J C Nickel

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. pmc Treatment of chronic prostatitis/chronic pelvic pain syndrome
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    Int J Antimicrob Agents 31:S112-6. 2008
  2. ncbi request reprint Consensus development of a histopathological classification system for chronic prostatic inflammation
    J C Nickel
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    BJU Int 87:797-805. 2001
  3. ncbi request reprint Prostatitis-like symptoms: one year later
    J C Nickel
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    BJU Int 90:678-81. 2002
  4. ncbi request reprint Chronic bacterial prostatitis: an evolving clinical enigma
    J Curtis Nickel
    Queen s University, Kingston, Ontario, Canada
    Urology 66:2-8. 2005
  5. ncbi request reprint Randomized, double-blind, dose-ranging study of pentosan polysulfate sodium for interstitial cystitis
    J Curtis Nickel
    Department of Urology, Queens University, Kingston General Hospital, Kingston, Ontario, Canada
    Urology 65:654-8. 2005
  6. ncbi request reprint Recommendations for the evaluation of patients with prostatitis
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, ON K7L 2V7, Canada
    World J Urol 21:75-81. 2003
  7. ncbi request reprint Classification and diagnosis of prostatitis: a gold standard?
    J C Nickel
    Queen s University Kingston, ON, Canada
    Andrologia 35:160-7. 2003
  8. ncbi request reprint Prostatitis: diagnosis and classification
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario K7L 2V7, Canada
    Curr Urol Rep 4:259-60. 2003
  9. ncbi request reprint Leukocytes and bacteria in men with chronic prostatitis/chronic pelvic pain syndrome compared to asymptomatic controls
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, 76 Stuart Street, Kingston, Ontario K7L 2V7, Canada
    J Urol 170:818-22. 2003
  10. ncbi request reprint Benign prostatic hyperplasia (BPH) and prostatitis: prevalence of painful ejaculation in men with clinical BPH
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston, ON, Canada
    BJU Int 95:571-4. 2005

Detail Information

Publications95

  1. pmc Treatment of chronic prostatitis/chronic pelvic pain syndrome
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    Int J Antimicrob Agents 31:S112-6. 2008
    ..At this time, surgery (including minimally invasive) is recommended only for definitive indications and not generally for CP/CPPS...
  2. ncbi request reprint Consensus development of a histopathological classification system for chronic prostatic inflammation
    J C Nickel
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    BJU Int 87:797-805. 2001
    ....
  3. ncbi request reprint Prostatitis-like symptoms: one year later
    J C Nickel
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    BJU Int 90:678-81. 2002
    ....
  4. ncbi request reprint Chronic bacterial prostatitis: an evolving clinical enigma
    J Curtis Nickel
    Queen s University, Kingston, Ontario, Canada
    Urology 66:2-8. 2005
  5. ncbi request reprint Randomized, double-blind, dose-ranging study of pentosan polysulfate sodium for interstitial cystitis
    J Curtis Nickel
    Department of Urology, Queens University, Kingston General Hospital, Kingston, Ontario, Canada
    Urology 65:654-8. 2005
    ..To compare the current recommended dose of pentosan polysulfate sodium (PPS) with doses two to three times higher...
  6. ncbi request reprint Recommendations for the evaluation of patients with prostatitis
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, ON K7L 2V7, Canada
    World J Urol 21:75-81. 2003
    ..As more evidence and data are accumulated and published, these recommendations may eventually evolve into practice guidelines for the evaluation of men presenting with prostatitis symptoms...
  7. ncbi request reprint Classification and diagnosis of prostatitis: a gold standard?
    J C Nickel
    Queen s University Kingston, ON, Canada
    Andrologia 35:160-7. 2003
    ..The physician must individualize a rational diagnostic strategy for each patient. There is no 'gold standard' for the diagnosis and evaluation of patients presenting with prostatitis...
  8. ncbi request reprint Prostatitis: diagnosis and classification
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario K7L 2V7, Canada
    Curr Urol Rep 4:259-60. 2003
  9. ncbi request reprint Leukocytes and bacteria in men with chronic prostatitis/chronic pelvic pain syndrome compared to asymptomatic controls
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, 76 Stuart Street, Kingston, Ontario K7L 2V7, Canada
    J Urol 170:818-22. 2003
    ....
  10. ncbi request reprint Benign prostatic hyperplasia (BPH) and prostatitis: prevalence of painful ejaculation in men with clinical BPH
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston, ON, Canada
    BJU Int 95:571-4. 2005
    ..To determine the prevalence and importance of pain/discomfort on ejaculation (prostatitis-like symptom) in men with lower urinary tract symptoms (LUTS) diagnosed with clinical benign prostatic hyperplasia (BPH)...
