Serge Rivest

Summary

Country: Canada

Publications

  1. ncbi The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS
    Hakima Zekki
    CHUL Research Center and Department of Anatomy and Physiology, Laval University, Laurier, Quebec, Canada
    Brain Pathol 12:308-19. 2002
  2. ncbi Lipid metabolism and neuroinflammation in Alzheimer's disease: a role for liver X receptors
    Jihong Kang
    Department of Physiology and Pathophysiology and Key Laboratory of Molecular Cardiovascular Sciences, State Education Ministry, Peking University Health Science Center, Beijing 100191, China
    Endocr Rev 33:715-46. 2012
  3. ncbi Molecular insights on the cerebral innate immune system
    Serge Rivest
    Department of Anatomy and Physiology, Laval University 2705, Boul Laurier, Quebec, Canada G1V 4G2
    Brain Behav Immun 17:13-9. 2003
  4. ncbi Interactions between the immune and neuroendocrine systems
    Serge Rivest
    Laboratory of Endocrinology and Genomics, CHUQ Research Center and Department of Molecular Medicine, Laval University, Quebec, Canada
    Prog Brain Res 181:43-53. 2010
  5. ncbi MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease
    Jean Philippe Michaud
    Laboratory of Endocrinology and Genomics, CHUL Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boul, Quebec, G1V 4G2, Canada
    Mol Neurodegener 6:5. 2011
  6. ncbi Regulation of innate immune responses in the brain
    Serge Rivest
    Laboratory of Endocrinology and Genomics, Centre Hospitalier Universitaire de Quebec Research Center, and Department of Anatomy and Physiology, Laval University, 2705 Laurier Boulevard, Quebec, G1V 4G2, Canada
    Nat Rev Immunol 9:429-39. 2009
  7. ncbi The promise of anti-inflammatory therapies for CNS injuries and diseases
    Serge Rivest
    Laboratory of Endocrinology and Genomics, CHUQ Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boulevard, Quebec, G1V 4G2, Canada
    Expert Rev Neurother 11:783-6. 2011
  8. ncbi How circulating cytokines trigger the neural circuits that control the hypothalamic-pituitary-adrenal axis
    S Rivest
    Laboratory of Molecular Endocrinology, CHUL Research Center and Laval University, 2705, Boul Laurier, G1V 4G2, Quebec, Canada
    Psychoneuroendocrinology 26:761-88. 2001
  9. ncbi How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli
    S Rivest
    Laboratory of Molecular Endocrinology, CHUL Research Center, Department of Anatomy, Quebec, Canada
    Proc Soc Exp Biol Med 223:22-38. 2000
  10. ncbi Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    Alain R Simard
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, 2705 Laurier Boul, , Canada
    Neuron 49:489-502. 2006

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. ncbi The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS
    Hakima Zekki
    CHUL Research Center and Department of Anatomy and Physiology, Laval University, Laurier, Quebec, Canada
    Brain Pathol 12:308-19. 2002
    ....
  2. ncbi Lipid metabolism and neuroinflammation in Alzheimer's disease: a role for liver X receptors
    Jihong Kang
    Department of Physiology and Pathophysiology and Key Laboratory of Molecular Cardiovascular Sciences, State Education Ministry, Peking University Health Science Center, Beijing 100191, China
    Endocr Rev 33:715-46. 2012
    ..The ability of LXR to attenuate AD pathology makes them potential therapeutic targets for this neurodegenerative disease...
  3. ncbi Molecular insights on the cerebral innate immune system
    Serge Rivest
    Department of Anatomy and Physiology, Laval University 2705, Boul Laurier, Quebec, Canada G1V 4G2
    Brain Behav Immun 17:13-9. 2003
    ..This review presents evidence supporting the existence of such a system in the brain, which is finely regulated at the transcription level. Transient activation of this system is not harmful toward neuronal elements...
  4. ncbi Interactions between the immune and neuroendocrine systems
    Serge Rivest
    Laboratory of Endocrinology and Genomics, CHUQ Research Center and Department of Molecular Medicine, Laval University, Quebec, Canada
    Prog Brain Res 181:43-53. 2010
    ..This chapter presents the brain circuits involved in the activation of the hypothalamic-pituitary-adrenal (HPA) axis by endogenously produced prostaglandin E(2) (PGE(2)) during systemic innate immune insults...
  5. ncbi MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease
    Jean Philippe Michaud
    Laboratory of Endocrinology and Genomics, CHUL Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boul, Quebec, G1V 4G2, Canada
    Mol Neurodegener 6:5. 2011
    ..abstract:..
  6. ncbi Regulation of innate immune responses in the brain
    Serge Rivest
    Laboratory of Endocrinology and Genomics, Centre Hospitalier Universitaire de Quebec Research Center, and Department of Anatomy and Physiology, Laval University, 2705 Laurier Boulevard, Quebec, G1V 4G2, Canada
    Nat Rev Immunol 9:429-39. 2009
    ..This Review discusses the molecular details underlying the innate immune response in the brain during infection, injury and disease...
  7. ncbi The promise of anti-inflammatory therapies for CNS injuries and diseases
    Serge Rivest
    Laboratory of Endocrinology and Genomics, CHUQ Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boulevard, Quebec, G1V 4G2, Canada
    Expert Rev Neurother 11:783-6. 2011
    ..This very important subject has been discussed at the 13th Annual Meeting of the American Society for Experimental Neurotherapeutics in Bethesda, MD, USA...
