Alastair V Ferguson

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. ncbi Metabolic signaling to the central nervous system: routes across the blood brain barrier
    Pauline M Smith
    Dept of Biomedical and Molecular Sciences, Queen s University, Kingston ON, Canada, K7L 3N6
    Curr Pharm Des 20:1392-9. 2014
  2. ncbi Cellular actions of nesfatin-1 on hypothalamic and medullary neurons
    Andrea Mimee
    Queen s University, Department of Biomedical and Molecular Sciences, Kingston, Ontario, Canada, K7L 3N6
    Curr Pharm Des 19:6949-54. 2013
  3. doi Glucose-responsive neurons in the subfornical organ of the rat--a novel site for direct CNS monitoring of circulating glucose
    N Medeiros
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, ON K7L 3N6, Canada
    Neuroscience 201:157-65. 2012
  4. doi Angiotensinergic regulation of autonomic and neuroendocrine outputs: critical roles for the subfornical organ and paraventricular nucleus
    Alastair V Ferguson
    Department of Physiology, Queen s University, Kingston, Ont, Canada
    Neuroendocrinology 89:370-6. 2009
  5. pmc The paraventricular nucleus of the hypothalamus - a potential target for integrative treatment of autonomic dysfunction
    Alastair V Ferguson
    Queen s University, Department of Physiology, Kingston, Ontario, K7L 3N6, Canada
    Expert Opin Ther Targets 12:717-27. 2008
  6. pmc Prokineticin 2 depolarizes paraventricular nucleus magnocellular and parvocellular neurons
    Erik A Yuill
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Eur J Neurosci 25:425-34. 2007
  7. doi Nesfatin-1 influences the excitability of neurons in the nucleus of the solitary tract and regulates cardiovascular function
    Andrea Mimee
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 302:R1297-304. 2012
  8. doi Prokineticin 2 influences subfornical organ neurons through regulation of MAP kinase and the modulation of sodium channels
    Mark Fry
    Dept of Physiology, Queen s Univ, Botterell Hall, 4floor, Kingston, ON, Canada K7L 3N6
    Am J Physiol Regul Integr Comp Physiol 295:R848-56. 2008
  9. pmc Nesfatin-1 inhibits NPY neurons in the arcuate nucleus
    Christopher J Price
    Department of Physiology, Queen s University, Kingston, ON, Canada, K7L 3N6
    Brain Res 1230:99-106. 2008
  10. ncbi Angiotensin depolarizes parvocellular neurons in paraventricular nucleus through modulation of putative nonselective cationic and potassium conductances
    Kevin J Latchford
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Am J Physiol Regul Integr Comp Physiol 289:R52-8. 2005

Collaborators

Detail Information

Publications51

  1. ncbi Metabolic signaling to the central nervous system: routes across the blood brain barrier
    Pauline M Smith
    Dept of Biomedical and Molecular Sciences, Queen s University, Kingston ON, Canada, K7L 3N6
    Curr Pharm Des 20:1392-9. 2014
    ....
  2. ncbi Cellular actions of nesfatin-1 on hypothalamic and medullary neurons
    Andrea Mimee
    Queen s University, Department of Biomedical and Molecular Sciences, Kingston, Ontario, Canada, K7L 3N6
    Curr Pharm Des 19:6949-54. 2013
    ....
  3. doi Glucose-responsive neurons in the subfornical organ of the rat--a novel site for direct CNS monitoring of circulating glucose
    N Medeiros
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, ON K7L 3N6, Canada
    Neuroscience 201:157-65. 2012
    ..These data demonstrate that SFO neurons are glucose responsive, further emphasizing the potential roles of this circumventricular organ as an important sensor and integrator of circulating signals of energy status...
  4. doi Angiotensinergic regulation of autonomic and neuroendocrine outputs: critical roles for the subfornical organ and paraventricular nucleus
    Alastair V Ferguson
    Department of Physiology, Queen s University, Kingston, Ont, Canada
    Neuroendocrinology 89:370-6. 2009
    ..It will also summarize the current knowledge describing cellular mechanisms through which this peptide controls the excitability of both SFO and PVN neurons...
