D E O'Donnell

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. ncbi request reprint Mechanisms of dyspnea during cycle exercise in symptomatic patients with GOLD stage I chronic obstructive pulmonary disease
    Dror Ofir
    F R C P C, 102 Stuart Street, Kingston, ON, K7L 2V6 Canada
    Am J Respir Crit Care Med 177:622-9. 2008
  2. doi request reprint Chronic obstructive pulmonary disease: clinical integrative physiology
    Denis E O'Donnell
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, 102 Stuart Street, Kingston, Ontario K7L 2V6, Canada Electronic address
    Clin Chest Med 35:51-69. 2014
  3. doi request reprint Physiological effects of roflumilast at rest and during exercise in COPD
    Denis E O'Donnell
    Respiratory Investigation Unit, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    Eur Respir J 39:1104-12. 2012
  4. doi request reprint Decline of resting inspiratory capacity in COPD: the impact on breathing pattern, dyspnea, and ventilatory capacity during exercise
    Denis E O'Donnell
    Department of Medicine, Queen sUniversity, Kingston, ON, Canada
    Chest 141:753-62. 2012
  5. pmc Effect of obesity on constant workrate exercise in hyperinflated men with COPD
    Louis Laviolette
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    BMC Pulm Med 10:33. 2010
  6. ncbi request reprint Dyspnea and activity limitation in COPD: mechanical factors
    Denis E O'Donnell
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    COPD 4:225-36. 2007
  7. doi request reprint The major limitation to exercise performance in COPD is dynamic hyperinflation
    Denis E O'Donnell
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    J Appl Physiol 105:753-5; discussion 755-7. 2008
  8. doi request reprint Reliability of ventilatory parameters during cycle ergometry in multicentre trials in COPD
    D E O'Donnell
    Dept of Medicine, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    Eur Respir J 34:866-74. 2009
  9. doi request reprint Effects of BMI on static lung volumes in patients with airway obstruction
    Denis E O'Donnell
    Department of Medicine, Queen s University and Kingston General Hospital, Canada
    Chest 140:461-8. 2011
  10. doi request reprint Evolution of dyspnea during exercise in chronic obstructive pulmonary disease: impact of critical volume constraints
    Pierantonio Laveneziana
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 184:1367-73. 2011

Detail Information

Publications51

  1. ncbi request reprint Mechanisms of dyspnea during cycle exercise in symptomatic patients with GOLD stage I chronic obstructive pulmonary disease
    Dror Ofir
    F R C P C, 102 Stuart Street, Kingston, ON, K7L 2V6 Canada
    Am J Respir Crit Care Med 177:622-9. 2008
    ..Smokers with a relatively preserved FEV(1) may experience dyspnea and activity limitation but little is known about underlying mechanisms...
  2. doi request reprint Chronic obstructive pulmonary disease: clinical integrative physiology
    Denis E O'Donnell
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, 102 Stuart Street, Kingston, Ontario K7L 2V6, Canada Electronic address
    Clin Chest Med 35:51-69. 2014
    ..Finally, emerging information on the role of cardiocirculatory impairment in contributing to exercise intolerance in patients with varying degrees of airway obstruction is reviewed. ..
  3. doi request reprint Physiological effects of roflumilast at rest and during exercise in COPD
    Denis E O'Donnell
    Respiratory Investigation Unit, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    Eur Respir J 39:1104-12. 2012
    ..Newly described non-bronchodilator effects of roflumilast included small but consistent improvements in air trapping and S(p,O(2)) during exercise...
  4. doi request reprint Decline of resting inspiratory capacity in COPD: the impact on breathing pattern, dyspnea, and ventilatory capacity during exercise
    Denis E O'Donnell
    Department of Medicine, Queen sUniversity, Kingston, ON, Canada
    Chest 141:753-62. 2012
    ..To better understand the interrelationships among disease severity, inspiratory capacity (IC), breathing pattern, and dyspnea, we studied responses to symptom-limited cycle exercise in a large cohort with COPD...
