Research Topics
Genomes and GenesSpecies | Alastair V FergusonSummaryAffiliation: Queen's University Country: Canada Publications
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Detail Information
Publications
Glucose-responsive neurons in the subfornical organ of the rat--a novel site for direct CNS monitoring of circulating glucoseN Medeiros
Department of Biomedical and Molecular Sciences, Queen s University, Kingston, ON K7L 3N6, Canada
Neuroscience 201:157-65. 2012..These data demonstrate that SFO neurons are glucose responsive, further emphasizing the potential roles of this circumventricular organ as an important sensor and integrator of circulating signals of energy status...
The paraventricular nucleus of the hypothalamus - a potential target for integrative treatment of autonomic dysfunctionAlastair V Ferguson
Queen s University, Department of Physiology, Kingston, Ontario, K7L 3N6, Canada
Expert Opin Ther Targets 12:717-27. 2008....- Angiotensinergic regulation of autonomic and neuroendocrine outputs: critical roles for the subfornical organ and paraventricular nucleusAlastair V Ferguson
Department of Physiology, Queen s University, Kingston, Ont, Canada
Neuroendocrinology 89:370-6. 2009..It will also summarize the current knowledge describing cellular mechanisms through which this peptide controls the excitability of both SFO and PVN neurons... - Prokineticin 2 depolarizes paraventricular nucleus magnocellular and parvocellular neuronsErik A Yuill
Department of Physiology, Queen s University, Kingston, Ontario, Canada
Eur J Neurosci 25:425-34. 2007..In combination, these studies have identified separate cellular mechanisms through which PK2 influences the excitability of different subpopulations of PVN neurons... - Prokineticin 2 influences subfornical organ neurons through regulation of MAP kinase and the modulation of sodium channelsMark Fry
Dept of Physiology, Queen s Univ, Botterell Hall, 4floor, Kingston, ON, Canada K7L 3N6
Am J Physiol Regul Integr Comp Physiol 295:R848-56. 2008..These data indicate that PK2 influences SFO neurons through the activation of a MAP kinase cascade, which, in turn, modulates Na(+) and K(+) conductances... - Nesfatin-1 inhibits NPY neurons in the arcuate nucleusChristopher J Price
Department of Physiology, Queen s University, Kingston, ON, Canada, K7L 3N6
Brain Res 1230:99-106. 2008..Therefore, nesfatin-1-induced inhibition of feeding may be mediated through the inhibition of orexigenic NPY neurons... - Nesfatin-1 influences the excitability of neurons in the nucleus of the solitary tract and regulates cardiovascular functionAndrea Mimee
Department of Physiology, Queen s University, Kingston, Ontario, Canada
Am J Physiol Regul Integr Comp Physiol 302:R1297-304. 2012..8 ± 78.5 beats, n = 6) in rats. Our results provide critical insight into the circuitry and physiology involved in the profound effects of nesfatin-1 and highlight the NTS as a key structure mediating these autonomic actions... 
