Denis E O'Donnell

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. ncbi request reprint Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable
    Denis E O'Donnell
    Department of Medicine, Queen s University, 102 Stuart Street, Kingston, ON, K7L 2V6 Canada
    Proc Am Thorac Soc 4:145-68. 2007
  2. ncbi request reprint Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD
    Denis E O'Donnell
    Department of Medicine, Respiratory Investigation Unit, Queen s University, Kingston, Ontario, Canada
    J Appl Physiol (1985) 101:1025-35. 2006
  3. ncbi request reprint Exercise hypercapnia in advanced chronic obstructive pulmonary disease: the role of lung hyperinflation
    Denis E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 166:663-8. 2002
  4. ncbi request reprint Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease--2003
    Denis E O'Donnell
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, 102 Stuart Street, Kingston, Ontario K7L 2V6, Canada
    Can Respir J 10:11A-65A. 2003
  5. ncbi request reprint Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease
    Denis E O'Donnell
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Proc Am Thorac Soc 3:180-4. 2006
  6. ncbi request reprint Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD
    D E O'Donnell
    Respiratory Investigation Unit, Dept of Medicine, Queen s University, Kingston, Ontario, Canada
    Eur Respir J 23:832-40. 2004
  7. ncbi request reprint Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Dept of Medicine, Queen s University, Kingston, Canada
    Eur Respir J 24:86-94. 2004
  8. ncbi request reprint State of the Art Compendium: Canadian Thoracic Society recommendations for the management of chronic obstructive pulmonary disease
    Denis E O'Donnell
    Queen s University, Kingston, Ontario
    Can Respir J 11:7B-59B. 2004
  9. pmc COPD exacerbations . 3: Pathophysiology
    D E O'Donnell
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, 102 Stuart Street, Kingston, Ontario, Canada K7L 2V6
    Thorax 61:354-61. 2006
  10. ncbi request reprint Effect of fluticasone propionate/salmeterol on lung hyperinflation and exercise endurance in COPD
    Denis E O'Donnell
    Queen s University, Kingston, ON, Canada
    Chest 130:647-56. 2006

Detail Information

Publications81

  1. ncbi request reprint Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable
    Denis E O'Donnell
    Department of Medicine, Queen s University, 102 Stuart Street, Kingston, ON, K7L 2V6 Canada
    Proc Am Thorac Soc 4:145-68. 2007
    ..Self-management strategies address the affective aspect of dyspnea and are essential to successful treatment...
  2. ncbi request reprint Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD
    Denis E O'Donnell
    Department of Medicine, Respiratory Investigation Unit, Queen s University, Kingston, Ontario, Canada
    J Appl Physiol (1985) 101:1025-35. 2006
    ..Changes in dyspnea intensity after tiotropium were positively correlated with changes in this index of neuromechanical coupling...
  3. ncbi request reprint Exercise hypercapnia in advanced chronic obstructive pulmonary disease: the role of lung hyperinflation
    Denis E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 166:663-8. 2002
    ..816, p < 0.0005). In severe COPD, the propensity to develop carbon dioxide retention during exercise reflects marked ventilatory constraints as a result of lung hyperinflation as well as reduced gas exchange capabilities...
  4. ncbi request reprint Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease--2003
    Denis E O'Donnell
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, 102 Stuart Street, Kingston, Ontario K7L 2V6, Canada
    Can Respir J 10:11A-65A. 2003
    ..Patients with advanced COPD and respiratory failure require a comprehensive management plan that incorporates structured end-of-life care...
  5. ncbi request reprint Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease
    Denis E O'Donnell
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Proc Am Thorac Soc 3:180-4. 2006
    ..This lung deflation allows greater Vt expansion for a given inspiratory effort during exercise with consequent improvement in dyspnea and exercise endurance...
