Ian Gilron

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. doi request reprint Sensory and affective pain descriptors respond differentially to pharmacological interventions in neuropathic conditions
    Ian Gilron
    Department of Anesthesiology and Perioperative Medicine, Queen s University, Kingston, ON, Canada
    Clin J Pain 29:124-31. 2013
  2. doi request reprint Combination pharmacotherapy for management of chronic pain: from bench to bedside
    Ian Gilron
    Departments of Anaesthesiology and Perioperative Medicine and Biomedical and Molecular Sciences, Queen s University, Kingston, ON, Canada Electronic address
    Lancet Neurol 12:1084-95. 2013
  3. doi request reprint Chronobiological characteristics of neuropathic pain: clinical predictors of diurnal pain rhythmicity
    Ian Gilron
    Department of Anesthesiology and Perioperative Medicine, School of Nursing, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    Clin J Pain 29:755-9. 2013
  4. doi request reprint Canadian survey of perianesthetic care for patients receiving electroconvulsive therapy
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, Ontario, Canada
    J ECT 28:219-24. 2012
  5. ncbi request reprint Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, ON, Canada
    Lancet 374:1252-61. 2009
  6. doi request reprint Clinical trial methodology of pain treatment studies: selection and measurement of self-report primary outcomes for efficacy
    Ian Gilron
    Clinical Pain Research and Departments of Anesthesiology and Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
    Reg Anesth Pain Med 36:374-81. 2011
  7. ncbi request reprint Morphine, gabapentin, or their combination for neuropathic pain
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, Ont, Canada
    N Engl J Med 352:1324-34. 2005
  8. ncbi request reprint Chronobiological characteristics of postoperative pain: diurnal variation of both static and dynamic pain and effects of analgesic therapy
    Rya Boscariol
    Department of Anesthesiology, Queen s University, Kingston General Hospital, 76 Stuart Street, Kingston, Ontario K7L 2V7, Canada
    Can J Anaesth 54:696-704. 2007
  9. doi request reprint A randomized, double-blind, controlled trial of perioperative administration of gabapentin, meloxicam and their combination for spontaneous and movement-evoked pain after ambulatory laparoscopic cholecystectomy
    Ian Gilron
    Department of Anesthesiology, Kingston General Hospital, Ontario, Canada
    Anesth Analg 108:623-30. 2009
  10. ncbi request reprint A placebo-controlled randomized clinical trial of perioperative administration of gabapentin, rofecoxib and their combination for spontaneous and movement-evoked pain after abdominal hysterectomy
    Ian Gilron
    Department of Anesthesiology, Queen s University, 76 Stuart Street, Kingston, Ont, Canada ON K7L 2V7
    Pain 113:191-200. 2005

Collaborators

Detail Information

Publications31

  1. doi request reprint Sensory and affective pain descriptors respond differentially to pharmacological interventions in neuropathic conditions
    Ian Gilron
    Department of Anesthesiology and Perioperative Medicine, Queen s University, Kingston, ON, Canada
    Clin J Pain 29:124-31. 2013
    ..Evidence suggests that self-report verbal pain descriptors characterize important pain dimensions and may reflect diverse underlying mechanisms...
  2. doi request reprint Combination pharmacotherapy for management of chronic pain: from bench to bedside
    Ian Gilron
    Departments of Anaesthesiology and Perioperative Medicine and Biomedical and Molecular Sciences, Queen s University, Kingston, ON, Canada Electronic address
    Lancet Neurol 12:1084-95. 2013
    ..Methodological improvements in future translational research efforts are needed to maximise the potential of combination pharmacotherapy for pain. ..
  3. doi request reprint Chronobiological characteristics of neuropathic pain: clinical predictors of diurnal pain rhythmicity
    Ian Gilron
    Department of Anesthesiology and Perioperative Medicine, School of Nursing, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    Clin J Pain 29:755-9. 2013
    ..We aimed to replicate previous observations of diurnal pain progression, evaluate associations between diurnal rhythmicity and clinical factors, and evaluate the impact of diurnal rhythmicity on treatment response...