  11. ncbi request reprint The use of alpha1-adrenoceptor antagonists in lower urinary tract symptoms: beyond benign prostatic hyperplasia
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    Urology 62:34-41. 2003
    ..We can therefore conclude that alpha(1)-adrenoceptor antagonists, such as tamsulosin, may be useful for treating men with LUTS beyond BPH...
  12. ncbi request reprint The three As of chronic prostatitis therapy: antibiotics, alpha-blockers and anti-inflammatories. What is the evidence?
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    BJU Int 94:1230-3. 2004
  13. ncbi request reprint Treatment of chronic prostatitis/chronic pelvic pain syndrome with tamsulosin: a randomized double blind trial
    J Curtis Nickel
    Queen s University, Kingston, Ontario, Canada
    J Urol 171:1594-7. 2004
    ..We compared the efficacy of tamsulosin with placebo for the treatment of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)...
  14. ncbi request reprint Interstitial cystitis: a chronic pelvic pain syndrome
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, 76 Stuart Street, Kingston, ON K7L 2V7, Canada
    Med Clin North Am 88:467-81, xii. 2004
    ..Diagnostic awareness, willingness to consider recently studied therapies, and reasonable therapeutic expectations on the part of both the physician and the patient seem to be the key to successful management of this condition...
  15. ncbi request reprint A randomized placebo-controlled multicentre study to evaluate the safety and efficacy of finasteride for male chronic pelvic pain syndrome (category IIIA chronic nonbacterial prostatitis)
    J C Nickel
    Queen s University, Kingston, ON, Canada
    BJU Int 93:991-5. 2004
    ..To determine if finasteride can reduce symptoms in men with a clinical diagnosis of chronic nonbacterial prostatitis (National Institutes of Health, NIH, category IIIA chronic pelvic pain syndrome, CPPS) compared with placebo...
  16. ncbi request reprint Management of urinary tract infections: historical perspective and current strategies: Part 2--Modern management
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada K7L 2V7
    J Urol 173:27-32. 2005
    ....
  17. ncbi request reprint The economics of medical therapy for lower urinary tract symptoms associated with benign prostatic hyperplasia
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Ontario, Canada
    Curr Urol Rep 7:282-7. 2006
    ....
  18. ncbi request reprint Failure of a monotherapy strategy for difficult chronic prostatitis/chronic pelvic pain syndrome
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    J Urol 172:551-4. 2004
    ..We determined the effect of a best evidence based monotherapeutic strategy for patients diagnosed with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) referred to a specialized prostatitis clinic...
  19. ncbi request reprint Prevalence, diagnosis, characterization, and treatment of prostatitis, interstitial cystitis, and epididymitis in outpatient urological practice: the Canadian PIE Study
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    Urology 66:935-40. 2005
    ..To determine the prevalence, diagnostic patterns, and management of prostatitis, interstitial cystitis, and epididymitis (PIE) in Canadian urology outpatient practice...
  20. ncbi request reprint The overlapping lower urinary tract symptoms of benign prostatic hyperplasia and prostatitis
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    Curr Opin Urol 16:5-10. 2006
    ..To investigate the relationship, diagnosis and treatment of the overlapping lower urinary tract symptoms experienced by men diagnosed with benign prostatic hyperplasia and prostatitis...
  21. ncbi request reprint Asymptomatic inflammation and/or infection in benign prostatic hyperplasia
    J C Nickel
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    BJU Int 84:976-81. 1999
    ..To determine the extent, pattern and clinical significance of asymptomatic histological inflammation and latent infection (National Institute of Health Category IV prostatitis) in benign prostatic hyperplasia (BPH)...
  22. ncbi request reprint Prostatitis: the last frontier
    J C Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Ontario, Canada
    World J Surg 24:1197-9. 2000
    ..Also offered is a series of personal challenges to the urologic community. As we enter the twenty-first century we must develop a rational management strategy for patients who present with symptoms of prostatitis...
  23. pmc Interstitial cystitis. Etiology, diagnosis, and treatment
    J C Nickel
    Department of Urology, Queen s University in Kingston, Ont
    Can Fam Physician 46:2430-4, 2437-40. 2000
    ..To review current knowledge about the epidemiology, etiology, diagnosis, and treatment of interstitial cystitis, with special emphasis on management of this condition by family physicians...