  5. pmc The paraventricular nucleus of the hypothalamus - a potential target for integrative treatment of autonomic dysfunction
    Alastair V Ferguson
    Queen s University, Department of Physiology, Kingston, Ontario, K7L 3N6, Canada
    Expert Opin Ther Targets 12:717-27. 2008
    ....
  6. pmc Prokineticin 2 depolarizes paraventricular nucleus magnocellular and parvocellular neurons
    Erik A Yuill
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Eur J Neurosci 25:425-34. 2007
    ..In combination, these studies have identified separate cellular mechanisms through which PK2 influences the excitability of different subpopulations of PVN neurons...
  7. doi Nesfatin-1 influences the excitability of neurons in the nucleus of the solitary tract and regulates cardiovascular function
    Andrea Mimee
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 302:R1297-304. 2012
    ..8 ± 78.5 beats, n = 6) in rats. Our results provide critical insight into the circuitry and physiology involved in the profound effects of nesfatin-1 and highlight the NTS as a key structure mediating these autonomic actions...
  8. doi Prokineticin 2 influences subfornical organ neurons through regulation of MAP kinase and the modulation of sodium channels
    Mark Fry
    Dept of Physiology, Queen s Univ, Botterell Hall, 4floor, Kingston, ON, Canada K7L 3N6
    Am J Physiol Regul Integr Comp Physiol 295:R848-56. 2008
    ..These data indicate that PK2 influences SFO neurons through the activation of a MAP kinase cascade, which, in turn, modulates Na(+) and K(+) conductances...
  9. pmc Nesfatin-1 inhibits NPY neurons in the arcuate nucleus
    Christopher J Price
    Department of Physiology, Queen s University, Kingston, ON, Canada, K7L 3N6
    Brain Res 1230:99-106. 2008
    ..Therefore, nesfatin-1-induced inhibition of feeding may be mediated through the inhibition of orexigenic NPY neurons...
  10. ncbi Angiotensin depolarizes parvocellular neurons in paraventricular nucleus through modulation of putative nonselective cationic and potassium conductances
    Kevin J Latchford
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Am J Physiol Regul Integr Comp Physiol 289:R52-8. 2005
    ....
  11. doi Prokineticin 2 modulates the excitability of area postrema neurons in vitro in the rat
    Matthew V Ingves
    Department of Physiology, Queen s University, Kingston, ON, Canada K7L 3N6
    Am J Physiol Regul Integr Comp Physiol 298:R617-26. 2010
    ..These data suggest that the level of AP neuronal excitability may be regulated by PK2, ultimately affecting AP autonomic control...
  12. doi Ghrelin modulates electrical activity of area postrema neurons
    Mark Fry
    Queen s Univ, Dept of Physiology, Botterell Hall, 4th Fl, Kingston, ON Canada K7L 3N6
    Am J Physiol Regul Integr Comp Physiol 296:R485-92. 2009
    ..These are the first data showing that ghrelin exerts a direct effect on electrical activity of AP neurons and supports the notion that ghrelin can act via the AP to regulate energy homeostasis...
  13. ncbi Excitatory effects of orexin-A on nucleus tractus solitarius neurons are mediated by phospholipase C and protein kinase C
    Bo Yang
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Neurosci 23:6215-22. 2003
    ..These results therefore show that the excitatory effects of ORX-A on NTS neurons are mediated through activation of the PLC-PKC-NSCC and -IK signaling pathways, which probably result from OXR-coupled activation of Gq...
  14. ncbi Transient potassium conductances protect nucleus tractus solitarius neurons from NMDA induced excitotoxic plateau depolarizations
    Bo Yang
    Department of Physiology, Queen s University, Kingston, ON, Canada K7L 3N6
    Brain Res 1056:1-9. 2005
    ....
  15. doi Circulating signals as critical regulators of autonomic state--central roles for the subfornical organ
    Pauline M Smith
    Dept of Physiology, Queen s Univ, Kingston, Ontario, Canada K7L 3N6
    Am J Physiol Regul Integr Comp Physiol 299:R405-15. 2010
    ..This review focuses on the role of the subfornical organ in sensing peripheral signals and transmitting this information to autonomic control centers in the hypothalamus...