  5. pmc Effect of obesity on constant workrate exercise in hyperinflated men with COPD
    Louis Laviolette
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    BMC Pulm Med 10:33. 2010
    ..The aim of this study was to investigate the effects of increased BMI during constant workrate cycle ergometry in patients with COPD...
  6. ncbi request reprint Dyspnea and activity limitation in COPD: mechanical factors
    Denis E O'Donnell
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    COPD 4:225-36. 2007
    ....
  7. doi request reprint The major limitation to exercise performance in COPD is dynamic hyperinflation
    Denis E O'Donnell
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    J Appl Physiol 105:753-5; discussion 755-7. 2008
  8. doi request reprint Reliability of ventilatory parameters during cycle ergometry in multicentre trials in COPD
    D E O'Donnell
    Dept of Medicine, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    Eur Respir J 34:866-74. 2009
    ..79) and at peak exercise (R = 0.81). In conclusion, key perceptual and ventilatory parameters can be reliably measured during CWR cycle exercise in multicentre clinical trials in moderate to very severe COPD...
  9. doi request reprint Effects of BMI on static lung volumes in patients with airway obstruction
    Denis E O'Donnell
    Department of Medicine, Queen s University and Kingston General Hospital, Canada
    Chest 140:461-8. 2011
    ..Both chronic airway obstruction and obesity are increasing in prevalence but the effect of their combination on pulmonary function parameters across the range of airway obstruction is unknown...
  10. doi request reprint Evolution of dyspnea during exercise in chronic obstructive pulmonary disease: impact of critical volume constraints
    Pierantonio Laveneziana
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 184:1367-73. 2011
    ..Patients with chronic obstructive pulmonary disease (COPD) primarily describe their exertional dyspnea using descriptors alluding to increased effort or work of breathing and unsatisfied inspiration or inspiratory difficulty...
  11. doi request reprint Evaluation of acute bronchodilator reversibility in patients with symptoms of GOLD stage I COPD
    D E O'Donnell
    Department of Medicine, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    Thorax 64:216-23. 2009
    ..In such patients the impact of bronchodilator therapy remains unknown and is difficult to evaluate...
  12. pmc Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease - 2008 update - highlights for primary care
    Denis E O'Donnell
    Queen s University, Kingston, Canada
    Can Respir J 15:1A-8A. 2008
    ....
  13. ncbi request reprint Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Departments of Medicine, and Community Health and Epidemiology, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 158:1557-65. 1998
    ..35, p < 0.001). We concluded that Borg dyspnea ratings, and measurements of IC and endurance time during submaximal cycle exercise testing are highly reproducible and responsive to change in severe COPD...
  14. ncbi request reprint Mechanisms of exertional dyspnea in patients with cancer
    J Travers
    Respiratory Investigation Unit, Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    J Appl Physiol (1985) 104:57-66. 2008
    ....
  15. ncbi request reprint Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD
    D E O'Donnell
    Respiratory Investigation Unit, Dept of Medicine, Queen s University, Kingston, Ontario, Canada
    Eur Respir J 23:832-40. 2004
    ..Resultant increases in inspiratory capacity permitted greater expansion of tidal volume and contributed to improvements in both exertional dyspnoea and exercise endurance...
  16. ncbi request reprint Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Dept of Medicine, Queen s University, Kingston, Canada
    Eur Respir J 24:86-94. 2004
    ..Bronchodilator-induced lung deflation reduced mechanical restriction, increased ventilatory capacity and decreased respiratory discomfort, thereby increasing exercise endurance...
  17. ncbi request reprint Spirometric correlates of improvement in exercise performance after anticholinergic therapy in chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Departments of Medicine and Community Health and Epidemiology, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 160:542-9. 1999
    ..IC should be used in conjunction with FEV(1) when evaluating therapeutic responses in COPD...
  18. ncbi request reprint Effects of hyperoxia on ventilatory limitation during exercise in advanced chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 163:892-8. 2001
    ..83, p < 0.0005). In conclusion, improved exercise endurance during hyperoxia was explained, in part, by a combination of reduced ventilatory demand, improved operational lung volumes, and dyspnea alleviation...