  4. doi request reprint Canadian survey of perianesthetic care for patients receiving electroconvulsive therapy
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, Ontario, Canada
    J ECT 28:219-24. 2012
    ..We report on the anesthesia subsection of a comprehensive nationwide survey (Canadian Electroconvulsive Therapy Survey/EnquĂȘte canadienne sur les electrochocs) on the practice of electroconvulsive therapy (ECT) in Canada...
  5. ncbi request reprint Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, ON, Canada
    Lancet 374:1252-61. 2009
    ..Drugs for neuropathic pain have incomplete efficacy and dose-limiting side-effects when given as monotherapy. We assessed the efficacy and tolerability of combined nortriptyline and gabapentin compared with each drug given alone...
  6. doi request reprint Clinical trial methodology of pain treatment studies: selection and measurement of self-report primary outcomes for efficacy
    Ian Gilron
    Clinical Pain Research and Departments of Anesthesiology and Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
    Reg Anesth Pain Med 36:374-81. 2011
    ..Future research is needed to directly compare current methods with newer measurement approaches for the critical goal of maximizing validity, reliability, and utility of different outcome measures in clinical trials of pain treatment...
  7. ncbi request reprint Morphine, gabapentin, or their combination for neuropathic pain
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, Ont, Canada
    N Engl J Med 352:1324-34. 2005
    ..We compared the efficacy of a combination of gabapentin and morphine with that of each as a single agent in patients with painful diabetic neuropathy or postherpetic neuralgia...
  8. ncbi request reprint Chronobiological characteristics of postoperative pain: diurnal variation of both static and dynamic pain and effects of analgesic therapy
    Rya Boscariol
    Department of Anesthesiology, Queen s University, Kingston General Hospital, 76 Stuart Street, Kingston, Ontario K7L 2V7, Canada
    Can J Anaesth 54:696-704. 2007
    ..Previous postoperative investigations report morning peaks in analgesic administration. However, few studies have examined diurnal variation of both pain and analgesic consumption and little is known about dynamic pain in this context...
  9. doi request reprint A randomized, double-blind, controlled trial of perioperative administration of gabapentin, meloxicam and their combination for spontaneous and movement-evoked pain after ambulatory laparoscopic cholecystectomy
    Ian Gilron
    Department of Anesthesiology, Kingston General Hospital, Ontario, Canada
    Anesth Analg 108:623-30. 2009
    ..We present the first trial of meloxicam-gabapentin combination after outpatient laparoscopic cholecystectomy...
  10. ncbi request reprint A placebo-controlled randomized clinical trial of perioperative administration of gabapentin, rofecoxib and their combination for spontaneous and movement-evoked pain after abdominal hysterectomy
    Ian Gilron
    Department of Anesthesiology, Queen s University, 76 Stuart Street, Kingston, Ont, Canada ON K7L 2V7
    Pain 113:191-200. 2005
    ..Future research should identify optimal dose-ratios for this and other analgesic combinations...
  11. doi request reprint Chronic pain, healthcare utilization, and quality of life following gastrointestinal surgery
    Elizabeth G VanDenKerkhof
    Department of Anesthesiology and Perioperative Medicine, School of Nursing, Queen s University, Kingston, ON, Canada
    Can J Anaesth 59:670-80. 2012
    ..Our aim in this pilot study was to identify potential predictors of chronic post-surgical pain (CPSP) and other outcomes to consider for inclusion in future prospective studies of CPSP following abdominal gastrointestinal surgery...
  12. ncbi request reprint Combination pharmacotherapy for neuropathic pain: current evidence and future directions
    Ian Gilron
    Queen s University, Department of Anaesthesiology, c o Kingston General Hospital, 76 Stuart Street, Kingston, ON, K7L 2V7, Canada
    Expert Rev Neurother 5:823-30. 2005
    ..Continued close integration of basic and clinical sciences is crucial in further harnessing the potential of combination pharmacotherapy in neuropathic pain...