Angiotensin depolarizes parvocellular neurons in paraventricular nucleus through modulation of putative nonselective cationic and potassium conductancesKevin J Latchford
Department of Physiology, Queen's University, Kingston, Ontario, Canada K7L 3N6
Am J Physiol Regul Integr Comp Physiol 289:R52-8. 2005....- Prokineticin 2 modulates the excitability of area postrema neurons in vitro in the ratMatthew V Ingves
Department of Physiology, Queen s University, Kingston, ON, Canada K7L 3N6
Am J Physiol Regul Integr Comp Physiol 298:R617-26. 2010..These data suggest that the level of AP neuronal excitability may be regulated by PK2, ultimately affecting AP autonomic control... - Ghrelin modulates electrical activity of area postrema neuronsMark Fry
Queen s Univ, Dept of Physiology, Botterell Hall, 4th Fl, Kingston, ON Canada K7L 3N6
Am J Physiol Regul Integr Comp Physiol 296:R485-92. 2009..These are the first data showing that ghrelin exerts a direct effect on electrical activity of AP neurons and supports the notion that ghrelin can act via the AP to regulate energy homeostasis... - Excitatory effects of orexin-A on nucleus tractus solitarius neurons are mediated by phospholipase C and protein kinase CBo Yang
Department of Physiology, Queen's University, Kingston, Ontario, Canada K7L 3N6
J Neurosci 23:6215-22. 2003..These results therefore show that the excitatory effects of ORX-A on NTS neurons are mediated through activation of the PLC-PKC-NSCC and -IK signaling pathways, which probably result from OXR-coupled activation of Gq... - Transient potassium conductances protect nucleus tractus solitarius neurons from NMDA induced excitotoxic plateau depolarizationsBo Yang
Department of Physiology, Queen's University, Kingston, ON, Canada K7L 3N6
Brain Res 1056:1-9. 2005.... - Circulating signals as critical regulators of autonomic state--central roles for the subfornical organPauline M Smith
Dept of Physiology, Queen s Univ, Kingston, Ontario, Canada K7L 3N6
Am J Physiol Regul Integr Comp Physiol 299:R405-15. 2010..This review focuses on the role of the subfornical organ in sensing peripheral signals and transmitting this information to autonomic control centers in the hypothalamus... - Subthreshold oscillations of membrane potential of rat subfornical organ neuronsMark Fry
Department of Physiology, Queen s University, Kingston, ON, Canada
Neuroreport 18:1389-93. 2007..Voltage clamp experiments demonstrated that the activation of persistent Na+ current, but not transient Na+ current, matched with the voltage dependence of activation of the oscillation... - Actions of adiponectin on the excitability of subfornical organ neurons are altered by food deprivationIshraq Alim
Department of Physiology, Queen s University, Kingston, Ontario, Canada
Brain Res 1330:72-82. 2010..These observations support the concept that the SFO may be a key player in sensing circulating ADP and transmitting such information to critical CNS sites involved in the regulation of energy balance... - Adiponectin selectively inhibits oxytocin neurons of the paraventricular nucleus of the hypothalamusTed D Hoyda
Department of Physiology, Faculty of Life Sciences, Queen s University, 18 Stuart Street, Kingston, Ontario, Canada
J Physiol 585:805-16. 2007.... - Making sense of it: roles of the sensory circumventricular organs in feeding and regulation of energy homeostasisMark Fry
Department of Physiology, Faculty of Life Sciences, Queen s University, Kingston, ON, Canada
Exp Biol Med (Maywood) 232:14-26. 2007.... - Neuropeptide W influences the excitability of neurons in the rat hypothalamic arcuate nucleusChristopher J Price
Department of Physiology, Queen s University, Kingston, Ont, Canada
Neuroendocrinology 88:88-94. 2008.... - Prokineticin 2 modulates the excitability of subfornical organ neuronsG Trevor Cottrell
Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
J Neurosci 24:2375-9. 2004..The activation of SFO neurons by PK2 illustrates a mechanism through which this peptide may exert circadian control of autonomic functions... - The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic functionAlastair V Ferguson
Department of Physiology, Queen s University, Kingston, ON, Canada
Front Neuroendocrinol 24:141-50. 2003..This review focuses upon evidence for potential physiologic roles for the peptides in these sites... - Adiponectin modulates excitability of rat paraventricular nucleus neurons by differential modulation of potassium currentsTed D Hoyda
