Glenville Jones

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. ncbi Vitamin D analogs
    Glenville Jones
    Department of Biochemistry Queen s University, Kingston, Ontario, Canada K7L 3N6
    Endocrinol Metab Clin North Am 39:447-72, table of contents. 2010
  2. ncbi 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D
    Glenville Jones
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, ON, Canada K7L 3N6
    Arch Biochem Biophys 523:9-18. 2012
  3. ncbi Metabolism and biomarkers of vitamin D
    Glenville Jones
    Department of Biomedical and Molecular Sciences, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Scand J Clin Lab Invest Suppl 243:7-13. 2012
  4. ncbi Vitamin D analogs
    Glenville Jones
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    Rheum Dis Clin North Am 38:207-32, xi. 2012
  5. ncbi Pharmacokinetics of vitamin D toxicity
    Glenville Jones
    Departments of Biochemistry and Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Clin Nutr 88:582S-586S. 2008
  6. ncbi Hepatic activation and inactivation of clinically-relevant vitamin D analogs and prodrugs
    Glenville Jones
    Department of Biochemistry, Queen s University, Kingston, ON, Canada
    Anticancer Res 26:2589-95. 2006
  7. ncbi Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone
    David E Prosser
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    Proc Natl Acad Sci U S A 104:12673-8. 2007
  8. ncbi Altered pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouse
    Sonoko Masuda
    Department of Biochemistry, Queen s University, Kingston Ontario, Canada K7L 3N6
    Endocrinology 146:825-34. 2005
  9. ncbi Selective conversion by microglia of dehydroepiandrosterone to 5-androstenediol-A steroid with inherent estrogenic properties
    Peter H Jellinck
    Department of Biochemistry, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Steroid Biochem Mol Biol 107:156-62. 2007
  10. ncbi Dehydroepiandrosterone (DHEA) metabolism in the brain: identification by liquid chromatography/mass spectrometry of the delta-4-isomer of DHEA and related steroids formed from androstenedione by mouse BV2 microglia
    Peter H Jellinck
    Department of Biochemistry, Queen's University, Kingston, Ont, Canada K7L 3N6
    J Steroid Biochem Mol Biol 98:41-7. 2006

