Feng Bao

Summary

Affiliation: Robarts Research Institute
Country: Canada

Publications

  1. pmc Mn (III) tetrakis (4-benzoic acid) porphyrin scavenges reactive species, reduces oxidative stress, and improves functional recovery after experimental spinal cord injury in rats: comparison with methylprednisolone
    Danxia Liu
    Department of Neurology, University of Texas Medical Branch, 301 University Blvd, Rt 0881, Galveston, TX 77555 0881, USA
    BMC Neurosci 14:23. 2013
  2. doi request reprint An integrin inhibiting molecule decreases oxidative damage and improves neurological function after spinal cord injury
    Feng Bao
    Spinal Cord Injury Laboratory, BioTherapeutics Research Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, The University of Western Ontario, PO Box 5015, 100 Perth Drive, London, Ontario Canada
    Exp Neurol 214:160-7. 2008
  3. ncbi request reprint Anti-CD11d antibody treatment reduces free radical formation and cell death in the injured spinal cord of rats
    Feng Bao
    Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
    J Neurochem 94:1361-73. 2005
  4. doi request reprint Alpha4beta1 integrin blockade after spinal cord injury decreases damage and improves neurological function
    Jennifer C Fleming
    Spinal Cord Injury Laboratory, BioTherapeutics Research Group, Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5K8
    Exp Neurol 214:147-59. 2008
  5. doi request reprint Timing and duration of anti-alpha4beta1 integrin treatment after spinal cord injury: effect on therapeutic efficacy
    Jennifer C Fleming
    Spinal Cord Injury Laboratory, The University of Western Ontario, London, Ontario, Canada
    J Neurosurg Spine 11:575-87. 2009
  6. doi request reprint The systemic inflammatory response after spinal cord injury in the rat is decreased by α4β1 integrin blockade
    Feng Bao
    Spinal Cord Injury Team, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Neurotrauma 29:1626-37. 2012
  7. doi request reprint CD11d Antibody Treatment Improves Recovery in Spinal Cord-Injured Mice
    Nicole M Geremia
    The Spinal Cord Injury Team, Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada
    J Neurotrauma 29:539-50. 2012
  8. ncbi request reprint Early anti-inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats
    Feng Bao
    Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
    J Neurochem 88:1335-44. 2004
  9. doi request reprint CD11d integrin blockade reduces the systemic inflammatory response syndrome after spinal cord injury
    Feng Bao
    Spinal Cord Injury Team, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5K8
    Exp Neurol 231:272-83. 2011
  10. ncbi request reprint A therapeutic time window for anti-CD 11d monoclonal antibody treatment yielding reduced secondary tissue damage and enhanced behavioral recovery following severe spinal cord injury
    David S Ditor
    Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
    J Neurosurg Spine 5:343-52. 2006

