R M Procyshyn

Summary

Affiliation: Riverview Hospital
Country: Canada

Publications

  1. doi request reprint Clozapine administered once versus twice daily: Does it make a difference?
    Ric M Procyshyn
    British Columbia Mental Health and Addictions Research Institute, 938 W 28th Avenue, Vancouver, B C V5Z 4H4, Canada Department of Psychiatry, University of British Columbia, Vancouver V6T 1Z3, Canada Electronic address
    Med Hypotheses 82:225-8. 2014
  2. pmc Gender-specific profiles of tobacco use among non-institutionalized people with serious mental illness
    Joy L Johnson
    School of Nursing, University of British Columbia, T201 2211 Wesbrook Mall, Vancouver, BC, Canada
    BMC Psychiatry 10:101. 2010
  3. doi request reprint Persistent antipsychotic polypharmacy and excessive dosing in the community psychiatric treatment setting: a review of medication profiles in 435 Canadian outpatients
    Ric M Procyshyn
    British Columbia Mental Health and Addictions Research Institute, A3 113, 938 W 28th Ave, Vancouver, British Columbia, Canada, V5Z 4H4
    J Clin Psychiatry 71:566-73. 2010
  4. pmc Changes in serum lipids, independent of weight, are associated with changes in symptoms during long-term clozapine treatment
    Ric M Procyshyn
    Department of Research, Riverview Hospital, Port Coquitlam, BC, Canada
    J Psychiatry Neurosci 32:331-8. 2007
  5. ncbi request reprint Competitive displacement of clozapine from plasma proteins in normolipidemic and hyperlipidemic plasma samples: clinical implications
    Ric M Procyshyn
    Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada
    Drug Dev Ind Pharm 31:331-7. 2005
  6. ncbi request reprint Prevalence and outcomes of pharmaceutical industry-sponsored clinical trials involving clozapine, risperidone, or olanzapine
    Ric M Procyshyn
    Division of Research, Riverview Hosptal, Port Coquitlam, British Columbia
    Can J Psychiatry 49:601-6. 2004
  7. ncbi request reprint Clozapine's effects on body weight and resting metabolic rate: a case series
    Ric M Procyshyn
    Division of Research, Riverview Hospital, Port Coquitlam, British Columbia, Canada
    Schizophr Res 66:159-62. 2004
  8. ncbi request reprint Patterns of antipsychotic utilization in a tertiary care psychiatric institution
    R M Procyshyn
    Division of Research, Riverview Hospital, Port Coquitlam, BC, Canada
    Pharmacopsychiatry 37:12-7. 2004
  9. ncbi request reprint Antipsychotic polypharmacy: a survey of discharge prescriptions from a tertiary care psychiatric institution
    R M Procyshyn
    Division of Medical Services, 422 Henry Esson Young Building, Riverview Hospital, 500 Lougheed Highway, Port Coquitlam, BC V3C 4J2
    Can J Psychiatry 46:334-9. 2001
  10. ncbi request reprint The influence of dyslipidemia on the plasma protein and lipoprotein distribution of haloperidol
    Ric M Procyshyn
    Division of Pharmaceutics amd Biopharmaceutics, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada
    Eur Neuropsychopharmacol 13:33-7. 2003