  8. ncbi How circulating cytokines trigger the neural circuits that control the hypothalamic-pituitary-adrenal axis
    S Rivest
    Laboratory of Molecular Endocrinology, CHUL Research Center and Laval University, 2705, Boul Laurier, G1V 4G2, Quebec, Canada
    Psychoneuroendocrinology 26:761-88. 2001
    ....
  9. ncbi How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli
    S Rivest
    Laboratory of Molecular Endocrinology, CHUL Research Center, Department of Anatomy, Quebec, Canada
    Proc Soc Exp Biol Med 223:22-38. 2000
    ..The induction of fever, the hypothalamic-pituitary adrenal (HPA) axis, and other autonomic functions are among the physiological outcomes necessary for the protection of the mammalian organism in the presence of foreign material...
  10. ncbi Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    Alain R Simard
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, 2705 Laurier Boul, , Canada
    Neuron 49:489-502. 2006
    ..Therapeutic strategies aiming to improve their recruitment could potentially lead to a new powerful tool for the elimination of toxic senile plaques...
  11. ncbi Irradiation does not compromise or exacerbate the innate immune response in the brains of mice that were transplanted with bone marrow stem cells
    Nicolas P Turrin
    Centre Hospitalier de l Universite Laval Research Center, Laboratory of Molecular Endocrinology, Department of Anatomy and Physiology, Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada
    Stem Cells 25:3165-72. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  12. ncbi Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease
    Karine L Richard
    Laboratory of Molecular Endocrinology, Centre Hospitalier de l Universite Laval Research Center, Department of Anatomy and Physiology, Laval University, Quebec, Canada
    J Neurosci 28:5784-93. 2008
    ..The cognitive decline is markedly accelerated in a context of TLR2 deficiency. Upregulating this innate immune receptor may then be considered as a potential new powerful therapeutic approach for AD...
  13. ncbi Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli
    Veronique Blais
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, Quebec, Canada
    J Neurochem 95:1563-74. 2005
    ..This may have a major impact on the use of these drugs in diseases where inflammation is believed to be a contributing and detrimental factor...
  14. ncbi Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury
    Audrey Boivin
    Laboratory of Molecular Endocrinology, CHUL Research Center, and Department of Anatomy and Physiology, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada G1V 4G2
    J Neurosci 27:12565-76. 2007
    ..Our results provide strong evidence that TLR signaling plays a critical role in orchestrating the innate immune response leading to efficient and rapid clearance of inhibitory myelin debris and nerve regeneration...
  15. ncbi Toll-like receptor 2-independent and MyD88-dependent gene expression in the mouse brain
    Gaelle Naert
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, Quebec, Quebec, Canada
    J Innate Immun 1:480-93. 2009
    ..On the other hand, MyD88 pathway is essential for the endotoxin to induce expression of immune genes in the central nervous system...
  16. ncbi Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease
    Vincent Boissonneault
    Laboratory of Molecular Endocrinology, CHUL Research Center, CHUQ, 2705 Blvd Laurier, Quebec, G1V 4G2, Canada
    Brain 132:1078-92. 2009
    ....
  17. ncbi Hematopoietic MyD88-adaptor protein acts as a natural defense mechanism for cognitive deficits in Alzheimer's disease
    Jean Philippe Michaud
    Laboratory of Endocrinology and Genomics, CHUQ CHUL Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boul, Quebec, Canada G1V 4G2
    Stem Cell Rev 8:898-904. 2012
    ..Moreover, we found that monocytes and microglia deficient for MyD88 exhibit a functionally impaired phagocytic reaction to Aβ...
  18. ncbi Genes involved in the balance between neuronal survival and death during inflammation
    Isaias Glezer
    Laboratory of Molecular Endocrinology, Centre Hospitalier de l Université Laval CHUL Research Center and Department of Anatomy and Physiology, Laval University, Laurier, Quebec, Canada
    PLoS ONE 2:e310. 2007
    ..This study has identified genes that can play a critical role in programming the innate immune response, helping to clarify the mechanisms leading to protection or damage during inflammatory conditions in the CNS...
  19. ncbi Glucocorticoids play a fundamental role in protecting the brain during innate immune response
    Sylvain Nadeau
    Laboratory of Molecular Endocrinology, , Laval University, , Canada G1V 4G2
    J Neurosci 23:5536-44. 2003
    ..In controlling the cerebral innate immunity and microglial TNF-alpha production, glucocorticoids play a major role in protecting the brain against bacterial cell wall components...
  20. ncbi Unraveling the molecular details involved in the intimate link between the immune and neuroendocrine systems
    Nicolas P Turrin
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, 2705 Boulevard Laurier, , Canada
    Exp Biol Med (Maywood) 229:996-1006. 2004
    ..We also provide an innovative view supporting the concept of "fast and delayed response" involving the same ligands but different groups of cells, signal transduction pathways, and target genes...
