D Richard

Summary

Country: Canada

Publications

  1. doi request reprint The role of the endocannabinoid system in lipogenesis and fatty acid metabolism
    Roberto Vettor
    Internal Medicine 3, Endocrine Metabolic Laboratory, Department of Medical and Surgical Sciences, University of Padova, Via Ospedale 105, 35128 Padova, Italy
    Best Pract Res Clin Endocrinol Metab 23:51-63. 2009
  2. ncbi request reprint Energy expenditure: a critical determinant of energy balance with key hypothalamic controls
    D Richard
    Laval Hospital Research Center and Merck Frosst CIHR Research Chair in Obesity Chemin Sainte Foy, Quebec, Canada
    Minerva Endocrinol 32:173-83. 2007
  3. ncbi request reprint Circuitries involved in the control of energy homeostasis and the hypothalamic-pituitary-adrenal axis activity
    Denis Richard
    D B Brown Obesity Research Chair, Centre de Recherche, l Hôpital Laval, Institut universitaire de cardiologie et de pneumologie Québec, Quebec, Canada
    Treat Endocrinol 3:269-77. 2004
  4. doi request reprint The brain endocannabinoid system in the regulation of energy balance
    Denis Richard
    Laval Hospital Research Center, Quebec, Canada, G1V 4G5
    Best Pract Res Clin Endocrinol Metab 23:17-32. 2009
  5. ncbi request reprint Influence of topiramate in the regulation of energy balance
    D Richard
    Centre de Recherche de l Hôpital Laval et Centre de Recherche sur le Métabolisme Energétique de l Université Laval, Faculte de Medecine, Universite Laval, Quebec, Canada
    Nutrition 16:961-6. 2000
  6. doi request reprint Palatable high-energy diet decreases the expression of cannabinoid type 1 receptor messenger RNA in specific brain regions in the rat
    E Timofeeva
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, l Université Laval, Quebec, Canada
    J Neuroendocrinol 21:982-92. 2009
  7. ncbi request reprint Effects of the biliopancreatic diversion on energy balance in the rat
    E Nadreau
    Laval Hospital Research Center, 2725, Chemin Sainte Foy, Quebec, Canada
    Int J Obes (Lond) 30:419-29. 2006
  8. ncbi request reprint Distribution of the uncoupling protein 2 mRNA in the mouse brain
    D Richard
    Departement de Physiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    J Comp Neurol 397:549-60. 1998
  9. ncbi request reprint Brain distribution of UCP2 mRNA: in situ hybridization histochemistry studies
    D Richard
    Centre de Recherche sur le Métabolisme Energétique et Département de Physiologie, Universite Laval, Quebec, Canada
    Int J Obes Relat Metab Disord 23:S53-5. 1999
  10. ncbi request reprint Expression of corticotropin-releasing factor and its receptors in the brain of lean and obese Zucker rats
    D Richard
    Departement de Physiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Endocrinology 137:4786-95. 1996

Detail Information

Publications84

  1. doi request reprint The role of the endocannabinoid system in lipogenesis and fatty acid metabolism
    Roberto Vettor
    Internal Medicine 3, Endocrine Metabolic Laboratory, Department of Medical and Surgical Sciences, University of Padova, Via Ospedale 105, 35128 Padova, Italy
    Best Pract Res Clin Endocrinol Metab 23:51-63. 2009
    ..This review focuses on the role of ECs in adipose tissue metabolism, adipokine production, and interactions between ECs and peroxisome proliferator-activated receptors (PPARs) during adipogenesis...
  2. ncbi request reprint Energy expenditure: a critical determinant of energy balance with key hypothalamic controls
    D Richard
    Laval Hospital Research Center and Merck Frosst CIHR Research Chair in Obesity Chemin Sainte Foy, Quebec, Canada
    Minerva Endocrinol 32:173-83. 2007
    ....
  3. ncbi request reprint Circuitries involved in the control of energy homeostasis and the hypothalamic-pituitary-adrenal axis activity
    Denis Richard
    D B Brown Obesity Research Chair, Centre de Recherche, l Hôpital Laval, Institut universitaire de cardiologie et de pneumologie Québec, Quebec, Canada
    Treat Endocrinol 3:269-77. 2004
    ..A link is made between the pathways regulating energy balance and those modulating the activity of the hypothalamic-pituitary-adrenal axis...
  4. doi request reprint The brain endocannabinoid system in the regulation of energy balance
    Denis Richard
    Laval Hospital Research Center, Quebec, Canada, G1V 4G5
    Best Pract Res Clin Endocrinol Metab 23:17-32. 2009
    ..This article aims at reviewing the potential mechanisms whereby the brain endocannabinoid system influences the regulation energy balance...
