D K Heyland

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. ncbi End-of-life care in acute care hospitals in Canada: a quality finish?
    Daren K Heyland
    Department of Medicine, Kingston General Hospital, Ontario, Canada
    J Palliat Care 21:142-50. 2005
  2. pmc A long-term follow-up study investigating health-related quality of life and resource use in survivors of severe sepsis: comparison of recombinant human activated protein C with standard care
    Christopher J Longo
    McMaster University, Main Street West, Hamilton, Ontario, Canada, L8S 4M4
    Crit Care 11:R128. 2007
  3. pmc Longitudinal increases in mitochondrial DNA levels in blood cells are associated with survival in critically ill patients
    Helene C F Cote
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada V6T 2B5
    Crit Care 11:R88. 2007
  4. pmc Reduction of nosocomial pneumonia after major burns by trace element supplementation: aggregation of two randomised trials
    Mette M Berger
    Department of Adult Intensive Care Medicine and Burn Centre, Centre Hospitalier Universitaire Vaudois CHUV, Rue du Bugnon 46, 1011 Lausanne, Switzerland
    Crit Care 10:R153. 2006
  5. pmc Selenium supplementation in critically ill patients: can too much of a good thing be a bad thing?
    Daren K Heyland
    Crit Care 11:153. 2007
  6. ncbi Decision-making in the ICU: perspectives of the substitute decision-maker
    Daren K Heyland
    Department of Medicine, Angada 3, Kingston General Hospital, Ontario, Canada
    Intensive Care Med 29:75-82. 2003
  7. ncbi Nutrition support in the critical care setting: current practice in canadian ICUs--opportunities for improvement?
    Daren K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    JPEN J Parenter Enteral Nutr 27:74-83. 2003
  8. ncbi The seriously ill hospitalized patient: preferred role in end-of-life decision making?
    Daren K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    J Crit Care 18:3-10. 2003
  9. ncbi Dying in the ICU: perspectives of family members
    Daren K Heyland
    Department of Medicine, Kingston General Hospital, Kingston, ON, Canada
    Chest 124:392-7. 2003
  10. ncbi Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients
    Daren K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    JPEN J Parenter Enteral Nutr 27:355-73. 2003

Detail Information

Publications79

  1. ncbi End-of-life care in acute care hospitals in Canada: a quality finish?
    Daren K Heyland
    Department of Medicine, Kingston General Hospital, Ontario, Canada
    J Palliat Care 21:142-50. 2005
    ..Improvement initiatives to target key elements identified by patients and FCGs have the potential to improve satisfaction with EOL care across care settings...
  2. pmc A long-term follow-up study investigating health-related quality of life and resource use in survivors of severe sepsis: comparison of recombinant human activated protein C with standard care
    Christopher J Longo
    McMaster University, Main Street West, Hamilton, Ontario, Canada, L8S 4M4
    Crit Care 11:R128. 2007
    ..The objective of this study was to evaluate prospectively the effect of APC on long-term HRQoL and resource utilization compared with a nonrandomized control group that received standard care...
  3. pmc Longitudinal increases in mitochondrial DNA levels in blood cells are associated with survival in critically ill patients
    Helene C F Cote
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada V6T 2B5
    Crit Care 11:R88. 2007
    ..Decreased mitochondrial DNA (mtDNA) levels have been associated with mitochondrial dysfunction and were investigated here in relation to short-term (31-day) survival...
  4. pmc Reduction of nosocomial pneumonia after major burns by trace element supplementation: aggregation of two randomised trials
    Mette M Berger
    Department of Adult Intensive Care Medicine and Burn Centre, Centre Hospitalier Universitaire Vaudois CHUV, Rue du Bugnon 46, 1011 Lausanne, Switzerland
    Crit Care 10:R153. 2006
    ..Burned patients suffer trace element deficiencies and depressed antioxidant and immune defences. This study aimed at determining the effect of trace element supplementation on nosocomial or intensive care unit (ICU)-acquired pneumonia...
  5. pmc Selenium supplementation in critically ill patients: can too much of a good thing be a bad thing?
    Daren K Heyland
    Crit Care 11:153. 2007
    ..Perhaps the key to understanding the differences between these discrepant observations lies in considering the dose and timing of selenium administration...