  6. ncbi request reprint Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD
    D E O'Donnell
    Respiratory Investigation Unit, Dept of Medicine, Queen s University, Kingston, Ontario, Canada
    Eur Respir J 23:832-40. 2004
    ..Resultant increases in inspiratory capacity permitted greater expansion of tidal volume and contributed to improvements in both exertional dyspnoea and exercise endurance...
  7. ncbi request reprint Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Dept of Medicine, Queen s University, Kingston, Canada
    Eur Respir J 24:86-94. 2004
    ..Bronchodilator-induced lung deflation reduced mechanical restriction, increased ventilatory capacity and decreased respiratory discomfort, thereby increasing exercise endurance...
  8. ncbi request reprint State of the Art Compendium: Canadian Thoracic Society recommendations for the management of chronic obstructive pulmonary disease
    Denis E O'Donnell
    Queen s University, Kingston, Ontario
    Can Respir J 11:7B-59B. 2004
    ....
  9. pmc COPD exacerbations . 3: Pathophysiology
    D E O'Donnell
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, 102 Stuart Street, Kingston, Ontario, Canada K7L 2V6
    Thorax 61:354-61. 2006
    ..Finally, we review the chain of physiological events that leads to acute ventilatory insufficiency in severe exacerbations...
  10. ncbi request reprint Effect of fluticasone propionate/salmeterol on lung hyperinflation and exercise endurance in COPD
    Denis E O'Donnell
    Queen s University, Kingston, ON, Canada
    Chest 130:647-56. 2006
    ..To examine the effect of fluticasone propionate, 250 microg/salmeterol, 50 microg combination (FSC 250/50) twice daily on lung hyperinflation and associated measures of exercise performance in patients with COPD...
  11. ncbi request reprint [Dynamic lung hyperinflation and its clinical implication in COPD]
    D E O'Donnell
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Rev Mal Respir 25:1305-18. 2008
    ..These events explain exercise intolerance. Several approaches may help combat dynamic hyperinflation and its deleterious clinical effects: bronchodilators, hyperoxia, helium-oxygen mixtures, lung volume reduction surgery.....
  12. ncbi request reprint Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Departments of Medicine, and Community Health and Epidemiology, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 158:1557-65. 1998
    ..35, p < 0.001). We concluded that Borg dyspnea ratings, and measurements of IC and endurance time during submaximal cycle exercise testing are highly reproducible and responsive to change in severe COPD...
  13. ncbi request reprint Spirometric correlates of improvement in exercise performance after anticholinergic therapy in chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Departments of Medicine and Community Health and Epidemiology, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 160:542-9. 1999
    ..IC should be used in conjunction with FEV(1) when evaluating therapeutic responses in COPD...
  14. ncbi request reprint The clinical importance of dynamic lung hyperinflation in COPD
    Denis E O'Donnell
    Division of Respiratory and Critical Care Medicine, Departments of Medicine and Physiology, Queen s University, Kingston, Ontario, Canada
    COPD 3:219-32. 2006
    ..Finally, we will review current concepts of the mechanisms of symptom relief and improved exercise endurance following pharmacological lung volume reduction...
  15. ncbi request reprint Assessment of bronchodilator efficacy in symptomatic COPD: is spirometry useful?
    D E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Chest 117:42S-7S. 2000
    ....
  16. ncbi request reprint Respiratory sensation during chest wall restriction and dead space loading in exercising men
    D E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada K7L 2V7
    J Appl Physiol (1985) 88:1859-69. 2000
    ..In conclusion, severe dyspnea and exercise intolerance were provoked in healthy normal subjects when tidal volume responses were constrained in the face of increased ventilatory drive during exercise...
  17. ncbi request reprint Effects of hyperoxia on ventilatory limitation during exercise in advanced chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 163:892-8. 2001
    ..83, p < 0.0005). In conclusion, improved exercise endurance during hyperoxia was explained, in part, by a combination of reduced ventilatory demand, improved operational lung volumes, and dyspnea alleviation...
