Roger G Deeley

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. ncbi request reprint Substrate recognition and transport by multidrug resistance protein 1 (ABCC1)
    Roger G Deeley
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ont, Canada K7L 3N6
    FEBS Lett 580:1103-11. 2006
  2. ncbi request reprint Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
    Roger G Deeley
    Division of Cancer Biology and Genetics, Cancer Research Institute and Department of Biochemistry, Queen s University Kingdom, Ontario, Canada
    Physiol Rev 86:849-99. 2006
  3. doi request reprint Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3)
    Caroline E Grant
    Division of Cancer Biology and Genetics, Queen s University Cancer Research Institute, Kingston, ON, Canada K7L3N6
    Drug Metab Dispos 36:2571-81. 2008
  4. doi request reprint Identification of regions required for apical membrane localization of human multidrug resistance protein 2
    Paul E Bandler
    Division of Cancer Biology and Genetics, Queen s University Cancer Research Institute, Kingston, ON, Canada
    Mol Pharmacol 74:9-19. 2008
  5. ncbi request reprint Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter
    Donna Situ
    Department of Pathology and Molecular Medicine and Cancer Research Laboratories, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 279:38871-80. 2004
  6. ncbi request reprint Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions
    Koji Koike
    Cancer Research Laboratories, Botterell Hall, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 279:12325-36. 2004
  7. ncbi request reprint Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state
    Da Wei Zhang
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 278:46052-63. 2003
  8. ncbi request reprint Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3
    Da Wei Zhang
    Division of Cancer Biology and Genetics, Cancer Research Institute, and Department of Pathology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Biochemistry 42:9989-10000. 2003
  9. ncbi request reprint Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region
    Christopher J Westlake
    Department of Biochemistry, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 279:53571-83. 2004
  10. ncbi request reprint Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function
    Isabelle J Létourneau
    Department of Pharmacology and Toxicology, Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
    Drug Metab Dispos 35:1372-9. 2007

Collaborators

  • Susan P C Cole
  • Da Wei Zhang
  • Akio Nakajima
  • Robert L Shepard
  • Anne H Dantzig
  • Qingcheng Mao
  • Linda B Tabas
  • Richard Callaghan
  • Giovanna Chimini
  • Terrence J Monks
  • Ebba U Kurz
  • Gwenaëlle Conseil
  • Isabelle J Létourneau
  • Elaine M Leslie
  • Christopher J Westlake
  • Caroline E Grant
  • Koji Koike
  • Alice Rothnie
  • Lei Qin
  • Anass Haimeur
  • Mian Gao
  • Shui Pang Tam
  • Marianne K DeGorter
  • Andrew J Slot
  • Curtis J Oleschuk
  • Lea Payen
  • Kazuma Maeno
  • Ken Ichi Ito
  • Yue Ming Qian
  • Paul E Bandler
  • Peng Wu
  • Monika Vasa
  • Raymond J Bowers
  • Donna Situ
  • Jeff D Campbell
  • Mario Muredda
  • Lea F Payen
  • Kenichi Nunoya
  • Silke Conrad
  • Alice J Rothnie
  • Dana D Wise
  • Jimin Zheng
  • Zongchao Jia
  • Andrea Y T Lau
  • Robert L Campbell
  • Leo Mok
  • Ashley Theis
  • Christopher Westlake
  • Bernd O Keller
  • Kathryn E Sparks
  • Michael S P Sansom
  • Christophe Moreau
  • Ken Ichi Nunoya
  • Ruth A Burtch-Wright
  • Kevin E Weigl
  • Sharon L Olsen
  • Peter A Lander
  • Dieter Schrenk
  • Hans Martin Kauffmann

Detail Information

Publications50

  1. ncbi request reprint Substrate recognition and transport by multidrug resistance protein 1 (ABCC1)
    Roger G Deeley
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ont, Canada K7L 3N6
    FEBS Lett 580:1103-11. 2006
    ..Here, we summarize current knowledge of the substrate specificity and modes of transport of MRP1 and discuss how the protein may recognize its structurally diverse substrates...