  5. ncbi request reprint Influence of topiramate in the regulation of energy balance
    D Richard
    Centre de Recherche de l Hôpital Laval et Centre de Recherche sur le Métabolisme Energétique de l Université Laval, Faculte de Medecine, Universite Laval, Quebec, Canada
    Nutrition 16:961-6. 2000
    ..The mechanisms whereby an AED such as TPM controls food intake and energy expenditure remains to be delineated. Copyright1999 ASCRS and ESCRS..
  6. doi request reprint Palatable high-energy diet decreases the expression of cannabinoid type 1 receptor messenger RNA in specific brain regions in the rat
    E Timofeeva
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, l Université Laval, Quebec, Canada
    J Neuroendocrinol 21:982-92. 2009
    ..Altogether, the present results demonstrate that long-term PHED leads to an increase in the hypothalamic expression of SOCS-3 mRNA and a decrease in expression of CB1R mRNA in the Cg cortex and specific hypothalamic regions...
  7. ncbi request reprint Effects of the biliopancreatic diversion on energy balance in the rat
    E Nadreau
    Laval Hospital Research Center, 2725, Chemin Sainte Foy, Quebec, Canada
    Int J Obes (Lond) 30:419-29. 2006
    ..This study was carried out to determine the effects of the biliopancreatic diversion (BPD), a bariatric surgery applied to the treatment of morbidly obese humans, on energy balance in rats...
  8. ncbi request reprint Distribution of the uncoupling protein 2 mRNA in the mouse brain
    D Richard
    Departement de Physiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    J Comp Neurol 397:549-60. 1998
    ..In addition, by promoting oxygen consumption in the brain, UCP2 could control the production of reactive oxygen species and thereby influence the process of neural degeneration...
  9. ncbi request reprint Brain distribution of UCP2 mRNA: in situ hybridization histochemistry studies
    D Richard
    Centre de Recherche sur le Métabolisme Energétique et Département de Physiologie, Universite Laval, Quebec, Canada
    Int J Obes Relat Metab Disord 23:S53-5. 1999
    ..In addition, by elevating oxygen consumption in the brain, UCP2 could in specific regions control the production of reactive oxygen species and thereby influence the process of neural degeneration...
  10. ncbi request reprint Expression of corticotropin-releasing factor and its receptors in the brain of lean and obese Zucker rats
    D Richard
    Departement de Physiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Endocrinology 137:4786-95. 1996
    ....
  11. ncbi request reprint Effects of leptin and corticosterone on the expression of corticotropin-releasing hormone, agouti-related protein, and proopiomelanocortin in the brain of ob/ob mouse
    K Arvaniti
    Centre de Recherche de l Hôpital Laval et Centre de Recherche sur le Métabolisme Energétique, Universite Laval, Quebec, Canada
    Neuroendocrinology 73:227-36. 2001
    ..Finally, the present results suggest that the effects of leptin on the expression of CRH, POMC and AGRP are not curbed by glucocorticoids...
  12. ncbi request reprint The effects of topiramate and sex hormones on energy balance of male and female rats
    D Richard
    Centre de Recherche de l Hôpital Laval et Centre de Recherche sur le Métabolisme Energétique de l Université Laval, Quebec, Canada
    Int J Obes Relat Metab Disord 26:344-53. 2002
    ....
  13. ncbi request reprint The corticotropin-releasing hormone system in the regulation of energy balance in obesity
    D Richard
    Centre de recherche sur le métabolisme énergétique, and Départment d anatomie et de physiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Int J Obes Relat Metab Disord 24:S36-9. 2000
    ....
  14. ncbi request reprint Regulation of corticotropin-releasing factor and its types 1 and 2 receptors by leptin in rats subjected to treadmill running-induced stress
    Qingling Huang
    Laval Hospital Research Center and Merck Frosst IRSC Obesity Research Chair, 2725 Chemin Sainte Foy, Quebec, Canada
    J Endocrinol 191:179-88. 2006
    ....
  15. doi request reprint Effect of secretin on preadipocyte, differentiating and mature adipocyte functions
    P Miegueu
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, Quebec, Canada
    Int J Obes (Lond) 37:366-74. 2013
    ..Several gastrointestinal peptides are now recognized to have target functions beyond the intestinal wall, including effects on adipocytes. Secretin (SEC), one of the first identified, has not been evaluated in this context...
  16. doi request reprint Determinants of brown adipocyte development and thermogenesis
    D Richard
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, et Groupe interdisciplinaire de Recherche sur l Obésité de l Université Laval, Quebec, Canada
    Int J Obes (Lond) 34:S59-66. 2010
    ..This short review summarizes recent progress made in the biology of the brown fat cell and focuses on the determinants of the brown adipocyte development and activity...