  18. ncbi request reprint Ventilatory limitations in chronic obstructive pulmonary disease
    D E O'Donnell
    Department of Medicine, Division of Respiratory and Critical Care Medicine, Queen s University, Kingston, Ontario, Canada
    Med Sci Sports Exerc 33:S647-55. 2001
    ....
  19. ncbi request reprint Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 164:770-7. 2001
    ..DH curtailed the VT response to exercise. This inability to expand VT in response to increasing metabolic demand contributed importantly to exercise intolerance in COPD...
  20. ncbi request reprint Physiological changes during symptom recovery from moderate exacerbations of COPD
    C M Parker
    102 Stuart Street, Kingston, Ontario, Canada
    Eur Respir J 26:420-8. 2005
    ..Improvement of dyspnoea following acute exacerbations of chronic obstructive pulmonary disease was associated with reduction in lung hyperinflation and consequent increase in expiratory flow rates...
  21. doi request reprint Effect of obesity on respiratory mechanics during rest and exercise in COPD
    Josuel Ora
    Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    J Appl Physiol (1985) 111:10-9. 2011
    ..Potential contributory factors included alterations in the elastic properties of the lungs, raised intra-abdominal pressures, reduced lung hyperinflation, and preserved inspiratory capacity...
  22. doi request reprint Effects of obesity on perceptual and mechanical responses to bronchoconstriction in asthma
    Athavudh Deesomchok
    Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 181:125-33. 2010
    ..The influence of obesity on the perception of respiratory discomfort during acute bronchoconstriction in asthma is unknown...
  23. doi request reprint Sex differences in exertional dyspnea in patients with mild COPD: physiological mechanisms
    Jordan A Guenette
    Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    Respir Physiol Neurobiol 177:218-27. 2011
    ..Superimposing mild COPD on the normal aging effects had greater sensory consequences in women because of their naturally reduced ventilatory reserve...
  24. doi request reprint Combined effects of obesity and chronic obstructive pulmonary disease on dyspnea and exercise tolerance
    Josuel Ora
    Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 180:964-71. 2009
    ..Lung volume components are consistently affected by body mass index (BMI) in health and in disease...
  25. doi request reprint Decline of resting inspiratory capacity in COPD: the impact on breathing pattern, dyspnea, and ventilatory capacity during exercise
    Denis E O'Donnell
    Department of Medicine, Queen sUniversity, Kingston, ON, Canada
    Chest 141:753-62. 2012
    ..To better understand the interrelationships among disease severity, inspiratory capacity (IC), breathing pattern, and dyspnea, we studied responses to symptom-limited cycle exercise in a large cohort with COPD...
  26. doi request reprint Effects of BMI on static lung volumes in patients with airway obstruction
    Denis E O'Donnell
    Department of Medicine, Queen s University and Kingston General Hospital, Canada
    Chest 140:461-8. 2011
    ..Both chronic airway obstruction and obesity are increasing in prevalence but the effect of their combination on pulmonary function parameters across the range of airway obstruction is unknown...
  27. pmc Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease - 2008 update - highlights for primary care
    Denis E O'Donnell
    Queen s University, Kingston, Canada
    Can Respir J 15:1A-8A. 2008
    ....
  28. doi request reprint Sex differences in the perceived intensity of breathlessness during exercise with advancing age
    Dror Ofir
    Department of Medicine, Queen s University, Kingston, Ontario K7L 2V6, Canada
    J Appl Physiol (1985) 104:1583-93. 2008
    ..The sensory consequences of this age-related respiratory impairment were more pronounced in women, who, by nature, have relatively reduced maximal ventilatory reserve...
  29. doi request reprint The increased ventilatory response to exercise in pregnancy reflects alterations in the respiratory control systems ventilatory recruitment threshold for CO2
    Dennis Jensen
    Respiratory Investigation Unit, Department of Medicine, Queen s University c o Kingston General Hospital, Kingston, Ontario, Canada
    Respir Physiol Neurobiol 171:75-82. 2010
    ....