  13. ncbi request reprint Gabapentin and pregabalin for chronic neuropathic and early postsurgical pain: current evidence and future directions
    Ian Gilron
    Departments of Anesthesiology and Pharmacology and Toxicology, Queen s University, 76 Stuart Street, Kingston, Ontario, Canada
    Curr Opin Anaesthesiol 20:456-72. 2007
    ..Gabapentin and pregabalin bind to the alpha-2-delta calcium channel subunit and represent a novel analgesic drug class. The evidence base supporting their use for chronic neuropathic and early postsurgical pain is reviewed...
  14. ncbi request reprint Gabapentin blocks and reverses antinociceptive morphine tolerance in the rat paw-pressure and tail-flick tests
    Ian Gilron
    Department of Anesthesiology, Kingston General Hospital Queen s University, Ontario, Canada
    Anesthesiology 98:1288-92. 2003
  15. ncbi request reprint Emerging drugs in neuropathic pain
    Ian Gilron
    Clinical Pain Research, Queen s University, Kingston, Ontario, ON, Canada
    Expert Opin Emerg Drugs 12:113-26. 2007
    ..In the interest of improving patient care, the authors recommend implementing comparative studies throughout the development process in order to demonstrate the increased value of novel agents...
  16. pmc Neuropathic pain: a practical guide for the clinician
    Ian Gilron
    Department of Anesthesiology, Queen s University and Kingston General Hospital, Kingston, Ont
    CMAJ 175:265-75. 2006
    ..In coming years, several advances are expected in the basic and clinical sciences of neuropathic pain, which will provide new and improved therapies for patients who continue to experience this disabling condition...
  17. doi request reprint Cardiopulmonary bypass does not affect plasma concentration of preoperatively administered gabapentin
    Joel Parlow
    Department of Anesthesiology and Perioperative Medicine, Queen s University and Kingston General Hospital, 76 Stuart Street, Kingston, Ontario, Canada
    Can J Anaesth 57:337-42. 2010
    ..The primary aim of the current investigation was to determine whether plasma gabapentin concentration is altered by cardiopulmonary bypass (CPB)...
  18. ncbi request reprint Gabapentin: a viewpoint by Ian Gilron
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, Ontario, Canada
    CNS Drugs 17:983-4. 2003
  19. doi request reprint Combination pharmacotherapy for the treatment of neuropathic pain in adults
    Luis Enrique Chaparro
    Anesthesiology and Perioperative Medicine, Queen s University, Kingston, Canada
    Cochrane Database Syst Rev 7:CD008943. 2012
    ..Combining two or more different drugs may improve analgesic efficacy and, in some situations, reduce overall side effects (e.g. if synergistic interactions allow for dose reductions of combined drugs)...
  20. ncbi request reprint The impact of therapy on quality of life and mood in neuropathic pain: what is the effect of pain reduction?
    Maneesh A Deshpande
    Department of Anesthesiology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    Anesth Analg 102:1473-9. 2006
    ..However, other beneficial or adverse treatment-related side effects may also affect mood/QOL. Therefore, future studies are needed to also evaluate the impact of treatment-related side effects on mood/QOL in analgesic trials...
  21. ncbi request reprint Chronobiological characteristics of painful diabetic neuropathy and postherpetic neuralgia: diurnal pain variation and effects of analgesic therapy
    Mark Odrcich
    Department of Anesthesiology, Queen s University, Kingston General Hospital, ON, Canada
    Pain 120:207-12. 2006
    ..Furthermore, recognizing diurnal pain patterns may guide treatment strategies such as the targeted timing of analgesic therapies...
