I Gilron

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. ncbi LY-293558. Eli Lilly & Co
    I Gilron
    Departments of Anesthesiology and Pharmacology and Toxicology, Queen s University, Kingston General Hospital, Kingston, Ontario K7L 2V7, Canada
    Curr Opin Investig Drugs 2:1273-8. 2001
  2. ncbi Morphine, gabapentin, or their combination for neuropathic pain
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, Ont, Canada
    N Engl J Med 352:1324-34. 2005
  3. ncbi Combination pharmacotherapy for neuropathic pain: current evidence and future directions
    Ian Gilron
    Queen s University, Department of Anaesthesiology, c o Kingston General Hospital, 76 Stuart Street, Kingston, ON, K7L 2V7, Canada
    Expert Rev Neurother 5:823-30. 2005
  4. doi Pregabalin for peripheral neuropathic pain: a multicenter, enriched enrollment randomized withdrawal placebo-controlled trial
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, Ontario, Canada
    Clin J Pain 27:185-93. 2011
  5. ncbi Review article: the role of anticonvulsant drugs in postoperative pain management: a bench-to-bedside perspective
    Ian Gilron
    Department of Anesthesiology, Kingston General Hospital, Queen s University, Kingston, Ontario, Canada
    Can J Anaesth 53:562-71. 2006
  6. pmc Neuropathic pain: a practical guide for the clinician
    Ian Gilron
    Department of Anesthesiology, Queen s University and Kingston General Hospital, Kingston, Ont
    CMAJ 175:265-75. 2006
  7. ncbi Emerging drugs in neuropathic pain
    Ian Gilron
    Clinical Pain Research, Queen s University, Kingston, Ontario, ON, Canada
    Expert Opin Emerg Drugs 12:113-26. 2007
  8. ncbi Gabapentin and pregabalin for chronic neuropathic and early postsurgical pain: current evidence and future directions
    Ian Gilron
    Departments of Anesthesiology and Pharmacology and Toxicology, Queen s University, 76 Stuart Street, Kingston, Ontario, Canada
    Curr Opin Anaesthesiol 20:456-72. 2007
  9. doi A randomized, double-blind, controlled trial of perioperative administration of gabapentin, meloxicam and their combination for spontaneous and movement-evoked pain after ambulatory laparoscopic cholecystectomy
    Ian Gilron
    Department of Anesthesiology, Kingston General Hospital, Ontario, Canada
    Anesth Analg 108:623-30. 2009
  10. ncbi A placebo-controlled randomized clinical trial of perioperative administration of gabapentin, rofecoxib and their combination for spontaneous and movement-evoked pain after abdominal hysterectomy
    Ian Gilron
    Department of Anesthesiology, Queen s University, 76 Stuart Street, Kingston, Ont, Canada ON K7L 2V7
    Pain 113:191-200. 2005

Detail Information

Publications29

  1. ncbi LY-293558. Eli Lilly & Co
    I Gilron
    Departments of Anesthesiology and Pharmacology and Toxicology, Queen s University, Kingston General Hospital, Kingston, Ontario K7L 2V7, Canada
    Curr Opin Investig Drugs 2:1273-8. 2001
    ..By January 2000, LY-293558 was undergoing phase II trials for pain [414000]...
  2. ncbi Morphine, gabapentin, or their combination for neuropathic pain
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, Ont, Canada
    N Engl J Med 352:1324-34. 2005
    ..We compared the efficacy of a combination of gabapentin and morphine with that of each as a single agent in patients with painful diabetic neuropathy or postherpetic neuralgia...
  3. ncbi Combination pharmacotherapy for neuropathic pain: current evidence and future directions
    Ian Gilron
    Queen s University, Department of Anaesthesiology, c o Kingston General Hospital, 76 Stuart Street, Kingston, ON, K7L 2V7, Canada
    Expert Rev Neurother 5:823-30. 2005
    ..Continued close integration of basic and clinical sciences is crucial in further harnessing the potential of combination pharmacotherapy in neuropathic pain...
  4. doi Pregabalin for peripheral neuropathic pain: a multicenter, enriched enrollment randomized withdrawal placebo-controlled trial
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, Ontario, Canada
    Clin J Pain 27:185-93. 2011
    ..This multicenter trial evaluated pregabalin in a broader range of neuropathic pain etiologies...