  21. ncbi Neuroprotective effects of resident microglia following acute brain injury
    Alain R Simard
    Laboratory of Molecular Endocrinology, CHUL Research Center, Laval University, Quebec, Canada G1V 4G2
    J Comp Neurol 504:716-29. 2007
    ..These data indicate that MyD88/NF-kappaB signaling in resident non-proliferating microglia plays a critical role by restricting damage during acute excitotoxicity...
  22. ncbi Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain
    Sylvain Nadeau
    Centre de recherche du Centre hospitalier de l Université Laval and Department of Molecular Medicine, Universite Laval, Quebec, G1V 4G2, Canada
    J Neurosci 31:12533-42. 2011
    ....
  23. ncbi Modulation of the innate immune response by NMDA receptors has neuropathological consequences
    Isaias Glezer
    Laboratory of Molecular Endocrinology, , and Department of Anatomy and Physiology, Laval University, , Canada G1V 4G2
    J Neurosci 23:11094-103. 2003
    ..However, sustained deregulation of proinflammatory signaling involving NMDA receptors leads to demyelination and is likely to be a mechanism participating in such pathological conditions...
  24. ncbi Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology
    Jean Philippe Michaud
    Neuroscience Laboratory, Department of Molecular Medicine, Centre Hospitalier Universitaire de Quebec Research Center, Laval University, Quebec City, QC, Canada G1V 4G2
    Proc Natl Acad Sci U S A 110:1941-6. 2013
    ..MPL induced a potent phagocytic response by microglia while triggering a moderate inflammatory reaction. Our data suggest that the Toll-like receptor 4 agonist MPL may be a treatment for AD...
  25. ncbi Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system
    Denis Soulet
    Laboratory of Molecular Endocrinology, CHUL Research Center, Laval University, Quebec, Canada G1V 4G2
    J Cell Biol 162:257-68. 2003
    ..Thus, polyamines have a major impact on the neuronal integrity and cerebral homeostasis during immune insults...
  26. ncbi Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries
    Isaias Glezer
    Laboratory of Molecular Endocrinology CHUL Research Center and Department of Anatomy and Physiology, Laval University, , Canada
    FASEB J 20:750-2. 2006
    ..In conclusion, TLR4 activation in microglia is a powerful mechanism for improving repair at the remyelination level and protecting the cerebral tissue in presence of agents with strong cytolytic properties...
  27. ncbi Glucocorticoids: protectors of the brain during innate immune responses
    Isaias Glezer
    Laboratory of Molecular Endocrinology, CHUL Research Center, Department of Anatomy and Physiology, Laval University, , Canada
    Neuroscientist 10:538-52. 2004
    ....
  28. ncbi Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain
    Ji Zhang
    Unite de Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec, Canada G1J 2G3
    J Neurosci 27:12396-406. 2007
    ....
  29. ncbi Effects of myeloablation, peripheral chimerism, and whole-body irradiation on the entry of bone marrow-derived cells into the brain
    Antoine Lampron
    Laboratory of Endocrinology and Genomics, CHUL Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec, Canada
    Cell Transplant 21:1149-59. 2012
    ..We conclude that myeloablation, damages to the brain integrity, or the BBB and peripheral chimerism are not responsible for the entry of BMDCs into the CNS following irradiation...
  30. ncbi Cooperation between toll-like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gram-negative and gram-positive bacteria
    Nathalie Laflamme
    Laboratory of Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Eur J Immunol 33:1127-38. 2003
    ..Such collaboration between TLR4 and TLR2 may be determinant for the transfer from the innate to the adaptive immunity within the CNS of infected animals...
  31. ncbi Estradiol is required for a proper immune response to bacterial and viral pathogens in the female brain
    Genevieve Soucy
    Laboratory of Molecular Endocrinology, Centre Hospitalier de l Universite Laval Research Center, Quebec City, Quebec, Canada
    J Immunol 174:6391-8. 2005
    ..This transfer is deviant in mice lacking E(2), which allows pathogens to hide from immune surveillance and exacerbates neuronal damages during viral encephalitis...
  32. ncbi CC chemokine receptor 2 deficiency aggravates cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease
    Gaelle Naert
    Laboratory of Endocrinology and Genomics, Centre de Recherche du Centre Hospitalier de l Université Laval Research Center and Department of Molecular Medicine, Laval University, Quebec City, Quebec G1V 4G2, Canada
    J Neurosci 31:6208-20. 2011
    ..A decreased expression of CCR2 could play a potential role in the etiology of Alzheimer's disease, a neurodegenerative pathology that could be treated by a genetic upregulation of the transgene in monocytoid cells...
  33. ncbi Sensorimotor and cognitive functions in a SOD1(G37R) transgenic mouse model of amyotrophic lateral sclerosis
    Mohammed Filali
    Neurobehavioral Phenotyping Platform, CHUL Research Center CHUQ and Department of Molecular Medicine, Laval University, 2705 Laurier Boul, Quebec G1V 4G2, Canada
    Behav Brain Res 225:215-21. 2011
    ....
  34. ncbi Hematopoietic CC-chemokine receptor 2 (CCR2) competent cells are protective for the cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease
    Gaelle Naert
    Laboratory of Endocrinology and Genomics, Centre Hospitalier de l Université Laval CHUL Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec, Canada
    Mol Med 18:297-313. 2012
    ..Decreased CCR2 expression in bone marrow-derived microglia may therefore play a major role in the etiology of this neurodegenerative disease...