  16. ncbi Subthreshold oscillations of membrane potential of rat subfornical organ neurons
    Mark Fry
    Department of Physiology, Queen s University, Kingston, ON, Canada
    Neuroreport 18:1389-93. 2007
    ..Voltage clamp experiments demonstrated that the activation of persistent Na+ current, but not transient Na+ current, matched with the voltage dependence of activation of the oscillation...
  17. pmc Adiponectin selectively inhibits oxytocin neurons of the paraventricular nucleus of the hypothalamus
    Ted D Hoyda
    Department of Physiology, Faculty of Life Sciences, Queen s University, 18 Stuart Street, Kingston, Ontario, Canada
    J Physiol 585:805-16. 2007
    ....
  18. doi Actions of adiponectin on the excitability of subfornical organ neurons are altered by food deprivation
    Ishraq Alim
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Brain Res 1330:72-82. 2010
    ..These observations support the concept that the SFO may be a key player in sensing circulating ADP and transmitting such information to critical CNS sites involved in the regulation of energy balance...
  19. pmc Apelin acts in the subfornical organ to influence neuronal excitability and cardiovascular function
    Li Dai
    Biomedical and Molecular Sciences, Department of Physiology, Queen s University, Kingston, ON K7L 3N6, Canada
    J Physiol 591:3421-32. 2013
    ..1 mmHg.s, n = 5) and heart rate (HR) (-32.4 ± 10.39 beats, n = 5). Our data suggest that circulating apelin can directly affect BP and HR as a consequence of the ability of this peptide to modulate the excitability of SFO neurons...
  20. ncbi Making sense of it: roles of the sensory circumventricular organs in feeding and regulation of energy homeostasis
    Mark Fry
    Department of Physiology, Faculty of Life Sciences, Queen s University, Kingston, ON, Canada
    Exp Biol Med (Maywood) 232:14-26. 2007
    ....
  21. doi Neuropeptide W influences the excitability of neurons in the rat hypothalamic arcuate nucleus
    Christopher J Price
    Department of Physiology, Queen s University, Kingston, Ont, Canada
    Neuroendocrinology 88:88-94. 2008
    ....
  22. ncbi Prokineticin 2 modulates the excitability of subfornical organ neurons
    G Trevor Cottrell
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Neurosci 24:2375-9. 2004
    ..The activation of SFO neurons by PK2 illustrates a mechanism through which this peptide may exert circadian control of autonomic functions...
  23. ncbi The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic function
    Alastair V Ferguson
    Department of Physiology, Queen s University, Kingston, ON, Canada
    Front Neuroendocrinol 24:141-50. 2003
    ..This review focuses upon evidence for potential physiologic roles for the peptides in these sites...
  24. doi Adiponectin modulates excitability of rat paraventricular nucleus neurons by differential modulation of potassium currents
    Ted D Hoyda
    Department of Physiology, Queen s University, 4th Floor Botterell Hall, Kingston, Ontario, Canada K7L 3N6
    Endocrinology 151:3154-62. 2010
    ....
  25. doi Acute electrical stimulation of the subfornical organ induces feeding in satiated rats
    Pauline M Smith
    Department of Physiology, Queen s University, Kingston, ON, Canada
    Physiol Behav 99:534-7. 2010
    ..The results of the present study show that acute, short duration, SFO stimulation induces feeding in satiated rats, lending support for a role for the SFO as an integrator of circulating peptides that control feeding...
  26. ncbi Secretin depolarizes nucleus tractus solitarius neurons through activation of a nonselective cationic conductance
    Bo Yang
    Dept of Physiology, Queen s Univ, Kingston, Ontario, Canada K7L 3N6
    Am J Physiol Regul Integr Comp Physiol 286:R927-34. 2004
    ..These results show that NTS neurons are activated by secretin as a consequence of activation of a NSCC and support the emerging view that secretin can act as a neuropeptide within the CNS...