  5. ncbi Review article: the role of anticonvulsant drugs in postoperative pain management: a bench-to-bedside perspective
    Ian Gilron
    Department of Anesthesiology, Kingston General Hospital, Queen s University, Kingston, Ontario, Canada
    Can J Anaesth 53:562-71. 2006
    ..The purpose of this article is to review preclinical evidence and clinical trial data describing the efficacy and safety of anticonvulsant drugs in the setting of postoperative pain management...
  6. pmc Neuropathic pain: a practical guide for the clinician
    Ian Gilron
    Department of Anesthesiology, Queen s University and Kingston General Hospital, Kingston, Ont
    CMAJ 175:265-75. 2006
    ..In coming years, several advances are expected in the basic and clinical sciences of neuropathic pain, which will provide new and improved therapies for patients who continue to experience this disabling condition...
  7. ncbi Emerging drugs in neuropathic pain
    Ian Gilron
    Clinical Pain Research, Queen s University, Kingston, Ontario, ON, Canada
    Expert Opin Emerg Drugs 12:113-26. 2007
    ..In the interest of improving patient care, the authors recommend implementing comparative studies throughout the development process in order to demonstrate the increased value of novel agents...
  8. ncbi Gabapentin and pregabalin for chronic neuropathic and early postsurgical pain: current evidence and future directions
    Ian Gilron
    Departments of Anesthesiology and Pharmacology and Toxicology, Queen s University, 76 Stuart Street, Kingston, Ontario, Canada
    Curr Opin Anaesthesiol 20:456-72. 2007
    ..Gabapentin and pregabalin bind to the alpha-2-delta calcium channel subunit and represent a novel analgesic drug class. The evidence base supporting their use for chronic neuropathic and early postsurgical pain is reviewed...
  9. doi A randomized, double-blind, controlled trial of perioperative administration of gabapentin, meloxicam and their combination for spontaneous and movement-evoked pain after ambulatory laparoscopic cholecystectomy
    Ian Gilron
    Department of Anesthesiology, Kingston General Hospital, Ontario, Canada
    Anesth Analg 108:623-30. 2009
    ..We present the first trial of meloxicam-gabapentin combination after outpatient laparoscopic cholecystectomy...
  10. ncbi A placebo-controlled randomized clinical trial of perioperative administration of gabapentin, rofecoxib and their combination for spontaneous and movement-evoked pain after abdominal hysterectomy
    Ian Gilron
    Department of Anesthesiology, Queen s University, 76 Stuart Street, Kingston, Ont, Canada ON K7L 2V7
    Pain 113:191-200. 2005
    ..Future research should identify optimal dose-ratios for this and other analgesic combinations...
  11. ncbi Cyclooxygenase-2 inhibitors in postoperative pain management: current evidence and future directions
    Ian Gilron
    Department of Anesthesiology, Queens University, Kingston, Ontario, Canada
    Anesthesiology 99:1198-208. 2003
  12. ncbi The relationship between movement-evoked versus spontaneous pain and peak expiratory flow after abdominal hysterectomy
    Ian Gilron
    Department of Anesthesiology and Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
    Anesth Analg 95:1702-7, table of contents. 2002
    ..We hypothesize that the consistent negative correlation of COUGH-evoked pain with PEF is, in part, caused by avoidance of coughing, which ultimately limits deep inspiration, lung reexpansion, and clearance of secretions...
  13. ncbi Gabapentin blocks and reverses antinociceptive morphine tolerance in the rat paw-pressure and tail-flick tests
    Ian Gilron
    Department of Anesthesiology, Kingston General Hospital Queen s University, Ontario, Canada
    Anesthesiology 98:1288-92. 2003
  14. ncbi Patients' attitudes and prior treatments in neuropathic pain: a pilot study
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, Ontario, Canada
    Pain Res Manag 7:199-203. 2002
    ..Ongoing research continues to expand the knowledge of neuropathic pain. It is vital that established treatments and valuable discoveries ultimately improve patient care...
  15. ncbi Trends in opioid use for chronic neuropathic pain: a survey of patients pursuing enrollment in clinical trials
    Ian Gilron
    Department of Anesthesiology, Kingston General Hospital, Queen s University, Ontario, Canada
    Can J Anaesth 50:42-7. 2003
    ..Clinical trials suggest that opioids relieve neuropathic pain and decrease pain-related disability. We conducted a pilot study of current prescribing trends and patients' attitudes towards opioids for neuropathic pain...
