J E Van Eyk

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. ncbi request reprint Different molecular mechanisms for Rho family GTPase-dependent, Ca2+-independent contraction of smooth muscle
    J E Van Eyk
    Department of Biochemistry, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 273:23433-9. 1998
  2. ncbi request reprint The role of troponin abnormalities as a cause for stunned myocardium
    J E Van Eyk
    Department of Biochemistry, Queen s University, Kingston, Canada
    Coron Artery Dis 12:343-7. 2001
  3. ncbi request reprint Differential detection of skeletal troponin I isoforms in serum of a patient with rhabdomyolysis: markers of muscle injury?
    Jeremy A Simpson
    Department of Physiology, Queen s University, Kingston, Ontario, K7L 3N6 Canada
    Clin Chem 48:1112-4. 2002
  4. ncbi request reprint Proteomics: unraveling the complexity of heart disease and striving to change cardiology
    J E Van Eyk
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Curr Opin Mol Ther 3:546-53. 2001
  5. ncbi request reprint Calcium-independent contraction and sensitization of airway smooth muscle by p21-activated protein kinase
    P K McFawn
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Am J Physiol Lung Cell Mol Physiol 284:L863-70. 2003
  6. ncbi request reprint Cardiac troponin I is modified in the myocardium of bypass patients
    J L McDonough
    Department of Physiology, Queen's University, Kingston, Ontario, Canada, K7L 3N6
    Circulation 103:58-64. 2001
  7. ncbi request reprint Cardiovascular proteomics: evolution and potential
    D K Arrell
    Departments of Physiology, Queen's University, Kingston, Ontario, Canada
    Circ Res 88:763-73. 2001
  8. ncbi request reprint Proteomic analysis of pharmacologically preconditioned cardiomyocytes reveals novel phosphorylation of myosin light chain 1
    D K Arrell
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Circ Res 89:480-7. 2001
  9. ncbi request reprint A novel mechanism for myocardial stunning involving impaired Ca(2+) handling
    S J Kim
    Cardiovascular Research Institute, Department of Medicine, UMDNJ-New Jersey Medical School, Newark, NJ 07103-2714, USA
    Circ Res 89:831-7. 2001
  10. ncbi request reprint Transgenic mouse model of stunned myocardium
    A M Murphy
    Department of Pediatrics, Johns Hopkins University School of Medicine, Ross Building 1144, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Science 287:488-91. 2000

Collaborators

  • D Atar
  • Anne Murphy
  • Atsuko Yatani
  • D K Arrell
  • P K McFawn
  • Jeremy A Simpson
  • J L McDonough
  • I Neverova
  • S J Kim
  • A Mak
  • L Shen
  • J T Fisher
  • S G Vincent
  • Christine P Collier
  • Geoffrey G Hesketh
  • Denis O'Donnell
  • Christine D'Arsigny
  • Ralf Labugger
  • Steve Iscoe
  • Nobuko Matsumoto
  • G Ropchan
  • M Y Tse
  • R Labugger
  • H Fraser
  • S F Vatner
  • W Pickett
  • D A Colantonio
  • R L Rasmusson
  • E Marban
  • D E Vatner
  • G Takagi
  • S C Pang
  • R Honda
  • R K Kudej
  • S MacKenzie
  • Y K Kim

Detail Information

Publications11

  1. ncbi request reprint Different molecular mechanisms for Rho family GTPase-dependent, Ca2+-independent contraction of smooth muscle
    J E Van Eyk
    Department of Biochemistry, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 273:23433-9. 1998
    ..Because ROK and PAK homologues are present in smooth muscle, they may work in parallel to regulate smooth muscle contraction...
  2. ncbi request reprint The role of troponin abnormalities as a cause for stunned myocardium
    J E Van Eyk
    Department of Biochemistry, Queen s University, Kingston, Canada
    Coron Artery Dis 12:343-7. 2001
    ..Selective proteolysis of the myofilament protein, troponin I, appears to underlie the phenotype of stunning in some models, but other myofilament protein modifications may also have a role...
  3. ncbi request reprint Differential detection of skeletal troponin I isoforms in serum of a patient with rhabdomyolysis: markers of muscle injury?
    Jeremy A Simpson
    Department of Physiology, Queen s University, Kingston, Ontario, K7L 3N6 Canada
    Clin Chem 48:1112-4. 2002
  4. ncbi request reprint Proteomics: unraveling the complexity of heart disease and striving to change cardiology
    J E Van Eyk
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Curr Opin Mol Ther 3:546-53. 2001
    ..All of this is feasible only with detailed information about the unique and selective protein modifications that occur during the development of heart disease...
  5. ncbi request reprint Calcium-independent contraction and sensitization of airway smooth muscle by p21-activated protein kinase
    P K McFawn
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Am J Physiol Lung Cell Mol Physiol 284:L863-70. 2003
    ..We conclude that PAK causes Ca(2+)-independent contractions and produces Ca(2+) sensitization of skinned phasic and tonic smooth muscle, which involves an incremental increase in caldesmon phosphorylation...
  6. ncbi request reprint Cardiac troponin I is modified in the myocardium of bypass patients
    J L McDonough
    Department of Physiology, Queen's University, Kingston, Ontario, Canada, K7L 3N6
    Circulation 103:58-64. 2001
    ..CONCLUSIONS: cTnI modification, in particular proteolysis, occurs in myocardium of bypass patients and may play a key role in stunning in some bypass patients...
  7. ncbi request reprint Cardiovascular proteomics: evolution and potential
    D K Arrell
    Departments of Physiology, Queen's University, Kingston, Ontario, Canada
    Circ Res 88:763-73. 2001
    ....
  8. ncbi request reprint Proteomic analysis of pharmacologically preconditioned cardiomyocytes reveals novel phosphorylation of myosin light chain 1
    D K Arrell
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Circ Res 89:480-7. 2001
    ..This proteomic analysis of preconditioned myocardium has revealed a previously unsuspected in vivo posttranslational modification to MLC1...
  9. ncbi request reprint A novel mechanism for myocardial stunning involving impaired Ca(2+) handling
    S J Kim
    Cardiovascular Research Institute, Department of Medicine, UMDNJ-New Jersey Medical School, Newark, NJ 07103-2714, USA
    Circ Res 89:831-7. 2001
    ..Thus, mechanisms of stunning in the pig are radically different from the widely held concepts derived from studies in rodents and involve impaired Ca(2+) handling and dephosphorylation of phospholamban, but not TnI degradation...
  10. ncbi request reprint Transgenic mouse model of stunned myocardium
    A M Murphy
    Department of Pediatrics, Johns Hopkins University School of Medicine, Ross Building 1144, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Science 287:488-91. 2000
    ..Proteolysis of troponin I also occurs in ischemic human cardiac muscle. Thus, troponin I proteolysis underlies the pathogenesis of a common acquired form of heart failure...
  11. ncbi request reprint Lessons from old and new kinases
    J E Van Eyk
    Circ Res 94:135-7. 2004