Department of Physiology, Queen s University, 4th Floor Botterell Hall, Kingston, Ontario, Canada K7L 3N6
Endocrinology 151:3154-62. 2010.... - Acute electrical stimulation of the subfornical organ induces feeding in satiated ratsPauline M Smith
Department of Physiology, Queen s University, Kingston, ON, Canada
Physiol Behav 99:534-7. 2010..The results of the present study show that acute, short duration, SFO stimulation induces feeding in satiated rats, lending support for a role for the SFO as an integrator of circulating peptides that control feeding... - Secretin depolarizes nucleus tractus solitarius neurons through activation of a nonselective cationic conductanceBo Yang
Dept of Physiology, Queen s Univ, Kingston, Ontario, Canada K7L 3N6
Am J Physiol Regul Integr Comp Physiol 286:R927-34. 2004..These results show that NTS neurons are activated by secretin as a consequence of activation of a NSCC and support the emerging view that secretin can act as a neuropeptide within the CNS... - Adiponectin acts in the nucleus of the solitary tract to decrease blood pressure by modulating the excitability of neuropeptide Y neuronsTed D Hoyda
Department of Physiology, Faculty of Arts and Science, Queen s University, Kingston, Ontario, Canada K7L 3N6
Brain Res 1256:76-84. 2009..These studies identify the mNTS as a new CNS site which adiponectin may act to influence central autonomic processing... - Orexin-A depolarizes nucleus tractus solitarius neurons through effects on nonselective cationic and K+ conductancesBo Yang
Department of Physiology, Queen s University, Kingston, Ontario K7L 3N6, Canada
J Neurophysiol 89:2167-75. 2003.... - Adrenomedullin influences dissociated rat area postrema neuronsBo Yang
Department of Physiology, Queen's University, Botterell Hall, K7L 3N6, Kingston, ON, Canada
Regul Pept 112:9-17. 2003..These data demonstrate direct effects of AM on dissociated AP neurons and identify ion channels, the modulation of which, may underlie these effects... - The area postrema: a brain monitor and integrator of systemic autonomic stateChristopher J Price
Department of Physiology, Queen s University, Kingston, Ontario, Canada
Neuroscientist 14:182-94. 2008..However, the area postrema is not simply a conduit through which signals flow into the brain, but it is now being recognized as the initial site of integration for these signals as they enter the circuitry of the central nervous system... - The subfornical organ: a central target for circulating feeding signalsKatherine J Pulman
Department of Physiology, Queen's University, Kingston, Ontario, K7L 3N6, Canada
J Neurosci 26:2022-30. 2006..These data support a role for the SFO as a center at which ghrelin and amylin may influence separate subpopulations of neurons to influence the hypothalamic regulation of feeding... - The sensory circumventricular organs: brain targets for circulating signals controlling ingestive behaviorMark Fry
Department of Physiology, Queen s University, Kingston, ON, Canada
Physiol Behav 91:413-23. 2007..This review focuses primarily on the roles played by the sensory CVOs in fluid balance and energy metabolism... - Neurophysiology of hunger and satietyPauline M Smith
Department of Physiology, Queen s University, Kingston, Ontario, Canada
Dev Disabil Res Rev 14:96-104. 2008.... - Angiotensin II activates a nitric-oxide-driven inhibitory feedback in the rat paraventricular nucleusKevin J Latchford
Department of Physiology, Queen's University, Kingston, Ontario K7L 3N6, Canada
J Neurophysiol 89:1238-44. 2003..9 +/- 1.2 vs. 11.9 +/- 2.3, P < 0.001). These data demonstrate that there exists within the PVN an intrinsic negative feedback loop that modulates neuronal excitability in response to peptidergic excitation... - Interleukin-1beta depolarizes magnocellular neurons in the paraventricular nucleus of the hypothalamus through prostaglandin-mediated activation of a non selective cationic conductanceCatharine C Ferri
Department of Physiology, Queen's University, Kingston, Ontario, Canada, K7L 3N6
Regul Pept 129:63-71. 2005..8+/-7.6 mV), suggesting that this prostanoid directly modifies cationic currents in MNC neurons. These data provide evidence that IL-1beta depolarizes MNC neurons in the PVN as a result of prostaglandin-mediated activation of a NSCC... - Cellular mechanisms of orexin actions on paraventricular nucleus neurones in rat hypothalamusMatthew J Follwell
Department of Physiology, Queen's University, Kingston, Ontario, Canada K7L 3N6