  16. ncbi Chronobiological characteristics of postoperative pain: diurnal variation of both static and dynamic pain and effects of analgesic therapy
    Rya Boscariol
    Department of Anesthesiology, Queen s University, Kingston General Hospital, 76 Stuart Street, Kingston, Ontario K7L 2V7, Canada
    Can J Anaesth 54:696-704. 2007
    ..Previous postoperative investigations report morning peaks in analgesic administration. However, few studies have examined diurnal variation of both pain and analgesic consumption and little is known about dynamic pain in this context...
  17. ncbi The effects of intrathecal gabapentin on spinal morphine tolerance in the rat tail-flick and paw pressure tests
    C Hansen
    Department of Pharmacology and Toxicology, Kingston General Hospital, Queen s University, Ontario, Canada
    Anesth Analg 99:1180-4, table of contents. 2004
    ..Future studies are required to examine the respective roles of supraspinal and peripheral sites of GBP-morphine interaction and to investigate the mechanisms underlying the action of GBP on opioid tolerance...
  18. pmc Pharmacological management of chronic neuropathic pain - consensus statement and guidelines from the Canadian Pain Society
    D E Moulin
    University of Western Ontario, London, Ontario, Canada
    Pain Res Manag 12:13-21. 2007
    ..Further studies are required to examine head-to-head comparisons among analgesics, combinations of analgesics, long-term outcomes, and treatment of pediatric and central NeP...
  19. ncbi The impact of therapy on quality of life and mood in neuropathic pain: what is the effect of pain reduction?
    Maneesh A Deshpande
    Department of Anesthesiology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    Anesth Analg 102:1473-9. 2006
    ..However, other beneficial or adverse treatment-related side effects may also affect mood/QOL. Therefore, future studies are needed to also evaluate the impact of treatment-related side effects on mood/QOL in analgesic trials...
  20. doi Cardiopulmonary bypass does not affect plasma concentration of preoperatively administered gabapentin
    Joel Parlow
    Department of Anesthesiology and Perioperative Medicine, Queen s University and Kingston General Hospital, 76 Stuart Street, Kingston, Ontario, Canada
    Can J Anaesth 57:337-42. 2010
    ..The primary aim of the current investigation was to determine whether plasma gabapentin concentration is altered by cardiopulmonary bypass (CPB)...
  21. ncbi Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, ON, Canada
    Lancet 374:1252-61. 2009
    ..Drugs for neuropathic pain have incomplete efficacy and dose-limiting side-effects when given as monotherapy. We assessed the efficacy and tolerability of combined nortriptyline and gabapentin compared with each drug given alone...
  22. doi Interactions between pulmonary performance and movement-evoked pain in the immediate postsurgical period: implications for perioperative research and treatment
    Jason Erb
    Department of Anesthesiology, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    Reg Anesth Pain Med 33:312-9. 2008
    ....
  23. ncbi Gabapentin: a viewpoint by Ian Gilron
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, Ontario, Canada
    CNS Drugs 17:983-4. 2003
  24. ncbi Chronobiological characteristics of painful diabetic neuropathy and postherpetic neuralgia: diurnal pain variation and effects of analgesic therapy
    Mark Odrcich
    Department of Anesthesiology, Queen s University, Kingston General Hospital, ON, Canada
    Pain 120:207-12. 2006
    ..Furthermore, recognizing diurnal pain patterns may guide treatment strategies such as the targeted timing of analgesic therapies...
  25. pmc A qualitative systematic review of head-to-head randomized controlled trials of oral analgesics in neuropathic pain
    C Peter N Watson
    University of Toronto, Toronto, Ontario, Canada
    Pain Res Manag 15:147-57. 2010
    ..Well-designed head-to-head comparative trials are an effective way to determine the relative efficacy and safety of a new drug...
  26. doi Analgesia controlled with patience: towards a better understanding of analgesic self-administration behaviour
    Ian Gilron
    Can J Anaesth 55:75-81. 2008
  27. ncbi Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trials
    Christine N Sang
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    Anesthesiology 96:1053-61. 2002
    ..The authors sought to evaluate two low-affinity N-methyl-d-aspartate antagonists using a novel two-stage design...
  28. ncbi Is gabapentin a "Broad-spectrum" analgesic?
    Ian Gilron
    Anesthesiology 97:537-9. 2002
  29. pmc Quantitative somatic sensory testing and functional imaging of the response to painful stimuli before and after cingulotomy for obsessive-compulsive disorder (OCD)
    Joel D Greenspan
    Department of Biomedical Sciences, School of Dentistry, and Program in Neuroscience, University of Maryland, Baltimore, MD, USA
    Eur J Pain 12:990-9. 2008
    ....