  24. pmc Category III chronic prostatitis/chronic pelvic pain syndrome: insights from the National Institutes of Health Chronic Prostatitis Collaborative Research Network studies
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario K7L 2V7, Canada
    Curr Urol Rep 9:320-7. 2008
    ..Landmark publications of the CPCRN document a decade of progress. Insights from these CPCRN studies have improved our management of chronic prostatitis/chronic pelvic pain syndrome and offer hope for continued progress...
  25. ncbi request reprint Management of urinary tract infections: historical perspective and current strategies: Part 1--Before antibiotics
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada K7L 2V7
    J Urol 173:21-6. 2005
    ..To our knowledge a comprehensive review of the recorded medical history of UTI from its first description in ancient Egyptian papyri through today has not been attempted until now...
  26. ncbi request reprint Pentosan polysulfate sodium therapy for men with chronic pelvic pain syndrome: a multicenter, randomized, placebo controlled study
    J Curtis Nickel
    Department of Urology, Queens University, Kingston, Ontario, Canada
    J Urol 173:1252-5. 2005
    ..We evaluated the efficacy and tolerability of pentosan polysulfate sodium (PPS) for the treatment of men with chronic pelvic pain syndrome (CPPS), National Institutes of Health (NIH) category III...
  27. ncbi request reprint Examination of the relationship between symptoms of prostatitis and histological inflammation: baseline data from the REDUCE chemoprevention trial
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    J Urol 178:896-900; discussion 900-1. 2007
    ..5 mg dutasteride daily decreases the risk of biopsy detectable prostate cancer. All men underwent biopsy before study entry, allowing review of the relationship between histological prostate inflammation and prostatitis symptoms...
  28. ncbi request reprint Sexual function is a determinant of poor quality of life for women with treatment refractory interstitial cystitis
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    J Urol 177:1832-6. 2007
    ..Interstitial cystitis significantly negatively impacts quality of life. The demographic and clinical factors associated with decreased quality of life in these patients have not been well studied...
  29. ncbi request reprint BPH: costs and treatment outcomes
    J Curtis Nickel
    Empire 4, Kingston, Ontario, Canada
    Am J Manag Care 12:S141-8. 2006
    ..The publication of additional analyses would contribute to the appropriate selection of therapy in patients with BPH...
  30. ncbi request reprint The beneficial effect of alfuzosin 10 mg once daily in 'real-life' practice on lower urinary tract symptoms (LUTS), quality of life and sexual dysfunction in men with LUTS and painful ejaculation
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston, ON, Canada
    BJU Int 97:1242-6. 2006
    ....
  31. ncbi request reprint How does the pre-massage and post-massage 2-glass test compare to the Meares-Stamey 4-glass test in men with chronic prostatitis/chronic pelvic pain syndrome?
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    J Urol 176:119-24. 2006
    ..We evaluated a simpler test, the 2-glass pre-massage and post-massage test, and compared it with the Meares-Stamey 4-glass test to detect inflammation and bacteria in men with chronic prostatitis/chronic pelvic pain syndrome...
  32. ncbi request reprint Predictors of patient response to antibiotic therapy for the chronic prostatitis/chronic pelvic pain syndrome: a prospective multicenter clinical trial
    J C Nickel
    Department of Urology, Queen's University, Kingston, Canada
    J Urol 165:1539-44. 2001
    ..The perceived beneficial effect of antibiotics needs to be evaluated in a randomized placebo controlled trial...
  33. doi request reprint Clinical phenotyping of women with interstitial cystitis/painful bladder syndrome: a key to classification and potentially improved management
    J Curtis Nickel
    Department of Urology, Queen s University at Kingston, Kingston, Ontario, Canada
    J Urol 182:155-60. 2009
    ..We examined the relationship between UPOINT and symptoms in patients with interstitial cystitis/painful bladder syndrome...
  34. ncbi request reprint Improvement in sexual functioning in patients with interstitial cystitis/painful bladder syndrome
    J Curtis Nickel
    Queen s University Urology, Kingston, Ontario, Canada
    J Sex Med 5:394-9. 2008
    ..Sexual functioning is one of the strongest predictors of poorer quality of life (QOL) in patients diagnosed with interstitial cystitis/painful bladder syndrome (IC/PBS)...
  35. ncbi request reprint What questions do patients with curable prostate cancer want answered?
    D Feldman-Stewart
    Radiation Oncology Research Unit, Kingston Regional Cancer Centre, Ontario, Canada
    Med Decis Making 20:7-19. 2000
    ..To determine the questions that recently diagnosed early-stage prostate cancer patients think should be addressed with patients like themselves...