Detail Information

Publications31

  1. doi request reprint Clozapine administered once versus twice daily: Does it make a difference?
    Ric M Procyshyn
    British Columbia Mental Health and Addictions Research Institute, 938 W 28th Avenue, Vancouver, B C V5Z 4H4, Canada Department of Psychiatry, University of British Columbia, Vancouver V6T 1Z3, Canada Electronic address
    Med Hypotheses 82:225-8. 2014
    ..We present here some pharmacokinetic simulations and published data to support our hypothesis. ..
  2. pmc Gender-specific profiles of tobacco use among non-institutionalized people with serious mental illness
    Joy L Johnson
    School of Nursing, University of British Columbia, T201 2211 Wesbrook Mall, Vancouver, BC, Canada
    BMC Psychiatry 10:101. 2010
    ....
  3. doi request reprint Persistent antipsychotic polypharmacy and excessive dosing in the community psychiatric treatment setting: a review of medication profiles in 435 Canadian outpatients
    Ric M Procyshyn
    British Columbia Mental Health and Addictions Research Institute, A3 113, 938 W 28th Ave, Vancouver, British Columbia, Canada, V5Z 4H4
    J Clin Psychiatry 71:566-73. 2010
    ....
  4. pmc Changes in serum lipids, independent of weight, are associated with changes in symptoms during long-term clozapine treatment
    Ric M Procyshyn
    Department of Research, Riverview Hospital, Port Coquitlam, BC, Canada
    J Psychiatry Neurosci 32:331-8. 2007
    ..The primary objective of this study was to determine whether an increase in serum lipids is associated with improvement in schizophrenia symptoms during steady state treatment with clozapine...
  5. ncbi request reprint Competitive displacement of clozapine from plasma proteins in normolipidemic and hyperlipidemic plasma samples: clinical implications
    Ric M Procyshyn
    Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada
    Drug Dev Ind Pharm 31:331-7. 2005
    ..This study assesses whether competitive displacement of clozapine by warfarin affects clozapine's overall plasma distribution...
  6. ncbi request reprint Prevalence and outcomes of pharmaceutical industry-sponsored clinical trials involving clozapine, risperidone, or olanzapine
    Ric M Procyshyn
    Division of Research, Riverview Hosptal, Port Coquitlam, British Columbia
    Can J Psychiatry 49:601-6. 2004
    ..This study attempts to determine the prevalence and outcomes of industry-sponsored trials involving clozapine, risperidone, or olanzapine...
  7. ncbi request reprint Clozapine's effects on body weight and resting metabolic rate: a case series
    Ric M Procyshyn
    Division of Research, Riverview Hospital, Port Coquitlam, British Columbia, Canada
    Schizophr Res 66:159-62. 2004
    ..3-16.0% whereas total body weights had increased between 2.9 and 9 kg. To our knowledge, this is the first documentation of an antipsychotic medication being associated with the reduction in resting metabolic rate...
  8. ncbi request reprint Patterns of antipsychotic utilization in a tertiary care psychiatric institution
    R M Procyshyn
    Division of Research, Riverview Hospital, Port Coquitlam, BC, Canada
    Pharmacopsychiatry 37:12-7. 2004
    ....
  9. ncbi request reprint Antipsychotic polypharmacy: a survey of discharge prescriptions from a tertiary care psychiatric institution
    R M Procyshyn
    Division of Medical Services, 422 Henry Esson Young Building, Riverview Hospital, 500 Lougheed Highway, Port Coquitlam, BC V3C 4J2
    Can J Psychiatry 46:334-9. 2001
    ..To perform a retrospective survey of discharge medications at a tertiary care psychiatric facility and to assess the incidence of antipsychotic polypharmacy...
  10. ncbi request reprint The influence of dyslipidemia on the plasma protein and lipoprotein distribution of haloperidol
    Ric M Procyshyn
    Division of Pharmaceutics amd Biopharmaceutics, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada
    Eur Neuropsychopharmacol 13:33-7. 2003
    ..This redistribution was the result of haloperidol leaving the lipoprotein-deficient fraction were it is primarily bound to albumin and alpha(1)-acid glycoprotein. This redistribution of haloperidol may influence its clinical efficacy...
  11. ncbi request reprint Concomitant clozapine reduces smoking in patients treated with risperidone
    Ric M Procyshyn