  35. ncbi MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis
    Jihong Kang
    Laboratory of Molecular Endocrinology, Centre hospitalier de l Université Laval Research Center and Department of Anatomy and Physiology, Laval University, Quebec G1V 4G2, Canada
    J Cell Biol 179:1219-30. 2007
    ..This compelling beneficial effect of MyD88-competent BMDM is a previously unrecognized natural innate immune mechanism of neuroprotection in a mouse model of late-onset motor neuron disease...
  36. ncbi Effects of TNF-alpha and IFN-gamma on nitric oxide-induced neurotoxicity in the mouse brain
    Veronique Blais
    Laboratory of Molecular Endocrinology, Centre Hospitalier de l Universite Laval Research Center, and Department of Anatomy and Physiology, Laval University, Quebec City, Quebec, Canada
    J Immunol 172:7043-52. 2004
    ..However, SNP-induced NO production together with TNF-alpha in the cerebral environment are critical events leading to intense neurodegeneration and demyelination in vivo...
  37. ncbi Tumor necrosis factor alpha but not interleukin 1 beta mediates neuroprotection in response to acute nitric oxide excitotoxicity
    Nicolas P Turrin
    Laboratory of Molecular Endocrinology, , Sainte-Foy, , G1V 4G2, Canada
    J Neurosci 26:143-51. 2006
    ..These findings may have direct implications for the use anti-inflammatory drugs in acute neurodegenerative and demyelinating disorders...
  38. ncbi Tumor necrosis factor-alpha and interleukin-1 beta play a critical role in the resistance against lethal herpes simplex virus encephalitis
    Yan Sergerie
    Research Center in Infectious Diseases, Centre Hospitalier Universitaire de Quebec Centre Hospitalier de l Universite Laval, Laval University, Quebec City, Quebec, Canada
    J Infect Dis 196:853-60. 2007
    ..We investigated the role of the innate immune response in such infection using a C57BL/6 mouse knockout (KO) model for tumor necrosis factor (TNF)-alpha and/or interleukin (IL)-1beta...
  39. ncbi Role of inflammation in the neurobiology of stem cells
    Alain R Simard
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, 2705 Laurier Blvd, , Canada G1V 4G2
    Neuroreport 15:2305-10. 2004
    ..It is therefore very important to better understand the role of these newly differentiated microglia before devising therapeutic strategies to either inhibit or improve their recruitment at diseased and injured sites...
  40. ncbi Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy
    Nicolas P Turrin
    Laboratory of Molecular Endocrinology, Department of Anatomy and Physiology, CHUL Research Center, Laval University, Quebec, Canada G1V 4G2
    Neurobiol Dis 16:321-34. 2004
    ..These data suggest a different mechanism involved in regulating the innate immune reaction in response to seizures and could have direct implications for the neuropathology associated with epilepsy...
  41. ncbi Immune receptors involved in Streptococcus suis recognition by dendritic cells
    Marie Pier Lecours
    Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Universite de Montreal, St Hyacinthe, Quebec, Canada
    PLoS ONE 7:e44746. 2012
    ..suis suggests a major involvement of MyD88 signaling pathways, mainly (but not exclusively) through TLR2. A multimodal recognition involving a combination of different receptors seems essential for DC effective response to S. suis...
  42. ncbi An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice
    Jennifer E A Wells
    Department of Clinical Neurosciences, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Neurosci 23:10107-15. 2003
    ..The data indicate that MMP-12 expression after spinal cord trauma is deleterious and contributes to the development of secondary injury in SCI...
  43. ncbi Delayed but not early glucocorticoid treatment protects the host during experimental herpes simplex virus encephalitis in mice
    Yan Sergerie
    Centre Hospitalier de l Universite Laval Research Center and Laval University, Quebec, G1V 4G2, Canada
    J Infect Dis 195:817-25. 2007
    ..Glucocorticoids (GCs) have not been established as an evidence-based therapy for herpes simplex virus (HSV) encephalitis. We sought to evaluate the effects of early versus delayed GC administration in a model of HSV-1 encephalitis...
  44. ncbi Molecular and cellular immune mediators of neuroprotection
    Nicolas P Turrin
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, Quebec, Canada
    Mol Neurobiol 34:221-42. 2006
    ..This article presents and discusses these data, supporting a powerful neuroprotective role for microglia and their innate immune reactions in response to pathogens and central nervous system insults...
  45. ncbi Neuronal expression of Cd36, Cd44, and Cd83 antigen transcripts maps to distinct and specific murine brain circuits
    Isaias Glezer
    Department of Anatomy and Physiology, Laval University, Quebec, Canada G1V 4G2
    J Comp Neurol 517:906-24. 2009
    ..The data also suggest that these surface proteins, or their associated mRNA, could be used to label neurons in specific circuits/regions...
  46. ncbi The neuroendocrine control of the innate immune system in health and brain diseases
    Marc André Bellavance
    Laboratory of Endocrinology and Genomics, CHUQ Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec, Canada
    Immunol Rev 248:36-55. 2012
    ..Here we review these mechanisms and discuss data supporting both neuroprotective and detrimental roles of the neuroendocrine control of innate immunity...
  47. ncbi Do pathogen exposure and innate immunity cause brain diseases?