  30. doi request reprint Effect of fluticasone/salmeterol combination on dyspnea and respiratory mechanics in mild-to-moderate COPD
    Jordan A Guenette
    Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    Respir Med 107:708-16. 2013
    ..Despite important mechanical improvements, there were no significant effects on dyspnea intensity and exercise endurance...
  31. doi request reprint Lung hyperinflation and its reversibility in patients with airway obstruction of varying severity
    Athavudh Deesomchok
    Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    COPD 7:428-37. 2010
    ..Those with the greatest resting lung hyperinflation showed the largest bronchodilator-induced volume deflation effects. Reduced air trapping was the predominant response to acute bronchodilation across severity subgroups...
  32. doi request reprint Evolution of dyspnea during exercise in chronic obstructive pulmonary disease: impact of critical volume constraints
    Pierantonio Laveneziana
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 184:1367-73. 2011
    ..Patients with chronic obstructive pulmonary disease (COPD) primarily describe their exertional dyspnea using descriptors alluding to increased effort or work of breathing and unsatisfied inspiration or inspiratory difficulty...
  33. doi request reprint Effect of biventricular pacing on ventilatory and perceptual responses to exercise in patients with stable chronic heart failure
    Pierantonio Laveneziana
    Pulmonologist, Respiratory Investigation Unit, Queen s Univ, 76 Stuart St, K7L 2V7 Kingston, ON, Canada
    J Appl Physiol (1985) 106:1574-83. 2009
    ..The decreased ventilatory demand, improved dynamic operating lung volumes, and the increased ability to expand tidal volume during exercise are potential factors in the reduction of exertional dyspnea...
  34. doi request reprint Does dynamic hyperinflation contribute to dyspnoea during exercise in patients with COPD?
    Jordan A Guenette
    Respiratory Investigation Unit, Queen s University and Kingston General Hospital, 76 Stuart Street, Kingston, ON, K7L 2V7, Canada
    Eur Respir J 40:322-9. 2012
    ..Dyspnoea intensity during exercise was associated with progressive mechanical constraints on tidal volume expansion regardless of the presence of DH...
  35. doi request reprint Physiological effects of roflumilast at rest and during exercise in COPD
    Denis E O'Donnell
    Respiratory Investigation Unit, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    Eur Respir J 39:1104-12. 2012
    ..Newly described non-bronchodilator effects of roflumilast included small but consistent improvements in air trapping and S(p,O(2)) during exercise...
  36. doi request reprint Can an 86-year-old woman with advanced lung disease be a world class athlete?
    Jordan A Guenette
    Division of Respirology, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    Respir Physiol Neurobiol 181:162-6. 2012
    ....
  37. ncbi request reprint Dynamic hyperinflation during bronchoconstriction in asthma: implications for symptom perception
    M Diane Lougheed
    Asthma Research Unit, Department of Medicine, Queen s University, 102 Stuart St, Kingston, ON, K7L 2V6, Canada
    Chest 130:1072-81. 2006
    ..The objective of this study was to examine the relationship between respiratory symptom intensity and quality and dynamic lung hyperinflation (DH) during induced bronchoconstriction in asthma...
  38. ncbi request reprint Mechanisms of dyspnea during cycle exercise in symptomatic patients with GOLD stage I chronic obstructive pulmonary disease
    Dror Ofir
    F R C P C, 102 Stuart Street, Kingston, ON, K7L 2V6 Canada
    Am J Respir Crit Care Med 177:622-9. 2008
    ..Smokers with a relatively preserved FEV(1) may experience dyspnea and activity limitation but little is known about underlying mechanisms...
