Darabid H, St Pierre See A, Robitaille R. Purinergic-Dependent Glial Regulation of Synaptic Plasticity of Competing Terminals and Synapse Elimination at the Neuromuscular Junction. Cell Rep. 2018;25:2070-2082.e6 pubmed publisher
..In addition, blockade of P2Y1Rs delays synapse elimination in vivo. Hence, P2Y1Rs drive glial cell regulation of strong synaptic inputs and influence synapse competition and elimination. ..
Matos M, Bosson A, Riebe I, Reynell C, Vallée J, Laplante I, et al
. Astrocytes detect and upregulate transmission at inhibitory synapses of somatostatin interneurons onto pyramidal cells. Nat Commun. 2018;9:4254 pubmed publisher
..Our findings uncover functional interactions between a specific subpopulation of interneurons, astrocytes and pyramidal cells, involved in positive feedback autoregulation of dendritic inhibition of pyramidal cells. ..
Arbour D, Tremblay E, Martineau Ã, Julien J, Robitaille R. Early and persistent abnormal decoding by glial cells at the neuromuscular junction in an ALS model. J Neurosci. 2015;35:688-706 pubmed publisher
..Together, these results suggest that PSC properties are altered in the disease process in a manner that would be detrimental for NMJ repair. The impairments of PSC functions may contribute to NMJ dysfunction and ALS pathogenesis. ..
Tremblay E, Martineau E, Robitaille R. Opposite Synaptic Alterations at the Neuromuscular Junction in an ALS Mouse Model: When Motor Units Matter. J Neurosci. 2017;37:8901-8918 pubmed publisher
..These data provide a novel framework of analysis and comparison of synaptic transmission alterations in neurodegenerative disorders. ..