  17. ncbi request reprint Effects of leptin on melanin-concentrating hormone expression in the brain of lean and obese Lep(ob)/Lep(ob) mice
    Q Huang
    Centre de recherche sur le métabolisme énergétique CREME et Département d anatomie et de physiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Neuroendocrinology 69:145-53. 1999
    ..It may also indicate that MCH mediates the metabolic actions of leptin indirectly or else that leptin influences actions of MCH other than those related to the regulation of energy balance...
  18. ncbi request reprint Estrogen receptor alpha-mediated adiposity-lowering and hypocholesterolemic actions of the selective estrogen receptor modulator acolbifene
    C Lemieux
    Department of Anatomy and Physiology, Faculty of Medicine, Laval Hospital Research Center, Laval University, Quebec City, Quebec, Canada
    Int J Obes (Lond) 29:1236-44. 2005
    ..ACOL binds ERs alpha and beta, both of which have been involved in the metabolic actions of estrogen. This study aimed at determining the identity of the ER involved in the beneficial metabolic actions of ACOL...
  19. ncbi request reprint Actions of PPARgamma agonism on adipose tissue remodeling, insulin sensitivity, and lipemia in absence of glucocorticoids
    Magalie Berthiaume
    Laval Hospital Research Center, Department of Anatomy and Physiology, School of Medicine, Laval University, Quebec, QC, Canada G1K 7P4
    Am J Physiol Regul Integr Comp Physiol 287:R1116-23. 2004
    ....
  20. ncbi request reprint PPAR-gamma activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: mechanisms for modulation of postprandial lipemia and differential adipose accretion
    Mathieu Laplante
    Department of Anatomy and Physiology, Laval Hospital Research Center, School of Medicine, Laval University, Quebec, Canada
    Diabetes 52:291-9. 2003
    ..These depot-specific effects may be mediated by differential regulation of key metabolic genes, including LPL, 11beta-HSD-1, and UCP-1...
  21. doi request reprint Additive effects of olanzapine and melanin-concentrating hormone agonism on energy balance
    Benjamin Guesdon
    Centre de recherche de l Institut de cardiologie et de pneumologie de Québec Hôpital Laval et Centre de recherche sur le métabolisme énergétique de l Université Laval, 2725 Chemin Sainte Foy, Quebec, Canada
    Behav Brain Res 207:14-20. 2010
    ..AAPDs and MCH agonism exert additive effects on energy balance and selective effects on the brain expression of energy balance-related genes...
  22. doi request reprint Effects of intracerebroventricular and intra-accumbens melanin-concentrating hormone agonism on food intake and energy expenditure
    Benjamin Guesdon
    Centre de Recherche de l Hôpital Laval et Centre de Recherche sur le Métabolisme Energétique de l Université Laval, Quebec, Canada
    Am J Physiol Regul Integr Comp Physiol 296:R469-75. 2009
    ..The present results further delineate the influence of MCH on energy expenditure and substrate oxidation while confirming the key role of the NAcSH in the effects of the MCH system on food intake...
  23. ncbi request reprint Metabolic fitness in active reduced-obese individuals
    A Tremblay
    Division of Kinesiology, Laval University, Ste Foy, Quebec, Canada
    Obes Res 7:556-63. 1999
    ..To verify whether a physical activity-low-fat diet follow-up could normalize the metabolic risk profile of reduced-obese men and women having undergone considerable weight loss through energy restriction and drug therapy...
  24. ncbi request reprint Uncoupling protein 2 in the brain: distribution and function
    D Richard
    Centre de Recherche de l Hôpital Laval et Centre de Recherche sur le Métabolisme Energétique de l Université Laval, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    Biochem Soc Trans 29:812-7. 2001
    ..The role of UCP2 in neuroprotection warrants further investigation...
  25. doi request reprint Effects of ramipril and rosiglitazone on cardiovascular and renal outcomes in people with impaired glucose tolerance or impaired fasting glucose: results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial
    G R Dagenais
    Laval University Heart and Lung Institute, 2725 Chemin Ste Foy, Quebec, Quebec City, Canada
    Diabetes Care 31:1007-14. 2008
    ..We determined the effects of ramipril and rosiglitazone on combined and individual CVD and renal outcomes in people with IGT and/or IFG in the Diabetes REduction Assessment With ramipril and rosiglitazone Medication (DREAM) trial...
  26. ncbi request reprint Effects of treadmill running on brain activation and the corticotropin-releasing hormone system
    Elena Timofeeva
    Centre de recherche de l Hôpital Laval et Centre de recherche sur le métabolisme énergétique de l Université, Laval, Quebec, Canada
    Neuroendocrinology 77:388-405. 2003
    ....
