M L Sivilotti

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. ncbi request reprint A risk quantification instrument for acute acetaminophen overdose patients treated with N-acetylcysteine
    Marco L A Sivilotti
    Department of Emergency Medicine, Queen s University, Kingston, Ontario, Canada
    Ann Emerg Med 46:263-71. 2005
  2. ncbi request reprint Deliberate self-poisoning in Ontario following the terrorist attacks of September 11, 2001
    Michael E Detsky
    JAMA 294:1900-1. 2005
  3. ncbi request reprint Multiple centrally acting antidotes protect against severe organophosphate toxicity
    Marco L A Sivilotti
    Department of Emergency Medicine, Queen s University, Kingston, Ontario, Canada
    Acad Emerg Med 13:359-64. 2006
  4. ncbi request reprint Oxidant stress and haemolysis of the human erythrocyte
    Marco L A Sivilotti
    Department of Emergency Medicine, Queen s University, Kingston, Ontario, Canada
    Toxicol Rev 23:169-88. 2004
  5. ncbi request reprint A new predictor of toxicity following acetaminophen overdose based on pretreatment exposure
    Marco L A Sivilotti
    Department of Emergency Medicine, Queen s University, Kingston, Ontario, Canada
    Clin Toxicol (Phila) 43:229-34. 2005
  6. ncbi request reprint Reversal of severe methanol-induced visual impairment: no evidence of retinal toxicity due to fomepizole
    M L Sivilotti
    University of Massachusetts Medical School, Worcester, USA
    J Toxicol Clin Toxicol 39:627-31. 2001
  7. ncbi request reprint Pentobarbital for severe gamma-butyrolactone withdrawal
    M L Sivilotti
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Ann Emerg Med 38:660-5. 2001
  8. ncbi request reprint Toxicokinetics of ethylene glycol during fomepizole therapy: implications for management. For the Methylpyrazole for Toxic Alcohols Study Group
    M L Sivilotti
    University of Massachusetts Medical School, Worcester, MA, USA
    Ann Emerg Med 36:114-25. 2000
  9. doi request reprint When do the aminotransferases rise after acute acetaminophen overdose?
    Thomas J Green
    Department of Emergency Medicine, Queen s University, Kingston, ON, Canada
    Clin Toxicol (Phila) 48:787-92. 2010
  10. doi request reprint Multiplying the serum aminotransferase by the acetaminophen concentration to predict toxicity following overdose
    Marco L A Sivilotti
    Department of Emergency Medicine, Queen s University, Kingston, ON, Canada
    Clin Toxicol (Phila) 48:793-9. 2010

Detail Information

Publications25

  1. ncbi request reprint A risk quantification instrument for acute acetaminophen overdose patients treated with N-acetylcysteine
    Marco L A Sivilotti
    Department of Emergency Medicine, Queen s University, Kingston, Ontario, Canada
    Ann Emerg Med 46:263-71. 2005
    ..We quantitatively estimate the risk of hepatotoxicity based on the degree and duration of pretreatment exposure to supratherapeutic concentrations of acetaminophen...
  2. ncbi request reprint Deliberate self-poisoning in Ontario following the terrorist attacks of September 11, 2001
    Michael E Detsky
    JAMA 294:1900-1. 2005
  3. ncbi request reprint Multiple centrally acting antidotes protect against severe organophosphate toxicity
    Marco L A Sivilotti
    Department of Emergency Medicine, Queen s University, Kingston, Ontario, Canada
    Acad Emerg Med 13:359-64. 2006
    ..Diazepam is known to supplement atropine therapy, but its specific mechanism of action is uncertain...
  4. ncbi request reprint Oxidant stress and haemolysis of the human erythrocyte
    Marco L A Sivilotti
    Department of Emergency Medicine, Queen s University, Kingston, Ontario, Canada
    Toxicol Rev 23:169-88. 2004
    ..This review will also briefly review glucose-6-phosphate deficiency, a common but heterogeneous range of enzyme-deficient states, which impairs the ability of the erythrocyte to respond to oxidant injury...