    Alain R Simard
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, 2705 Boul Laurier, Quebec, Canada G1V 4G2
    Neurol Res 27:717-25. 2005
    ..The mechanisms by which pathogens interact with the brain and whether such an interaction leads to neurodegenerative disorders are also discussed...
  48. ncbi Innate immunity: the missing link in neuroprotection and neurodegeneration?
    Minh Dang Nguyen
    Centre for Research in Neurosciences, McGill University, The Montreal General Hospital Research Institute, Montreal, Quebec, H3G 1A4, Canada
    Nat Rev Neurosci 3:216-27. 2002
    ..Paradoxically, this response also protects neurons by favouring remyelination and trophic support afforded by glial cells...
  49. ncbi [Role of the innate immune response in the brain]
    Veronique Blais
    Laboratoire d Endocrinologie Moléculaire, Centre de Recherche du Centre Hospitalier de l Université Laval CHUL, Département d anatomie et de physiologie, Universite Laval, 2705, boulevard Laurier, Quebec, G1V 4G2 Canada
    Med Sci (Paris) 19:981-7. 2003
    ..The fate of this newly identified cascade of events is therefore likely to have a determinant impact on the central nervous system during infection and injury...
  50. ncbi Anomalies in social behaviors and exploratory activities in an APPswe/PS1 mouse model of Alzheimer's disease
    Mohammed Filali
    Neurobehavioral Phenotyping Platform, Laboratory of Endocrinology and Genomics, CHUQ Research Center, Department of Molecular Medicine, Laval University, Quebec, Canada
    Physiol Behav 104:880-5. 2011
    ..This study reveals reduced "sociability" combined with hyperactivity in an APPswe/PS1 mouse model of Alzheimer dementia...
  51. ncbi Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease
    Mohammed Filali
    Laboratory of Endocrinology and Genomics, CHUQ Research Center and Department of Molecular Medicine, Laval University, 2705 Boulevard Laurier, Quebec G1V 4G2, Canada
    Neuropharmacology 60:930-6. 2011
    ..The drug had no effect on non-learned behaviors in elevated plus-maze exploration and nest-building. These results support a specific action of the NMDA receptor antagonist on behavioral flexibility in mutant mice with amyloid pathology...
  52. ncbi Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection
    María C Domínguez Punaro
    Groupe de Recherche sur les Maladies Infectieuses du Porc, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, Quebec, Canada
    J Immunol 179:1842-54. 2007
    ..suis infection in mice. This experimental model may be useful for studying the mechanisms underlying sepsis and meningitis during bacterial infection...
  53. ncbi Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: role of glucocorticoids and CD14
    Sylvain Nadeau
    Laboratory of Molecular Endocrinology, Centre Hospitalier de l Universite Laval Research Center, and Department of Anatomy and Physiology, Laval University, Quebec City, Quebec, Canada
    J Immunol 169:3370-81. 2002
    ..This study also further consolidates the existence of such system in the brain, which is finely regulated and its transient activation is not harmful for the neuronal elements...
  54. ncbi Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia
    Alain R Simard
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, , Canada
    FASEB J 18:998-1000. 2004
    ..Therefore, these results may have great clinical relevance for both immune-derived neuronal disorders and cancer patients undergoing allogeneic hematopoietic stem-cell transplantation...
  55. ncbi Effect of pretreatment with toll-like receptor agonists in a mouse model of herpes simplex virus type 1 encephalitis
    Nicolas Boivin
    Research Center in Infectious Diseases, CHUQ CHUL, Quebec City, Canada
    J Infect Dis 198:664-72. 2008
    ..We evaluated the effect of pretreatment with Toll-like receptor (TLR) agonists in a mouse model of herpes simplex virus type 1 (HSV-1) encephalitis...
  56. ncbi Inhibitory action of nitric oxide on circulating tumor necrosis factor-induced NF-kappaB activity and COX-2 transcription in the endothelium of the brain capillaries
    V Blais
    Laboratory of Molecular Endocrinology, CHUL Research Center, Laval University, Quebec, Canada
    J Neuropathol Exp Neurol 60:893-905. 2001
    ..This autoregulatory feedback of NO on these proinflammatory signal transduction events may be an essential element to prevent an exaggerated response that takes place in cells of the BBB during systemic immune challenges...
  57. ncbi What is the cellular source of prostaglandins in the brain in response to systemic inflammation? Facts and controversies
    S Rivest
    Laboratory of Molecular Endocrinology, CHUL, Department of Anatomy, Laval University, 2705 Boul Laurier, Quebec, Canada G1V 4G2
    Mol Psychiatry 4:500-7. 1999
    ..Whether there is more than a single cell type in the blood-brain barrier responsible for the synthesis of prostanoids in the presence of circulating proinflammatory cytokines is an interesting debate that will be summarized here...
  58. ncbi An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia
    N Laflamme
    Laboratory of Molecular Endocrinology, Centre de Recherche de l Université Laval Research Center, Department of Anatomy, Laval University, Quebec, Canada G1V 4G2
    J Neurosci 19:10923-30. 1999
    ....
  59. ncbi Expression of corticotropin-releasing factor and its receptors in the brain of lean and obese Zucker rats
    D Richard
    Departement de Physiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Endocrinology 137:4786-95. 1996
    ....