  27. ncbi request reprint Brown fat biology and thermogenesis
    Denis Richard
    Quebec Heart And Lung Institute Research Center and Laval University Interdisciplinary Group In Obesity Research, 2725 Chemin Sainte Foy, Quebec G1V 4G5, Canada
    Front Biosci (Landmark Ed) 16:1233-60. 2011
    ..This review aims at the unique biology of BAT with the emphasis put on the recent discoveries regarding the brown adipocyte development and function...
  28. doi request reprint Peanut protein reduces body protein mass and alters skeletal muscle contractile properties and lipid metabolism in rats
    Helene Jacques
    Department of Food Science and Nutrition, Institute of Nutraceuticals and Functional Foods, Laval University, Quebec, Canada G1V 0A6
    Br J Nutr 103:1331-9. 2010
    ..Adding a complete protein such as C might partially counteract these adverse effects...
  29. ncbi request reprint The corticotropin-releasing factor family of peptides and CRF receptors: their roles in the regulation of energy balance
    Denis Richard
    D B Brown Chair on Obesity Research and Laval Hospital Research Center, Laval University, Quebec Qué, Canada G1K 7P4
    Eur J Pharmacol 440:189-97. 2002
    ..Although there are still important unresolved issues in the field of CRF research, the progress made recently warrants investigations aimed at evaluating the CRF system as a potential target for anti-obesity drugs...
  30. ncbi request reprint A survey of genes differentially expressed in subcutaneous and visceral adipose tissue in men
    Marie Claude Vohl
    Lipid Research Center, 2705 Laurier Blvd TR 93, Quebec City, PQ, Canada G1V 4G2
    Obes Res 12:1217-22. 2004
    ....
  31. ncbi request reprint The role of gene regulation in obesity and its complications: introduction
    D Richard
    DB Brown Research Chair on Obesity, Laval Hospital Research Center, Universite Laval, Quebec, Canada
    Int J Obes (Lond) 29:S1-2. 2005
  32. ncbi request reprint The food-hoarding threshold is not raised by acute intraventricular NPY in male rats
    M Cabanac
    Departement de Physiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Physiol Behav 61:131-5. 1997
    ..Mean food intake during the hoarding sessions was also unchanged. These results suggest that intracerebral NPY at 4 micrograms did not acutely alter the set-point for body weight regulation...
  33. ncbi request reprint Is visceral obesity a physiological adaptation to stress?
    V Drapeau
    Division of Kinesiology, Laval University, Ste Foy, Quebec, Canada
    Panminerva Med 45:189-95. 2003
    ..In this context, visceral obesity treatment should focus on stress management and weight loss strategies in order to stop this vicious circle...
  34. ncbi request reprint Gene expression variability in subcutaneous and omental adipose tissue of obese men
    Yonghua Zhang
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Research Center, Quebec, Canada
    Gene Expr 14:35-46. 2007
    ....
  35. pmc Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2
    Olivier Le Bacquer
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Clin Invest 117:387-96. 2007
    ..These data clearly demonstrate the role of 4E-BPs as a metabolic brake in the development of obesity and reinforce the idea that deregulated mTOR signaling is associated with the development of the metabolic syndrome...
  36. ncbi request reprint The corticotropin-releasing factor system as a potential target for antiobesity drugs
    Christian Doyon
    Département d anatomie et de physiologie, Universite Laval, Quebec, Canada
    Drug News Perspect 17:505-17. 2004
    ..Based on recent progress, we conclude that the CRF(2) receptor could be a potential target for the development of an antiobesity drug...
  37. pmc The effects of acylation stimulating protein supplementation VS antibody neutralization on energy expenditure in wildtype mice
    Sabina Paglialunga
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, QC, G1V 4G5, Canada
    BMC Physiol 10:4. 2010
    ..Continuous administration for 4 weeks via osmotic mini-pump of Anti-ASP or rASP was evaluated in wildtype mice on a high-fat diet (HFD) to examine their effects on body weight, food intake and energy expenditure...
  38. ncbi request reprint Effects of rimonabant (SR141716) on fasting-induced hypothalamic-pituitary-adrenal axis and neuronal activation in lean and obese Zucker rats
    Christian Doyon
    Direction de la recherche, Hopital Laval, 2725 Chemin Sainte Foy, Quebec, Quebec, Canada, G1V 4G5
    Diabetes 55:3403-10. 2006
    ..This, however, does not prevent CB(1) antagonism from exerting beneficial effects on energy and glucose metabolism...
  39. ncbi request reprint Awakening cortisol response in relation to psychosocial profiles and eating behaviors
    Fanny Therrien
    Laval Hospital Research Center, Quebec, Canada
    Physiol Behav 93:282-8. 2008
    ..020) and strategic (r=-0.28, p=0.049) restraint behaviors. This study highlights a gender-dependent relationship between ACR, hence the activity of the hypothalamic-pituitary-adrenal axis, and eating behaviors and psychological profiles...