  5. ncbi request reprint A new predictor of toxicity following acetaminophen overdose based on pretreatment exposure
    Marco L A Sivilotti
    Department of Emergency Medicine, Queen s University, Kingston, Ontario, Canada
    Clin Toxicol (Phila) 43:229-34. 2005
    ..We set out to parameterize both the degree and duration of pretreatment exposure into a single, continuous measure of exposure, which will serve as the x-axis of an eventual dose-response curve...
  6. ncbi request reprint Reversal of severe methanol-induced visual impairment: no evidence of retinal toxicity due to fomepizole
    M L Sivilotti
    University of Massachusetts Medical School, Worcester, USA
    J Toxicol Clin Toxicol 39:627-31. 2001
    ..The potential for fomepizole to inhibit retinol dehydrogenase, an isoenzyme of alcohol dehydrogenase essential to vision, did not appear to be clinically significant in this symptomatic methanol-poisoned patient...
  7. ncbi request reprint Pentobarbital for severe gamma-butyrolactone withdrawal
    M L Sivilotti
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Ann Emerg Med 38:660-5. 2001
    ..Recently, a withdrawal syndrome has been described for GHB. We report a severe form of GBL withdrawal, characterized by delirium, psychosis, autonomic instability, and resistance to benzodiazepine therapy...
  8. ncbi request reprint Toxicokinetics of ethylene glycol during fomepizole therapy: implications for management. For the Methylpyrazole for Toxic Alcohols Study Group
    M L Sivilotti
    University of Massachusetts Medical School, Worcester, MA, USA
    Ann Emerg Med 36:114-25. 2000
    ..The elimination kinetics of ethylene glycol (EG) in human subjects treated with fomepizole (4-methylpyrazole) were analyzed to establish the efficacy of alcohol dehydrogenase (ADH) inhibition and to characterize elimination pathways...
  9. doi request reprint When do the aminotransferases rise after acute acetaminophen overdose?
    Thomas J Green
    Department of Emergency Medicine, Queen s University, Kingston, ON, Canada
    Clin Toxicol (Phila) 48:787-92. 2010
    ..However, the timing and speed of such rises are not well characterized, hampering early risk prediction...
  10. doi request reprint Multiplying the serum aminotransferase by the acetaminophen concentration to predict toxicity following overdose
    Marco L A Sivilotti
    Department of Emergency Medicine, Queen s University, Kingston, ON, Canada
    Clin Toxicol (Phila) 48:793-9. 2010
    ..The first available predictors of hepatic injury following acetaminophen (APAP) overdose are the serum APAP and aminotransferases [AT, i.e., aspartate (AST) aminotransferase or alanine (ALT) aminotransferase]...
  11. doi request reprint Subdissociative-dose ketamine versus fentanyl for analgesia during propofol procedural sedation: a randomized clinical trial
    David W Messenger
    Department of Emergency Medicine, Critical Care Program, Queen s University, Kingston, Ontario, Canada
    Acad Emerg Med 15:877-86. 2008
    ..The authors sought to compare the safety and efficacy of subdissociative-dose ketamine versus fentanyl as adjunct analgesics for emergency department (ED) procedural sedation and analgesia (PSA) with propofol...
  12. ncbi request reprint A comparative evaluation of capnometry versus pulse oximetry during procedural sedation and analgesia on room air
    Marco L A Sivilotti
    Departments of Emergency Medicine, Queen s University, Kingston, Ontario, Canada
    CJEM 12:397-404. 2010
    ..The purpose of this study was to determine whether the capnometer or the pulse oximeter would first detect respiratory events in adults breathing room air...
  13. ncbi request reprint Randomized, double-blind study on sedatives and hemodynamics during rapid-sequence intubation in the emergency department: The SHRED Study
    M L Sivilotti
    Department of Emergency Medicine, Royal Victoria Hospital, McGill University, Montreal, Canada
    Ann Emerg Med 31:313-24. 1998
    ..To compare thiopental, fentanyl, and midazolam for rapid-sequence induction and intubation (RSI)...
