R Kisilevsky

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. doi request reprint Acute-phase serum amyloid A: perspectives on its physiological and pathological roles
    Robert Kisilevsky
    Department of Pathology and Molecular Medicine, Ontario, Canada
    Amyloid 19:5-14. 2012
  2. ncbi request reprint Novel glycosaminoglycan precursors as anti-amyloid agents, part III
    Robert Kisilevsky
    Department of Pathology, Queen s University, The Syl and Molly Apps Research Center Kingston General Hospital, Ontario, Canada
    J Mol Neurosci 20:291-7. 2003
  3. ncbi request reprint Macrophage cholesterol efflux and the active domains of serum amyloid A 2.1
    Robert Kisilevsky
    Department of Pathology, Queen s Hospital, Kingston, Ontario K7L 3N6, Canada
    J Lipid Res 44:2257-69. 2003
  4. ncbi request reprint Novel glycosaminoglycan precursors as anti-amyloid agents part II
    Robert Kisilevsky
    Department of Pathology, Queen s University, Kingston, Ontario, Canada
    J Mol Neurosci 19:45-50. 2002
  5. pmc Short-chain aliphatic polysulfonates inhibit the entry of Plasmodium into red blood cells
    Robert Kisilevsky
    Department of Pathology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Antimicrob Agents Chemother 46:2619-26. 2002
  6. ncbi request reprint Acute phase serum amyloid A, cholesterol metabolism, and cardiovascular disease
    Robert Kisilevsky
    Queen s University, Department of Pathology, Kingston General Hospital, Ontario, Canada
    Pediatr Pathol Mol Med 21:291-305. 2002
  7. ncbi request reprint The anti-atherogenic potential of serum amyloid A peptides
    Robert Kisilevsky
    Queen s University, Department of Pathology and Molecular Medicine, and The Syl and Molly Apps Research Center, Kingston General Hospital, Kingston, Ontario K7L 3N6, Canada
    Curr Opin Investig Drugs 9:265-73. 2008
  8. ncbi request reprint Novel glycosaminoglycan precursors as antiamyloid agents: Part IV
    Robert Kisilevsky
    Department of Pathology, Queen s University, and The Syl and Molly Apps Research Center Kingston General Hospital, Kingston, Ontario K7L 3N6, Canada
    J Mol Neurosci 24:167-72. 2004
  9. ncbi request reprint Can deposition of amyloid be prevented in Alzheimer's disease?
    R Kisilevsky
    Department of Pathology, Queen s University, Kingston, Ontario, Canada
    Ann N Y Acad Sci 826:117-27. 1997
  10. ncbi request reprint The in-vitro influence of serum amyloid A isoforms on enzymes that regulate the balance between esterified and un-esterified cholesterol
    S Ely
    Department of Pathology, Queen's University, Kingston General Hospital, Ontario, Canada
    Amyloid 8:169-81. 2001

Collaborators

Detail Information

Publications35

  1. doi request reprint Acute-phase serum amyloid A: perspectives on its physiological and pathological roles
    Robert Kisilevsky
    Department of Pathology and Molecular Medicine, Ontario, Canada
    Amyloid 19:5-14. 2012
    ..Furthermore, in apoE(-/-) mice, domains near the N- and C- termini of SAA inhibit the initiation and progression of aortic lipid lesions illustrating the conflicting nature of these two sets of data...
  2. ncbi request reprint Novel glycosaminoglycan precursors as anti-amyloid agents, part III
    Robert Kisilevsky
    Department of Pathology, Queen s University, The Syl and Molly Apps Research Center Kingston General Hospital, Ontario, Canada
    J Mol Neurosci 20:291-7. 2003
    ..To date 3-deoxy and 3,4-dideoxy analogs have failed to affect HS synthesis significantly. Compounds incorporating the 6-deoxy structural feature are currently being designed and synthesized...
  3. ncbi request reprint Macrophage cholesterol efflux and the active domains of serum amyloid A 2.1
    Robert Kisilevsky
    Department of Pathology, Queen s Hospital, Kingston, Ontario K7L 3N6, Canada
    J Lipid Res 44:2257-69. 2003
    ..1 or its residues 1-20 or 74-103 promoted the efflux of cholesterol in vivo. A single injection of each of the active peptides is effective in promoting cholesterol efflux in vivo for at least 4 days...