  40. ncbi request reprint Complications of obesity: the inflammatory link. Introduction
    D Richard
    DB Brown Research Chair on Obesity, Research Center of Laval Hospital and Center for Research on Energy Metabolism, Department of Anatomy and Physiology, Faculty of Medicine, Laval University, Quebec, Canada
    Int J Obes Relat Metab Disord 27:S2-3. 2003
  41. ncbi request reprint Fenfluramine-induced activation of the immediate-early gene c-fos in the striatum: possible interaction between serotonin and dopamine
    C Rouillard
    Department of Pharmacology, Laval University, Quebec, Canada
    Brain Res Mol Brain Res 37:105-15. 1996
    ..Moreover, the mechanism by which fenfluramine induces c-fos expression in the striatum differs from other brain regions...
  42. ncbi request reprint Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
    D Arsenijevic
    Centre de Recherche de Hôpital Laval et Centre de Recherche sur le Métabolisme Energétique, Universite Laval, Quebec, Canada
    Nat Genet 26:435-9. 2000
    ..001 ), which was absent in the presence of a quencher of reactive oxygen species (ROS). Our results indicate a role for Ucp2 in the limitation of ROS and macrophage-mediated immunity...
  43. ncbi request reprint Interaction of CRH and energy balance in the modulation of brain stimulation reward
    Stephanie Fulton
    Center for Studies in Behavioural Neurobiology, Concordia University, Montreal, Quebec, Canada
    Behav Neurosci 116:651-9. 2002
    ..These findings provide further evidence that sensitivity to food restriction is an important factor in determining the influence of hormones and neuropeptides on brain reward circuitry...
  44. ncbi request reprint Neuronal activation and corticotropin-releasing hormone expression in the brain of obese (fa/fa) and lean (fa/?) Zucker rats in response to refeeding
    Elena Timofeeva
    Centre de Recherche de l Hôpital Laval et Centre de Recherche sur le Métabolisme Energétique de l Université Laval, Quebec, Canada, G1K 7P4
    Eur J Neurosci 15:1013-29. 2002
    ..The most apparent of these differences was seen in the lateral hypothalamus in which refeeding failed to up-regulate CRH expression in obese rats...
  45. pmc Responses of adipose and muscle lipoprotein lipase to chronic infection and subsequent acute lipopolysaccharide challenge
    Frederic Picard
    Centre de recherche de l Hôpital Laval and Centre de recherche sur le métabolisme énergétique, Département d anatomie et physiologie, Faculte de Medecine, Universite Laval, Quebec, Quebec, Canada G1K 7P4
    Clin Diagn Lab Immunol 9:771-6. 2002
    ..gondii infection favors TG partitioning towards adipose tissue; and (iii) skeletal muscle LPL is a key determinant of the acute response of triglyceridemia to LPS...
  46. ncbi request reprint Contribution of the vagus nerve and lamina terminalis to brain activation induced by refeeding
    Elena Timofeeva
    Centre de Recherche de l Hôpital Laval et Centre de Recherche sur le Métabolisme Energétique de l Université Laval, Quebec, Canada
    Eur J Neurosci 22:1489-501. 2005
    ..The results of the present study suggest that the postprandial activation of the brain requires the integrity of both the vagal- and lamina terminalis-associated pathways...
  47. ncbi request reprint The selective estrogen receptor modulator acolbifene reduces cholesterolemia independently of its anorectic action in control and cholesterol-fed rats
    Christian Lemieux
    Laval Hospital Research Center, Department of Anatomy and Physiology, Faculty of Medicine, Laval University, Quebec City, QC, Canada
    J Nutr 135:2225-9. 2005
    ..These findings demonstrate that the potent hypocholesterolemic action of ACOL is independent of the concomitant reduction in food intake and fat accretion, and that such action occurs in rats with overt diet-induced hypercholesterolemia...
  48. doi request reprint Cortisol response to the Trier Social Stress Test in obese and reduced obese individuals
    Fanny Therrien
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    Biol Psychol 84:325-9. 2010
    ..These finding suggest that weight status in men influences cortisol reactivity to a psychological stress and the different responses seen among genders could be linked to the different fat distributions that characterize men and women...
  49. ncbi request reprint Waist girth does not predict metabolic complications in severely obese men
    Isabelle Lemieux
    Division of Kinesiology, Laval Hospital Research Center, Laval University, Quebec, Canada G1K 7P4
    Diabetes Care 29:1417-9. 2006
  50. ncbi request reprint Induction of Ucp2 expression in brain phagocytes and neurons following murine toxoplasmosis: an essential role of IFN-gamma and an association with negative energy balance
    Denis Arsenijevic
    Department of Medicine, Division of Physiology, University of Fribourg, Ch Du Musée 5, Fribourg, Switzerland
    J Neuroimmunol 186:121-32. 2007
    ..Our study indicates that an association exists between negative energy balance and neuronal Ucp2 levels in the NST, in particular...