  14. ncbi request reprint Core rewarming via warm lavage liquid ventilation in a swine model of hypothermia-associated ventricular fibrillation
    E W Dickson
    Department of Physiology, University of Massachusetts Medical School, Worcester MA, USA
    Acad Emerg Med 8:82-4. 2001
    ..To determine whether warm lavage liquid ventilation (LV) would provide rapid cardiopulmonary rewarming in swine with severe hypothermia and ventricular fibrillation...
  15. ncbi request reprint Phentolamine reduces myocardial injury and mortality in a rat model of phenylpropanolamine poisoning
    M J Burns
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Toxicol Clin Toxicol 39:129-34. 2001
    ..We sought to determine if pretreatment with phentolamine could reduce acute myocardial injury and mortality in rats administered an overdose of phenylpropanolamine...
  16. ncbi request reprint Should spectrophotometry be used to identify xanthochromia in the cerebrospinal fluid of alert patients suspected of having subarachnoid hemorrhage?
    Jeffrey J Perry
    Department of Emergency Medicine, University of Ottawa, ON, Canada
    Stroke 37:2467-72. 2006
    ..Authorities advocate spectrophotometry to measure xanthochromia, but most North American hospitals use visual inspection. We studied the diagnostic accuracy of spectrophotometry for SAH, and its potential impact on current practice...
  17. ncbi request reprint Does the sedative agent facilitate emergency rapid sequence intubation?
    Marco L A Sivilotti
    Department of Emergency Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Acad Emerg Med 10:612-20. 2003
    ..To ascertain whether the sedative agent administered during neuromuscular-blocking agent-facilitated intubation (rapid sequence intubation [RSI]) influences the number of attempts and overall success at RSI...
  18. pmc High risk clinical characteristics for subarachnoid haemorrhage in patients with acute headache: prospective cohort study
    Jeffrey J Perry
    Department of Emergency Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1Y 4E9
    BMJ 341:c5204. 2010
    ..To identify high risk clinical characteristics for subarachnoid haemorrhage in neurologically intact patients with headache...
  19. ncbi request reprint Potential impact of N-terminal pro-BNP testing on the emergency department evaluation of acute dyspnea
    Heather Murray
    Department of Emergency Medicine, Queen s University, Kingston, Ontario, Canada
    CJEM 8:251-8. 2006
    ..We sought to determine the potential impact of adding NT-proBNP testing to the routine evaluation of emergency patients with acute dyspnea...
  20. doi request reprint Predictors of hospital admission for chronic obstructive pulmonary disease exacerbations in Canadian emergency departments
    Brian H Rowe
    Department of Emergency Medicine, University of Alberta, Edmonton, Alberta, Canada
    Acad Emerg Med 16:316-24. 2009
    ..Current acute treatment approaches and outcomes 2 weeks after the ED visit are also described...
  21. ncbi request reprint Withholding 4-methylpyrazole pretreatment in suspected toxic alcohol ingestions
    Marco L A Sivilotti
    Acad Emerg Med 12:574-5. 2005
  22. ncbi request reprint Multidose activated charcoal for yellow oleander poisoning
    David N Juurlink
    Lancet 362:581; author reply 581. 2003
  23. ncbi request reprint The role of subspecialization in emergency medicine: a rebuttal
    Marco L A Sivilotti
    CJEM 8:76-7; author reply 77. 2006
  24. ncbi request reprint Pharmacokinetic effects of diphenhydramine or oxycodone in simulated acetaminophen overdose
    S Eliza Halcomb
    Division of Emergency Medicine, Washington University School of Medicine, Campus Box 8072, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Acad Emerg Med 12:169-72. 2005
    ..To determine the effects of co-ingested diphenhydramine (DPH) or oxycodone (OXY) on the absorption kinetics of simulated acetaminophen (APAP) overdose...
  25. pmc An evaluation of the osmole gap as a screening test for toxic alcohol poisoning
    Larry D Lynd
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
    BMC Emerg Med 8:5. 2008
    ....