  19. doi request reprint Mechanisms of dyspnoea relief and improved exercise endurance after furosemide inhalation in COPD
    D Jensen
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Thorax 63:606-13. 2008
    ..This study examined the effects of inhaled furosemide on the ventilatory and perceptual response to high-intensity constant-load cycle exercise in chronic obstructive pulmonary disease (COPD)...
  20. pmc Combined physiological effects of bronchodilators and hyperoxia on exertional dyspnoea in normoxic COPD
    M M Peters
    Department of Medicine, Respiratory Investigation Unit, Queen s University, Kingston, Ontario, Canada
    Thorax 61:559-67. 2006
    ..We examined the effects of O(2) and BD, alone and in combination, on dyspnoea, ventilation (e), breathing pattern, operating lung volumes, and exercise endurance...
  21. ncbi request reprint [Dynamic lung hyperinflation and its clinical implication in COPD]
    D E O'Donnell
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Rev Mal Respir 25:1305-18. 2008
    ..These events explain exercise intolerance. Several approaches may help combat dynamic hyperinflation and its deleterious clinical effects: bronchodilators, hyperoxia, helium-oxygen mixtures, lung volume reduction surgery.....
  22. ncbi request reprint Ventilatory assistance improves exercise endurance in stable congestive heart failure
    D E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 160:1804-11. 1999
    ..61, p < 0.01) and tidal Pes-time (r = 0.52, p < 0.01). in conclusion, ventilatory muscle unloading with PS reduced exertional leg discomfort and increased exercise endurance in patients with stable advanced CHF...
  23. ncbi request reprint Physiological changes during symptom recovery from moderate exacerbations of COPD
    C M Parker
    102 Stuart Street, Kingston, Ontario, Canada
    Eur Respir J 26:420-8. 2005
    ..Improvement of dyspnoea following acute exacerbations of chronic obstructive pulmonary disease was associated with reduction in lung hyperinflation and consequent increase in expiratory flow rates...
  24. ncbi request reprint Exertional breathlessness in patients with chronic airflow limitation. The role of lung hyperinflation
    D E O'Donnell
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am Rev Respir Dis 148:1351-7. 1993
    ..63, p < 0.001).(abstract truncated at 250 words)..
  25. ncbi request reprint Assessment of bronchodilator efficacy in symptomatic COPD: is spirometry useful?
    D E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Chest 117:42S-7S. 2000
    ....
  26. doi request reprint Abnormal sarcoplasmic reticulum Ca2+-sequestering properties in skeletal muscle in chronic obstructive pulmonary disease
    H J Green
    Dept of Kinesiology, Univ of Waterloo, Waterloo, ON, Canada, N2L3G1
    Am J Physiol Cell Physiol 295:C350-7. 2008
    ..The reduced catalytic properties of SERCA in COPD suggest a disturbance in Ca(2+) cycling, possibly resulting in impairment in Ca(2+)-mediated mechanical function and/or second messenger regulated processes...
  27. doi request reprint Effect of biventricular pacing on ventilatory and perceptual responses to exercise in patients with stable chronic heart failure
    Pierantonio Laveneziana
    Pulmonologist, Respiratory Investigation Unit, Queen s Univ, 76 Stuart St, K7L 2V7 Kingston, ON, Canada
    J Appl Physiol (1985) 106:1574-83. 2009
    ..The decreased ventilatory demand, improved dynamic operating lung volumes, and the increased ability to expand tidal volume during exercise are potential factors in the reduction of exertional dyspnea...
  28. ncbi request reprint Ventilatory constraints and dyspnea during exercise in chronic obstructive pulmonary disease
    Pierantonio Laveneziana
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, 102 Stuart St, Kingston, ON K7L 2V6
    Appl Physiol Nutr Metab 32:1225-38. 2007
    ..This review examines the specific derangements of ventilatory mechanics that occur in COPD during exercise and attempts to provide a mechanistic rationale for the attendant respiratory discomfort and activity limitation...
  29. doi request reprint Combined effects of obesity and chronic obstructive pulmonary disease on dyspnea and exercise tolerance
    Josuel Ora
    Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 180:964-71. 2009
    ..Lung volume components are consistently affected by body mass index (BMI) in health and in disease...