  6. ncbi Decision-making in the ICU: perspectives of the substitute decision-maker
    Daren K Heyland
    Department of Medicine, Angada 3, Kingston General Hospital, Ontario, Canada
    Intensive Care Med 29:75-82. 2003
    ..To describe the substitute decision-makers' perspectives related to decision-making in the intensive care unit (ICU) and to determine those variables associated with their overall satisfaction with decision-making...
  7. ncbi Nutrition support in the critical care setting: current practice in canadian ICUs--opportunities for improvement?
    Daren K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    JPEN J Parenter Enteral Nutr 27:74-83. 2003
    ..The purpose of this project was to describe current nutrition support practice in the critical care setting and to identify interventions to target for quality improvement initiatives...
  8. ncbi The seriously ill hospitalized patient: preferred role in end-of-life decision making?
    Daren K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    J Crit Care 18:3-10. 2003
    ..Specifically, we ascertained the seriously ill patients' preferred role in the decision-making process, what factors were associated with this role, and how this stated preference related to physicians' perception of preferred role...
  9. ncbi Dying in the ICU: perspectives of family members
    Daren K Heyland
    Department of Medicine, Kingston General Hospital, Kingston, ON, Canada
    Chest 124:392-7. 2003
    ..To describe the perspectives of family members to the care provided to critically ill patients who died in the ICU...
  10. ncbi Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients
    Daren K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    JPEN J Parenter Enteral Nutr 27:355-73. 2003
    ..This study was conducted to develop evidence-based clinical practice guidelines for nutrition support (ie, enteral and parenteral nutrition) in mechanically ventilated critically ill adults...
  11. ncbi Antioxidant nutrients: a systematic review of trace elements and vitamins in the critically ill patient
    Daren K Heyland
    Department of Medicine, Queen s University, Kingston, Ont, Canada
    Intensive Care Med 31:327-37. 2005
    ..We investigated whether supplementing critically ill patients with antioxidants, trace elements, and vitamins improves their survival...
  12. ncbi Nutrition and infection in the intensive care unit: what does the evidence show?
    Rupinder Dhaliwal
    Department of Medicine, Queen s University Kingston, Ontario, Canada
    Curr Opin Crit Care 11:461-7. 2005
    ..The newly published data will be used to update the Canadian Clinical Practice Guidelines...
  13. pmc What matters most in end-of-life care: perceptions of seriously ill patients and their family members
    Daren K Heyland
    Department of Medicine, Kingston General Hospital, Kingston, Ont
    CMAJ 174:627-33. 2006
    ..The primary purpose of this study was to describe what seriously ill patients in hospital and their family members consider to be the key elements of quality end-of-life care...
  14. ncbi REducing Deaths due to OXidative Stress (The REDOXS Study): Rationale and study design for a randomized trial of glutamine and antioxidant supplementation in critically-ill patients
    Daren K Heyland
    Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, Ontario K7L 2V7, Canada
    Proc Nutr Soc 65:250-63. 2006
    ..The trial will be conducted in approximately twenty tertiary-care ICU in Canada and the first results are expected in 2009...
  15. ncbi Optimizing the dose of glutamine dipeptides and antioxidants in critically ill patients: a phase I dose-finding study
    Daren K Heyland
    Kingston General Hospital Queen s University, Kingston, Ontario, Canada
    JPEN J Parenter Enteral Nutr 31:109-18. 2007
    ..The purpose of this study was to determine the safety of high doses of glutamine combined with antioxidants in critically ill patients...
  16. ncbi Optimizing the benefits and minimizing the risks of enteral nutrition in the critically ill: role of small bowel feeding
    Daren K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    JPEN J Parenter Enteral Nutr 26:S51-5; discussion S56-7. 2002
    ..The purpose of this paper is to systematically review those studies that compare gastric with small bowel feeding...
  17. ncbi Family satisfaction with care in the intensive care unit: results of a multiple center study
    Daren K Heyland
    Departments of Medicine, Kingston General Hospital, Kingston, Ontario, Canada
    Crit Care Med 30:1413-8. 2002
    ..To determine the level of satisfaction of family members with the care that they and their critically ill relative received...