  2. ncbi request reprint Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
    Roger G Deeley
    Division of Cancer Biology and Genetics, Cancer Research Institute and Department of Biochemistry, Queen s University Kingdom, Ontario, Canada
    Physiol Rev 86:849-99. 2006
    ..We also summarize knowledge of their possible physiological functions and evidence that they may be involved in the clinical drug resistance of various forms of cancer...
  3. doi request reprint Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3)
    Caroline E Grant
    Division of Cancer Biology and Genetics, Queen s University Cancer Research Institute, Kingston, ON, Canada K7L3N6
    Drug Metab Dispos 36:2571-81. 2008
    ..These results suggest that Tyr(440) makes a major contribution to recognition of GSH and the GSH moiety of conjugates such as LTC(4)...
  4. doi request reprint Identification of regions required for apical membrane localization of human multidrug resistance protein 2
    Paul E Bandler
    Division of Cancer Biology and Genetics, Queen s University Cancer Research Institute, Kingston, ON, Canada
    Mol Pharmacol 74:9-19. 2008
    ..Our results indicate that CL3 is important for interaction with both the glutathione and glucuronide conjugates tested, but that different regions may be involved...
  5. ncbi request reprint Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter
    Donna Situ
    Department of Pathology and Molecular Medicine and Cancer Research Laboratories, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 279:38871-80. 2004
    ..Thus, Glu(1204) serves a dual role in membrane expression of MRP1 and a step in its catalytic cycle subsequent to initial substrate binding...
  6. ncbi request reprint Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions
    Koji Koike
    Cancer Research Laboratories, Botterell Hall, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 279:12325-36. 2004
    ....
  7. ncbi request reprint Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state
    Da Wei Zhang
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 278:46052-63. 2003
    ....
  8. ncbi request reprint Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3
    Da Wei Zhang
    Division of Cancer Biology and Genetics, Cancer Research Institute, and Department of Pathology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Biochemistry 42:9989-10000. 2003
    ..Furthermore, elimination of the hydrogen-bonding potential of a single amino acid, Thr(1237), markedly enhanced the ability of the protein to confer drug resistance and to transport all substrates examined...
  9. ncbi request reprint Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region
    Christopher J Westlake
    Department of Biochemistry, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 279:53571-83. 2004
    ....
  10. ncbi request reprint Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function
    Isabelle J Létourneau
    Department of Pharmacology and Toxicology, Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
    Drug Metab Dispos 35:1372-9. 2007
    ..We conclude that MRP1-Pro(1150), MRP2-Pro(1158), and MRP3-Pro(1147) in CL7 differ in their influence on substrate specificity but share a common role in the nucleotide interactions of these transporters...
  11. ncbi request reprint Functional importance of three basic residues clustered at the cytosolic interface of transmembrane helix 15 in the multidrug and organic anion transporter MRP1 (ABCC1)
    Gwenaëlle Conseil
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 281:43-50. 2006
    ....
  12. ncbi request reprint Functional and structural consequences of cysteine substitutions in the NH2 proximal region of the human multidrug resistance protein 1 (MRP1/ABCC1)
    Elaine M Leslie
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Biochemistry 42:5214-24. 2003
    ..These results indicate that certain Cys residues in the NH(2) proximal region of MRP1 can be important for its structure and selected transport activities...
  13. ncbi request reprint Mutational analysis of polar amino acid residues within predicted transmembrane helices 10 and 16 of multidrug resistance protein 1 (ABCC1): effect on substrate specificity
    Da Wei Zhang
    Cancer Research Institute, Suite 300, 10 Stuart St Kingston, Ontario K7L 3N6, Canada
    Drug Metab Dispos 34:539-46. 2006
    ..The location of these and other functionally important residues in TM helices 11, 16, and 17 is discussed in the context of an energy-minimized model of the membrane-spanning domains of MRP1...