J Physiol 545:855-67. 2002..These studies have identified separate cellular mechanisms through which OX-A influences the excitability of magnocellular and parvocellular PVN neurones... - Circuitries involved in the regulation of energy homeostasis: view from the chairAlastair V Ferguson
Department of Physiology, Queen's University, Kingston, Ontario, Canada K7L 3N6
Obesity (Silver Spring) 14:214S-215S. 2006 - Area postrema neurons are modulated by the adipocyte hormone adiponectinMark Fry
Department of Physiology, Queen s University, Kingston, Ontario, Canada, K7L 3N6
J Neurosci 26:9695-702. 2006.... - Orexin-A depolarizes dissociated rat area postrema neurons through activation of a nonselective cationic conductanceBo Yang
Department of Physiology, Queen's University, Kingston, Ontario, Canada K7L 3N6
J Neurosci 22:6303-8. 2002..These data demonstrate that AP neurons are directly influenced by ORX-A and suggest that ORX-A may exert its effects on the central control of feeding behavior and cardiovascular function through direct actions in AP... - Microinjection of orexin into the rat nucleus tractus solitarius causes increases in blood pressurePauline M Smith
Department of Physiology, Queen's University, Ont. K7L3N6, Kingston, Canada
Brain Res 950:261-7. 2002..These observations support the conclusion that orexins act as chemical messengers in the NTS likely influencing the excitability of cardiovascular neurons in this region and thus regulating global cardiovascular function... - Sensory circumventricular organs: central roles in integrated autonomic regulationG Trevor Cottrell
Department of Physiology, Queen s University, Botterell Hall, 4th Floor, Kingston, ON, Canada K7L 3N6
Regul Pept 117:11-23. 2004..The complexities associated with sensory CVO exploration are intense, but should continue to result in valuable contributions to our understanding of brain function... - Adrenomedullin influences magnocellular and parvocellular neurons of paraventricular nucleus via separate mechanismsMatthew J Follwell
Department of Physiology, Queen's University, Kingston, Ontario, Canada, K7L 3N6
Am J Physiol Regul Integr Comp Physiol 283:R1293-302. 2002.... - Adiponectin, ghrelin, and leptin differentially influence human platelet and human vascular endothelial cell functions: implication in obesity-associated cardiovascular diseasesHisham S Elbatarny
Department of Pharmacology and Toxicology, Botterell Hall, 229, Queen s University, Kingston, ON, Canada
Eur J Pharmacol 558:7-13. 2007.... - Orexin actions in hypothalamic paraventricular nucleus: physiological consequences and cellular correlatesWillis K Samson
Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
Regul Pept 104:97-103. 2002..0+/-0.6 mV), accompanied by increases in spike frequency in identified magno- and parvocellular neurons in the PVN. Our data suggest a potential role for endogenous orexin in the hypothalamic regulation of stress hormone secretion... - Hypocretin/orexin type 1 receptor in brain: role in cardiovascular control and the neuroendocrine response to immobilization stressWillis K Samson
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
Am J Physiol Regul Integr Comp Physiol 292:R382-7. 2007..These data suggest receptor subtype-selective responses to hypocretin/orexin and provide further evidence for the importance of endogenously produced peptide in the physiological control of stress hormone secretion... - Non-sleep effects of hypocretin/orexinWillis K Samson
Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
Sleep Med Rev 9:243-52. 2005.... - Time to consider new brain clock signalsAlastair V Ferguson
Trends Endocrinol Metab 13:276-7. 2002 - Actions of neuropeptide W in paraventricular hypothalamus: implications for the control of stress hormone secretionMeghan M Taylor
Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
Am J Physiol Regul Integr Comp Physiol 288:R270-5. 2005..Our data suggest that endogenous NPW, produced in brain, may play a physiologically relevant role in the neuroendocrine response to stress... - Obestatin acts in brain to inhibit thirstWillis K Samson
Department of Pharmacological and Physiological Science, Saint Louis University, 1402 South Grand Boulevard, St Louis, MO 63104, USA
Am J Physiol Regul Integr Comp Physiol 292:R637-43. 2007..Importantly, in rats the effects of obestatin on food intake may be secondary to an action of the peptide to inhibit water drinking...