  60. ncbi Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease
    M Filali
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, Quebec, Canada
    Genes Brain Behav 8:143-8. 2009
    ..In addition, APPswe/PS1 bigenic mice were deficient in retention of passive avoidance learning and left-right discrimination learning, concordant with previous findings in other Alzheimer-like models...
  61. ncbi Interleukin-6 is a needed proinflammatory cytokine in the prolonged neural activity and transcriptional activation of corticotropin-releasing factor during endotoxemia
    L Vallières
    Department of Anatomy and Physiology, Laval University, Sainte Foy, Quebec, Canada
    Endocrinology 140:3890-903. 1999
    ....
  62. ncbi Corticotropin-releasing hormone and its receptors; an evaluation at the transcription level in vivo
    G Drolet
    Neuroscience Unit and Laboratory of Molecular Endocrinology, CHUL Research Center and Laval University 2705, boul. Laurier, G1V 4G2, , Canada
    Peptides 22:761-7. 2001
    ..This review will present evidence of such phenomenon by stressors of different categories as well as the possible neuromediators involved...
  63. ncbi In altering the release of glucocorticoids, ketorolac exacerbates the effects of systemic immune stimuli on expression of proinflammatory genes in the brain
    Veronique Blais
    Laboratory of Molecular Endocrinology, Centre hospitalier de l Université Laval Research Center and Department of Anatomy and Physiology, Laval University, Quebec, Canada G1V 4G2
    Endocrinology 143:4820-7. 2002
    ..In altering the production of key prostaglandins that are involved in the control of hypothalamic-pituitary-adrenal axis, ketorolac may have proinflammatory properties in the central nervous system during systemic immune stimuli...
  64. ncbi Cannabinoids in microglia: a new trick for immune surveillance and neuroprotection
    Serge Rivest
    Laboratory of Molecular Endocrinology, CHUL Research Center, and Department of Anatomy and Physiology, Laval University, , Canada G1V-4G2
    Neuron 49:4-8. 2006
    ..MKP-1 interferes with lipopolysaccharide-induced toll-like receptor 4 signaling and limits brain damage due to exaggerated microglial reactivity following acute NMDA injury...
  65. ncbi Targeting the hematopoietic system for the treatment of Alzheimer's disease
    Antoine Lampron
    Laboratory of Endocrinology and Genomics, CHUL Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boul, Quebec G1V4G2, Canada
    Brain Behav Immun 25:S71-9. 2011
    ..However, numerous limitations have to be taken into consideration before recommending such a cellular therapy and these are discussed in the present review...
  66. ncbi Role of IL-1 and TNF in the brain: twenty years of progress on a Dr. Jekyll/Mr. Hyde duality of the innate immune system
    David Gosselin
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University 2705, boulevard Laurier, Que, Canada G1V 4G2
    Brain Behav Immun 21:281-9. 2007
    ..This review presents the history of these two cytokines during immune responses in the brain and where we are now two decades later...
  67. ncbi Anti-inflammatory effects of prostaglandin E2 in the central nervous system in response to brain injury and circulating lipopolysaccharide
    J Zhang
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, , Canada
    J Neurochem 76:855-64. 2001
    ....
  68. ncbi IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults
    David Gosselin
    Faculty of Medicine, Neuroscience Laboratory, CHU de Québec Research Center and Department of Molecular Medicine, Laval University Quebec City, QC, Canada
    Front Cell Neurosci 7:9. 2013
    ..These data suggest that in a context of excitotoxicity, stimulation of IL-1RAcPb signaling may promote the activity of a key neuroprotective mechanism...
  69. ncbi Effects of mild chronic cerebral hypoperfusion and early amyloid pathology on spatial learning and the cellular innate immune response in mice
    Pedro M Pimentel-Coelho
    Laboratory of Endocrinology and Genomics, CHUQ CHUL Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec, Canada
    Neurobiol Aging 34:679-93. 2013
    ..These results indicate that a mild reduction of cerebral blood flow can selectively induce cognitive deficits at an early stage of amyloid pathology, eliciting a cellular innate immune response, even without causing neuronal death...
  70. ncbi Immune mechanisms underlying the beneficial effects of autologous hematopoietic stem cell transplantation in multiple sclerosis
    David Gosselin
    Laboratory of Endocrinology and Genomics, CHUQ Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec G1V4G2, Canada
    Neurotherapeutics 8:643-9. 2011
    ....
  71. ncbi A fluorescent probe of polyamine transport accumulates into intracellular acidic vesicles via a two-step mechanism
    Denis Soulet
    Oncological and Molecular Endocrinology Research Center, CHUL Research Center, Sainte Foy, Quebec G1V 4G2, Canada
    J Biol Chem 279:49355-66. 2004
    ..The present data thus support model A, and indicate that polyamine accumulation is primarily driven by the activity of a vesicular H+:polyamine carrier...
  72. ncbi MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1
    Vincent Boissonneault
    Centre de Recherche en Rhumatologie et Immunologie and Laboratory of Molecular Endocrinology, Centre Hospitalier de l Université Laval Research Center Centre Hospitalier Universitaire de Québec, Quebec, Quebec G1V 4G2, Canada
    J Biol Chem 284:1971-81. 2009
    ..Our results may provide the molecular basis underlying BACE1 deregulation in AD and offer new perspectives on the etiology of this neurological disorder...
