Mary C Olmstead

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. ncbi request reprint Animal models of drug addiction: Where do we go from here?
    Mary C Olmstead
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    Q J Exp Psychol (Hove) 59:625-53. 2006
  2. ncbi request reprint Alcohol-induced impulsivity in rats: an effect of cue salience?
    Mary C Olmstead
    Department of Psychology, Queen s University, 62 Arch Street, Kingston, ON, Canada, K7L 3N6
    Psychopharmacology (Berl) 184:221-8. 2006
  3. ncbi request reprint Ultra-low-dose naltrexone suppresses rewarding effects of opiates and aversive effects of opiate withdrawal in rats
    Mary C Olmstead
    Department of Psychology, Queen s University, Kingston, Ontario, K7L 3N6, Canada
    Psychopharmacology (Berl) 181:576-81. 2005
  4. ncbi request reprint Repeated exposure to stress across the childhood-adolescent period alters rats' anxiety- and depression-like behaviors in adulthood: The importance of stressor type and gender
    Joanna Pohl
    Department of Psychology, Queen s University, Kingston, ON, Canada
    Behav Neurosci 121:462-74. 2007
  5. ncbi request reprint Adolescent enrichment partially reverses the social isolation syndrome
    Kim G C Hellemans
    Department of Psychology, Queen s University, Kingston, ON, Canada K7L 3N6
    Brain Res Dev Brain Res 150:103-15. 2004
  6. ncbi request reprint Early environmental experience alters baseline and ethanol-induced cognitive impulsivity: relationship to forebrain 5-HT1A receptor binding
    Kim G C Hellemans
    Department of Psychology, Queen s University, Kingston, Ont, Canada K7L 3N6
    Behav Brain Res 159:207-20. 2005
  7. ncbi request reprint Instructional cues modify performance on the Iowa Gambling Task
    Iris M Balodis
    Department of Psychology, Queen s University, Kingston Ontario, Canada
    Brain Cogn 60:109-17. 2006
  8. doi request reprint Behavioral traits predicting alcohol drinking in outbred rats: an investigation of anxiety, novelty seeking, and cognitive flexibility
    Scott J Hayton
    Centre for Neuroscience Studies, Queen s University, Kingston, ON, Canada
    Alcohol Clin Exp Res 36:594-603. 2012
  9. pmc Shift in the intrinsic excitability of medial prefrontal cortex neurons following training in impulse control and cued-responding tasks
    Scott J Hayton
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    PLoS ONE 6:e23885. 2011
  10. ncbi request reprint Intact preference conditioning in acute intoxication despite deficient declarative knowledge and working memory
    Iris M Balodis
    Department of Psychology, Queen s University, Kingston, Ontario
    Alcohol Clin Exp Res 31:1800-10. 2007

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Animal models of drug addiction: Where do we go from here?
    Mary C Olmstead
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    Q J Exp Psychol (Hove) 59:625-53. 2006
    ..Most importantly, this review emphasizes a critical role for animal research in understanding the role of impulsivity in the development and maintenance of drug addiction...
  2. ncbi request reprint Alcohol-induced impulsivity in rats: an effect of cue salience?
    Mary C Olmstead
    Department of Psychology, Queen s University, 62 Arch Street, Kingston, ON, Canada, K7L 3N6
    Psychopharmacology (Berl) 184:221-8. 2006
    ..An alternative explanation, provided by alcohol myopia theory, is that alcohol alters attentional processes such that intoxicated individuals respond exclusively to the most salient cues in their environment...
  3. ncbi request reprint Ultra-low-dose naltrexone suppresses rewarding effects of opiates and aversive effects of opiate withdrawal in rats
    Mary C Olmstead
    Department of Psychology, Queen s University, Kingston, Ontario, K7L 3N6, Canada
    Psychopharmacology (Berl) 181:576-81. 2005
    ..Ultra-low-dose opioid antagonists enhance opiate analgesia and attenuate tolerance and withdrawal...
  4. ncbi request reprint Repeated exposure to stress across the childhood-adolescent period alters rats' anxiety- and depression-like behaviors in adulthood: The importance of stressor type and gender
    Joanna Pohl
    Department of Psychology, Queen s University, Kingston, ON, Canada
    Behav Neurosci 121:462-74. 2007
    ..Findings reiterate the importance of early life experience to the development of adult psychopathologies and emphasize the need to consider both the type of early experience and gender differences in these analyses...
  5. ncbi request reprint Adolescent enrichment partially reverses the social isolation syndrome
    Kim G C Hellemans
    Department of Psychology, Queen s University, Kingston, ON, Canada K7L 3N6
    Brain Res Dev Brain Res 150:103-15. 2004
    ..Taken together, these results provide novel and interesting information regarding the effects of pre- or post-adolescent enrichment experience on behavioural and neural expression of the social isolation syndrome...
  6. ncbi request reprint Early environmental experience alters baseline and ethanol-induced cognitive impulsivity: relationship to forebrain 5-HT1A receptor binding
    Kim G C Hellemans
    Department of Psychology, Queen s University, Kingston, Ont, Canada K7L 3N6
    Behav Brain Res 159:207-20. 2005
    ..These data indicate that differential rearing has a significant influence on cognitive impulsivity, and that altered serotonergic function may underlie these differences...