  51. ncbi request reprint Peroxisome proliferator-activated receptor gamma agonism increases the capacity for sympathetically mediated thermogenesis in lean and ob/ob mice
    Henrike Sell
    Department of Anatomy and Physiology, School of Medicine, Laval University, Quebec, Canada G1K 7P4
    Endocrinology 145:3925-34. 2004
    ..This enhanced capacity leads to increased thermogenesis under beta-adrenergic stimulation, suggesting that the sympathetic drive is blunted by PPARgamma agonism...
  52. ncbi request reprint Reduced adipose tissue triglyceride synthesis and increased muscle fatty acid oxidation in C5L2 knockout mice
    Sabina Paglialunga
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Endocrinol 194:293-304. 2007
    ..05) were significantly increased in C5L2KO mice versus WT (100%). The study shows that in response to reduced TG storage in white adipose tissue, C5L2KO mice have developed a compensatory mechanism of increased muscle fat oxidation...
  53. ncbi request reprint Additive effects of leptin and topiramate in reducing fat deposition in lean and obese ob/ob mice
    Josee Lalonde
    D B Brown Obesity Research Chair and Research Center of Laval Hospital, Laval University, Quebec, PQ, Canada G1K 7P4
    Physiol Behav 80:415-20. 2004
    ..They also show that the effects of leptin and TPM can be additive. The treatment with leptin in ob/ob mice neither accentuated nor blunted the effect of TPM on energy balance...
  54. doi request reprint Peroxisome proliferator-activated receptor-gamma-mediated positive energy balance in the rat is associated with reduced sympathetic drive to adipose tissues and thyroid status
    William T Festuccia
    Laval Hospital Research Centre, Faculty of Medicine, Laval University, Laval Hospital d Youville Y3110, 2725 Chemin Sainte Foy, Quebec, Canada G1V 4G5
    Endocrinology 149:2121-30. 2008
    ....
  55. pmc Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha
    Jiangming Luo
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Mol Cell Biol 23:7947-56. 2003
    ..This study suggests that ERRalpha functions as a metabolic regulator and that the ERRalpha-/- mice provide a novel model for the investigation of metabolic regulation by nuclear receptors...
  56. ncbi request reprint Differences in response to corticotropin-releasing factor after short- and long-term consumption of a high-fat diet
    Ariadne Legendre
    Department of Foods and Nutrition, University of Georgia, Athens, GA 30602, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1076-85. 2007
    ....
  57. ncbi request reprint The estrogen antagonist EM-652 and dehydroepiandrosterone prevent diet- and ovariectomy-induced obesity
    Christian Lemieux
    Centre de Recherche de l Hôpital Laval and Département d Anatomie et Physiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Obes Res 11:477-90. 2003
    ..This study aimed to assess the ability of EM-652, alone or with dehydroepiandrosterone (DHEA), to prevent obesity and related metabolic abnormalities induced by an obesity-promoting diet and ovariectomy...
  58. ncbi request reprint Leptin regulates appetite-related neuropeptides in the hypothalamus of developing rats without affecting food intake
    Karine Proulx
    McGill University, Department of Psychiatry, Douglas Hospital Research Center, Montreal, Quebec, Canada H4H 1R3
    Endocrinology 143:4683-92. 2002
    ..We conclude that despite adult-like effects of leptin on POMC, NPY, and CRFR-2 expression in neonates, leptin does not regulate food intake during early development...
  59. ncbi request reprint Effects of the CRF1 receptor antagonist SSR125543 on energy balance and food deprivation-induced neuronal activation in obese Zucker rats
    Christian Doyon
    Chaire de recherche Merck Frosst IRSC sur l obésité and Centre de recherche de l Hôpital Laval, 2725 Chemin Sainte Foy, Quebec, Canada G1V 4G5
    J Endocrinol 193:11-9. 2007
    ....
  60. ncbi request reprint Chronic disruption of body weight but not of stress peptides or receptors in rats exposed to repeated restraint stress
    Ruth B S Harris
    Department of Foods and Nutrition, Dawson Hall, University of Georgia, Athens, GA 30605, USA
    Horm Behav 49:615-25. 2006
    ....
  61. ncbi request reprint Hormone-sensitive lipase-independent adipocyte lipolysis during beta-adrenergic stimulation, fasting, and dietary fat loading
    Melanie Fortier
    Division of Medical Genetics, Research Centre, Hopital Ste Justine, Montreal, Quebec H3T 1C5, Canada
    Am J Physiol Endocrinol Metab 287:E282-8. 2004
    ..However, HSL-independent lipolysis can markedly increase during fasting, both in isolated adipocytes and in intact mice, and can mediate a normal flux of fatty acids during fasting...