Collaborators

Detail Information

Publications25

  1. pmc Mn (III) tetrakis (4-benzoic acid) porphyrin scavenges reactive species, reduces oxidative stress, and improves functional recovery after experimental spinal cord injury in rats: comparison with methylprednisolone
    Danxia Liu
    Department of Neurology, University of Texas Medical Branch, 301 University Blvd, Rt 0881, Galveston, TX 77555 0881, USA
    BMC Neurosci 14:23. 2013
    ..The efficiency of MnTBAP was also compared with that of methylprednisolone - the only drug used clinically in treating acute SCI...
  2. doi request reprint An integrin inhibiting molecule decreases oxidative damage and improves neurological function after spinal cord injury
    Feng Bao
    Spinal Cord Injury Laboratory, BioTherapeutics Research Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, The University of Western Ontario, PO Box 5015, 100 Perth Drive, London, Ontario Canada
    Exp Neurol 214:160-7. 2008
    ..This improved function correlated with decreased lesion size and spared myelin-containing white matter. The neurological improvement offered by this neuroprotective strategy supports the potential for an anti-integrin treatment for SCI...
  3. ncbi request reprint Anti-CD11d antibody treatment reduces free radical formation and cell death in the injured spinal cord of rats
    Feng Bao
    Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
    J Neurochem 94:1361-73. 2005
    ..These effects likely underlie tissue preservation and improved neurological function that result from the mAb treatment...
  4. doi request reprint Alpha4beta1 integrin blockade after spinal cord injury decreases damage and improves neurological function
    Jennifer C Fleming
    Spinal Cord Injury Laboratory, BioTherapeutics Research Group, Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada N6A 5K8
    Exp Neurol 214:147-59. 2008
    ..The significant neurological improvement offered by this neuroprotective strategy underscores the potential for an anti-integrin treatment for SCI...
  5. doi request reprint Timing and duration of anti-alpha4beta1 integrin treatment after spinal cord injury: effect on therapeutic efficacy
    Jennifer C Fleming
    Spinal Cord Injury Laboratory, The University of Western Ontario, London, Ontario, Canada
    J Neurosurg Spine 11:575-87. 2009
    ....
  6. doi request reprint The systemic inflammatory response after spinal cord injury in the rat is decreased by α4β1 integrin blockade
    Feng Bao
    Spinal Cord Injury Team, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Neurotrauma 29:1626-37. 2012
    ..The SIRS after SCI impedes recovery, and attenuation of the SIRS with an anti-integrin treatment is an important, clinically-relevant finding...
  7. doi request reprint CD11d Antibody Treatment Improves Recovery in Spinal Cord-Injured Mice
    Nicole M Geremia
    The Spinal Cord Injury Team, Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada
    J Neurotrauma 29:539-50. 2012
    ..Our results with the 205C CD11d mAb treatment complement previous work using this anti-integrin treatment in a rat model of SCI...
  8. ncbi request reprint Early anti-inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats
    Feng Bao
    Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
    J Neurochem 88:1335-44. 2004
    ..These effects likely underlie improved tissue preservation and neurological function resulting from the mAb treatment...
  9. doi request reprint CD11d integrin blockade reduces the systemic inflammatory response syndrome after spinal cord injury
    Feng Bao
    Spinal Cord Injury Team, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5K8
    Exp Neurol 231:272-83. 2011
    ..Clinical studies show that SIRS, with its associated organ failure, contributes significantly to the morbidity and mortality of SCI patients. This anti-integrin treatment may block the onset of SIRS after SCI...
  10. ncbi request reprint A therapeutic time window for anti-CD 11d monoclonal antibody treatment yielding reduced secondary tissue damage and enhanced behavioral recovery following severe spinal cord injury
    David S Ditor
    Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
    J Neurosurg Spine 5:343-52. 2006
    ..A more clinically relevant time for the initiation of treatment after SCI, however, is 6 or more hours postinjury...
  11. doi request reprint Anti-alpha4beta1 integrin antibody induces receptor internalization and does not impair the function of circulating neutrophilic leukocytes
    Jennifer C Fleming
    Schulich School of Medicine and Dentistry, Robarts Research Institute, The University of Western Ontario, London, ON, Canada
    Inflamm Res 59:647-57. 2010
    ..This study assessed the effects of anti-alpha4 mAb binding on neutrophil activation [reactive oxygen species (ROS) production], function (phagocytic activity) and anti-alpha4-mAb/alpha4beta1-integrin-complex internalization...
  12. pmc A selective phosphodiesterase-4 inhibitor reduces leukocyte infiltration, oxidative processes, and tissue damage after spinal cord injury
    Feng Bao
    Spinal Cord Injury Team, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Neurotrauma 28:1035-49. 2011
    ..Early inhibition of PDE4 is neuroprotective after SCI when given acutely and briefly at sufficient doses...