  36. ncbi request reprint Prevalence of prostatitis-like symptoms in a population based study using the National Institutes of Health chronic prostatitis symptom index
    J C Nickel
    Department of Urology, Queen's University, Kingston, Ontario, Canada
    J Urol 165:842-5. 2001
    ..Of the prostatitis group 60% sought medical help for their symptoms. CONCLUSIONS: In our opinion this community based study using the new prostatitis symptom index confirms that chronic prostatitis-like symptoms are common...
  37. ncbi request reprint Acupuncture ameliorates symptoms in men with chronic prostatitis/chronic pelvic pain syndrome
    Richard Chen
    Trillium Medical Center, Acupuncture Foundation of Canada, Mississauga, Ontario, Canada
    Urology 61:1156-9; discussion 1159. 2003
    ..To determine in a pilot study whether acupuncture improved pain, voiding symptoms, and the quality of life of men with chronic prostatitis/chronic pelvic pain syndrome...
  38. ncbi request reprint Levofloxacin for chronic prostatitis/chronic pelvic pain syndrome in men: a randomized placebo-controlled multicenter trial
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    Urology 62:614-7. 2003
    ..Uncontrolled studies have supported the use of antibiotics in CP/CPPS...
  39. doi request reprint Prostatitis and chronic pelvic pain syndrome in men
    Naji J Touma
    Department of Urology, Queen s University, Kingston General Hospital, 76 Stuart Street, Kingston, ON K7L 2V7, Canada
    Med Clin North Am 95:75-86. 2011
    ..Patients who are unfortunate to be diagnosed with a prostatitis syndrome have the best chance for successful therapy at initial presentation. Those patients will ultimately benefit from an informed and educated physician...
  40. ncbi request reprint Clinical evaluation of the man with chronic prostatitis/chronic pelvic pain syndrome
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    Urology 60:20-2; discussion 22-3. 2002
    ....
  41. ncbi request reprint Immunotherapy of an experimental adenocarcinoma of the prostate
    A Morales
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    J Urol 153:1706-10. 1995
    ..Additional studies to elucidate the effect of the compound in relation to dose and tumor volume are underway...
  42. ncbi request reprint Treatment of refractory interstitial cystitis
    A Morales
    Department of Urology, Queen's University, Kingston, Ontario, Canada
    Int Urogynecol J Pelvic Floor Dysfunct 7:215-20. 1996
    ..Effective and durable treatment will not be available until the nature of the disease is better understood and the mechanisms of action of current therapies are elucidated...
  43. ncbi request reprint An economic evaluation of doxazosin, finasteride and combination therapy in the treatment of benign prostatic hyperplasia
    Heather McDonald
    Innovus Research Inc, Burlington, Ontario, Canada
    Can J Urol 11:2327-40. 2004
    ....
  44. doi request reprint A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystitis
    J Curtis Nickel
    Department of Urology, Centre for Applied Urological Research, Queen s University, Kingston, ON, Canada
    BJU Int 103:56-60. 2009
    ....
  45. doi request reprint Role of alpha1-blockers in chronic prostatitis syndromes
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston, ON, Canada
    BJU Int 101:11-6. 2008
    ....
  46. doi request reprint Optimizing the management of prostate diseases: prostatitis and benign prostatic hyperplasia. Introduction
    J Curtis Nickel
    Queen s University, Kingston, ON, Canada
    BJU Int 101:1. 2008
  47. ncbi request reprint Catastrophizing and pain-contingent rest predict patient adjustment in men with chronic prostatitis/chronic pelvic pain syndrome
    Dean A Tripp
    Department of Psychology, Anesthesiology and Urology, Queen s University, Kingston, Ontario, Canada
    J Pain 7:697-708. 2006
    ..Findings support the need for greater research of such pain-related variables in CP/CPPS...
  48. doi request reprint Clinical significance of nontraditional bacterial uropathogens in the management of chronic prostatitis
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    J Urol 179:1391-5. 2008
    ..We compared the clinical benefits of eradicating traditional accepted uropathogens and nontraditional uropathogens (gram-positive bacteria other than enterococci) in prostate specific specimens in men with clinical prostatitis...
  49. ncbi request reprint Sexual and relationship functioning in men with chronic prostatitis/chronic pelvic pain syndrome and their partners
    Kelly B Smith
    Department of Psychology, Queen s University, 62 Arch Street, Kingston, Ontario, K7L 3N6, Canada
    Arch Sex Behav 36:301-11. 2007
    ..Furthermore, the sexual and relationship functioning of patients and partners was significantly associated. The results of this study have implications for the assessment and management of CP/CPPS and for future research in this area...