  39. doi request reprint Bronchodilator effect on ventilatory, pulmonary gas exchange, and heart rate kinetics during high-intensity exercise in COPD
    Pierantonio Laveneziana
    Respiratory Investigation Unit, Department of Medicine, Kingston General Hospital, Queen s University, 102 Stuart Street, Kingston, ON K7L 2V6, Canada
    Eur J Appl Physiol 107:633-43. 2009
    ..025) and EELV at isotime (r = -0.77, p = 0.0032). The results confirm an important interaction between abnormal dynamic respiratory mechanics and indices of cardio-circulatory function in the rest-to-exercise transition in COPD patients...
  40. ncbi request reprint Chronic obstructive pulmonary disease: clinical integrative physiology
    Denis E O'Donnell
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, 102 Stuart Street, Kingston, Ontario K7L 2V6, Canada Electronic address
    Clin Chest Med 35:51-69. 2014
    ..Finally, emerging information on the role of cardiocirculatory impairment in contributing to exercise intolerance in patients with varying degrees of airway obstruction is reviewed. ..
  41. ncbi request reprint Effects of human pregnancy on the ventilatory chemoreflex response to carbon dioxide
    Dennis Jensen
    School of Physical and Health Education, Queen s Univ, Kingston, ON, Canada K7L 3N6
    Am J Physiol Regul Integr Comp Physiol 288:R1369-75. 2005
    ..These changes may be due to the effects of gestational hormones on chemoreflex and/or nonchemoreflex drives to breathe...
  42. doi request reprint Components of the COPD Assessment Test (CAT) associated with a diagnosis of COPD in a random population sample
    Natya Raghavan
    Department of Medicine, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    COPD 9:175-83. 2012
    ..This may help identify patients at risk for COPD for whom spirometry testing is recommended...
  43. doi request reprint Effects of dead space loading on neuro-muscular and neuro-ventilatory coupling of the respiratory system during exercise in healthy adults: implications for dyspnea and exercise tolerance
    Dennis Jensen
    Department of Kinesiology and Physical Education, McGill University, Montreal, QC, Canada
    Respir Physiol Neurobiol 179:219-26. 2011
    ..Under these circumstances, DSL-induced increases in exertional dyspnea intensity ratings reflected, at least in part, the awareness of increased neural respiratory drive, contractile respiratory muscle effort and ventilatory output...
  44. doi request reprint Effect of adjunct fluticasone propionate on airway physiology during rest and exercise in COPD
    Jordan A Guenette
    Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    Respir Med 105:1836-45. 2011
    ..The physiological effects of adding inhaled corticosteroid monotherapy to maintenance bronchodilator therapy (long-acting anticholinergics and LABA singly or in combination) in COPD are unknown...
  45. ncbi request reprint Chemical and mechanical adaptations of the respiratory system at rest and during exercise in human pregnancy
    Dennis Jensen
    School of Kinesiology and Health Studies, Clinical Exercise Physiology Laboratory, Physical Education Center, Queen s University, Kingston, ON K7L 3N6
    Appl Physiol Nutr Metab 32:1239-50. 2007
    ....
  46. ncbi request reprint Effects of human pregnancy and advancing gestation on respiratory discomfort during exercise
    Dennis Jensen
    School of Kinesiology and Health Studies, Clinical Exercise Physiology Laboratory, Physical Education Center, Queen s University, Kingston, Ont K7L 3N6, Canada
    Respir Physiol Neurobiol 156:85-93. 2007
    ....
  47. doi request reprint Mechanisms of activity-related breathlessness in healthy human pregnancy
    Dennis Jensen
    School of Kinesiology and Health Studies, Queen s University, Kingston, ON, Canada
    Eur J Appl Physiol 106:253-65. 2009
    ..In conclusion, gestational breathlessness could not be explained by alterations in central ventilatory control or respiratory mechanical/muscular factors, but reflected the normal awareness of increased ventilation...
  48. ncbi request reprint Impact of pulmonary rehabilitation on the major dimensions of dyspnea in COPD
    Karin Wadell
    Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    COPD 10:425-35. 2013
    ..In conclusion, clinically meaningful improvements in the affective and impact domains of dyspnea occurred in response to PR in the absence of consistent physiological training effects...