  7. ncbi request reprint Instructional cues modify performance on the Iowa Gambling Task
    Iris M Balodis
    Department of Psychology, Queen s University, Kingston Ontario, Canada
    Brain Cogn 60:109-17. 2006
    ..Most importantly, the instruction-sensitivity of the IGT emphasizes the importance of salient cues for decision-making...
  8. doi request reprint Behavioral traits predicting alcohol drinking in outbred rats: an investigation of anxiety, novelty seeking, and cognitive flexibility
    Scott J Hayton
    Centre for Neuroscience Studies, Queen s University, Kingston, ON, Canada
    Alcohol Clin Exp Res 36:594-603. 2012
    ..To that end, we used a rat model to determine whether anxiety-related behaviors, novelty seeking, or cognitive flexibility predict excessive alcohol drinking under both limited and continuous access conditions...
  9. pmc Shift in the intrinsic excitability of medial prefrontal cortex neurons following training in impulse control and cued-responding tasks
    Scott J Hayton
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    PLoS ONE 6:e23885. 2011
    ..This dissociation suggests that both prelimbic and infralimbic neurons are involved in directing action, but specialized for different types of information, inhibitory or anticipatory, respectively...
  10. ncbi request reprint Intact preference conditioning in acute intoxication despite deficient declarative knowledge and working memory
    Iris M Balodis
    Department of Psychology, Queen s University, Kingston, Ontario
    Alcohol Clin Exp Res 31:1800-10. 2007
    ..The conditioned pattern preference (CPP) task provides a more ecologically valid means to investigate implicit cognition in the lab because it has low demand awareness and relies on learning to associate nonverbal cues with reward...
  11. doi request reprint Chronic prenatal ethanol exposure increases disinhibition and perseverative responding in the adult guinea pig
    Mary C Olmstead
    Department of Pharmacology, Queen s University, Kingston, Ontario, Canada
    Behav Pharmacol 20:554-7. 2009
    ..These data show that CPEE induces behavioural deficits in the guinea pig that are remarkably similar to the executive function deficits that follow prenatal ethanol exposure in humans...
  12. doi request reprint Maternal ethanol consumption by pregnant guinea pigs causes neurobehavioral deficits and increases ethanol preference in offspring
    Kayla M Shea
    Division of Pharmacology and Toxicology, Department of Biomedical and Molecular Sciences, Queen s University, Kingston, Ontario, Canada
    Behav Pharmacol 23:105-12. 2012
    ..These data demonstrate that moderate maternal consumption of ethanol produces hyperactivity, enhances ethanol preference, and impairs learning and memory in guinea pig offspring...
  13. ncbi request reprint Dimenhydrinate produces a conditioned place preference in rats
    Alison G Halpert
    Department of Psychology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Pharmacol Biochem Behav 75:173-9. 2003
    ..Future investigations into the neurotransmitter systems modulating this effect are awaited...
  14. doi request reprint Dissociable effects of ultralow-dose naltrexone on tolerance to the antinociceptive and cataleptic effects of morphine
    Katharine J Tuerke
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    Behav Pharmacol 22:558-63. 2011
    ....
  15. ncbi request reprint Ultra-low dose naltrexone enhances cannabinoid-induced antinociception
    Jay Paquette
    Departments of aPsychology bPharmacology and Toxicology, Center for Neuroscience Studies, Queen s University, Kingston, Ontario, Canada
    Behav Pharmacol 16:597-603. 2005
    ..These data suggest a mechanism of cannabinoid-opioid interaction whereby activated opioid receptors that couple to Gs-proteins may attenuate cannabinoid-induced antinociception and/or motor functioning...
  16. ncbi request reprint Cannabinoid-induced tolerance is associated with a CB1 receptor G protein coupling switch that is prevented by ultra-low dose rimonabant
    Jay J Paquette
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    Behav Pharmacol 18:767-76. 2007
    ..Cannabinoid-induced tolerance is thus associated with a G protein coupling switch from the inhibitory Gi protein to the excitatory Gs protein, an effect which is prevented by the ultra-low dose rimonabant...
  17. ncbi request reprint Effects of chronic cocaine on impulsivity: relation to cortical serotonin mechanisms
    Tracie A Paine
    Department of Psychology, Queen s University, Kingston, Canada ON, K7L 3N6
    Behav Brain Res 147:135-47. 2003
    ..Given the differential time courses of the behavioural and electrocorticographic data, however, this change probably does not mediate the effects of chronic cocaine in the delayed reinforcement paradigm...
  18. ncbi request reprint Cocaine disrupts both behavioural inhibition and conditional discrimination in rats
    Tracie A Paine
    Department of Psychology, Queen s University, Kingston, ON, Canada
    Psychopharmacology (Berl) 175:443-50. 2004
    ..In laboratory animals, however, the effects of amphetamine on behavioural disinhibition are equivocal, and the effects of cocaine have not been investigated...