  50. doi request reprint Development of an evidence-based cognitive behavioral treatment program for men with chronic prostatitis/chronic pelvic pain syndrome
    J Curtis Nickel
    Department of Urology and Psychology, Queen s University, Kingston, ON, K7L 2V7, Canada
    World J Urol 26:167-72. 2008
    ..We targeted those parameters in the development of a cognitive-behavioral (CB) program designed specifically for CP/CPPS...
  51. ncbi request reprint Predictors of sexual and relationship functioning in couples with Chronic Prostatitis/Chronic Pelvic Pain Syndrome
    Kelly B Smith
    Queen s University, Department of Psychology, Kingston, Ontario, Canada
    J Sex Med 4:734-44. 2007
    ..However, couple functioning has rarely been investigated in Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS), a common condition in men involving pelvic pain and sexual dysfunction...
  52. doi request reprint Time to initiation of pentosan polysulfate sodium treatment after interstitial cystitis diagnosis: effect on symptom improvement
    J Curtis Nickel
    Queen s University, Department of Urology, Kingston General Hospital, 76 Stuart Street, Kingston, Ontario, Canada K7L2V7
    Urology 71:57-61. 2008
    ..The purpose of this study was to determine whether the length of time from initial diagnosis to start of treatment impacts subsequent symptom improvement...
  53. ncbi request reprint Psychosocial variables affect the quality of life of men diagnosed with chronic prostatitis/chronic pelvic pain syndrome
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    BJU Int 101:59-64. 2008
    ..To examine interactions between demographic, pain, urinary, psychological and environmental predictors of quality of life (QOL) in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)...
  54. pmc Inflammation and benign prostatic hyperplasia
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    Urol Clin North Am 35:109-15; vii. 2008
    ..This article describes these relationships and their impact on the management of, in particular, BPH...
  55. pmc Alfuzosin and symptoms of chronic prostatitis-chronic pelvic pain syndrome
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston, ON, Canada
    N Engl J Med 359:2663-73. 2008
    ..In men with chronic prostatitis-chronic pelvic pain syndrome, treatment with alpha-adrenergic receptor blockers early in the course of the disorder has been reported to be effective in some, but not all, relatively small randomized trials...
  56. doi request reprint Prevalence, symptom impact and predictors of chronic prostatitis-like symptoms in Canadian males aged 16-19 years
    Dean A Tripp
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    BJU Int 103:1080-4. 2009
    ....
  57. doi request reprint Phenotypic approach to the management of the chronic prostatitis/chronic pelvic pain syndrome
    J Curtis Nickel
    Queen s University, Kingston, Ontario, Canada
    BJU Int 106:1252-63. 2010
    ..By considering each patient as a unique individual and tailoring treatments to a specific patient's clinical 'phenotype' we improve our therapeutic outcomes...
  58. doi request reprint Interstitial cystitis/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    J Urol 184:1358-63. 2010
    ....
  59. doi request reprint Prevalence and impact of bacteriuria and/or urinary tract infection in interstitial cystitis/painful bladder syndrome
    J Curtis Nickel
    Department of Urology, Queen s University Kingston General Hospital, Kingston, Ontario, Canada
    Urology 76:799-803. 2010
    ..To determine the prevalence and clinical significance of documented bacteriuria and/or urinary tract infection in an interstitial cystitis/painful bladder syndrome (IC/PBS) population...
  60. doi request reprint A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with interstitial cystitis/painful bladder syndrome
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    Urology 76:804-9. 2010
    ..The goal of this pilot study was to gather information on differences between intravesical chondroitin sulfate and inactive vehicle control for treatment of interstitial cystitis/painful bladder syndrome (IC/PBS)...
  61. doi request reprint Psychosocial phenotyping in women with interstitial cystitis/painful bladder syndrome: a case control study
    J Curtis Nickel
    Queen s University, Kingston, Ontario, Canada
    J Urol 183:167-72. 2010
    ..We characterized and compared psychosocial phenotypes in a female interstitial cystitis/painful bladder syndrome cohort and an age matched cohort without that diagnosis...
  62. ncbi request reprint Phenotypic approach to the management of chronic prostatitis/chronic pelvic pain syndrome
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    Curr Urol Rep 10:307-12. 2009
    ....