  30. doi request reprint Sex differences in the perceived intensity of breathlessness during exercise with advancing age
    Dror Ofir
    Department of Medicine, Queen s University, Kingston, Ontario K7L 2V6, Canada
    J Appl Physiol (1985) 104:1583-93. 2008
    ..The sensory consequences of this age-related respiratory impairment were more pronounced in women, who, by nature, have relatively reduced maximal ventilatory reserve...
  31. ncbi request reprint Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 164:770-7. 2001
    ..DH curtailed the VT response to exercise. This inability to expand VT in response to increasing metabolic demand contributed importantly to exercise intolerance in COPD...
  32. ncbi request reprint Respiratory sensation during chest wall restriction and dead space loading in exercising men
    D E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada K7L 2V7
    J Appl Physiol (1985) 88:1859-69. 2000
    ..In conclusion, severe dyspnea and exercise intolerance were provoked in healthy normal subjects when tidal volume responses were constrained in the face of increased ventilatory drive during exercise...
  33. pmc COPD exacerbations . 3: Pathophysiology
    D E O'Donnell
    Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, 102 Stuart Street, Kingston, Ontario, Canada K7L 2V6
    Thorax 61:354-61. 2006
    ..Finally, we review the chain of physiological events that leads to acute ventilatory insufficiency in severe exacerbations...
  34. doi request reprint Bronchodilator effect on ventilatory, pulmonary gas exchange, and heart rate kinetics during high-intensity exercise in COPD
    Pierantonio Laveneziana
    Respiratory Investigation Unit, Department of Medicine, Kingston General Hospital, Queen s University, 102 Stuart Street, Kingston, ON K7L 2V6, Canada
    Eur J Appl Physiol 107:633-43. 2009
    ..025) and EELV at isotime (r = -0.77, p = 0.0032). The results confirm an important interaction between abnormal dynamic respiratory mechanics and indices of cardio-circulatory function in the rest-to-exercise transition in COPD patients...
  35. ncbi request reprint The clinical importance of dynamic lung hyperinflation in COPD
    Denis E O'Donnell
    Division of Respiratory and Critical Care Medicine, Departments of Medicine and Physiology, Queen s University, Kingston, Ontario, Canada
    COPD 3:219-32. 2006
    ..Finally, we will review current concepts of the mechanisms of symptom relief and improved exercise endurance following pharmacological lung volume reduction...
  36. ncbi request reprint Ventilatory and perceptual responses to cycle exercise in obese women
    Dror Ofir
    Respiratory Investigation Unit, Department of Medicine, Queen s University, 102 Stuart St, Kingston, Ontario, Canada K7L 2V6
    J Appl Physiol 102:2217-26. 2007
    ....
  37. ncbi request reprint Hemopneumothorax in a COPD patient treated with noninvasive positive pressure ventilation: the risk of attendant anticoagulation
    R Raghavan
    Department of Medicine, Queen s University, Kingston, Ontario
    Can Respir J 11:159-62. 2004
    ..This is the first reported case of hemopneumothorax complicating NIPPV therapy...
  38. ncbi request reprint Ventilatory limitations in chronic obstructive pulmonary disease
    D E O'Donnell
    Department of Medicine, Division of Respiratory and Critical Care Medicine, Queen s University, Kingston, Ontario, Canada
    Med Sci Sports Exerc 33:S647-55. 2001
    ....
  39. doi request reprint Effect of obesity on respiratory mechanics during rest and exercise in COPD
    Josuel Ora
    Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    J Appl Physiol (1985) 111:10-9. 2011
    ..Potential contributory factors included alterations in the elastic properties of the lungs, raised intra-abdominal pressures, reduced lung hyperinflation, and preserved inspiratory capacity...
  40. doi request reprint Physiological mechanisms of hyperventilation during human pregnancy
    Dennis Jensen
    School of Kinesiology and Health Studies, Queen s University, Kingston, Ontorio, Canada K7L 3N6
    Respir Physiol Neurobiol 161:76-86. 2008
    ....
  41. ncbi request reprint Muscle blood-flow dynamics at exercise onset: do the limbs differ?