  49. doi request reprint Physiological mechanisms of hyperventilation during human pregnancy
    Dennis Jensen
    School of Kinesiology and Health Studies, Queen s University, Kingston, Ontorio, Canada K7L 3N6
    Respir Physiol Neurobiol 161:76-86. 2008
    ....
  50. doi request reprint Effect of indacaterol on exercise endurance and lung hyperinflation in COPD
    Denis E O'Donnell
    Queen s University and Kingston General Hospital, Kingston, Ontario K7L 2V7, Canada
    Respir Med 105:1030-6. 2011
    ..This study investigated the effect of indacaterol on exercise endurance, and on lung hyperinflation during exercise and at rest in patients with moderate-to-severe COPD...
  51. pmc Mechanical ventilatory constraints during incremental cycle exercise in human pregnancy: implications for respiratory sensation
    Dennis Jensen
    School of Kinesiology and Health Studies, Queen s University, Kingston, ON, Canada
    J Physiol 586:4735-50. 2008
    ....
  52. ncbi request reprint Dyspnea and activity limitation in COPD: mechanical factors
    Denis E O'Donnell
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    COPD 4:225-36. 2007
    ....
  53. ncbi request reprint Response of lung volumes to inhaled salbutamol in a large population of patients with severe hyperinflation
    Marcus F Newton
    Pulmonary Function Laboratory, Kingston General Hospital, Kingston, ON, Canada
    Chest 121:1042-50. 2002
    ..e., by IC, total lung capacity [TLC], functional residual capacity [FRC], residual volume [RV], and FVC) to salbutamol and the relationship of these changes to improvements in the spirometry in these patients...
  54. doi request reprint The impact of human pregnancy on perceptual responses to chemoreflex vs. exercise stimulation of ventilation: a retrospective analysis
    Dennis Jensen
    Respiratory Investigation Unit, Department of Medicine, Queen s University c o Kingston General Hospital, Kingston, Ontario, Canada
    Respir Physiol Neurobiol 175:55-61. 2011
    ....
  55. ncbi request reprint Chemoreflex control of breathing during wakefulness in healthy men and women
    Dennis Jensen
    School of Physical and Health Education, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Appl Physiol 98:822-8. 2005
    ..However, gender has no significant effect on the central chemoreflex VRT for CO(2). The peripheral chemoreflex control of breathing during wakefulness is similar between men and women...
  56. doi request reprint The major limitation to exercise performance in COPD is dynamic hyperinflation
    Denis E O'Donnell
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    J Appl Physiol 105:753-5; discussion 755-7. 2008
  57. doi request reprint Does the respiratory system limit exercise in mild chronic obstructive pulmonary disease?
    Roberto C Chin
    Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 187:1315-23. 2013
    ..We reasoned that failure to increase peak ventilation and Vt in response to dead space (DS) loading during exercise would indicate true ventilatory limitation to exercise in mild COPD...
  58. doi request reprint Mechanisms of dyspnoea relief and improved exercise endurance after furosemide inhalation in COPD
    D Jensen
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Thorax 63:606-13. 2008
    ..This study examined the effects of inhaled furosemide on the ventilatory and perceptual response to high-intensity constant-load cycle exercise in chronic obstructive pulmonary disease (COPD)...
  59. ncbi request reprint Effect of tiotropium bromide on the cardiovascular response to exercise in COPD
    J Travers
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ont, Canada
    Respir Med 101:2017-24. 2007
    ..Although the mechanism of relief is multifactorial, improved dynamic ventilatory mechanics appear to be important. It is not however known whether tiotropium may also act by improving cardiovascular function during exercise...
