Rachel M Holden

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. pmc Vitamin K status in chronic kidney disease
    Kristin M McCabe
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, ON K7L 3V6, Canada
    Nutrients 5:4390-8. 2013
  2. doi request reprint Fat-soluble vitamins in advanced CKD/ESKD: a review
    Rachel M Holden
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Semin Dial 25:334-43. 2012
  3. doi request reprint FGF-23 is associated with cardiac troponin T and mortality in hemodialysis patients
    Rachel M Holden
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Hemodial Int 16:53-8. 2012
  4. pmc Major bleeding in hemodialysis patients
    Rachel M Holden
    Division of Nephrology, Queen s University, Kingston, Ontario, Canada
    Clin J Am Soc Nephrol 3:105-10. 2008
  5. ncbi request reprint Vascular calcification in chronic kidney disease: the role of vitamin K
    Rachel M Holden
    Queen s University, Department of Medicine, Kingston, ON, Canada
    Nat Clin Pract Nephrol 3:522-3. 2007
  6. ncbi request reprint Warfarin and aortic valve calcification in hemodialysis patients
    Rachel M Holden
    Division of Nephrology, Queen s University, Kingston, Ontario, Canada
    J Nephrol 20:417-22. 2007
  7. pmc Vitamins K and D status in stages 3-5 chronic kidney disease
    Rachel M Holden
    3048C Etherington Hall, Queen s University, Kingston, ON, Canada K7L 3V6
    Clin J Am Soc Nephrol 5:590-7. 2010
  8. doi request reprint Dietary vitamin K and therapeutic warfarin alter the susceptibility to vascular calcification in experimental chronic kidney disease
    Kristin M McCabe
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, Ontario, Canada
    Kidney Int 83:835-44. 2013
  9. doi request reprint Systematic review and meta-analysis of incidence, prevalence and outcomes of atrial fibrillation in patients on dialysis
    Deborah Zimmerman
    Department of Medicine, Ottawa Hospital, University of Ottawa, Canada
    Nephrol Dial Transplant 27:3816-22. 2012
  10. pmc Associations of epicardial fat with coronary calcification, insulin resistance, inflammation, and fibroblast growth factor-23 in stage 3-5 chronic kidney disease
    Jasmine D Kerr
    Department of Medicine, Queen s University, Kingston, ON, Canada
    BMC Nephrol 14:26. 2013