  4. ncbi request reprint Novel glycosaminoglycan precursors as anti-amyloid agents part II
    Robert Kisilevsky
    Department of Pathology, Queen s University, Kingston, Ontario, Canada
    J Mol Neurosci 19:45-50. 2002
    ..The results provide further evidence that heparan sulfate is a critical factor in amyloidogenesis and modifications of sugar precursors of heparan sulfate synthesis may provide leads for therapeutic intervention in amyloidogenesis...
  5. pmc Short-chain aliphatic polysulfonates inhibit the entry of Plasmodium into red blood cells
    Robert Kisilevsky
    Department of Pathology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Antimicrob Agents Chemother 46:2619-26. 2002
    ..Structure-activity studies conducted to enhance these properties may provide compounds with scope for significant further analysis and development...
  6. ncbi request reprint Acute phase serum amyloid A, cholesterol metabolism, and cardiovascular disease
    Robert Kisilevsky
    Queen s University, Department of Pathology, Kingston General Hospital, Ontario, Canada
    Pediatr Pathol Mol Med 21:291-305. 2002
    ..In this context, the possible role of serum amyloid A as a prognostic indicator of unstable angina and its significance in relation to cardiovascular disease is discussed...
  7. ncbi request reprint The anti-atherogenic potential of serum amyloid A peptides
    Robert Kisilevsky
    Queen s University, Department of Pathology and Molecular Medicine, and The Syl and Molly Apps Research Center, Kingston General Hospital, Kingston, Ontario K7L 3N6, Canada
    Curr Opin Investig Drugs 9:265-73. 2008
    ..A brief history of the role of SAA in amyloid A amyloidosis and its potential role in atherogenesis is included, along with a description of the function of SAA in mobilizing macrophage cholesterol for export...
  8. ncbi request reprint Novel glycosaminoglycan precursors as antiamyloid agents: Part IV
    Robert Kisilevsky
    Department of Pathology, Queen s University, and The Syl and Molly Apps Research Center Kingston General Hospital, Kingston, Ontario K7L 3N6, Canada
    J Mol Neurosci 24:167-72. 2004
    ..Very instructive results with regard to HS structure and its relation to AA amyloid deposition should be forthcoming from analyses of the AA-associated HS generated with this compound...
  9. ncbi request reprint Can deposition of amyloid be prevented in Alzheimer's disease?
    R Kisilevsky
    Department of Pathology, Queen s University, Kingston, Ontario, Canada
    Ann N Y Acad Sci 826:117-27. 1997
    ....
  10. ncbi request reprint The in-vitro influence of serum amyloid A isoforms on enzymes that regulate the balance between esterified and un-esterified cholesterol
    S Ely
    Department of Pathology, Queen's University, Kingston General Hospital, Ontario, Canada
    Amyloid 8:169-81. 2001
    ..They suggest that apoSAA2.1 may mediate cholesterol mobilization at sites of tissue injury...
  11. ncbi request reprint Assembly of Alzheimer's amyloid-beta fibrils and approaches for therapeutic intervention
    D S Yang
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario, Canada
    Amyloid 8:10-9. 2001
    ..In addition, the use of small compounds that interfere with the proteoglycan-amyloid pathway may be effective therapeutic agents that can be assessed through the use of these transgenic models...
  12. ncbi request reprint Promoting export of macrophage cholesterol: the physiological role of a major acute-phase protein, serum amyloid A 2.1
    Shui Pang Tam
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Lipid Res 43:1410-20. 2002
    ....
  13. ncbi request reprint Rapid recycling of cholesterol: the joint biologic role of C-reactive protein and serum amyloid A
    P N Manley
    Department of Pathology and Molecular Medicine, Queen s University, Richardson Laboratory, Kingston, Ont, Canada K7L 3N6
    Med Hypotheses 66:784-92. 2006
    ....
  14. ncbi request reprint Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A
    J B Ancsin
    Department of Pathology, Queen s University, Syl and Molly Apps Research Center, Kingston General Hospital, Ontario, Canada
    J Biol Chem 272:406-13. 1997
    ..The specificity and avidity of the laminin-apoSAA interaction also implies that it may be a normal event occurring during the inflammatory process, which mediates one or more of the functions recently proposed for apoSAA...