  18. ncbi The effect of acidified enteral feeds on gastric colonization in critically ill patients: results of a multicenter randomized trial. Canadian Critical Care Trials Group
    D K Heyland
    Department of Medicine, Queen s University, Kingston, ON, Canada
    Crit Care Med 27:2399-406. 1999
    ..To evaluate the effect of acidified enteral feeds on gastric colonization in critically ill patients compared with a standard feeding formula...
  19. ncbi Effect of postpyloric feeding on gastroesophageal regurgitation and pulmonary microaspiration: results of a randomized controlled trial
    D K Heyland
    Department of Medicine, Kingston General Hospital, Queen s University, 76 Stuart Street, Kingston, Ontario, KVL 2V7, Canada
    Crit Care Med 29:1495-501. 2001
    ..To determine the extent to which postpyloric feeding reduces gastroesophageal regurgitation and pulmonary microaspiration in critically ill patients...
  20. ncbi Total parenteral nutrition in the surgical patient: a meta-analysis
    D K Heyland
    Department of Medicine, Queen s University, Kingston, Ont
    Can J Surg 44:102-11. 2001
    ..To examine the relationship between total parenteral nutrition(TPN) and complication and death rates in surgical patients...
  21. ncbi Should immunonutrition become routine in critically ill patients? A systematic review of the evidence
    D K Heyland
    Angada 3, Kingston General Hospital, 76 Stuart St, Kingston, Ontario K7L 2V7, Canada
    JAMA 286:944-53. 2001
    ..Several nutrients have been shown to influence immunologic and inflammatory responses in humans. Whether these effects translate into an improvement in clinical outcomes in critically ill patients remains unclear...
  22. ncbi Long-term health-related quality of life in survivors of sepsis. Short Form 36: a valid and reliable measure of health-related quality of life
    D K Heyland
    Department of Medicine, Queen s University, Kingston, ON
    Crit Care Med 28:3599-605. 2000
    ..To describe the long-term health-related quality of life (HRQL) of survivors of sepsis and to evaluate the reliability and validity of the medical outcomes study Short Form-36 (SF-36) in this population...
  23. ncbi Do potential patients prefer tissue plasminogen activator (TPA) over streptokinase (SK)? An evaluation of the risks and benefits of TPA from the patient's perspective
    D K Heyland
    Department of Medicine, Queen s University, Ontario, Kingston, Canada
    J Clin Epidemiol 53:888-94. 2000
    ..Our hypothesis is that, for many informed individuals, regardless of cost, the increased risk of stroke may deter them from selecting TPA over SK...
  24. ncbi Prevention of ventilator-associated pneumonia: current practice in Canadian intensive care units
    Daren K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    J Crit Care 17:161-7. 2002
    ..To evaluate the current use of strategies to prevent ventilator-associated pneumonia (VAP) and to identify interventions to target for quality-improvement initiatives...
  25. ncbi The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient. The Canadian Critical Trials Group
    D K Heyland
    Department of Medicine, Queen s University, Kingston, ON, Canada
    Am J Respir Crit Care Med 159:1249-56. 1999
    ..We conclude that VAP prolongs ICU length of stay and may increase the risk of death in critically ill patients. The attributable risk of VAP appears to vary with patient population and infecting organism...
  26. ncbi The clinical utility of invasive diagnostic techniques in the setting of ventilator-associated pneumonia. Canadian Critical Care Trials Group
    D K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Chest 115:1076-84. 1999
    ..To evaluate the clinical utility of bronchoscopy with protected brush catheter (PBC) and BAL for patients with ventilator-associated pneumonia (VAP)...
  27. ncbi Fluid restriction for postoperative patients?
    Daren K Heyland
    Division of Gastroenterology, Department of Medicine, Queen s University, Kingston, Ontario K7L 5G2, Canada
    Lancet 359:1792-3. 2002
  28. ncbi Parenteral nutrition in the critically-ill patient: more harm than good?
    D K Heyland
    Department of Medicine, Queen s University Faculty of Health Sciences, Kingston, Ontario, Canada
    Proc Nutr Soc 59:457-66. 2000
    ..Further studies are needed to define the optimal timing and composition of PN in patients not tolerating sufficient EN. Strategies to optimize EN delivery and minimize PN utilization in critically-ill patients are indicated...