  22. ncbi request reprint Patients' attitudes and prior treatments in neuropathic pain: a pilot study
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, Ontario, Canada
    Pain Res Manag 7:199-203. 2002
    ..Ongoing research continues to expand the knowledge of neuropathic pain. It is vital that established treatments and valuable discoveries ultimately improve patient care...
  23. doi request reprint Pregabalin for peripheral neuropathic pain: a multicenter, enriched enrollment randomized withdrawal placebo-controlled trial
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, Ontario, Canada
    Clin J Pain 27:185-93. 2011
    ..This multicenter trial evaluated pregabalin in a broader range of neuropathic pain etiologies...
  24. pmc A qualitative systematic review of head-to-head randomized controlled trials of oral analgesics in neuropathic pain
    C Peter N Watson
    University of Toronto, Toronto, Ontario, Canada
    Pain Res Manag 15:147-57. 2010
    ..Well-designed head-to-head comparative trials are an effective way to determine the relative efficacy and safety of a new drug...
  25. ncbi request reprint The relationship between movement-evoked versus spontaneous pain and peak expiratory flow after abdominal hysterectomy
    Ian Gilron
    Department of Anesthesiology and Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
    Anesth Analg 95:1702-7, table of contents. 2002
    ..We hypothesize that the consistent negative correlation of COUGH-evoked pain with PEF is, in part, caused by avoidance of coughing, which ultimately limits deep inspiration, lung reexpansion, and clearance of secretions...
  26. doi request reprint Interactions between pulmonary performance and movement-evoked pain in the immediate postsurgical period: implications for perioperative research and treatment
    Jason Erb
    Department of Anesthesiology, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    Reg Anesth Pain Med 33:312-9. 2008
    ....
  27. ncbi request reprint Review article: the role of anticonvulsant drugs in postoperative pain management: a bench-to-bedside perspective
    Ian Gilron
    Department of Anesthesiology, Kingston General Hospital, Queen s University, Kingston, Ontario, Canada
    Can J Anaesth 53:562-71. 2006
    ..The purpose of this article is to review preclinical evidence and clinical trial data describing the efficacy and safety of anticonvulsant drugs in the setting of postoperative pain management...
  28. doi request reprint Systematic review of movement-evoked pain versus pain at rest in postsurgical clinical trials and meta-analyses: a fundamental distinction requiring standardized measurement
    Sanjho Srikandarajah
    Department of Anesthesiology and Perioperative Medicine, Queen s University, Kingston, Ontario, Canada
    Pain 152:1734-9. 2011
    ..We therefore recommend developing consistent terminology regarding PAR and MEP, considering inclusion of MEP as a pain outcome in every postsurgical trial, and standardizing measurement of PAR and MEP on a procedure-specific basis...
  29. doi request reprint Impact of perioperative pain intensity, pain qualities, and opioid use on chronic pain after surgery: a prospective cohort study
    Elizabeth G VanDenKerkhof
    Department of Anesthesiology and Perioperative Medicine, Queen s University, Kingston, Ontario, Canada
    Reg Anesth Pain Med 37:19-27. 2012
    ..The objective of this study was to evaluate the incidence and risk factors for chronic postsurgical pain in women undergoing gynecologic surgery...
  30. ncbi request reprint Trends in opioid use for chronic neuropathic pain: a survey of patients pursuing enrollment in clinical trials
    Ian Gilron
    Department of Anesthesiology, Kingston General Hospital, Queen s University, Ontario, Canada
    Can J Anaesth 50:42-7. 2003
    ..Clinical trials suggest that opioids relieve neuropathic pain and decrease pain-related disability. We conducted a pilot study of current prescribing trends and patients' attitudes towards opioids for neuropathic pain...
  31. ncbi request reprint Cyclooxygenase-2 inhibitors in postoperative pain management: current evidence and future directions
    Ian Gilron
    Department of Anesthesiology, Queens University, Kingston, Ontario, Canada
    Anesthesiology 99:1198-208. 2003