  14. doi request reprint Mechanistic differences between GSH transport by multidrug resistance protein 1 (MRP1/ABCC1) and GSH modulation of MRP1-mediated transport
    Alice Rothnie
    Division of Cancer Biology and Genetics, Queen s University Cancer Research Institute, Kingston, ON, Canada
    Mol Pharmacol 74:1630-40. 2008
    ..Overall, these results indicate significant mechanistic differences between MRP1-mediated transport of GSH and the ability of GSH to modulate MRP1 transport...
  15. doi request reprint Molecular basis for reduced estrone sulfate transport and altered modulator sensitivity of transmembrane helix (TM) 6 and TM17 mutants of multidrug resistance protein 1 (ABCC1)
    Kazuma Maeno
    Division of Cancer Biology and Genetics, Queen s University Cancer Research Institute, Kingston, ON, Canada K7L 3N6
    Drug Metab Dispos 37:1411-20. 2009
    ....
  16. ncbi request reprint Multiple membrane-associated tryptophan residues contribute to the transport activity and substrate specificity of the human multidrug resistance protein, MRP1
    Koji Koike
    Cancer Research Laboratories, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 277:49495-503. 2002
    ..Our findings suggest that the bulky polar aromatic indole side chain of each of these five Trp residues contributes significantly to the transport activity and substrate specificity of MRP1...
  17. ncbi request reprint Mutations of charged amino acids in or near the transmembrane helices of the second membrane spanning domain differentially affect the substrate specificity and transport activity of the multidrug resistance protein MRP1 (ABCC1)
    Anass Haimeur
    Cancer Research Laboratories, Queen s University, Kingston, Ontario, Canada
    Mol Pharmacol 65:1375-85. 2004
    ..We conclude that MSD2-charged residues in or proximal to TM6, TM7, TM8, and TM11 play critical but differential roles in MRP1 transport activity and substrate specificity...
  18. ncbi request reprint Transmembrane helix 11 of multidrug resistance protein 1 (MRP1/ABCC1): identification of polar amino acids important for substrate specificity and binding of ATP at nucleotide binding domain 1
    Da Wei Zhang
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, K7L 3N6, Canada
    Biochemistry 43:9413-25. 2004
    ..Thus, polar interactions involving residues in TM11 influence not only the substrate specificity of MRP1 but also an early step in the proposed catalytic cycle of the protein...
  19. ncbi request reprint Functional characterization of non-synonymous single nucleotide polymorphisms in the gene encoding human multidrug resistance protein 1 (MRP1/ABCC1)
    Isabelle J Létourneau
    Department of Pharmacology and Toxicology, Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
    Pharmacogenet Genomics 15:647-57. 2005
    ....
  20. ncbi request reprint Identification of the structural and functional boundaries of the multidrug resistance protein 1 cytoplasmic loop 3
    Christopher J Westlake
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    Biochemistry 42:14099-113. 2003
    ..Finally, we show that regions in CL3 necessary for LTC(4) binding and transport are also required for binding of the photoactivatable GSH derivative azidophenacyl-GSH...
  21. ncbi request reprint Role of carboxylate residues adjacent to the conserved core Walker B motifs in the catalytic cycle of multidrug resistance protein 1 (ABCC1)
    Lea F Payen
    Cancer Research Laboratories, Queen s University, Kingston, Ontario, Canada
    J Biol Chem 278:38537-47. 2003
    ..These observations are discussed in the context of catalytic models proposed for MRP1 and other ABC drug transport proteins...
  22. pmc Role of the NH2-terminal membrane spanning domain of multidrug resistance protein 1/ABCC1 in protein processing and trafficking
    Christopher J Westlake
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Mol Biol Cell 16:2483-92. 2005
    ..These data explain apparent differences in the trafficking requirement for MSD0 and the COOH-terminal region of MRP1 compared with other ABCC proteins...
  23. doi request reprint Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter
    Isabelle J Létourneau
    Department of Pharmacology and Toxicology, Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Biochem Pharmacol 75:1659-69. 2008
    ..We hypothesize that loss of Pro1150 alters the role of CL7 as a coupling helix that mediates signaling between the nucleotide binding domains and some substrate binding sites in the membrane spanning domains of MRP1...
