Research Topics
Genomes and GenesSpecies | Louise M WinnSummaryAffiliation: Queen's University Country: Canada Publications
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Publications
Pim-1 phosphorylates the DNA binding domain of c-MybLouise M Winn
Department of Pharmacology and Toxicology, Botterell Hall, Queen s University, Kingston, Ontario K7L 3N6, Canada
Cell Cycle 2:258-62. 2003..Pim-1 associated with Myb both in cells and in vitro, and phosphorylated the Myb DNA binding domain, suggesting that it regulates Myb protein activity by direct phosphorylation...- Valproic acid increases conservative homologous recombination frequency and reactive oxygen species formation: a potential mechanism for valproic acid-induced neural tube defectsEricka N Defoort
Department of Pharmacology and Toxicology and School of Environmental Studies, Queen's University, Kingston, Ontario, Canada
Mol Pharmacol 69:1304-10. 2006..These data demonstrate that valproic acid increases HR frequency and provides a possible mechanism for valproic acid-induced neural tube defects... - Homologous recombination initiated by benzene metabolites: a potential role of oxidative stressLouise M Winn
Department of Pharmacology and Toxicology, Queen s University, Kingston K7L 3N6, Ontario, Canada
Toxicol Sci 72:143-9. 2003..These data support the hypothesis that increased homologous recombination mediates benzene-initiated toxicity and supports a role for oxidative stress in this mechanism... - Oxidative stress-induced homologous recombination as a novel mechanism for phenytoin-initiated toxicityLouise M Winn
Department of Pharmacology and Toxicology and School of Environmental Studies, Queen s University, Kingston, ON, Canada
J Pharmacol Exp Ther 306:523-7. 2003..Our data demonstrate that phenytoin-initiated DNA damage can induce homologous recombination, which may be a novel mechanism mediating phenytoin-initiated toxicity... - Benzene's metabolites alter c-MYB activity via reactive oxygen species in HD3 cellsJoanne Wan
Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
Toxicol Appl Pharmacol 222:180-9. 2007..More importantly, this study supports the hypothesis that benzene may mediate its toxicity through ROS-mediated alterations in the c-Myb signaling pathway... 
Characterization of valproic acid-initiated homologous recombinationKevin Sha
Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
Birth Defects Res B Dev Reprod Toxicol 89:124-32. 2010..We have also shown that VPA exposure leads to both an increase in reactive oxygen species (ROS) production and increased frequency of homologous recombination (HR)...- In utero exposure to benzene disrupts fetal hematopoietic progenitor cell growth via reactive oxygen speciesHelen J Badham
Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada K7L 3N6
Toxicol Sci 113:207-15. 2010..These results suggest that ROS play a key role in the development of in utero-initiated benzene toxicity potentially through disruption of hematopoietic cell signaling pathways... - TCDD-induced homologous recombination: the role of the Ah receptor versus oxidative DNA damageClara Y Y Chan
Department of Pharmacology and Toxicology, Botterell Hall Room 557, Queen's University, Kingston, Ontario, Canada K7L 3N6
Mutat Res 563:71-9. 2004..These results suggest that TCDD-initiated homologous recombination in CHO 3-6 cells is mediated by the AhR and not via increased oxidative stress... - In utero and in vitro effects of benzene and its metabolites on erythroid differentiation and the role of reactive oxygen speciesHelen J Badham
Department of Pharmacology and Toxicology Queen s University, Kingston, Ontario, Canada K7L 3N6
Toxicol Appl Pharmacol 244:273-9. 2010..In conclusion, this study provided evidence that ROS generated as a result of benzene metabolism may significantly alter erythroid differentiation, potentially leading to the development of Blood Disorders... - Benzene-initiated oxidative stress: Effects on embryonic signaling pathwaysHelen J Badham
Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
Chem Biol Interact 184:218-21. 2010..Further studies evaluating the reason for this gender difference are ongoing... - The effects of 1,4-benzoquinone on c-Myb and topoisomerase II in K-562 cellsRoopam Singh
Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
Mutat Res 645:33-8. 2008.... - In utero exposure to benzene increases embryonic c-Myb and Pim-1 protein levels in CD-1 miceJoanne Wan
Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada K7L 3N6
Toxicol Appl Pharmacol 228:326-33. 2008..These results support a role for ROS in c-Myb and Pim-1 alterations after in utero benzene exposure... - DNA double-strand breaks and DNA recombination in benzene metabolite-induced genotoxicityEmily W Y Tung
Department of Biomedical and Molecular Sciences, Queen s University, Room 557, Botterell Hall, Kingston, Ontario K7L 3N6, Canada
Toxicol Sci 126:569-77. 2012..These studies indicate that BQ is able to induce DNA damage and recombination in fetal liver cells and that ROS may be important in the mechanism of toxicity... - Valproic acid-induced DNA damage increases embryonic p27(KIP1) and caspase-3 expression: a mechanism for valproic-acid induced neural tube defectsEmily W Y Tung
Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
Reprod Toxicol 32:255-60. 2011..Immunohistochemistry revealed increased staining for γH2A.X, p27(KIP1), and cleaved caspase 3 in the head, confirming our hypothesis that DNA damage, cell cycle inhibition, and apoptosis are induced by VPA... - The effect of TiO(2) and Ag nanoparticles on reproduction and development of Drosophila melanogaster and CD-1 miceNicola A Philbrook
School of Environmental Studies, Biosciences Complex, Queen s University, 116 Barrie Street, Kingston, Ontario, Canada K7L 3N6