  62. ncbi request reprint Corticotropin-releasing factor and its receptors in the brain of rats with insulin and corticosterone deficits
    Qingling Huang
    Merck Frosst CIHR Research Chair in Obesity, Centre de Recherche de l Hopital Laval, Hopital Laval, Quebec, G1V 4G5 Canada
    J Mol Endocrinol 37:213-26. 2006
    ....
  63. ncbi request reprint Corticosterone-dependent metabolic and neuroendocrine abnormalities in obese Zucker rats in relation to feeding
    Martine Duclos
    Laboratoire Neurogénétique, Universite Laval, Quebec, Canada
    Am J Physiol Endocrinol Metab 288:E254-66. 2005
    ..They also demonstrate that not all the abnormalities of the obese Zucker rats are attributable to the hyperactivity of the HPA axis...
  64. pmc A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2
    Anna Coppola
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Metab 5:21-33. 2007
    ..These results reveal a physiological role for a thyroid-hormone-regulated mitochondrial uncoupling in hypothalamic neuronal networks...
  65. ncbi request reprint Comparative effects of the antipsychotics sulpiride and risperidone in female rats on energy balance, body composition, fat morphology and macronutrient selection
    Trino Baptista
    Department of Physiology, Los Andes University Medical School, P O Box 93, Merida 5101 A, Venezuela
    Prog Neuropsychopharmacol Biol Psychiatry 28:1305-11. 2004
    ..Other diet protocols and lower APD doses must be tested to further characterize the RIS model...
  66. ncbi request reprint A new renal mitochondrial carrier, KMCP1, is up-regulated during tubular cell regeneration and induction of antioxidant enzymes
    Anne Haguenauer
    CNRS UPR9078, Faculté Necker Enfants Malades, 156 rue de Vaugirard, 75730 Paris Cedex 15, France
    J Biol Chem 280:22036-43. 2005
    ....
  67. pmc Mother to infant or infant to mother? Reciprocal regulation of responsiveness to stress in rodents and the implications for humans
    Claire Dominique Walker
    Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Blvd, Montréal QC H4H IR3, Canada
    J Psychiatry Neurosci 29:364-82. 2004
    ....
  68. ncbi request reprint Appetite sensations as a marker of overall intake
    Vicky Drapeau
    Division of Kinesiology, Laval University, Ste Foy, Quebec, Canada, G1K 7P4
    Br J Nutr 93:273-80. 2005
    ..Thus, assessment of appetite sensation such as fullness in response to a fixed load may be useful to evaluate individual overall energy intake...
  69. ncbi request reprint Comparative effects of the antipsychotics sulpiride or risperidone in rats. I: bodyweight, food intake, body composition, hormones and glucose tolerance
    Trino Baptista
    Department of Physiology, Los Andes University Medical School, 5101 A, Merida, Venezuela
    Brain Res 957:144-51. 2002
    ..The animal model of RIS-induced obesity in rats might be improved by testing other doses, route of administration and type of diet...
  70. ncbi request reprint Melanocortin-4 receptor mRNA is expressed in sympathetic nervous system outflow neurons to white adipose tissue
    C Kay Song
    Department of Biology, Neurobiology and Behavior Program, Georgia State University, 24 Peachtree Center Ave NE, Atlanta, Georgia 30302 4010, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1467-76. 2005
    ..These data provide compelling neuroanatomical evidence that could underlie a direct central modulation of the sympathetic outflow to WAT by the melanocortins through the MC4-Rs resulting in changes in lipid mobilization and adiposity...
  71. ncbi request reprint Uncoupling protein 2, but not uncoupling protein 1, is expressed in the female mouse reproductive tract
    Sophie Rousset
    CNRS, Unité Propre de Recherche 9078, Faculte de Medecine Necker Enfants Malades, 156 rue de Vaugirard, 75730 Paris Cedex 15, France
    J Biol Chem 278:45843-7. 2003
    ..Because UCP2 down-regulates reactive oxygen species, a role in the regulation of inflammatory events linked to the preparation of ovulation is suggested...
  72. ncbi request reprint Increased infarct size and lack of hyperphagic response after focal cerebral ischemia in peroxisome proliferator-activated receptor beta-deficient mice
    Denis Arsenijevic
    Institute of Animal Sciences, ETHZ, Zurich, Switzerland
    J Cereb Blood Flow Metab 26:433-45. 2006
    ....