Collaborators

Detail Information

Publications23

  1. pmc Vitamin K status in chronic kidney disease
    Kristin M McCabe
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, ON K7L 3V6, Canada
    Nutrients 5:4390-8. 2013
    ..It also describes two current clinical trials that are underway evaluating vitamin K treatment in CKD patients. These data may inform future clinical practice in this population. ..
  2. doi request reprint Fat-soluble vitamins in advanced CKD/ESKD: a review
    Rachel M Holden
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Semin Dial 25:334-43. 2012
    ..The purpose of this study was to summarize the current state of knowledge regarding the status of the fat-soluble vitamins (A, D, E, and K) in patients with chronic kidney disease receiving hemodialysis...
  3. doi request reprint FGF-23 is associated with cardiac troponin T and mortality in hemodialysis patients
    Rachel M Holden
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Hemodial Int 16:53-8. 2012
    ..Whether this relationship supports the possibility that a downstream effect of dysregulated phosphorous homeostasis may be enhanced cardiac remodeling requires further study...
  4. pmc Major bleeding in hemodialysis patients
    Rachel M Holden
    Division of Nephrology, Queen s University, Kingston, Ontario, Canada
    Clin J Am Soc Nephrol 3:105-10. 2008
    ..Few studies have examined risk factors for hemorrhage in hemodialysis patients. The contribution of warfarin and antiplatelet agent exposure to the incidence of first major bleeding episodes in hemodialysis patients was determined...
  5. ncbi request reprint Vascular calcification in chronic kidney disease: the role of vitamin K
    Rachel M Holden
    Queen s University, Department of Medicine, Kingston, ON, Canada
    Nat Clin Pract Nephrol 3:522-3. 2007
  6. ncbi request reprint Warfarin and aortic valve calcification in hemodialysis patients
    Rachel M Holden
    Division of Nephrology, Queen s University, Kingston, Ontario, Canada
    J Nephrol 20:417-22. 2007
    ..This retrospective cohort study was designed to determine the association between long-term exposure to warfarin and severity of aortic valve (AV) calcification in hemodialysis (HD) patients...
  7. pmc Vitamins K and D status in stages 3-5 chronic kidney disease
    Rachel M Holden
    3048C Etherington Hall, Queen s University, Kingston, ON, Canada K7L 3V6
    Clin J Am Soc Nephrol 5:590-7. 2010
    ..Vitamin K, vitamin K-dependent proteins, and vitamin D may be involved in the regulation of calcification in chronic kidney disease (CKD)...
  8. doi request reprint Dietary vitamin K and therapeutic warfarin alter the susceptibility to vascular calcification in experimental chronic kidney disease
    Kristin M McCabe
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, Ontario, Canada
    Kidney Int 83:835-44. 2013
    ..Thus, vitamin K has an important role in modifying mechanisms linked to the susceptibility of arteries to calcify in an experimental model of CKD...
  9. doi request reprint Systematic review and meta-analysis of incidence, prevalence and outcomes of atrial fibrillation in patients on dialysis
    Deborah Zimmerman
    Department of Medicine, Ottawa Hospital, University of Ottawa, Canada
    Nephrol Dial Transplant 27:3816-22. 2012
    ..The risks and benefits of warfarin anticoagulation need to be defined as the risk of bleeding in ESRD patients may overwhelm the benefits of embolic stroke prevention. We undertook a systematic literature review to clarify these issues...
  10. pmc Associations of epicardial fat with coronary calcification, insulin resistance, inflammation, and fibroblast growth factor-23 in stage 3-5 chronic kidney disease
    Jasmine D Kerr
    Department of Medicine, Queen s University, Kingston, ON, Canada
    BMC Nephrol 14:26. 2013
    ..Our primary objective was to determine the association between ssEFV and coronary artery calcification (CAC)...
  11. doi request reprint Body mass index, coronary artery calcification, and kidney function decline in stage 3 to 5 chronic kidney disease patients
    Jocelyn S Garland
    Division of Nephrology, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    J Ren Nutr 23:4-11. 2013
    ..To determine whether body mass index (BMI) and coronary artery calcification (CAC) are risk factors for kidney function decline in predialysis chronic kidney disease (CKD) patients...
  12. doi request reprint Is the calcium correct? Measuring serum calcium in dialysis patients
    A Ross Morton
    Division of Nephrology, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Semin Dial 23:283-9. 2010
    ..This review examines the merits of making any adjustment to the total calcium measurement, and suggests when it is appropriate to measure the ionized or free calcium...
  13. doi request reprint Prevalence and associations of coronary artery calcification in patients with stages 3 to 5 CKD without cardiovascular disease
    Jocelyn S Garland
    Department of Medicine, Division of Nephrology, Ontario, Canada
    Am J Kidney Dis 52:849-58. 2008
    ..Existing studies are confounded by the inclusion of patients who may not have CKD by means of diagnostic criteria and by failing to account for existing cardiovascular disease...
  14. pmc Antiplatelet medications in hemodialysis patients: a systematic review of bleeding rates
    Swapnil Hiremath
    Division of Nephrology, University of Ottawa, Kidney Research Centre, Ottawa, Ontario, Canada
    Clin J Am Soc Nephrol 4:1347-55. 2009
    ..However, these patients are also at increased risk of bleeding compared with the general population, and an aim was made to quantify this risk with antiplatelet agents...
  15. doi request reprint Insulin resistance is associated with Fibroblast Growth Factor-23 in stage 3-5 chronic kidney disease patients
    Jocelyn S Garland
    Department of Medicine, Queen s University, Kingston, ON, Canada Queen s University Vascular Calcification Investigators, Queen s University, Kingston, ON, Canada Electronic address
    J Diabetes Complications 28:61-5. 2014
    ..To determine the associations between insulin resistance, fibroblast growth factor 23 (FGF-23), and coronary artery calcification (CAC) in chronic kidney disease (CKD) patients...
  16. doi request reprint Use of warfarin in people with low glomerular filtration rate or on dialysis
    Rachel M Holden
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Semin Dial 22:503-11. 2009
    ..It is possible that it may contribute also to accelerated vascular calcification. Large randomized studies are needed to assess the risk-benefit ratio of warfarin in people with low GFR or on dialysis for a range of indications...
  17. doi request reprint Should patients with advanced chronic kidney disease and atrial fibrillation receive chronic anticoagulation?
    Catherine M Clase
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Nephrol Dial Transplant 27:3719-24. 2012
    ..Randomized trials of new agents are needed in this area...
  18. doi request reprint Statins are associated with a reduced risk of bone fracture in hemodialysis (HD) patients
    Robert Nichols
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Hemodial Int 12:275-9. 2008
    ..007), and absence of statin exposure (p=0.019). Statin exposure appears to be associated with a reduced frequency of bone fracture in HD patients. Future studies evaluating the potential anabolic effect of statins on bone are required...
  19. ncbi request reprint Warfarin anticoagulation in hemodialysis patients: a systematic review of bleeding rates
    Meghan J Elliott
    Division of Nephrology, Queen s University, Kingston, Ontario, Canada
    Am J Kidney Dis 50:433-40. 2007
    ..Despite common use of warfarin, the bleeding risk associated with this treatment in hemodialysis (HD) patients is unknown...
  20. doi request reprint Vascular calcification in animal models of CKD: A review
    Navid Shobeiri
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ont, Canada
    Am J Nephrol 31:471-81. 2010
    ..In summary, animal models are useful to study CKD-associated vascular calcification and the results obtained in these pre-clinical animal studies appear to translate to the evidence, however limited, which exists in humans with CKD...
  21. doi request reprint Phosphate: an old bone molecule but new cardiovascular risk factor
    Navid Shobeiri
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, ON, Canada
    Br J Clin Pharmacol 77:39-54. 2014
    ..e. osteoblasts and vascular smooth muscle cells) as well as pathological consequences of hyperphosphataemia. Finally, conventional as well as new and experimental therapeutics in the treatment of hyperphosphataemia are explored. ..
  22. doi request reprint Water-soluble vitamins in people with low glomerular filtration rate or on dialysis: a review
    Catherine M Clase
    Department of Medicine, McMaster University, Hamilton, ON, Canada Department of Clinical Epidemiology, McMaster University, Hamilton, ON, Canada
    Semin Dial 26:546-67. 2013
    ..Vitamins for dialysis patients contain most or all of the B vitamins and low-dose vitamin C. We are not aware of any medical reasons to choose one over another. ..
  23. doi request reprint Cardiovascular disease in an adenine-induced model of chronic kidney disease: the temporal link between vascular calcification and haemodynamic consequences
    Navid Shobeiri
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, Ontario, Canada
    J Hypertens 31:160-8. 2013
    ..This study characterizes the time course and the link between calcification of major arteries, changes in blood pressure (BP) and cardiac growth in experimental CKD...