Collaborators

Detail Information

Publications34

  1. ncbi Vitamin D analogs
    Glenville Jones
    Department of Biochemistry Queen s University, Kingston, Ontario, Canada K7L 3N6
    Endocrinol Metab Clin North Am 39:447-72, table of contents. 2010
    ..This review will discuss the full range of vitamin D compounds currently available, some of their possible uses, and potential mechanisms of action...
  2. ncbi 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D
    Glenville Jones
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, ON, Canada K7L 3N6
    Arch Biochem Biophys 523:9-18. 2012
    ..This review concludes by evaluating the potential clinical utility of blocking this enzyme with CYP24A1 inhibitors in various disease states...
  3. ncbi Metabolism and biomarkers of vitamin D
    Glenville Jones
    Department of Biomedical and Molecular Sciences, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Scand J Clin Lab Invest Suppl 243:7-13. 2012
    ..The review will end by discussing the appropriate biomarkers to assess vitamin D metabolism and vitamin D status in various clinical disease settings...
  4. ncbi Vitamin D analogs
    Glenville Jones
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    Rheum Dis Clin North Am 38:207-32, xi. 2012
    ..This review will discuss the full range of vitamin D compounds currently available, some of their possible uses, and potential mechanisms of action...
  5. ncbi Pharmacokinetics of vitamin D toxicity
    Glenville Jones
    Departments of Biochemistry and Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Clin Nutr 88:582S-586S. 2008
    ....
  6. ncbi Hepatic activation and inactivation of clinically-relevant vitamin D analogs and prodrugs
    Glenville Jones
    Department of Biochemistry, Queen s University, Kingston, ON, Canada
    Anticancer Res 26:2589-95. 2006
    ..The implications of hepatic metabolism in the context of other facets thought to play a role in the mechanism of action of anticancer and antiproliferative vitamin D analogs are discussed...
  7. ncbi Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone
    David E Prosser
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    Proc Natl Acad Sci U S A 104:12673-8. 2007
    ..We discuss the physiological ramifications of these results for species possessing the A326G substitution, as well as implications for optimal vitamin D analog design...
  8. ncbi Altered pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouse
    Sonoko Masuda
    Department of Biochemistry, Queen s University, Kingston Ontario, Canada K7L 3N6
    Endocrinology 146:825-34. 2005
    ..These results suggest that the absence of CYP24A1 or VDR retards catabolism of 1alpha,25(OH)2D3 and 25(OH)D3, reinforcing the physiological importance of CYP24A1 in vitamin D homeostasis...
  9. ncbi Selective conversion by microglia of dehydroepiandrosterone to 5-androstenediol-A steroid with inherent estrogenic properties
    Peter H Jellinck
    Department of Biochemistry, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Steroid Biochem Mol Biol 107:156-62. 2007
    ..Our findings suggest that the microglia-produced Delta(5)-Adiol might have a role in modulating estrogen-sensitive neuroplastic events in the brain, in the absence of adequate local synthesis of estrone and estradiol...
  10. ncbi Dehydroepiandrosterone (DHEA) metabolism in the brain: identification by liquid chromatography/mass spectrometry of the delta-4-isomer of DHEA and related steroids formed from androstenedione by mouse BV2 microglia
    Peter H Jellinck
    Department of Biochemistry, Queen's University, Kingston, Ont, Canada K7L 3N6
    J Steroid Biochem Mol Biol 98:41-7. 2006
    ..Possible mechanisms for the formation of this isomer of DHEA by BV2 microglia are proposed, together with that of other C-19 steroids detected which include testosterone (T), 5alpha-dihydrotestosterone and 5alpha-androstanedione...
  11. ncbi Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2
    Sonoko Masuda
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Biochim Biophys Acta 1761:221-34. 2006
    ....
  12. ncbi Insights into Vitamin D metabolism using cyp24 over-expression and knockout systems in conjunction with liquid chromatography/mass spectrometry (LC/MS)
    Sonoko Masuda
    Department of Biochemistry, Queen s University, Kingston, Ont, Canada
    J Steroid Biochem Mol Biol 89:149-53. 2004
    ..Similar experiments using the same wild type and CYP24-XO animals and cells and [3H] 1alpha-OH-D2 resulted in the apparent paradox that the Vitamin D prodrug was 25-hydroxylated in vivo but 24-hydroxylated in vitro...
  13. ncbi Generation of a homology model for the human cytochrome P450, CYP24A1, and the testing of putative substrate binding residues by site-directed mutagenesis and enzyme activity studies
    Sonoko Masuda
    Department of Biochemistry, Queen s University, Kingston, ON, Canada K7L 3N6
    Arch Biochem Biophys 460:177-91. 2007
    ..Our findings validate the new model of CYP24A1, which can now be used to predict structural modifications for rational vitamin D drug design...
  14. ncbi CYP24A1 and kidney disease
    Martin Petkovich
    Division of Cancer Biology and Genetics, Cancer Research Institute, Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    Curr Opin Nephrol Hypertens 20:337-44. 2011
    ..This review focuses on the biochemistry and pathophysiology of CYP24A1 and the utility of blocking this enzyme with CYP24A1 inhibitors in chronic kidney disease (CKD) patients...
  15. ncbi Bioengineering anabolic vitamin D-25-hydroxylase activity into the human vitamin D catabolic enzyme, cytochrome P450 CYP24A1, by a V391L mutation
    Martin Kaufmann
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Biol Chem 286:28729-37. 2011
    ....
  16. ncbi Structural motif-based homology modeling of CYP27A1 and site-directed mutational analyses affecting vitamin D hydroxylation
    David E Prosser
    Department of Biochemistry, Queen's University, Kingston, Ontario, Canada
    Biophys J 90:3389-409. 2006
    ..Mutations directed toward the beta-3a strand suggested a possible heme-binding interaction centered on Asn-403 and a structural role for substrate contact residues Thr-402 and Ser-404...
  17. ncbi Promise of vitamin D analogues in the treatment of hyperproliferative conditions
    Sonoko Masuda
    Department of Biochemistry, Queen's University, Kingston, Ontario, Canada K7L 3N6