  29. ncbi Validation of the Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients: results of a prospective observational study
    Daren K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario
    Crit Care Med 32:2260-6. 2004
    ..To validate these guidelines, we hypothesized that intensive care units whose practice, on average, was more consistent with the guidelines would have greater success in providing enteral nutrition...
  30. ncbi Total parenteral nutrition in the critically ill patient: a meta-analysis
    D K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    JAMA 280:2013-9. 1998
    ..Nutritional support has become a standard of care for hospitalized patients, but whether total parenteral nutrition (TPN) affects morbidity and mortality is unclear...
  31. pmc Multicentre, cluster-randomized clinical trial of algorithms for critical-care enteral and parenteral therapy (ACCEPT)
    Claudio M Martin
    Department of Medicine, Faculty of Medicine, University of Western Ontario, London, Ont
    CMAJ 170:197-204. 2004
    ..We tested the hypothesis that evidence-based algorithms to improve nutritional support in the ICU would improve patient outcomes...
  32. ncbi Most critically ill patients are perceived to die in comfort during withdrawal of life support: a Canadian multicentre study
    Graeme M Rocker
    Department of Medicine, Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada
    Can J Anaesth 51:623-30. 2004
    ..Most deaths in intensive care units (ICUs) follow a withdrawal of life support (LS). Evaluation of this process including the related perspectives of grieving family members is integral to improvement of palliation in the ICU...
  33. ncbi Does enteral nutrition compared to parenteral nutrition result in better outcomes in critically ill adult patients? A systematic review of the literature
    Leah Gramlich
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Nutrition 20:843-8. 2004
    ..Because EN and PN are associated with risks and benefits, we systematically reviewed and critically appraised the literature to compare EN with PN the critically ill patient...
  34. ncbi Measuring family satisfaction with care in the intensive care unit: the development of a questionnaire and preliminary results
    D K Heyland
    Department of Medicine, Kingston General Hospital, Kingston, Ontario, Canada
    J Crit Care 16:142-9. 2001
    ..85). CONCLUSIONS: This questionnaire has some measure of reliability and validity and is feasible to administer to next of kin of critically ill patients...
  35. pmc The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients
    D J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care 5:368-75. 2001
    ..To estimate the mortality and length of stay in the intensive care unit (ICU) attributable to clinically important gastrointestinal bleeding in mechanically ventilated critically ill patients...
  36. ncbi In search of the magic nutraceutical: problems with current approaches
    D K Heyland
    Department of Medicine, Queen's University, Kingston, Ontario, Canada
    J Nutr 131:2591S-5S. 2001
    ..Although such trials are costly, they are feasible and are much more likely to be believable and generalizable than the current approach...
  37. ncbi Glutamine supplementation in serious illness: a systematic review of the evidence
    Frantisek Novak
    Department of Medicine, Queens University, Kingston General Hospital, Ontario, Canada
    Crit Care Med 30:2022-9. 2002
    ..To examine the relationship between glutamine supplementation and hospital length of stay, complication rates, and mortality in patients undergoing surgery and experiencing critical illness...
  38. doi Determinants of outcome in patients with a clinical suspicion of ventilator-associated pneumonia
    John G Muscedere
    Department of Medicine, Queen s University, Kingston, Ontario, Canada K7L 2V7
    J Crit Care 23:41-9. 2008
    ..In addition, we studied the impact of the clinical and microbiological components of CSVAP on the processes of care and outcomes...
  39. ncbi Understanding cardiopulmonary resuscitation decision making: perspectives of seriously ill hospitalized patients and family members
    Daren K Heyland
    Department of Medicine, Kingston General Hospital, ON, Canada
    Chest 130:419-28. 2006
    ..To improve communication and decision making related to cardiopulmonary resuscitation (CPR), a greater understanding of the perspectives of hospitalized patients with advanced diseases and their family members are needed...
  40. ncbi Capnography confirms correct feeding tube placement in intensive care unit patients
    A S Kindopp
    Department of Anesthesiology, Queen s University, Kingston, Ontario, Canada
    Can J Anaesth 48:705-10. 2001
    ..To test the accuracy and potential time savings of capnography as compared with a two-step radiographic method in placing feeding tubes in critically ill patients...