Toxicol Appl Pharmacol 257:429-36. 2011..Taken together, however, this study warns that these common NPs could be detrimental to the reproductive and developmental health of both invertebrates and vertebrates... - The effects of benzene and the metabolites phenol and catechol on c-Myb and Pim-1 signaling in HD3 cellsJoanne Wan
Department of Pharmacology and Toxicology, Queen's University, Kingston, ON, Canada K7L 3N6
Toxicol Appl Pharmacol 201:194-201. 2004..More importantly, this study supports the hypothesis that benzene may mediate its toxicity through metabolite-mediated alterations in the c-Myb signaling pathway... - Valproic acid increases formation of reactive oxygen species and induces apoptosis in postimplantation embryos: a role for oxidative stress in valproic acid-induced neural tube defectsEmily W Y Tung
Department of Biomedical and Molecular Sciences, Graduate Program in Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
Mol Pharmacol 80:979-87. 2011..These studies identify regions of the embryo susceptible to ROS and apoptosis induced by VPA, thus establishing a possible molecular pathway by which VPA exerts teratogenicity... - Assessment of xenobiotic biotransformation including reactive oxygen species generation in the embryo using benzene as an exampleHelen J Renaud
Department of Pharmacology and Toxicology, Queen s University, Kingston, ON, Canada
Methods Mol Biol 889:253-63. 2012.... - Investigating the role of the aryl hydrocarbon receptor in benzene-initiated toxicity in vitroHelen J Badham
Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario K7L 3N6, Canada
Toxicology 229:177-85. 2007..These results indicate that the involvement of the AhR in benzene toxicity does not seem to be through classical activation of this receptor or through interference of oxidative stress pathways... - Epigenetic modifications in valproic acid-induced teratogenesisEmily W Y Tung
Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario K7L3N6, Canada
Toxicol Appl Pharmacol 248:201-9. 2010..These results support the possibility that epigenetic modifications caused by VPA during early mouse organogenesis results in congenital malformations... - TCDD affects DNA double strand-break repairClara Y Y Chan
Department of Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada 27L3N6
Toxicol Sci 81:133-8. 2004..Exposure of cells to alpha-naphthoflavone resulted in a significant decrease in TCDD-induced HR frequency. These results demonstrate that TCDD, potentially acting via the AhR, can modulate HR repair of DNA DSBs in CHO 33 cells... - Transplacental benzene exposure increases tumor incidence in mouse offspring: possible role of fetal benzene metabolismHelen J Badham
Department of Pharmacology and Toxicology, Queen s Cancer Research Institute, Queen s University, Kingston, Ontario, Canada K7L 3N6
Carcinogenesis 31:1142-8. 2010..This is the first demonstration that transplacental benzene exposure can induce hepatic and hematopoietic tumors in mice, which may be dependent on fetal benzene metabolism capability... - In utero-initiated cancer: the role of reactive oxygen speciesJoanne Wan
Department of Pharmacology and Toxicology, School of Environmental Studies, Queen's University, Kingston, Ontario, Canada
Birth Defects Res C Embryo Today 78:326-32. 2006..Using a number of examples, this review will focus on the role of reactive oxygen species (ROS) in the mechanisms pertaining to in utero initiated cancers... - Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 miceJennifer E Dawson
Department of Pharmacology and Toxicology and School of Environmental Studies, Queen's University, Kingston, Ontario, Canada K7L 3N6
Toxicol Appl Pharmacol 211:124-32. 2006.... - Assessment of embryotoxicity using mouse embryo cultureLouise M Winn
Department of Pharmacology and School of Environmental Studies, Queen s University, Kingston, Ontario, Canada
Methods Mol Biol 550:241-9. 2009..Additional biochemical analysis, including molecular approaches to assess embryonic signal transduction, as well as some limitations of the technique will also be discussed... - In utero and acute exposure to benzene: investigation of DNA double-strand breaks and DNA recombination in miceAnnette Lau
Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada, K7L3N6
Mutat Res 676:74-82. 2009..Further investigations into different types of DNA damage and repair pathways are warranted to fully elucidate the role of genotoxic mechanisms in the etiology of benzene-induced childhood leukemias... - Investigating the effects of functionalized carbon nanotubes on reproduction and development in Drosophila melanogaster and CD-1 miceNicola A Philbrook
School of Environmental Studies, Biosciences Complex, Queen s University, 116 Barrie Street, Kingston, Ontario, Canada
Reprod Toxicol 32:442-8. 2011..This research underscores the need to examine the effects of fCNTs on reproductive health and development before the opportunities for maternal exposure by fCNTs increase further... - Evidence for Ras-dependent signal transduction in phenytoin teratogenicityLouise M Winn
Faculty of Pharmacy, University of Toronto, Toronto, Ontario, M5S 2S2, Canada
Toxicol Appl Pharmacol 184:144-52. 2002..These results provide the first direct evidence that Ras proteins may be involved in the teratogenicity of phenytoin, likely via a mechanism other than mutational activation... - Thalidomide alters c-MYB and PIM-1 signaling in K-562 cellsNatasha A Thadani
Department of Pharmacology, School of Environmental Studies, Queen's University, Botterell Hall Room 557, Kingston, Ont, Canada K7L 3N6
Pharmacol Res 54:91-6. 2006..Together these results demonstrate that thalidomide affects c-Myb signaling, in part, through increased ROS production...