    Division of Medical Services, Riverview Hospital, Port Coquitlam, BC, Canada
    Eur Neuropsychopharmacol 12:77-80. 2002
    ..1+/-9.3 vs. 37.8+/-19.1 ppm CO, respectively, P=0.03). These data are consistent with previous studies showing that clozapine treatment is associated with significantly reduced smoking behavior relative to other antipsychotic agents...
  12. ncbi request reprint Plasma protein and lipoprotein distribution of clozapine
    R M Procyshyn
    Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 E. Mall Ave, Vancouver, Canada V6T 1Z3
    Am J Psychiatry 158:949-51. 2001
    ..This redistribution of clozapine may affect the pharmacological activity of clozapine...
  13. ncbi request reprint The effects of competitive displacement on haloperidol's plasma distribution in normolipidemic and hyperlipidemic plasma
    Ric M Procyshyn
    Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada
    Drug Dev Ind Pharm 31:901-5. 2005
    ..To assess whether dyslipidemia affects haloperidol's overall plasma distribution when it is in the presence of another highly protein bound drug that competes for plasma protein binding sites...
  14. ncbi request reprint A comparison of smoking behaviours between patients treated with clozapine and depot neuroleptics
    R M Procyshyn
    Division of Medical Services, Riverview Hospital, Port Coquitlam, British Columbia, Canada
    Int Clin Psychopharmacol 16:291-4. 2001
    ..7 +/- 11.3 versus 26.8 +/- 18.3 cigarettes per day, respectively, P = 0.08). Thus, according to measurements of expired CO levels, patients treated with clozapine smoke less than patients treated with depot neuroleptics...
  15. doi request reprint A parametric study of the acute effects of antipsychotic drugs on glucose sensitivity in an animal model
    Heidi N Boyda
    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
    Prog Neuropsychopharmacol Biol Psychiatry 34:945-54. 2010
    ..Together, these findings indicate that acute administration of antipsychotic drugs has potent effects on metabolic regulation of glucose and insulin sensitivities, which may contribute to metabolic side-effects seen in humans...
  16. pmc A translational research approach to poor treatment response in patients with schizophrenia: clozapine-antipsychotic polypharmacy
    William G Honer
    BC Mental Health and Addictions Research Institute, University of British Columbia, Vancouver, BC, Canada
    J Psychiatry Neurosci 34:433-42. 2009
    ..Better linkage between the components of translational research may improve the appropriate use of medications such as clozapine in psychiatric practice...
  17. doi request reprint Effects of chronic exercise and treatment with the antipsychotic drug olanzapine on hippocampal volume in adult female rats
    A M Barr
    Department of Pharmacology, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada British Columbia Mental Health and Addictions Research Institute, 938 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada Electronic address
    Neuroscience 255:147-57. 2013
    ..These findings indicate that exercise may have beneficial effects on the hippocampus when antipsychotic medication can contribute to changes in volume. ..
  18. doi request reprint Differential effects of alcohol intoxication on S100B levels following traumatic brain injury
    Rael T Lange
    Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
    J Trauma 68:1065-71. 2010
    ..The purpose of this study is to evaluate the clinical utility of the protein S100B as a biochemical marker for identifying brain injury in patients who are intoxicated at the time of injury...
  19. doi request reprint Self-reported motivation to smoke in schizophrenia is related to antipsychotic drug treatment
    Alasdair M Barr
    Faculty of Medicine, Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
    Schizophr Res 100:252-60. 2008
    ..While a number of theories have been proposed to account for such high rates of smoking, little is known about the subjective motivation for why schizophrenia patients smoke in comparison with those without the disease...
  20. ncbi request reprint Corrected QT intervals in newly admitted geriatric psychiatric patients: an examination of risk factors
    Jane Dumontet
    Department of Pharmacy, Riverview Hospital, Coquitlam, British Columbia