  41. ncbi Factors predicting adherence to the Canadian Clinical Practice Guidelines for nutrition support in mechanically ventilated, critically ill adult patients
    Naomi E Jones
    Department of Community Health and Epidemiology, Queen s University, Kingston, ON, Canada
    J Crit Care 23:301-7. 2008
    ..The aim of this study was to determine factors that are associated with adherence to the Canadian nutrition support clinical practice guidelines (CPGs)...
  42. doi The development and validation of a novel questionnaire to measure patient and family satisfaction with end-of-life care: the Canadian Health Care Evaluation Project (CANHELP) Questionnaire
    Daren K Heyland
    Department of Medicine, Kingston General Hospital, Kingston, Ontario, Canada
    Palliat Med 24:682-95. 2010
    ..We conclude that the CANHELP Questionnaire is a valid and internally consistent instrument to measure satisfaction with end-of-life care...
  43. ncbi Satisfaction with end-of-life care: a longitudinal study of patients and their family caregivers in the last months of life
    Daren K Heyland
    Clinical Evaluation Research Unit, Angada 4, Kingston General Hospital, 76 Stuart Street, Kingston, Ontario, Canada K7L 2V7
    J Palliat Care 25:245-56. 2009
    ..Satisfaction with care tends to vary based on location of interview and may vary across time with respect to certain aspects of EOL care...
  44. doi Lost in (knowledge) translation!
    Daren K Heyland
    Department of Community Health and Epidemiology, Queen s University, Kingston, Ontario, Canada
    JPEN J Parenter Enteral Nutr 34:610-5. 2010
    ....
  45. pmc Defining priorities for improving end-of-life care in Canada
    Daren K Heyland
    Department of Medicine, Kingston General Hospital, Kingston, Ont
    CMAJ 182:E747-52. 2010
    ..The objective of this study was to identify aspects of end-of-life care that are high in priority as targets for improvement using feedback elicited from patients and their families...
  46. doi Creating a culture of clinical excellence in critical care nutrition: the 2008 "Best of the Best" award
    Daren K Heyland
    Department of Medicine, Queen s University, Kingston, ON, Canada
    JPEN J Parenter Enteral Nutr 34:707-15. 2010
    ..To develop, validate, and implement a system to reward top performers in critical care nutrition practice and to illuminate characteristics of top-performing intensive care units (ICUs)...
  47. doi Zinc supplementation in critically ill patients: a key pharmaconutrient?
    Daren K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    JPEN J Parenter Enteral Nutr 32:509-19. 2008
    ..Subsequently, large, rigorously designed, randomized trials are required to elucidate the efficacy of such doses of zinc supplementation in this patient population...
  48. pmc Enhanced protein-energy provision via the enteral route in critically ill patients: a single center feasibility trial of the PEP uP protocol
    Daren K Heyland
    Department of Medicine, Queen s University, Kingston, ON, Canada
    Crit Care 14:R78. 2010
    ..The purpose of this pilot study is to assess the feasibility, acceptability, and safety of a new feeding protocol designed to enhance the delivery of enteral nutrition (EN)...
  49. ncbi Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia
    Daren K Heyland
    Kingston General Hospital and Queen s University, Kingston, ON, Canada
    Crit Care Med 36:737-44. 2008
    ..To compare a strategy of combination therapy with a strategy of monotherapy with broad-spectrum antibiotics for suspected late ventilator-associated pneumonia...
  50. doi Ventilator-associated pneumonia caused by multidrug-resistant organisms or Pseudomonas aeruginosa: prevalence, incidence, risk factors, and outcomes
    Chris M Parker
    Department of Medicine, Queen s University, Kingston, Ontario, Canada K7L 2V7
    J Crit Care 23:18-26. 2008
    ....
  51. pmc Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data
    Donald E G Griesdale
    Department of Medicine, University of British Columbia, Vancouver, Canada
    CMAJ 180:821-7. 2009
    ..We conducted a meta-analysis to update the totality of evidence regarding the influence of intensive insulin therapy compared with conventional insulin therapy on mortality and severe hypoglycemia in the intensive care unit (ICU)...