  24. ncbi request reprint Modulation of human multidrug resistance protein (MRP) 1 (ABCC1) and MRP2 (ABCC2) transport activities by endogenous and exogenous glutathione-conjugated catechol metabolites
    Andrew J Slot
    Department of Pathology and Molecular Medicine and Division of Cancer Biology and Genetics, Queen s University, Kingston, Ontario, Canada
    Drug Metab Dispos 36:552-60. 2008
    ..In conclusion, we have identified three new classes of MRP1 and MRP2 modulators and demonstrated that one of these, the estrogen conjugates, shows unanticipated differences in their interactions with the two transporters...
  25. doi request reprint Effect of multiple cysteine substitutions on the functionality of human multidrug resistance protein 1 expressed in human embryonic kidney 293 cells: identification of residues essential for function
    Lei Qin
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, ON, Canada
    Drug Metab Dispos 40:1403-13. 2012
    ..The distribution of the remaining Cys residues is such that the protein will provide a useful template for a variety of cysteine based mutagenesis studies...
  26. ncbi request reprint Role of two adjacent cytoplasmic tyrosine residues in MRP1 (ABCC1) transport activity and sensitivity to sulfonylureas
    Gwenaëlle Conseil
    Divison of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ont, K7L 3N6, Canada
    Biochem Pharmacol 69:451-61. 2005
    ....
  27. ncbi request reprint Role of GSH in estrone sulfate binding and translocation by the multidrug resistance protein 1 (MRP1/ABCC1)
    Alice Rothnie
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 281:13906-14. 2006
    ..A model for the mechanism of GSH-stimulated estrone sulfate transport is proposed...
  28. ncbi request reprint Mapping of the MRPm5 epitope to the cytosolic region between transmembrane helices 13 and 14 in the drug and organic anion transporter, MRP1 (ABCC1)
    Koji Koike
    Cancer Research Laboratories, Queen s University, Kingston, Ont, Canada K7L 3N6
    Biochem Biophys Res Commun 315:719-25. 2004
    ..None of the other MRP1-reactive MAbs described to date map to CL6 of MRP1 which in turn enhances the utility of MAb MRPm5 for both clinical and experimental investigations of this transporter...
  29. doi request reprint Residues responsible for the asymmetric function of the nucleotide binding domains of multidrug resistance protein 1
    Lei Qin
    Division of Cancer Biology and Genetics, Cancer Research Institute, Departments of Biochemistry, Pathology and Molecular Medicine, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Biochemistry 47:13952-65. 2008
    ..Overall, these results suggest that the rate of release of ADP by NBD1 in the D793E background may be the rate-limiting step in the transport cycle of MRP1...
  30. doi request reprint Multiple roles of charged amino acids in cytoplasmic loop 7 for expression and function of the multidrug and organic anion transporter MRP1 (ABCC1)
    Gwenaëlle Conseil
    Division of Cancer Biology and Genetics, Queen s University Cancer Research Institute, Kingston, Ontario, Canada
    Mol Pharmacol 75:397-406. 2009
    ..Together, our results demonstrate the extreme sensitivity of CL7 to mutation, consistent with its critical and complex dual role in both the proper folding and transport activity of MRP1...
  31. ncbi request reprint Molecular modeling of the human multidrug resistance protein 1 (MRP1/ABCC1)
    Marianne K DeGorter
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ont, Canada K7L 3N6
    Biochem Biophys Res Commun 365:29-34. 2008
    ..The functional importance of Tyr324 in transmembrane helix 6 predicted to project into the substrate translocation pathway was investigated...
  32. ncbi request reprint Functional interactions between nucleotide binding domains and leukotriene C4 binding sites of multidrug resistance protein 1 (ABCC1)
    Lea Payen
    Division of Camcer Biology and Genetics, Cancer Research Institute, Queen s University, 10 Stuart Street, Kingston, Ontario, K7L 3N6 Canada
    Mol Pharmacol 67:1944-53. 2005
    ....