    Mol Cancer Ther 5:797-808. 2006
    ....
  18. ncbi Enzymes involved in the activation and inactivation of vitamin D
    David E Prosser
    Department of Biochemistry, Queen's University, Kingston, Ontario, Canada K7L 3N6
    Trends Biochem Sci 29:664-73. 2004
    ....
  19. ncbi Importance of cytochrome P450-mediated metabolism in the mechanism of action of vitamin D analogs
    Sonoko Masuda
    Department of Biochemistry, Queen's University, Kingston, ON K7L 3N6, Canada
    Recent Results Cancer Res 164:189-202. 2003
    ..We conclude by placing metabolic considerations in the context of the other important aspects of vitamin D analogs...
  20. ncbi Expanding role for vitamin D in chronic kidney disease: importance of blood 25-OH-D levels and extra-renal 1alpha-hydroxylase in the classical and nonclassical actions of 1alpha,25-dihydroxyvitamin D(3)
    Glenville Jones
    Departments of Biochemistry and Medicine, Queen s University, Kingston, Ontario, Canada
    Semin Dial 20:316-24. 2007
    ..Physicians must start to manage the vitamin D insufficiency by vitamin D supplements throughout stages 1-5 whilst continuing to provide calcitriol replacement therapy, in the form of calcitriol or its analogs, in stages 3-5...
  21. ncbi Influence of 1,25-dihydroxy vitamin D3 on TLR4-induced activation of antigen presenting cells is dependent on the order of receptor engagement
    Vandana Gambhir
    Department of Microbiology and Immunology, Queen s University, Kingston, Ontario, Canada
    Immunobiology 216:988-96. 2011
    ..Consequently, engagement of VDR by 1,25-(OH)ā‚‚Dā‚ƒ can partially interfere with TLR-4-L-induced activation of pAPCs only when it occurs before TLR-4 stimulation...
  22. ncbi Structural analysis of CYP2R1 in complex with vitamin D3
    Natallia Strushkevich
    Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
    J Mol Biol 380:95-106. 2008
    ..The structure reveals the secosteroid binding mode in an extended active site and allows rationalization of the molecular basis of the inherited rickets associated with CYP2R1...
  23. ncbi Metabolism of dehydroepiandrosterone by rodent brain cell lines: relationship between 7-hydroxylation and aromatization
    Peter H Jellinck
    Department of Biochemistry, Queen's University Kingston, Ont, Canada K7L 3N6
    J Steroid Biochem Mol Biol 93:81-6. 2005
    ..Some could exert their effects by converting DHEA to its 7-hydroxylated form while others, like BV2 microglia, by converting DHEA primarily to other C-19 steroids and to estrogen by way of AD...
  24. ncbi Secondary hyperparathyroidism in primary osteoporosis and osteopenia: optimizing calcium and vitamin D intakes to levels recommended by expert panels may not be sufficient for correction
    Edmund R Yendt
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Clin Endocrinol (Oxf) 69:855-63. 2008
    ....
  25. ncbi Oxidation of vinyl carbamate and formation of 1,N6-ethenodeoxyadenosine in murine lung
    Poh Gek Forkert
    Department of Anatomy and Cell Biology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Drug Metab Dispos 35:713-20. 2007
    ..0 mM. These findings suggested that CYP2E1 is a major enzyme mediating VC oxidation, leading to the formation of a metabolite that alkylates DNA to form the epsilon dAS adduct...
  26. ncbi Contemporary diagnosis and treatment of vitamin D-related disorders
    Glenville Jones
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    J Bone Miner Res 22:V11-5. 2007
    ....
  27. ncbi Use of vitamin D(4) analogs to investigate differences in hepatic and target cell metabolism of vitamins D(2) and D(3)
    Valarie Byford
    Department of Biochemistry, Queen's University, Kingston, Ontario, Canada
    Biochim Biophys Acta 1583:151-66. 2002
    ..We conclude that vitamin D(4) analogs and their metabolites offer valuable insights into vitamin D analog design, metabolic enzymes and maybe useful clinically...
  28. ncbi Locust retinoid X receptors: 9-Cis-retinoic acid in embryos from a primitive insect
    Shaun M Nowickyj
    Departments of Biology, Biochemistry, Pathology, and Medicine, Queen s University, Kingston, ON, Canada K7L 3N6
    Proc Natl Acad Sci U S A 105:9540-5. 2008
    ..These findings strongly argue for a functional role for retinoids in primitive insects and favor a model where signaling through the binding of 9-cis-RA to its RXR is established relatively early in evolution and embryonic development...
  29. ncbi HPLC-MS/MS analysis of the products generated from all-trans-retinoic acid using recombinant human CYP26A
    James V Chithalen
    Department of Biochemistry, Queen's University, Kingston, ON, K7L 3N6, Canada
    J Lipid Res 43:1133-42. 2002
    ..Both initial and secondary metabolic steps after 4-oxo-all-trans-retinoic acid are ketoconazole-sensitive, suggesting that steps in the production of water-soluble metabolites are cytochrome P450-dependent...
  30. ncbi Vitamin D analogs--drug design based on proteins involved in vitamin D signal transduction
    Sonoko Masuda
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Curr Drug Targets Immune Endocr Metabol Disord 3:43-66. 2003
    ....
  31. ncbi CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids
    Samuel S Chuang
    Cytochroma, Inc, Markham, Ontario L3R 8E4, Canada
    J Biol Chem 279:6305-14. 2004
    ..Based on the ability of CYP2U1 to generate bioactive eicosanoid derivatives, we postulate that CYP2U1 plays an important physiological role in fatty acid signaling processes in both cerebellum and thymus...
  32. ncbi Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1alpha,25-dihydroxyvitamin D3
    Gary H Posner
    Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218 2685, USA
    J Steroid Biochem Mol Biol 89:5-12. 2004
    ..The new 24-phenylsulfone 4a, a low-calcemic analog of the natural hormone 1alpha,25-dihydroxyvitamin D(3), is a potent (IC(50) = 28nM) and highly selective inhibitor of the human 24-hydroxylase enzyme CYP24...
  33. ncbi 1,25(OH)2D, the preferred substrate for CYP24
    Glenville Jones
    J Bone Miner Res 17:179-81. 2002
  34. ncbi Hepatic osteodystrophy in chronic cholestasis: evidence for a multifactorial etiology
    Gordon L Klein
    Pediatric Gastroenterology Division, Children s Hospital, University of Texas Medical Branch, Galveston TX 77555 0352, USA
    Pediatr Transplant 6:136-40. 2002
    ....