  63. doi request reprint Plasma organochlorine levels and prostate cancer risk
    Kristan J Aronson
    Division of Cancer Care and Epidemiology, Department of Community Health and Epidemiology, Queen s University, Kingston, Ontario K7L3N6, Canada
    J Expo Sci Environ Epidemiol 20:434-45. 2010
    ..For pesticides, most ORs are very close to the null. This study suggests that long-term low-level exposure to organochlorine pesticides and PCBs in the general population does not contribute to increased prostate cancer risk...
  64. ncbi request reprint A randomized, placebo controlled, multicenter study to evaluate the safety and efficacy of rofecoxib in the treatment of chronic nonbacterial prostatitis
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Ontario, Canada
    J Urol 169:1401-5. 2003
    ..We determine the effects of treatment with rofecoxib and placebo in patients with chronic prostatitis...
  65. doi request reprint Sexual functioning, catastrophizing, depression, and pain, as predictors of quality of life in women with interstitial cystitis/painful bladder syndrome
    Dean A Tripp
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    Urology 73:987-92. 2009
    ..However, the deleterious association between sexual dysfunction and QOL has not been investigated in more inclusive models that use validated measures...
  66. doi request reprint The relationship among symptoms, sleep disturbances and quality of life in patients with interstitial cystitis
    J Curtis Nickel
    Queen s University, Kingston, Ontario, Canada
    J Urol 181:2555-61. 2009
    ..We conducted a retrospective analysis to determine associations among symptoms, sleep disturbances and quality of life in responder and nonresponder groups of patients with interstitial cystitis...
  67. pmc The relationship between prostate inflammation and lower urinary tract symptoms: examination of baseline data from the REDUCE trial
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, ON, Canada
    Eur Urol 54:1379-84. 2008
    ..Prostate biopsies performed in all men prior to entry were centrally reviewed, thus allowing an examination of the relationship between inflammatory changes and lower urinary tract symptoms (LUTS)...
  68. ncbi request reprint Absorption of alkalized intravesical lidocaine in normal and inflamed bladders: a simple method for improving bladder anesthesia
    R Henry
    Department of Anesthesiology, Queen's University, Kingston, Ontario, Canada
    J Urol 165:1900-3. 2001
    ..Furthermore, the decrease in acute pain scores in the interstitial cystitis group indicated a concentration of local anesthetic within the bladder wall that was sufficient to block the sensory neurons within the submucosal plexus...
  69. doi request reprint Intravesical alkalinized lidocaine (PSD597) offers sustained relief from symptoms of interstitial cystitis and painful bladder syndrome
    J Curtis Nickel
    Queens University, Kingston General Hospital, Kingston, ON, Canada
    BJU Int 103:910-8. 2009
    ....
  70. ncbi request reprint Opioids for chronic prostatitis and interstitial cystitis: lessons learned from the 11th World Congress on Pain
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    Urology 68:697-701. 2006
  71. ncbi request reprint Canadian guidelines for the management of benign prostatic hyperplasia
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Ontario, Canada
    Can J Urol 12:2677-83. 2005
    ..To develop the first Canadian guidelines for the management of lower urinary tract symptoms in men with benign prostatic hyperplasia (BPH)...
  72. ncbi request reprint Acupuncture for chronic prostatitis/chronic pelvic pain syndrome
    Richard C T Chen
    King Street Medical Arts Centre, 71 King Street, W Suite 400, Mississauga, Ontario, L5B4A2, Canada
    Curr Urol Rep 5:305-8. 2004
    ..This neuromodulatory therapy lends support to the hypothesis that the end stage of CP/CPPS may be a neuropathic pain syndrome...
  73. ncbi request reprint Hypersensitivity reaction associated with intravesical bacillus Calmette-Guerin for interstitial cystitis
    Chris Parker
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    J Urol 172:537. 2004
  74. pmc A meta-analysis of the vascular-related safety profile and efficacy of alpha-adrenergic blockers for symptoms related to benign prostatic hyperplasia
    J C Nickel
    Division of Urology, Queen s University, Kingston, Canada
    Int J Clin Pract 62:1547-59. 2008
    ..To evaluate the safety profile and efficacy of alpha1-adrenergic receptor blockers (A1Bs) currently prescribed for benign prostatic hyperplasia (BPH)...
  75. ncbi request reprint Impact of medical therapy on transurethral resection of the prostate: a decade of change
    C S Borth
    Department of Urology, Queen's University, Kingston, Ontario, Canada
    Urology 57:1082-5; discussion 1085-6. 2001
    ..The proportion of TURP patients presenting with urinary retention and hydronephrosis increased, but the average age, medical comorbidities, operative parameters, and postoperative complications have not significantly changed...