  27. doi Adiponectin acts in the nucleus of the solitary tract to decrease blood pressure by modulating the excitability of neuropeptide Y neurons
    Ted D Hoyda
    Department of Physiology, Faculty of Arts and Science, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Brain Res 1256:76-84. 2009
    ..These studies identify the mNTS as a new CNS site which adiponectin may act to influence central autonomic processing...
  28. ncbi Adrenomedullin influences dissociated rat area postrema neurons
    Bo Yang
    Department of Physiology, Queen s University, Botterell Hall, K7L 3N6, Kingston, ON, Canada
    Regul Pept 112:9-17. 2003
    ..These data demonstrate direct effects of AM on dissociated AP neurons and identify ion channels, the modulation of which, may underlie these effects...
  29. ncbi Orexin-A depolarizes nucleus tractus solitarius neurons through effects on nonselective cationic and K+ conductances
    Bo Yang
    Department of Physiology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Neurophysiol 89:2167-75. 2003
    ....
  30. ncbi The subfornical organ: a central target for circulating feeding signals
    Katherine J Pulman
    Department of Physiology, Queen s University, Kingston, Ontario, K7L 3N6, Canada
    J Neurosci 26:2022-30. 2006
    ..These data support a role for the SFO as a center at which ghrelin and amylin may influence separate subpopulations of neurons to influence the hypothalamic regulation of feeding...
  31. ncbi The area postrema: a brain monitor and integrator of systemic autonomic state
    Christopher J Price
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Neuroscientist 14:182-94. 2008
    ..However, the area postrema is not simply a conduit through which signals flow into the brain, but it is now being recognized as the initial site of integration for these signals as they enter the circuitry of the central nervous system...
  32. ncbi The sensory circumventricular organs: brain targets for circulating signals controlling ingestive behavior
    Mark Fry
    Department of Physiology, Queen s University, Kingston, ON, Canada
    Physiol Behav 91:413-23. 2007
    ..This review focuses primarily on the roles played by the sensory CVOs in fluid balance and energy metabolism...
  33. doi Neurophysiology of hunger and satiety
    Pauline M Smith
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Dev Disabil Res Rev 14:96-104. 2008
    ....
  34. ncbi Area postrema neurons are modulated by the adipocyte hormone adiponectin
    Mark Fry
    Department of Physiology, Queen s University, Kingston, Ontario, Canada, K7L 3N6
    J Neurosci 26:9695-702. 2006
    ....
  35. ncbi Angiotensin II activates a nitric-oxide-driven inhibitory feedback in the rat paraventricular nucleus
    Kevin J Latchford
    Department of Physiology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Neurophysiol 89:1238-44. 2003
    ..9 +/- 1.2 vs. 11.9 +/- 2.3, P < 0.001). These data demonstrate that there exists within the PVN an intrinsic negative feedback loop that modulates neuronal excitability in response to peptidergic excitation...
  36. ncbi Interleukin-1beta depolarizes magnocellular neurons in the paraventricular nucleus of the hypothalamus through prostaglandin-mediated activation of a non selective cationic conductance
    Catharine C Ferri
    Department of Physiology, Queen s University, Kingston, Ontario, Canada, K7L 3N6
    Regul Pept 129:63-71. 2005
    ..8+/-7.6 mV), suggesting that this prostanoid directly modifies cationic currents in MNC neurons. These data provide evidence that IL-1beta depolarizes MNC neurons in the PVN as a result of prostaglandin-mediated activation of a NSCC...
  37. ncbi Circuitries involved in the regulation of energy homeostasis: view from the chair
    Alastair V Ferguson
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Obesity (Silver Spring) 14:214S-215S. 2006
  38. pmc Cellular mechanisms of orexin actions on paraventricular nucleus neurones in rat hypothalamus
    Matthew J Follwell
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Physiol 545:855-67. 2002
    ..These studies have identified separate cellular mechanisms through which OX-A influences the excitability of magnocellular and parvocellular PVN neurones...
  39. pmc Depolarizing actions of hydrogen sulfide on hypothalamic paraventricular nucleus neurons
    C Sahara Khademullah
    Department of Biomedical and Molecular Science, Queen s University, Kingston, Ontario, Canada
    PLoS ONE 8:e64495. 2013
    ..The results from the neuronal population of the PVN shed light on the possible physiological role that H2S has in autonomic and endocrine function...