  52. doi Nutrition therapy in the critical care setting: what is "best achievable" practice? An international multicenter observational study
    Naomi E Cahill
    Department of Community Health and Epidemiology, Queen s University, and Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, ON, Canada
    Crit Care Med 38:395-401. 2010
    ..To describe current nutrition practices in intensive care units and determine "best achievable" practice relative to evidence-based Critical Care Nutrition Clinical Practice Guidelines...
  53. ncbi Implementation of the Canadian Clinical Practice Guidelines for Nutrition Support: a multiple case study of barriers and enablers
    Naomi E Jones
    Department of Community Health and Epidemiology, Queen s University, 76 Stuart Street, Kingston, ON, Canada, K7L 2V7
    Nutr Clin Pract 22:449-57. 2007
    ..However, their impact to date has been modest. This study aimed to identify important barriers and enablers to implementation of these guidelines...
  54. doi Pharmaconutrition: a new emerging paradigm
    Naomi E Jones
    Department of Community Health and Epidemiology, Queen s University, Kingston, Ontario, Canada
    Curr Opin Gastroenterol 24:215-22. 2008
    ....
  55. ncbi Venous thromboembolism in critical illness in a community intensive care unit
    John G Muscedere
    Department of Medicine, Kingston General Hospital and Queen s University, Kingston, Ontario, Canada K7L 2V7
    J Crit Care 22:285-9. 2007
    ....
  56. ncbi Combination enteral and parenteral nutrition in critically ill patients: harmful or beneficial? A systematic review of the evidence
    Rupinder Dhaliwal
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Intensive Care Med 30:1666-71. 2004
    ..This paper systematically reviewed studies that compare EN + PN to enteral nutrition (EN) alone in critically ill patients...
  57. pmc Determining resuscitation preferences of elderly inpatients: a review of the literature
    Christopher Frank
    Department of Medicine, Queen s University, Kingston, Ont
    CMAJ 169:795-9. 2003
    ..Documentation of discussions and patient preferences may help to minimize misunderstandings and increase the stability of the decision during subsequent admissions to hospital...
  58. ncbi Mechanism of injury influences quality of life in survivors of acute respiratory distress syndrome
    Chris M Parker
    Department of Medicine, Queen s University, Kingston, Canada
    Intensive Care Med 32:1895-900. 2006
    ..We examined whether there are differences in quality of life (QOL) in survivors of ARDS attributable to the mechanism of underlying lung injury...
  59. doi Mortality, attributable mortality, and clinical events as end points for clinical trials of ventilator-associated pneumonia and hospital-acquired pneumonia
    John G Muscedere
    Queens University and 2Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, Ontario, Canada
    Clin Infect Dis 51:S120-5. 2010
    ..Equivalency studies are possible, but there are sample size implications. The use of time to clinical event end points, especially when combined with mortality, may be the best option for trial in the future...
  60. ncbi Gastrointestinal promotility drugs in the critical care setting: a systematic review of the evidence
    Christopher M Booth
    Department of Medicine, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    Crit Care Med 30:1429-35. 2002
    ..Gastrointestinal promotility agents may improve tolerance to enteral nutrition, reduce gastroesophageal reflux and pulmonary aspiration, and therefore have the potential to improve outcomes of critically ill patients...
  61. ncbi Survivors of acute respiratory distress syndrome: relationship between pulmonary dysfunction and long-term health-related quality of life
    Daren K Heyland
    Department of Medicine, Kingston General Hospital, Kingston, Ontario, Canada
    Crit Care Med 33:1549-56. 2005
    ..We describe the pattern of recovery of patients surviving ARDS to illuminate any relationships between lung spirometry values, pulmonary symptoms, and overall HRQOL...
  62. ncbi Assessment of long-term physical function in acute respiratory distress syndrome (ARDS) patients: comparison of the Charlson Comorbidity Index and the Functional Comorbidity Index
    Dianne L Groll
    Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
    Am J Phys Med Rehabil 85:574-81. 2006
    ....
  63. ncbi Does immunonutrition in patients with sepsis do more harm than good?
    Daren K Heyland
    Intensive Care Med 29:669-71. 2003
  64. ncbi Translating family satisfaction data into quality improvement
    Peter M Dodek
    Program in Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St Paul s Hospital and University of British Columbia, Vancouver, British Columbia, Canada
    Crit Care Med 32:1922-7. 2004
    ....