  19. doi request reprint Preference conditioning in healthy individuals: correlates with hazardous drinking
    Iris M Balodis
    Department of Psychology, Queen s University, Kingston, ON, Canada
    Alcohol Clin Exp Res 34:1006-12. 2010
    ..Previously, we reported that alcohol intoxication does not affect CPP acquisition in humans, but our data indicated that prior drug use may impact conditioning scores...
  20. ncbi request reprint Effects of acute and prolonged opiate abstinence on extinction behaviour in rats
    Kim G C Hellemans
    Department of Psychology, Queen s University, Kingston, Ontario, K7L 3N6
    Can J Exp Psychol 56:241-52. 2002
    ..Results suggest that heroin abstinence has different effects on drug-seeking and drug-taking and that these effects do not temporally coincide with somatic measures of opioid withdrawal...
  21. doi request reprint Changes in morphine reward in a model of neuropathic pain
    Catherine M Cahill
    Department of Biomedical and Molecular Science, Queen s University, Kingston, Ontario, Canada
    Behav Pharmacol 24:207-13. 2013
    ..The increased potency of systemic morphine to produce a CPP in animals with neuropathic pain suggests that the motivation for opioid-induced reward is different in the two states...
  22. pmc Opposite effects of amphetamine on impulsive action with fixed and variable delays to respond
    Scott J Hayton
    Centre for Neuroscience Studies, Queen s University, Kingston, ON, Canada
    Neuropsychopharmacology 37:651-9. 2012
    ..The effect of amphetamine on impulsive action, therefore, is not universal, but depends on the subject's experience and expectation of the task demands...
  23. ncbi request reprint Variations in maternal care influence vulnerability to stress-induced binge eating in female rats
    Stephanie D Hancock
    Department of Psychology, Queen s University Kingston, Ontario, Canada K7L3N6
    Physiol Behav 85:430-9. 2005
    ....
  24. pmc Mu and delta opioid receptors oppositely regulate motor impulsivity in the signaled nose poke task
    Mary C Olmstead
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    PLoS ONE 4:e4410. 2009
    ..In a broader context, these data suggest that alterations in mu- or delta-opioid receptor function may contribute to impulse control disorders...
  25. doi request reprint Target-specific encoding of response inhibition: increased contribution of AMPA to NMDA receptors at excitatory synapses in the prefrontal cortex
    Scott J Hayton
    Queen s University, Centre for Neuroscience Studies, Kingston, Ontario K7L 3N6, Canada
    J Neurosci 30:11493-500. 2010
    ..This information could be exploited in therapeutic interventions for disorders of impulse control, such as addiction, attention deficit-hyperactivity disorder, and schizophrenia...
  26. ncbi request reprint Alcohol intoxication reduces impulsivity in the delay-discounting paradigm
    Catherine N M Ortner
    Department of Psychology, University of Toronto, Toronto, Ontario M5S 3G3, Canada
    Alcohol Alcohol 38:151-6. 2003
    ..To examine the moderating effects of alcohol myopia on cognitive impulsivity in humans using the delay-discounting paradigm...
  27. doi request reprint Neurobiology of an endophenotype: modeling the progression of alcohol addiction in rodents
    Megan K Mahoney
    Department of Psychology, Centre for Neuroscience Studies, Queen s University, Kingston, Ontario, Canada
    Curr Opin Neurobiol 23:607-14. 2013
    ..We conclude by noting gaps in the literature and outline important directions for future research. ..
  28. ncbi request reprint Mechanisms and abuse liability of the anti-histamine dimenhydrinate
    Alison G Halpert
    Department of Psychology, Queen s University, Kingston, Ont, Canada K7L 3N6
    Neurosci Biobehav Rev 26:61-7. 2002
    ..Further support comes from reports of acute and chronic abuse of DMH by humans. Collectively, results confirm the abuse liability of DMH...
  29. doi request reprint Increased impulsive action in rats: effects of morphine in a short and long fixed-delay response inhibition task
    Megan K Mahoney
    Department of Psychology, Queen s University, Kingston, ON, K7L 3N6, Canada
    Psychopharmacology (Berl) 230:569-77. 2013
    ..Previously, we speculated that these discrepancies reflect differences in the cognitive mechanisms that control responding in each task...
  30. pmc Recreational drug use and impulsivity in a population of canadian undergraduate drinkers
    Iris M Balodis
    Department of Psychology, Queen s University Kingston, ON, Canada
    Front Psychiatry 1:129. 2010
    ..Longitudinal studies should examine the contribution of impulsivity to the initiation and experimentation with illicit drugs and the influence of specific substances on impulsivity...
  31. ncbi request reprint Paradoxical effects of the opioid antagonist naltrexone on morphine analgesia, tolerance, and reward in rats
    Kelly J Powell
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
    J Pharmacol Exp Ther 300:588-96. 2002
    ..0 mg/kg) extended the duration of the morphine-induced conditioned place preference. These effects of naltrexone on morphine-induced reward may have implications for chronic treatment with agonist-antagonist combinations...