  73. ncbi MyD88 signaling in brain endothelial cells is essential for the neuronal activity and glucocorticoid release during systemic inflammation
    D Gosselin
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, QC, Canada
    Mol Psychiatry 13:480-97. 2008
    ..Therefore, BBB endothelial cells and not perivascular microglia are the main target of circulating inflammatory mediators to activate the brain circuits and key autonomic functions during systemic immune challenges...
  74. ncbi Age-related changes in synaptic markers and monocyte subsets link the cognitive decline of APP(Swe)/PS1 mice
    Gaelle Naert
    Laboratory of Endocrinology and Genomics, CHUQ Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University Quebec City, QC, Canada
    Front Cell Neurosci 6:51. 2012
    ..In conclusion, low CCR2(+) monocyte production by the hematopoietic system may be a direct biomarker of the cognitive decline in a context of AD...
  75. ncbi Perspective: how to make microarray, serial analysis of gene expression, and proteomic relevant to day-to-day endocrine problems and physiological systems
    Denis Soulet
    Laboratory of Molecular Endocrinology, , Laval University, , Canada G1V 4G2
    Endocrinology 143:1995-2001. 2002
  76. ncbi Estrogen receptor transrepresses brain inflammation
    David Gosselin
    Laboratory of Endocrinology and Genomics, CHUQ Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boulevard, Quebec, G1V 4G2, Canada
    Cell 145:495-7. 2011
    ..Now Saijo et al. (2011) provide evidence that ERβ activates a transrepression pathway that suppresses inflammation and inhibits progression of pathology in a mouse model of multiple sclerosis...
  77. ncbi Is survival possible without arachidonate metabolites in the brain during systemic infection?
    Ji Zhang
    Laboratory of Molecular Endocrinology, Centre de Recherche de l Université Laval and Department of Anatomy and Physiology, Laval University, Quebec City, Quebec, Canada G1V 4G2
    News Physiol Sci 18:137-42. 2003
    ..Coincidentally, centrally produced prostaglandins play a determinant role in activating the neuronal circuits involved in the control of autonomic functions...
  78. ncbi Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS
    N Laflamme
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, , Canada
    J Neurochem 79:648-57. 2001
    ..The robust wave of TLR2-expressing microglial cells may have a determinant impact on the innate immune response that occurs in the brain during systemic infection by Gram-negative, not Gram-positive, bacteria...
  79. ncbi Cloning of murine TReP-132, a novel transcription factor expressed in brain regions involved in behavioral and psychiatric disorders
    Y Duguay
    Laboratory of Molecular Endocrinology and Department of Anatomy and Physiology, Laval University, Sainte Foy, QC, Canada
    Mol Psychiatry 8:39-49. 2003
    ..The molecular cloning and the highly specific expression of mTReP-132 across the brain further consolidate the hypothesis that this tissue is able to synthesize de novo steroids in a region-specific manner...
  80. ncbi Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer's disease
    A R Simard
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, QC, Canada
    Mol Psychiatry 11:327-35. 2006
    ..This review presents the mechanisms involved in the control of the innate immune response by microglia and the beneficial properties of such a response in brain diseases, such as AD...
  81. ncbi The role of microglial cell subsets in Alzheimer's disease
    G Naert
    Laboratory of Endocrinology and Genomics, CHUL Research Center and, Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boul, Quebec, G1V 4G2, Canada
    Curr Alzheimer Res 8:151-5. 2011
    ..Here we review the role of microglia subsets in AD and how these cells have a great potential to fight against Aβ accumulation and cognitive impairment...
  82. ncbi Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor
    L M Herx
    Departments of Clinical Neurosciences and Oncology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Immunol 165:2232-9. 2000
    ..These findings provide the first evidence of the requirement for IL-1beta in the production of CNTF following CNS trauma, and suggest that inflammation can have a beneficial impact on the regenerative capacity of the CNS...
  83. ncbi Neuroprotective role of the innate immune system by microglia
    I Glezer
    Laboratory of Molecular Endocrinology, CHUL Research Center, Laval University, 2705 Laurier Boul, Quebec, Canada G1V 4G2
    Neuroscience 147:867-83. 2007
    ..This review presents new concepts regarding the neuroprotective role of the innate immune response in the brain and how microglia can be directed to improve recovery after injuries and prevent/delay neurodegeneration...
  84. ncbi Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components
    N Laflamme
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, Quebec, Canada G1V 4G2
    FASEB J 15:155-163. 2001
    ..The constitutive expression of both mCD14 and TLR4 may explain the innate immune response in the brain, which originates from the structures devoid of blood-brain barrier in presence of circulating LPS...
  85. ncbi Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines
    I Thibeault
    Laboratory of Molecular Endocrinology, CHUL Research Center, Laval University, , Canada
    J Comp Neurol 434:461-77. 2001
    ..This chemokine may therefore play a critical role in the cerebral innate immune response and contribute to the early chemotaxic events during chronic cerebral inflammation...
  86. ncbi Role of host phosphotyrosine phosphatase SHP-1 in the development of murine leishmaniasis
    G Forget
    Centre de Recherche en Infectiologie CHUQ, Universite Laval, Ste Foy, Quebec, Canada
    Eur J Immunol 31:3185-96. 2001
    ..Overall, this study firmly establishes that modulation of the signaling terminator SHP-1 by Leishmania is essential for its installment and propagation...