    Michael E Tschakovsky
    School of Physical and Health Education, Queen s University, Kingston, Ontario, Canada
    Med Sci Sports Exerc 38:1811-8. 2006
    ....
  42. ncbi request reprint Respiratory sensation and ventilatory mechanics during induced bronchoconstriction in spontaneously breathing low cervical quadriplegia
    M Diane Lougheed
    Respiratory Investigation Unit, Department of Medicine, Queen s University, 102 Stuart Street, Kingston, Ontario, K7L 2V6 Canada
    Am J Respir Crit Care Med 166:370-6. 2002
    ..We conclude that the quality and intensity of dyspnea during methacholine-induced bronchoconstriction and dynamic hyperinflation was not altered by extensive chest wall deafferentation...
  43. ncbi request reprint Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable
    Denis E O'Donnell
    Department of Medicine, Queen s University, 102 Stuart Street, Kingston, ON, K7L 2V6 Canada
    Proc Am Thorac Soc 4:145-68. 2007
    ..Self-management strategies address the affective aspect of dyspnea and are essential to successful treatment...
  44. ncbi request reprint Effects of human pregnancy and advancing gestation on respiratory discomfort during exercise
    Dennis Jensen
    School of Kinesiology and Health Studies, Clinical Exercise Physiology Laboratory, Physical Education Center, Queen s University, Kingston, Ont K7L 3N6, Canada
    Respir Physiol Neurobiol 156:85-93. 2007
    ....
  45. ncbi request reprint Effect of fluticasone propionate/salmeterol on lung hyperinflation and exercise endurance in COPD
    Denis E O'Donnell
    Queen s University, Kingston, ON, Canada
    Chest 130:647-56. 2006
    ..To examine the effect of fluticasone propionate, 250 microg/salmeterol, 50 microg combination (FSC 250/50) twice daily on lung hyperinflation and associated measures of exercise performance in patients with COPD...
  46. ncbi request reprint Exercise hypercapnia in advanced chronic obstructive pulmonary disease: the role of lung hyperinflation
    Denis E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 166:663-8. 2002
    ..816, p < 0.0005). In severe COPD, the propensity to develop carbon dioxide retention during exercise reflects marked ventilatory constraints as a result of lung hyperinflation as well as reduced gas exchange capabilities...
  47. ncbi request reprint Chemical and mechanical adaptations of the respiratory system at rest and during exercise in human pregnancy
    Dennis Jensen
    School of Kinesiology and Health Studies, Clinical Exercise Physiology Laboratory, Physical Education Center, Queen s University, Kingston, ON K7L 3N6
    Appl Physiol Nutr Metab 32:1239-50. 2007
    ....
  48. ncbi request reprint McArdle's disease presenting as unexplained dyspnea in a young woman
    Nha Voduc
    Department of Medicine, Queen s University, Kingston, Ontario
    Can Respir J 11:163-7. 2004
    ..No previous studies have evaluated respiratory muscle function during exercise in patients with myophosphorylase deficiency...
  49. ncbi request reprint Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD
    Denis E O'Donnell
    Department of Medicine, Respiratory Investigation Unit, Queen s University, Kingston, Ontario, Canada
    J Appl Physiol (1985) 101:1025-35. 2006
    ..Changes in dyspnea intensity after tiotropium were positively correlated with changes in this index of neuromechanical coupling...
  50. ncbi request reprint Effects of human pregnancy on the ventilatory chemoreflex response to carbon dioxide
    Dennis Jensen
    School of Physical and Health Education, Queen s Univ, Kingston, ON, Canada K7L 3N6
    Am J Physiol Regul Integr Comp Physiol 288:R1369-75. 2005
    ..These changes may be due to the effects of gestational hormones on chemoreflex and/or nonchemoreflex drives to breathe...
  51. doi request reprint Organization of metabolic pathways in vastus lateralis of patients with chronic obstructive pulmonary disease
    Howard J Green
    Dept of Kinesiology, Univ of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    Am J Physiol Regul Integr Comp Physiol 295:R935-41. 2008
    ..A comparison of enzyme ratios indicated greater potentials for glucose phosphorylation relative to the citric acid cycle and the electron transport chain and glycogenolysis and glycolysis relative to beta-oxidation...