  65. ncbi Early enteral nutrition vs. early parenteral nutrition: an irrelevant question for the critically ill?
    Daren K Heyland
    Crit Care Med 33:260-1. 2005
  66. ncbi Feeding critically ill patients: what is the optimal amount of energy?
    Renee D Stapleton
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA
    Crit Care Med 35:S535-40. 2007
    ..Further high-quality evidence from randomized trials investigating the optimal amount of energy intake in intensive care unit patients is needed...
  67. doi Utility of Gram stain in the clinical management of suspected ventilator-associated pneumonia. Secondary analysis of a multicenter randomized trial
    M Albert
    Division of Critical Care, Department of Medicine, Universite de Montreal, Montreal, Canada H3T 1J4
    J Crit Care 23:74-81. 2008
    ..The aim of the present study was to evaluate the relationship between EA or BAL Gram stains and final culture results in intensive care unit patients with a suspected VAP...
  68. doi The safety of targeted antibiotic therapy for ventilator-associated pneumonia: a multicenter observational study
    Ari R Joffe
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
    J Crit Care 23:82-90. 2008
    ..The aim of this study was to determine the safety of targeted antibiotic therapy (TT) in ventilator-associated pneumonia (VAP)...
  69. doi Preferences for location of death of seriously ill hospitalized patients: perspectives from Canadian patients and their family caregivers
    Kelli I Stajduhar
    Centre on Aging and School of Nursing, University of Victoria, BC, Canada
    Palliat Med 22:85-8. 2008
    ....
  70. ncbi Nutrition support in acute pancreatitis: a systematic review of the literature
    Stephen A McClave
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    JPEN J Parenter Enteral Nutr 30:143-56. 2006
    ....
  71. doi The impact of ventilator-associated pneumonia on the Canadian health care system
    John G Muscedere
    Queens University, Kingston, Canada K7L 2V7
    J Crit Care 23:5-10. 2008
    ..Using published data and information from public health care providers, we sought to determine the impact of VAP on the Canadian health care system...
  72. doi The clinical significance of Candida colonization of respiratory tract secretions in critically ill patients
    Marie Soleil Delisle
    Hopital de l Enfant Jesus, Quebec, Quebec, Canada
    J Crit Care 23:11-7. 2008
    ....
  73. ncbi Canadian nurses' and respiratory therapists' perspectives on withdrawal of life support in the intensive care unit
    Graeme M Rocker
    Department of Medicine, Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia
    J Crit Care 20:59-65. 2005
    ..To describe perspectives of nurses (RNs) and respiratory therapists (RTs) related to end-of-life care for critically ill patients...
  74. ncbi Refinement, scoring, and validation of the Family Satisfaction in the Intensive Care Unit (FS-ICU) survey
    Richard J Wall
    Harborview Medical Center, Division of Pulmonary and Critical Care, Department of Medicine, University of Washington, Seattle, WA, USA
    Crit Care Med 35:271-9. 2007
    ..To refine the Family Satisfaction in the Intensive Care Unit (FS-ICU) survey and develop a validated method for scoring the instrument...
  75. ncbi Burden of illness in venous thromboembolism in critical care: a multicenter observational study
    Rakesh Patel
    Department of Medicine, University of Ottawa, Canada K1Y 4E9
    J Crit Care 20:341-7. 2005
    ....
  76. ncbi Ventilator-associated pneumonia. Prevention, diagnosis, and therapy
    Sean P Keenan
    Royal Columbian Hospital, New Westminster, British Columbia, Canada
    Crit Care Clin 18:107-25. 2002
    ..Improvements in care of patients who are at risk for or who have developed VAP will depend on the judicious application of this information for individual patients...
  77. ncbi North American Summit on Aspiration in the Critically Ill Patient: consensus statement
    Stephen A McClave
    Department of Medicine, University of Louisville School of Medicine, Kentucky 40202, USA
    JPEN J Parenter Enteral Nutr 26:S80-5. 2002
    ..Management strategies for treating aspiration pneumonia are based on degree of diagnostic certainty, time of onset, and host factors...
  78. doi If you don't connect the dots, you may not see the whole picture!
    Daren K Heyland
    JPEN J Parenter Enteral Nutr 32:486-8. 2008