  40. ncbi Orexin-A depolarizes dissociated rat area postrema neurons through activation of a nonselective cationic conductance
    Bo Yang
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Neurosci 22:6303-8. 2002
    ..These data demonstrate that AP neurons are directly influenced by ORX-A and suggest that ORX-A may exert its effects on the central control of feeding behavior and cardiovascular function through direct actions in AP...
  41. doi Circumventricular organs: targets for integration of circulating fluid and energy balance signals?
    Andrea Mimee
    Queen s University, Department of Biomedical and Molecular Sciences, Kingston, Ontario, Canada K7L 3N6
    Physiol Behav 121:96-102. 2013
    ..The results examined in this review provide evidence for a role of the SFO as a mediator and integrative structure in the maintenance of cardiovascular and metabolic functions. ..
  42. ncbi Microinjection of orexin into the rat nucleus tractus solitarius causes increases in blood pressure
    Pauline M Smith
    Department of Physiology, Queen s University, Ont K7L3N6, Kingston, Canada
    Brain Res 950:261-7. 2002
    ..These observations support the conclusion that orexins act as chemical messengers in the NTS likely influencing the excitability of cardiovascular neurons in this region and thus regulating global cardiovascular function...
  43. ncbi Sensory circumventricular organs: central roles in integrated autonomic regulation
    G Trevor Cottrell
    Department of Physiology, Queen s University, Botterell Hall, 4th Floor, Kingston, ON, Canada K7L 3N6
    Regul Pept 117:11-23. 2004
    ..The complexities associated with sensory CVO exploration are intense, but should continue to result in valuable contributions to our understanding of brain function...
  44. ncbi Adrenomedullin influences magnocellular and parvocellular neurons of paraventricular nucleus via separate mechanisms
    Matthew J Follwell
    Department of Physiology, Queen s University, Kingston, Ontario, Canada, K7L 3N6
    Am J Physiol Regul Integr Comp Physiol 283:R1293-302. 2002
    ....
  45. ncbi Adiponectin, ghrelin, and leptin differentially influence human platelet and human vascular endothelial cell functions: implication in obesity-associated cardiovascular diseases
    Hisham S Elbatarny
    Department of Pharmacology and Toxicology, Botterell Hall, 229, Queen s University, Kingston, ON, Canada
    Eur J Pharmacol 558:7-13. 2007
    ....
  46. ncbi Hypocretin/orexin type 1 receptor in brain: role in cardiovascular control and the neuroendocrine response to immobilization stress
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 292:R382-7. 2007
    ..These data suggest receptor subtype-selective responses to hypocretin/orexin and provide further evidence for the importance of endogenously produced peptide in the physiological control of stress hormone secretion...
  47. ncbi Non-sleep effects of hypocretin/orexin
    Willis K Samson
    Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Sleep Med Rev 9:243-52. 2005
    ....
  48. ncbi Orexin actions in hypothalamic paraventricular nucleus: physiological consequences and cellular correlates
    Willis K Samson
    Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Regul Pept 104:97-103. 2002
    ..0+/-0.6 mV), accompanied by increases in spike frequency in identified magno- and parvocellular neurons in the PVN. Our data suggest a potential role for endogenous orexin in the hypothalamic regulation of stress hormone secretion...
  49. ncbi Obestatin acts in brain to inhibit thirst
    Willis K Samson
    Department of Pharmacological and Physiological Science, Saint Louis University, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 292:R637-43. 2007
    ..Importantly, in rats the effects of obestatin on food intake may be secondary to an action of the peptide to inhibit water drinking...
  50. ncbi Actions of neuropeptide W in paraventricular hypothalamus: implications for the control of stress hormone secretion
    Meghan M Taylor
    Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Am J Physiol Regul Integr Comp Physiol 288:R270-5. 2005
    ..Our data suggest that endogenous NPW, produced in brain, may play a physiologically relevant role in the neuroendocrine response to stress...
  51. ncbi Time to consider new brain clock signals
    Alastair V Ferguson
    Trends Endocrinol Metab 13:276-7. 2002