  13. doi request reprint Human spinal cord injury causes specific increases in surface expression of β integrins on leukocytes
    Feng Bao
    Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Neurotrauma 28:269-80. 2011
    ..Integrins may be excellent targets for anti-inflammatory treatment after human SCI...
  14. doi request reprint Increased oxidative activity in human blood neutrophils and monocytes after spinal cord injury
    Feng Bao
    Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, 100 Perth Drive, London, ON, Canada N6A 5K8
    Exp Neurol 215:308-16. 2009
    ..1.9-fold). Spinal cord injury causes a particularly intense systemic inflammatory response. Limiting this response briefly after cord injury should protect the spinal cord and tissues/organs outside the CNS from secondary damage...
  15. ncbi request reprint Effects of a novel tripeptide on neurological outcomes after spinal cord injury
    Sunil M John
    Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
    Neuroreport 17:1793-6. 2006
    ..In conclusion, the anti-inflammatory and anti-oxidative actions of feG treatment correlate with improved neurological outcomes after spinal cord injury...
  16. ncbi request reprint An anti-CD11d integrin antibody reduces cyclooxygenase-2 expression and protein and DNA oxidation after spinal cord injury in rats
    Feng Bao
    Laboratory of Spinal Cord Injury, BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
    J Neurochem 90:1194-204. 2004
    ..These effects likely underlie tissue preservation and improved neurological function resulting from the mAb treatment...
  17. pmc Treatment with an anti-CD11d integrin antibody reduces neuroinflammation and improves outcome in a rat model of repeated concussion
    Sandy R Shultz
    Robarts Research Institute, Schulich School of Medicine, University of Western Ontario, 100 Perth Drive St, London, Ontario, N6A 5K8, Canada
    J Neuroinflammation 10:26. 2013
    ..As similar processes may be involved in repeated concussion, here we studied the effects of the anti-CD11d treatment in a rat model of repeated concussion...
  18. doi request reprint A CD11d monoclonal antibody treatment reduces tissue injury and improves neurological outcome after fluid percussion brain injury in rats
    Feng Bao
    Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
    J Neurotrauma 29:2375-92. 2012
    ..These findings suggest that neuroinflammation is associated with behavioral deficits after TBI, and that anti-CD11d antibody treatment is a viable strategy to improve neurological outcomes after TBI...
  19. doi request reprint Schwann cell coculture improves the therapeutic effect of bone marrow stromal cells on recovery in spinal cord-injured mice
    Xiaoyun Xu
    The Spinal Cord Injury Team, BioTherapeutics Research Laboratories and Molecular Brain Research Group, Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada
    Cell Transplant 20:1065-86. 2011
    ....
  20. doi request reprint Repeated mild lateral fluid percussion brain injury in the rat causes cumulative long-term behavioral impairments, neuroinflammation, and cortical loss in an animal model of repeated concussion
    Sandy R Shultz
    Department of Medicine, Melbourne Brain Centre, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Neurotrauma 29:281-94. 2012
    ....
  21. ncbi request reprint Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: reduction by Mn (III) tetrakis (4-benzoic acid) porphyrin
    Feng Bao
    Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555 0653, USA
    J Neurosci Res 71:220-7. 2003
    ..7 for DNP and 0.2 for Ntyr). These results further demonstrate peroxynitrite-induced protein oxidation and nitration and the efficiency of MnTBAP in scavenging peroxynitrite...
  22. ncbi request reprint Exposure to short-lasting impulse noise causes neuronal c-Jun expression and induction of apoptosis in the adult rat brain
    Annette Säljö
    Department of Anatomy and Cell Biology, Goteborg University, Goteborg, Sweden
    J Neurotrauma 19:985-91. 2002
    ..The elevated expression of c-Jun products remained high at all postexposure times. TUNEL staining was positive among the same nerve cell populations 6 h after exposure and persisted even at 7 days at both exposure levels...
  23. ncbi request reprint Peroxynitrite generated at the level produced by spinal cord injury induces peroxidation of membrane phospholipids in normal rat cord: reduction by a metalloporphyrin
    Danxia Liu
    Departments of Neurology, Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0881, USA
    J Neurotrauma 22:1123-33. 2005
    ....
  24. ncbi request reprint Mn (III) tetrakis (4-benzoic acid) porphyrin administered into the intrathecal space reduces oxidative damage and neuron death after spinal cord injury: a comparison with methylprednisolone
    Jorge E Hachmeister
    Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555 0881, USA
    J Neurotrauma 23:1766-78. 2006
    ....
  25. ncbi request reprint Expression of c-Fos and c-Myc and deposition of beta-APP in neurons in the adult rat brain as a result of exposure to short-lasting impulse noise
    Annette Säljö
    Department of Anatomy and Cell Biology, University of Goteborg, Sweden
    J Neurotrauma 19:379-85. 2002
    ..We conclude that impulse noise influences the brain in a fashion similar to that in cases with progressive CNS degeneration...