induction of apoptosis in the adult rat brainAnnette Säljö
Department of Anatomy and Cell Biology, Goteborg University, Goteborg, Sweden
J Neurotrauma 19:985-91. 2002..The elevated expression of c-Jun products remained high at all postexposure times. TUNEL staining was positive among the same nerve cell populations 6 h after exposure and persisted even at 7 days at both exposure levels... - Expression of c-Fos and c-Myc and deposition of beta-APP in neurons in the adult rat brain as a result of exposure to short-lasting impulse noiseAnnette Säljö
Department of Anatomy and Cell Biology, University of Goteborg, Sweden
J Neurotrauma 19:379-85. 2002..We conclude that impulse noise influences the brain in a fashion similar to that in cases with progressive CNS degeneration...