  76. ncbi request reprint Prostatitis and prostate cancer: implications for prostate cancer screening
    Jun Kawakami
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    Urology 64:1075-80. 2004
  77. ncbi request reprint The patient with chronic epididymitis: characterization of an enigmatic syndrome
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    J Urol 167:1701-4. 2002
    ..We provide a baseline description of men diagnosed with chronic epididymitis, explore relevant associations that may be important etiological factors and suggest a classification system and specific symptom assessment tool...
  78. ncbi request reprint The information required by patients with early-stage prostate cancer in choosing their treatment
    D Feldman-Stewart
    Radiation Oncology Research Unit, Department of Oncology, Queen s University, Kingston, Canada
    BJU Int 87:218-23. 2001
    ..To determine the information that men diagnosed with early-stage prostate cancer think is necessary to choose their treatment (surgery, radiotherapy or 'watchful waiting')...
  79. ncbi request reprint Overview summary statement. Diagnosis and management of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)
    Anthony J Schaeffer
    Department of Urology, Northwestern University Medical School, Chicago, Illinois, USA
    Urology 60:1-4. 2002
    ....
  80. ncbi request reprint A randomized controlled trial of intravesical bacillus calmette-guerin for treatment refractory interstitial cystitis
    Robert Mayer
    University of Rochester, Rochester, New York, USA
    J Urol 173:1186-91. 2005
    ..We compared intravesical bacillus Calmette-Guerin (BCG) to placebo instillations in patients with treatment refractory interstitial cystitis (IC)...
  81. ncbi request reprint Alfuzosin treatment for chronic prostatitis/chronic pelvic pain syndrome: a prospective, randomized, double-blind, placebo-controlled, pilot study
    Aare Mehik
    Division of Urology, Department of Surgery, Oulu University, Oulu, Finland
    Urology 62:425-9. 2003
    ....
  82. ncbi request reprint Sustained decrease in incidence of acute urinary retention and surgery with finasteride for 6 years in men with benign prostatic hyperplasia
    Claus G Roehrborn
    The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9100, USA
    J Urol 171:1194-8. 2004
    ..We determined the effect of long-term treatment with finasteride on the incidence of acute urinary retention (AUR) and benign prostatic hyperplasia (BPH) related surgery in men with BPH...
  83. ncbi request reprint Ciprofloxacin or tamsulosin in men with chronic prostatitis/chronic pelvic pain syndrome: a randomized, double-blind trial
    Richard B Alexander
    Veterans Affairs Maryland Health Care System and University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Ann Intern Med 141:581-9. 2004
    ..No cause of the disease has been established, and therapies are empirical and mostly untested. Antimicrobial agents and alpha-adrenergic receptor blockers are frequently used...
  84. ncbi request reprint Early symptom improvement of benign prostatic hyperplasia (BPH) treated with once daily alfuzosin
    Fred Saad
    Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Can J Urol 12:2745-54. 2005
    ..The current study examined efficacy, at 9 days and 3 months, and safety of this formulation of alfuzosin in BPH patients...
  85. ncbi request reprint Efficacy and safety of a dual inhibitor of 5-alpha-reductase types 1 and 2 (dutasteride) in men with benign prostatic hyperplasia
    Claus G Roehrborn
    Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9110, USA
    Urology 60:434-41. 2002
    ..To study the efficacy and safety of dutasteride, a dual inhibitor of the 5-alpha-reductase isoenzymes types I and II...
  86. pmc Followup of patients with interstitial cystitis responsive to treatment with intravesical bacillus Calmette-Guerin or placebo
    Kathleen Joy Propert
    University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Urol 179:552-5. 2008
    ..We evaluated the longer term response in patients with interstitial cystitis who initially responded to intravesical bacillus Calmette-Guerin or placebo in a randomized clinical trial...
  87. ncbi request reprint The chronic prostatitis-chronic pelvic pain syndrome can be characterized by prostatic tissue pressure measurements
    Aare Mehik
    Division of Urology, Department of Surgery, Oulu University Hospital, Oulu, Finland
    J Urol 167:137-40. 2002
    ..We planned to determine further whether this technique would detect a significant difference in inflammatory and noninflammatory categories IIIA and IIIB...
