David P LeBrun

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. ncbi E2A basic helix-loop-helix transcription factors in human leukemia
    David P LeBrun
    Department of Pathology, Queen s University, Kingston, Ontario, Canada
    Front Biosci 8:s206-22. 2003
  2. ncbi Critical role for a single leucine residue in leukemia induction by E2A-PBX1
    Richard Bayly
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Mol Cell Biol 26:6442-52. 2006
  3. ncbi Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1
    Christopher M Denis
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, ON, Canada
    Blood 120:3968-77. 2012
  4. ncbi Mapping acetylation sites in E2A identifies a conserved lysine residue in activation domain 1 that promotes CBP/p300 recruitment and transcriptional activation
    Brandy D Hyndman
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada
    Biochim Biophys Acta 1819:375-81. 2012
  5. ncbi E2A proteins enhance the histone acetyltransferase activity of the transcriptional co-activators CBP and p300
    Brandy D Hyndman
    Department of Pathology and Molecular Medicine, Queen s University, Canada
    Biochim Biophys Acta 1819:446-53. 2012
  6. ncbi Differential expression of cell-cycle regulatory proteins defines distinct classes of follicular lymphoma
    Abdulmohsen Alhejaily
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Hum Pathol 42:972-82. 2011
  7. ncbi E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells
    Richard Bayly
    Queen s University Cancer Research Institute, Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, K7L 3N6, Canada
    J Biol Chem 279:55362-71. 2004

Collaborators

  • Feng Wang
  • Shuang Liu
  • GERD BLOBEL
  • Michael J Plevin
  • Brandy D Hyndman
  • Richard Bayly
  • Patrick Thompson
  • Christopher M Denis
  • Steven P Smith
  • Seth Chitayat
  • Abdulmohsen Alhejaily
  • Richard Casselman
  • Holly L Spencer
  • Mitsuhiko Ikura
  • Graham P Côté
  • Tara Baetz
  • Andrew G Day
  • Patricia L Farmer
  • C Blake Gilks
  • Julia Brettschneider
  • Harriet E Feilotter
  • Brianne Wood
  • Cheryl J Foster
  • Rachel Savage
  • Salima Nurmohamed
  • Kim Munro
  • Takayuki Murase
  • Richard A Currie
  • Luan Chuen

Detail Information

Publications7

  1. ncbi E2A basic helix-loop-helix transcription factors in human leukemia
    David P LeBrun
    Department of Pathology, Queen s University, Kingston, Ontario, Canada
    Front Biosci 8:s206-22. 2003
    ..In this article, I review the evidence pertaining to leukemogenesis by the well-characterized E2A-fusion proteins and consider its mechanistic implications...
  2. ncbi Critical role for a single leucine residue in leukemia induction by E2A-PBX1
    Richard Bayly
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Mol Cell Biol 26:6442-52. 2006
    ..Circumstantial evidence suggests that the side chain of L20 might interact with a deep hydrophobic pocket in the KIX domain. Therefore, our results serve to identify a potential new drug target...
  3. ncbi Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1
    Christopher M Denis
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, ON, Canada
    Blood 120:3968-77. 2012
    ..These results provide molecular insights into E-protein-driven differentiation of B-cells and the mechanism of E-protein silencing, and reveal the PCET/KIX interaction as a therapeutic target for E2A-PBX1-induced leukemia...
  4. ncbi Mapping acetylation sites in E2A identifies a conserved lysine residue in activation domain 1 that promotes CBP/p300 recruitment and transcriptional activation
    Brandy D Hyndman
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada
    Biochim Biophys Acta 1819:375-81. 2012
    ..Our results illustrate for the first time that AD1 can both recruit, and be acetylated by, KATs and that KAT recruitment may promote transcriptional induction in part through acetylation of AD1 itself...
  5. ncbi E2A proteins enhance the histone acetyltransferase activity of the transcriptional co-activators CBP and p300
    Brandy D Hyndman
    Department of Pathology and Molecular Medicine, Queen s University, Canada
    Biochim Biophys Acta 1819:446-53. 2012
    ..Our findings add to a growing body of literature indicating that interactions between CBP/p300 and transcription factors can function in a specific manner to modulate HAT catalytic activity...
  6. ncbi Differential expression of cell-cycle regulatory proteins defines distinct classes of follicular lymphoma
    Abdulmohsen Alhejaily
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Hum Pathol 42:972-82. 2011
    ..Therefore, subjective quantification of cell-cycle regulatory proteins by immunohistochemistry can identify biologically and clinically distinct subsets of follicular lymphoma cases...
  7. ncbi E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells
    Richard Bayly
    Queen s University Cancer Research Institute, Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, K7L 3N6, Canada
    J Biol Chem 279:55362-71. 2004
    ..Our findings suggest that some aspects of E2A-PBX1 oncogenesis involve a direct interaction with the KIX domain of CBP/p300...