  87. ncbi Intranasal herpes simplex virus type 2 inoculation causes a profound thymidine kinase dependent cerebral inflammatory response in the mouse hindbrain
    Guy Boivin
    Laboratory of Infectious Diseases, CHUL Research Centre and Laval University, 2705, boul. Laurier, , G1V 4G Canada
    Eur J Neurosci 16:29-43. 2002
    ..Such neurovirulence occurring in the hindbrain is proposed here to be directly responsible for neurodegeneration and to lead to the cerebral innate immune response, which in turn could play a key role in fatal HSV-2-induced encephalitis...
  88. ncbi Regulation of the Leishmania-induced innate inflammatory response by the protein tyrosine phosphatase SHP-1
    Geneviève Forget
    Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Quebec, Pavillon CHUL, Universite Laval, Ste Foy, Canada
    Eur J Immunol 35:1906-17. 2005
    ..Overall, this study suggests that the ability of Leishmania to induce SHP-1 activity in its host allows the taming of an otherwise strong innate inflammatory response that would be detrimental for its survival and progression...
  89. ncbi An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization
    Andrew Weaver
    University of Calgary, Calgary, Alberta, Canada
    FASEB J 19:1668-70. 2005
    ..These results emphasize that specific MMPs can have beneficial roles in inflammation, and they implicate MMPs in T effector polarization for the first time...
  90. ncbi Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis
    Minh Dang Nguyen
    McGill University Health Center, Centre for Research in Neurosciences, McGill University, The Montreal General Hospital Research Institute, , , Canada
    J Neurosci 24:1340-9. 2004
    ..Our results provide solid evidence that environmental factors and innate immunity can cooperate to influence the course of disease of an inherited neuropathology...
  91. ncbi Host immune response to Salmonella enterica serovar Typhimurium infection in mice derived from wild strains
    Giovanna Sebastiani
    Department of Biochemistry, McGill University, , , Canada H3G 1A4
    Infect Immun 70:1997-2009. 2002
    ..The high levels of IL-1 expression in the spleens and livers of MOLF/Ei mice may have important implications for the activation of peripheral and central innate immune mechanisms...
  92. ncbi Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation
    Alicia A Babcock
    Medical Biotechnology Center, University of Southern Denmark, 5000 Odense C, Denmark
    J Neurosci 26:12826-37. 2006
    ..These results identify a role for TLR2 signaling in the early glial response to brain injury, acting as an innate bridge to neuroinflammation...
  93. ncbi Toll-like receptor-2 deficiency is associated with enhanced brain TNF gene expression during pneumococcal meningitis
    Maryse Letiembre
    Division of Infectious Diseases, Department of Research, University Hospital, Hebelstrasse 20, CH-4031 Basel, Switzerland
    J Neuroimmunol 168:21-33. 2005
    ..TNF gene and protein expression was stronger in TLR2(-/-) than wt brains and associated with increased IkappaB expression suggesting that TLR2 is controlling inflammation via TNF regulation...
  94. ncbi Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury
    Kristina A Kigerl
    Integrated Biomedical Science Graduate Program, College of Medicine, Ohio State University, Columbus, Ohio, USA
    J Neurochem 102:37-50. 2007
    ..Together, these data suggest that in the absence of pathogens, TLR2 and TLR4 are important for coordinating post-injury sequelae and perhaps in regulating inflammation and gliosis after SCI...
  95. ncbi Characterization of the early neuroinflammation after spinal cord injury in mice
    Tiffany Rice
    Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Neuropathol Exp Neurol 66:184-95. 2007
    ..These results of an instantaneous inflammatory response validate approaches to modulate microglia/macrophage activity to improve recovery from SCI...
  96. ncbi Microglia
    Denis Soulet
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A10 221 84 Lund, Sweden
    Curr Biol 18:R506-8. 2008
  97. ncbi Immunotherapy for neurological diseases
    Pablo Villoslada
    Department of Neuroscience, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    Clin Immunol 128:294-305. 2008
    ....
  98. ncbi Are glucocorticoids good or bad for brain development and plasticity?
    Serge Rivest
    Endocrinology 143:1157-8. 2002
  99. ncbi Comparison of the susceptibilities of C57BL/6 and A/J mouse strains to Streptococcus suis serotype 2 infection
    María de la Cruz Domínguez-Punaro
    Faculte de Medecine Veterinaire, Groupe de Recherche sur les Maladies Infectieuses du Porc, Centre de Recherche en Infectiologie Porcine, Universite de Montreal, St Hyacinthe, QC J2S 7C6, Canada
    Infect Immun 76:3901-10. 2008
    ..Our findings demonstrate that A/J mice are very susceptible to S. suis infection and provide evidence that the balance between pro- and anti-inflammatory mediators is crucial for host survival during the septic phase...
  100. ncbi Does circulating leptin have the ability to cross the blood-brain barrier and target neurons directly?
    Serge Rivest
    Endocrinology 143:3211-3. 2002
  101. ncbi [Bone marrow stem cells to the rescue of Alzheimer's disease]
    Alain R Simard
    Med Sci (Paris) 22:822-4. 2006