  88. ncbi request reprint Chronic prostatitis/chronic pelvic pain syndrome and male interstitial cystitis: enigmas and opportunities
    John B Forrest
    University of Oklahoma Health Science Center Tulsa, Tulsa, Oklahoma, USA
    Urology 69:60-3. 2007
    ..In this article, we highlight the similarities and differences between male IC and CP and review the presentation, diagnosis, and treatment of IC in men, with particular attention to those who have received an initial diagnosis of CP...
  89. ncbi request reprint Effect of pentosan polysulfate therapy on intravesical potassium sensitivity
    C Lowell Parsons
    Division of Urology, University of California, San Diego, Medical Center, San Diego, California 92103 8897, USA
    Urology 59:329-33. 2002
    ..Most individuals with IC appear to have an abnormally permeable epithelium that allows urinary solutes such as potassium to penetrate to the bladder interstitium, provoking symptoms...
  90. ncbi request reprint Impact of post-ejaculatory pain in men with category III chronic prostatitis/chronic pelvic pain syndrome
    Daniel A Shoskes
    Cleveland Clinic Florida, Weston, 33331, USA
    J Urol 172:542-7. 2004
    ..We studied ejaculatory pain in a cohort with CPPS to investigate associations with symptoms, quality of life and risk factors...
  91. pmc Uncomplicated urinary tract infection in women. Current practice and the effect of antibiotic resistance on empiric treatment
    Lindsay Nicolle
    University of Manitoba, Winnipeg
    Can Fam Physician 52:612-8. 2006
    ..To review treatment recommendations for empiric therapy of uncomplicated urinary tract infection (uUTI) in light of evolving antibiotic resistance and to consider use of guidelines to promote optimal practice...
  92. ncbi request reprint Design of a multicenter randomized clinical trial for chronic prostatitis/chronic pelvic pain syndrome
    Kathleen J Propert
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Urology 59:870-6. 2002
    ..To describe the study design and rationale for the first placebo-controlled, randomized clinical trial to be conducted by the Chronic Prostatitis Collaborative Research Network sponsored by the National Institutes of Health...
  93. ncbi request reprint Demographic and clinical characteristics of men with chronic prostatitis: the national institutes of health chronic prostatitis cohort study
    Anthony J Schaeffer
    Department of Urology, Northwestern University, Chicago, Illinois 60611, USA
    J Urol 168:593-8. 2002
    ..We describe the study design of the National Institutes of Health Chronic Prostatitis Cohort (CPC) study characterizing men with chronic prostatitis/the chronic pelvic pain syndrome...
  94. ncbi request reprint Leukocyte and bacterial counts do not correlate with severity of symptoms in men with chronic prostatitis: the National Institutes of Health Chronic Prostatitis Cohort Study
    Anthony J Schaeffer
    Department of Urology, Northwestern University, Chicago, IL 60611, USA
    J Urol 168:1048-53. 2002
    ..We examine whether leukocytes and bacteria correlate with symptom severity in men with chronic prostatitis/chronic pelvic pain syndrome...
  95. ncbi request reprint Urogenital pain--time to accept a new approach to phenotyping and, as a consequence, management
    Andrew P Baranowski
    Eur Urol 53:33-6. 2008

Research Grants6

  1. CHARACTERIZATION & TREATMENT OF CATEGORY III PROSTATITIS
    J Nickel; Fiscal Year: 2003
    ..Results from this 3 part study will be analyzed and correlated between groups and within groups, both concurrently and sequentially. ..
  2. Alternative Therapies for Benign Prostatic Hyperplasia
    J Nickel; Fiscal Year: 2004
    ..The Canadian BPH study group would be a valuable partner in the proposed NIH phytotherapeutic BPH prevention trial. ..
  3. Interstitial Cystitis Clinical Research Network (ICCRN)
    J Nickel; Fiscal Year: 2007
    ..site with Dr. Nickel as PI has the experience, expertise and the proven ability to design, implement and enroll patients with IC in clinical strudies and will be a valuable partner in the proposed ICCRN and UCPPSCG. ..
  4. Chronic Prostatitis Collaborative Research Network CPCRN
    J Nickel; Fiscal Year: 2007
    ..Nickel as PI has the experience, expertise and the proven ability to design, implement and enroll patients with CPPS in clinical studies and will be a valuable partner in the proposed CPCRN and UCPPSCG. ..
  5. Chronic Prostatitis Collaborative Research Network CPCRN
    J Nickel; Fiscal Year: 2007
    ..Nickel as PI has the experience, expertise and the proven ability to design, implement and enroll patients with CPPS in clinical strudies and will be a valuable partner in the proposed CPCRN and UCPPSCG. ..