  15. ncbi request reprint Sulfated cyclodextrins inhibit the entry of Plasmodium into red blood cells. Implications for malarial therapy
    Ian E Crandall
    Toronto Medical Laboratories and Tropical Disease Unit, Division of Infectious Diseases, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Biochem Pharmacol 73:632-42. 2007
    ..berghei merozoite entry and could reduce the parasitemia of P. berghei infection in a mouse model, results suggesting that these compounds inhibit a common step in the merozoite invasion process of at least two Plasmodium species...
  16. doi request reprint Heparan sulfate promotes the aggregation of HDL-associated serum amyloid A: evidence for a proamyloidogenic histidine molecular switch
    Elena Elimova
    Department of Biochemistry, Queen s University, Kingston, ON K7L 3N6, Canada
    FASEB J 23:3436-48. 2009
    ..Similar histidine-dependent HS-binding sites are also found in other amyloidogenic polypeptides...
  17. ncbi request reprint Induction of perlecan gene expression precedes amyloid formation during experimental murine AA amyloidogenesis
    L Ailles
    Department of Pathology, Queen s University, Kingston, Ontario, Canada
    Lab Invest 69:443-8. 1993
    ....
  18. ncbi request reprint Peptides derived from serum amyloid A prevent, and reverse, aortic lipid lesions in apoE-/- mice
    Shui Pang Tam
    Department of Pathology and Molecular Medicine, Queen s University, and The Syl and Molly Apps Research Centre, Kingston General Hospital, Kingston, Ontario, Canada
    J Lipid Res 46:2091-101. 2005
    ..Such human peptides, or small molecule mimics of their structure, may prove to be potent antiatherogenic agents in humans...
  19. ncbi request reprint Amyloidogenesis recapitulated in cell culture: a peptide inhibitor provides direct evidence for the role of heparan sulfate and suggests a new treatment strategy
    Elena Elimova
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    FASEB J 18:1749-51. 2004
    ..These data provide direct evidence that SAA1.1:HS interactions are a critical step in AA-amyloidogenesis and suggest a novel treatment strategy for other amyloidoses...
  20. pmc Acute-phase-HDL remodeling by heparan sulfate generates a novel lipoprotein with exceptional cholesterol efflux activity from macrophages
    Shui Pang Tam
    Department of Pathology and Molecular Medicine, Queen s University, The Syl and Molly Apps Research Center, Kingston General Hospital, Kingston, Ontario, Canada
    PLoS ONE 3:e3867. 2008
    ..The mechanism may also be of relevance to aspects of atherogenesis...
  21. pmc Inhibition of amyloid A amyloidogenesis in vivo and in tissue culture by 4-deoxy analogues of peracetylated 2-acetamido-2-deoxy-alpha- and beta-d-glucose: implications for the treatment of various amyloidoses
    Robert Kisilevsky
    Department of Pathology, Queen s University and the Syl and Molly Apps Research Center, Kingston General Hospital, Kingston, Ontario, Canada
    Am J Pathol 164:2127-37. 2004
    ..They emphasize that heparan sulfate likely plays a critical role in amyloidogenesis, and compounds that interfere with heparan sulfate biosynthesis may provide leads for the development of anti-amyloid therapeutic agents...
  22. ncbi request reprint A binding site for highly sulfated heparan sulfate is identified in the N terminus of the circumsporozoite protein: significance for malarial sporozoite attachment to hepatocytes
    John B Ancsin
    Department of Pathology and Molecular Medicine, Queen s University and the Syl and Molly Apps Research Center, Kingston General Hospital, Kingston, Ontario Canada, K7L 3N6
    J Biol Chem 279:21824-32. 2004
    ....
  23. ncbi request reprint Biological evaluation of a series of 2-acetamido-2-deoxy-D-glucose analogs towards cellular glycosaminoglycan and protein synthesis in vitro
    Ali Berkin
    Department of Chemistry, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Glycoconj J 22:443-51. 2005
    ..The inability of compound 9 to form a UDP-sugar and, hence, be incorporated into GAGs presents another metabolic route for the inhibition of cellular GAG synthesis. Potential metabolic routes for each analog's effects are presented...