  60. ncbi request reprint McArdle's disease presenting as unexplained dyspnea in a young woman
    Nha Voduc
    Department of Medicine, Queen s University, Kingston, Ontario
    Can Respir J 11:163-7. 2004
    ..No previous studies have evaluated respiratory muscle function during exercise in patients with myophosphorylase deficiency...
  61. ncbi request reprint Respiratory sensation and ventilatory mechanics during induced bronchoconstriction in spontaneously breathing low cervical quadriplegia
    M Diane Lougheed
    Respiratory Investigation Unit, Department of Medicine, Queen s University, 102 Stuart Street, Kingston, Ontario, K7L 2V6 Canada
    Am J Respir Crit Care Med 166:370-6. 2002
    ..We conclude that the quality and intensity of dyspnea during methacholine-induced bronchoconstriction and dynamic hyperinflation was not altered by extensive chest wall deafferentation...
  62. pmc Combined physiological effects of bronchodilators and hyperoxia on exertional dyspnoea in normoxic COPD
    M M Peters
    Department of Medicine, Respiratory Investigation Unit, Queen s University, Kingston, Ontario, Canada
    Thorax 61:559-67. 2006
    ..We examined the effects of O(2) and BD, alone and in combination, on dyspnoea, ventilation (e), breathing pattern, operating lung volumes, and exercise endurance...
  63. ncbi request reprint Evaluation of bronchodilator responses in patients with "irreversible" emphysema
    L Forkert
    Respiratory Investigation Unit, Dept of Medicine, Queen's University, Kingston, Ontario, Canada
    Eur Respir J 18:914-20. 2001
    ....
  64. ncbi request reprint Does exercise test modality influence dyspnoea perception in obese patients with COPD?
    Casey E Ciavaglia
    Respiratory Investigation Unit, Dept of Medicine, Queen s University and Kingston General Hospital, Kingston, ON
    Eur Respir J 43:1621-30. 2014
    ..These data provide evidence that either exercise modality can be selected for reliable evaluation of exertional dyspnoea in this population in research and clinical settings...
  65. ncbi request reprint The role of tiotropium bromide, a long-acting anticholinergic bronchodilator, in the management of COPD
    Farzad Saberi
    Division of Respiratory and Critical Care Medicine, Queen s University, Kingston, Ontario, Canada
    Treat Respir Med 4:275-81. 2005
    ..Tiotropium bromide, because of its once-daily administration and its established efficacy and tolerability profile, has emerged as an attractive therapeutic option for this condition...
  66. doi request reprint Respiratory function and the obesity paradox
    Jordan A Guenette
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    Curr Opin Clin Nutr Metab Care 13:618-24. 2010
    ....
  67. ncbi request reprint Mechanisms of exertional dyspnea in patients with cancer
    J Travers
    Respiratory Investigation Unit, Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    J Appl Physiol (1985) 104:57-66. 2008
    ....
  68. doi request reprint The role of pharmacotherapy in mild to moderate chronic obstructive pulmonary disease
    Natya Raghavan
    Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    Ther Adv Respir Dis 5:245-54. 2011
    ..In this paper, we review the current knowledge base and emerging paradigm for the pharmacological treatment of mild to moderate COPD...
  69. ncbi request reprint Ventilatory assistance improves exercise endurance in stable congestive heart failure
    D E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 160:1804-11. 1999
    ..61, p < 0.01) and tidal Pes-time (r = 0.52, p < 0.01). in conclusion, ventilatory muscle unloading with PS reduced exertional leg discomfort and increased exercise endurance in patients with stable advanced CHF...
  70. doi request reprint Reliability of ventilatory parameters during cycle ergometry in multicentre trials in COPD
    D E O'Donnell
    Dept of Medicine, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    Eur Respir J 34:866-74. 2009
    ..79) and at peak exercise (R = 0.81). In conclusion, key perceptual and ventilatory parameters can be reliably measured during CWR cycle exercise in multicentre clinical trials in moderate to very severe COPD...