  73. pmc Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence
    C Kay Song
    Department of Biology, Georgia State University, 24 Peachtree Center Ave NE, Atlanta, GA 30302 4010, USA
    Am J Physiol Regul Integr Comp Physiol 295:R417-28. 2008
    ..Collectively, these data add significant support to the view that central melanocortins are important in controlling IBAT thermogenesis via the SNS innervation of this tissue, likely through the MC4-Rs...
  74. doi request reprint Shift in metabolic fuel in acylation-stimulating protein-deficient mice following a high-fat diet
    Christian Roy
    Centre de recherche Hopital Laval, Y 2186, Chemin Ste Foy, QC, Canada
    Am J Physiol Endocrinol Metab 294:E1051-9. 2008
    ..However, these in vivo data suggest that ASP inhibition could be a potentially viable approach in correcting muscle metabolic dysfunction in obesity...
  75. ncbi request reprint Awakening cortisol response in lean, obese, and reduced obese individuals: effect of gender and fat distribution
    Fanny Therrien
    Department of Anatomy and Physiology, Laval University, Sainte Foy, Quebec, Canada
    Obesity (Silver Spring) 15:377-85. 2007
    ..Our goal was to assess the awakening cortisol response (ACR) in obese and reduced obese men and women...
  76. ncbi request reprint Long-lasting effects of elevated neonatal leptin on rat hippocampal function, synaptic proteins and NMDA receptor subunits
    Claire Dominique Walker
    Douglas Hospital Research Center, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    J Neurosci Res 85:816-28. 2007
    ..Elevated exposure to leptin during a critical period of neonatal hippocampal development might serve to enhance NMDA-dependent functions other than LTP and have important effects on synaptogenesis and neurotransmitter release...
  77. ncbi request reprint The brown adipocyte: update on its metabolic role
    Henrike Sell
    Department of Anatomy and Physiology, School of Medicine, Laval Hospital Research Center and D B Brown Obesity Research Chair, Laval University, Pavillon Ferdinand Vandry, Local 3217, Quebec City, Que, Canada G1K 7P4
    Int J Biochem Cell Biol 36:2098-104. 2004
    ..Uncoupling protein 1 expression is modulated by diet and metabolic hormones such as leptin and glucocorticoids, which suggests that the protein is a player in energy balance regulation...
  78. ncbi request reprint Food restriction and leptin impact brain reward circuitry in lean and obese Zucker rats
    Stephanie Fulton
    Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Que, Canada H3G 1M8
    Behav Brain Res 155:319-29. 2004
    ..These results show that brain reward circuitry in the obese Zucker rat is sensitive to weight loss and leptin...
  79. ncbi request reprint Glucose homeostasis predicts weight gain: prospective and clinical evidence
    Normand G Boule
    Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada
    Diabetes Metab Res Rev 24:123-9. 2008
    ..The potential long-term impact of low glycaemia on body fat accumulation has not been verified. Therefore, we examined the effects of low glucose concentrations on long-term energy balance and weight gain in humans...
  80. ncbi request reprint Uncoupling protein 2: a novel player in neuroprotection
    Eric Paradis
    Centre de Recherche de l Hôpital Laval Institut universitaire de Cardiologie et de Pneumologie et Faculté de Médecine de l Université Laval, Quebec, Canada G1K 7P4
    Trends Mol Med 9:522-5. 2003
  81. ncbi request reprint Kainic acid upregulates uncoupling protein-2 mRNA expression in the mouse brain
    Sébastien Clavel
    Centre de Recherche de l Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie, Universite Laval, Québec GIK7P4, Canada
    Neuroreport 14:2015-7. 2003
    ..The neuronal induction of Ucp2 in response to KA was stronger in 129T2SvEmsJ mice than in C57BL/6J, which suggests a role for Ucp2 in excitotoxic challenges and neuroprotection...
  82. ncbi request reprint Metabolic profile in severely obese women is less deteriorated than expected when compared to moderately obese women
    Vicky Drapeau
    Division of Kinesiology, Department of Social and Preventive Medicine, Laval University, Sainte Foy, Quebec, Canada G1K 7P4
    Obes Surg 16:501-9. 2006
    ..This study aimed to compare the metabolic profile of pre- and postmenopausal severely obese women with moderately obese women...
  83. ncbi request reprint COPD results in a reduction in UCP3 long mRNA and UCP3 protein content in types I and IIa skeletal muscle fibers
    Aaron P Russell
    Clinique Romande de réadaptation SUVA Care, Sion, Switzerland
    J Cardiopulm Rehabil 24:332-9. 2004
    ....
  84. ncbi request reprint Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels
    Fabienne de Bilbao
    Department of Psychiatry, University Hospitals Geneva, Geneva, Switzerland
    J Neurochem 89:1283-92. 2004
    ..Moreover, our data imply that UCP2 is not directly involved in the regulation of ROS production but acts by regulating mitochondrial GSH levels in microglia...