  24. ncbi request reprint Electrophoresis of glycosaminoglycans isolated from normal human plasma. Direct evidence for the presence of a heparin-like molecule
    A D Snow
    Department of Pathology, Queen s University, Kingston, Ontario, Canada
    Biomed Biochim Acta 46:537-46. 1987
    ..In each case, in addition to chondroitin-4-SO4, chondroitin-6-SO4, and heparan-SO4, we were able to show the presence of a band which corresponds to that of heparin...
  25. doi request reprint Serum amyloid A, in vivo splenic cholesterol export and its potential implications in hemolytic disorders
    Chunyan Li
    Department of Pathology and Molecular Medicine, Queens University, Kingston, Ontario, Canada
    Amyloid 15:246-54. 2008
    ....
  26. ncbi request reprint Heparan sulfate as a therapeutic target in amyloidogenesis: prospects and possible complications
    Robert Kisilevsky
    Department of Pathology and Molecular Medicine, Queen s University, Kingston General Hospital, Ontario, Canada
    Amyloid 14:21-32. 2007
    ..Lastly, given the multiple roles that heparan sulfate plays in organ development, and organ and cell function, potential side effects of targeting heparan sulfate biosynthesis for therapeutic purposes are considered...
  27. ncbi request reprint Preparation and propagation of amyloid-enhancing factor
    Robert Kisilevsky
    Department of Pathology and Molecular Medicine, Queen s University and the Syl and Molly Apps Research Center, Kingston General Hospital, Ontario, Canada
    Methods Mol Biol 299:237-41. 2005
    ..The glycerol and AA fibril preparations are stable frozen for many years...
  28. ncbi request reprint The path of murine serum amyloid A through peritoneal macrophages
    Sarah M Kinkley
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada
    Amyloid 13:123-34. 2006
    ..1 is taken up by the cell in significant quantity, and is observed in the nucleus, suggesting that the two isoforms are handled differently and that they may have discrete physiological roles...
  29. pmc In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis
    Jin ping Li
    Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Box 582, SE 751 23 Uppsala, Sweden
    Proc Natl Acad Sci U S A 102:6473-7. 2005
    ..Our findings provide direct in vivo evidence that heparan sulfate is essential for the development of amyloid disease...
  30. ncbi request reprint Affinity binding of glycosaminoglycans with beta(2)-microglobulin
    Kenichi Ohashi
    Department of Pathology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Nephron 90:158-68. 2002
    ..However, the binding characteristics of PGs with beta 2m have not been elucidated yet...
  31. ncbi request reprint Synthesis and biological evaluation of a radiolabeled analog of methyl 2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranoside directed towards influencing cellular glycosaminoglycan biosynthesis
    Ali Berkin
    Department of Chemistry, Queen s University, Kinston, Ont, Canada K7L 3N6
    Carbohydr Res 337:37-44. 2002
    ..The mechanism of inhibition of glycosaminoglycan biosynthesis is due, in part, to the incorporation of a 4-deoxy moiety into glycosaminoglycan chains resulting in premature chain termination...
  32. ncbi request reprint IX International Symposium on Amyloidosis, July 15-21, 2001, Budapest, Hungary
    Jean D Sipe
    Tissue Engineering Study Section, Center for Scientific Review, National Institutes of Health, Bethesda, MD 20892 7814, USA
    Amyloid 9:52-65. 2002
  33. pmc Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro
    Rebecca L Hull
    Division of Metabolism, Endocrinology, and Nutrition, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    Am J Physiol Cell Physiol 293:C1586-93. 2007
    ....
  34. ncbi request reprint Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality
    Jin ping Li
    Department of Medical Biochemistry and Microbiology, University of Uppsala, The Biomedical Center, Box 582, SE 751 23 Uppsala, Sweden
    J Biol Chem 278:28363-6. 2003
    ..By contrast, major early developmental events known to critically depend on heparan sulfate apparently proceed normally even in the absence of IdoA...
  35. ncbi request reprint AA protein in experimental murine AA amyloid fibrils: a high resolution ultrastructural and immunohistochemical study comparing aldehyde-fixed and cryofixed tissues
    Sadayuk Inoue
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    Amyloid 9:115-25. 2002
    ..This information shoulld be of considerable value in comparing the structure of amyloid fibrils observed in situ with those isolated from tissue or generated in vitro...