  71. ncbi request reprint Evaluation of acute bronchodilator reversibility in patients with symptoms of GOLD stage I COPD
    D E O'Donnell
    Department of Medicine, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    Thorax 64:216-23. 2009
    ..In such patients the impact of bronchodilator therapy remains unknown and is difficult to evaluate...
  72. doi request reprint Abnormal sarcoplasmic reticulum Ca2+-sequestering properties in skeletal muscle in chronic obstructive pulmonary disease
    H J Green
    Dept of Kinesiology, Univ of Waterloo, Waterloo, ON, Canada, N2L3G1
    Am J Physiol Cell Physiol 295:C350-7. 2008
    ..The reduced catalytic properties of SERCA in COPD suggest a disturbance in Ca(2+) cycling, possibly resulting in impairment in Ca(2+)-mediated mechanical function and/or second messenger regulated processes...
  73. pmc Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease - 2007 update
    Shaw Aaron
    Queen s University, Kingston, Canada
    Can Respir J 14:5B-32B. 2007
    ..The Panel hopes that these new practice guidelines, which reflect a rigorous analysis of the recent literature, will assist caregivers in the diagnosis and management of this common condition...
  74. doi request reprint Recent advances in pharmacotherapy for dyspnea in COPD
    Natya Raghavan
    Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    Curr Opin Pharmacol 11:204-10. 2011
    ..Effective pharmacological manipulation of the affective dimension of dyspnea remains an important challenge. In this review of the recent literature in this field, we highlight the main advances that have been achieved...
  75. ncbi request reprint Muscle blood-flow dynamics at exercise onset: do the limbs differ?
    Michael E Tschakovsky
    School of Physical and Health Education, Queen s University, Kingston, Ontario, Canada
    Med Sci Sports Exerc 38:1811-8. 2006
    ....
  76. doi request reprint Exertional dyspnea in chronic obstructive pulmonary disease: mechanisms and treatment approaches
    Josuel Ora
    Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    Curr Opin Pulm Med 16:144-9. 2010
    ..Specifically, we highlight new scientific discoveries concerning the language of dyspnea, its underlying mechanisms and its clinical management...
  77. ncbi request reprint Exertional breathlessness in patients with chronic airflow limitation. The role of lung hyperinflation
    D E O'Donnell
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am Rev Respir Dis 148:1351-7. 1993
    ..63, p < 0.001).(abstract truncated at 250 words)..
  78. pmc Inspiratory Capacity during Exercise: Measurement, Analysis, and Interpretation
    Jordan A Guenette
    Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada V6T 1Z3 UBC James Hogg Research Centre, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, BC, Canada V6Z 1Y6 Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, ON, Canada K7L 2V7
    Pulm Med 2013:956081. 2013
    ..Our main conclusion is that IC measurements are both reproducible and responsive to therapy and provide important information on the mechanisms of dyspnea and exercise limitation during CPET...
  79. pmc Respiratory Consequences of Mild-to-Moderate Obesity: Impact on Exercise Performance in Health and in Chronic Obstructive Pulmonary Disease
    Denis E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, 102 Stuart Street, Kingston, ON, Canada K7L 2V6
    Pulm Med 2012:818925. 2012
    ....
  80. doi request reprint Inhaled fentanyl citrate improves exercise endurance during high-intensity constant work rate cycle exercise in chronic obstructive pulmonary disease
    Dennis Jensen
    Department of Kinesiology and Physical Education, McGill University, Montreal, Quebec, Canada
    J Pain Symptom Manage 43:706-19. 2012
    ..Nevertheless, many patients with COPD remain incapacitated by dyspnea and exercise intolerance despite optimal therapy...
  81. pmc Cellular assessment of muscle in COPD: case studies of two males
    Howard J Green
    Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada
    Int J Gen Med 2:227-42. 2009
    ..It is concluded that disturbances can occur in muscle to a wide range of excitation, contraction and metabolic processes in COPD...