    Can J Psychiatry 51:371-6. 2006
    ..Our secondary objective was to examine the associations between prolonged QTc intervals and risk factors identified as determinants in prolonging the QTc interval...
  21. doi request reprint Routine exercise ameliorates the metabolic side-effects of treatment with the atypical antipsychotic drug olanzapine in rats
    H N Boyda
    Department of Pharmacology, University of British Columbia, 2176 Health Sciences Mall, Vancouver, B C, V6T 1Z3, Canada
    Int J Neuropsychopharmacol 17:77-90. 2014
    ..The current animal model is suitable for evaluating physiological pathways involved with glucose intolerance. ..
  22. doi request reprint Peripheral adrenoceptors: the impetus behind glucose dysregulation and insulin resistance
    H N Boyda
    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada
    J Neuroendocrinol 25:217-28. 2013
    ..We highlight evidence relating to the clinical use of common adrenergic drugs and their impacts on glucose metabolism...
  23. ncbi request reprint Do triglycerides modulate the effectiveness of clozapine?
    S Pande
    Division of Medical Services, Riverview Hospital, Port Coquitlam, BC, Canada
    Int Clin Psychopharmacol 17:197-9. 2002
    ..Although this case only represents one patient, it highlights the possibility that serum lipids may be potential contributors to the clinical effectiveness of clozapine...
  24. doi request reprint Medication errors in psychiatry: a comprehensive review
    Ric M Procyshyn
    British Columbia Mental Health and Addictions Services Research Institute, Vancouver, British Columbia, Canada
    CNS Drugs 24:595-609. 2010
    ..Medication errors in psychiatry have been studied almost exclusively in the inpatient setting and thus little is known about the incidence and significance in outpatient and community settings...
  25. ncbi request reprint Generic clozapine: a cost-saving alternative to brand name clozapine?
    Gordon Tse
    Department of Pharmacy, Riverview Hospital, Port Coquitlam, British Columbia, Canada
    Pharmacoeconomics 21:1-11. 2003
    ..Finally, initiating a generic formulation in a 'clozapine-naïve' individual would be appropriate. The cost implications related to these recommendations will depend on the success or failure of treatment...
  26. doi request reprint Intermittent treatment with olanzapine causes sensitization of the metabolic side-effects in rats
    H N Boyda
    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Vancouver, B C, Canada
    Neuropharmacology 62:1391-400. 2012
    ..This previously unreported sensitization phenomenon represents a novel finding that may have clinical implications for patients receiving intermittent antipsychotic drug dosing or with variable adherence to treatment...
  27. ncbi request reprint Olanzapine associated weight gain, hyperglycemia and neuroleptic malignant syndrome: case report
    Rhonda Malyuk
    Department of Pharmacy, Riverview Hospital, Port Coquitlam, BC, Canada
    Int J Geriatr Psychiatry 17:326-8. 2002
    ..9 kg. We suggest that utilization of olanzapine in the less medically stable geriatric patient be implemented with vigilant monitoring for such complications mentioned above...
  28. doi request reprint Community mental healthcare providers' attitudes and practices related to smoking cessation interventions for people living with severe mental illness
    Joy L Johnson
    The Centre for Nursing and Health Behaviour Research and NEXUS, School of Nursing, University of British Columbia, Vancouver, BC, Canada
    Patient Educ Couns 77:289-95. 2009
    ..The study also aimed to determine whether the providers' attitudes, smoking status, and confidence were associated with offering smoking cessation support to clients...
  29. doi request reprint Smoking cessation interventions among individuals in methadone maintenance: a brief review
    Chizimuzo T C Okoli
    British Columbia Centre of Excellence for Women s Health, Box 48, Vancouver, British Columbia, Canada V6H 3N1
    J Subst Abuse Treat 38:191-9. 2010
    ....
  30. ncbi request reprint Smoking, anticholinergics and schizophrenia
    Ric M Procyshyn
    Schizophr Res 67:313-4. 2004
  31. ncbi request reprint Antipsychotic polypharmacy does not increase the risk for side effects
    Soma Ganesan
    Schizophr Res 98:323-4. 2008