  33. ncbi request reprint Charged amino acids in the sixth transmembrane helix of multidrug resistance protein 1 (MRP1/ABCC1) are critical determinants of transport activity
    Anass Haimeur
    Cancer Research Laboratories, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 277:41326-33. 2002
    ..The importance of Lys(332) and His(335) in determining substrate specificity and of Asp(336) in overall transport activity suggests that such interactions are critical for the binding and transport of LTC(4) and other substrates of MRP1...
  34. ncbi request reprint Mutation of proline residues in the NH(2)-terminal region of the multidrug resistance protein, MRP1 (ABCC1): effects on protein expression, membrane localization, and transport function
    Ken Ichi Ito
    Cancer Research Laboratories, Queen s University, Kingston, Ontario, Canada
    Biochim Biophys Acta 1615:103-14. 2003
    ..We conclude that certain prolines in MSD1 and CL3 play a role in the expression and structure of MRP1...
  35. ncbi request reprint Analysis of human multidrug resistance protein 1 (ABCC1) by matrix-assisted laser desorption ionization/time of flight mass spectrometry: toward identification of leukotriene C4 binding sites
    Peng Wu
    Division of Cancer Biology and Genetics, Cancer Research Institute, 3rd Floor Botterell Hall, Queen s University, Kingston, ON, Canada K7L 3N6
    Mol Pharmacol 68:1455-65. 2005
    ..Our studies confirm the usefulness of mass spectrometry for analysis of mammalian polytopic membrane proteins and for identification of substrate binding sites of human MRP1...
  36. ncbi request reprint Photolabeling of human and murine multidrug resistance protein 1 with the high affinity inhibitor [125I]LY475776 and azidophenacyl-[35S]glutathione
    Yue Ming Qian
    Cancer Research Laboratories, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Biol Chem 277:35225-31. 2002
    ..Although required for binding, CL3 is not photolabeled by azidophenacyl-GSH. Finally, we identify non-conserved amino acids in the third MSD that contribute to the high affinity with which LY475776 binds to MRP1...
  37. ncbi request reprint Substitution of Trp1242 of TM17 alters substrate specificity of human multidrug resistance protein 3
    Curtis J Oleschuk
    Department of Pharmacology and Toxicology and Cancer Research Laboratories, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Am J Physiol Gastrointest Liver Physiol 284:G280-9. 2003
    ..Thus Trp(1242) substitutions markedly alter the substrate specificity of MRP3 but leave bile salt binding and transport intact...
  38. ncbi request reprint Limited modulation of the transport activity of the human multidrug resistance proteins MRP1, MRP2 and MRP3 by nicotine glucuronide metabolites
    Isabelle J Létourneau
    Department of Pharmacology and Toxicology, Queen s University, Botterell Hall, Stuart Street, Kingston, Ont, Canada K7L 3N6
    Toxicol Lett 157:9-19. 2005
    ..We conclude that the physiological functions of MRP1, MRP2 and MRP3 are not likely to be substantially affected by nicotine glucuronide metabolites at concentrations achievable in human serum...
  39. ncbi request reprint Polymorphisms of MRP1 (ABCC1) and related ATP-dependent drug transporters
    Gwenaëlle Conseil
    Cancer Research Laboratories, Queen s University, Kingston, Ontario, Canada
    Pharmacogenet Genomics 15:523-33. 2005
    ....
  40. ncbi request reprint ABCA1 mediates high-affinity uptake of 25-hydroxycholesterol by membrane vesicles and rapid efflux of oxysterol by intact cells
    Shui Pang Tam
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, 10 Stuart Street, Kingston, Ontario, Canada K7L 3N6
    Am J Physiol Cell Physiol 291:C490-502. 2006
    ....
  41. ncbi request reprint Structural requirements for functional interaction of glutathione tripeptide analogs with the human multidrug resistance protein 1 (MRP1)
    Elaine M Leslie
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
    J Pharmacol Exp Ther 304:643-53. 2003
    ..These data provide insight into the architecture of the GSH binding domain of MRP1...
  42. ncbi request reprint Cloning and Characterization of the Murine and Rat mrp1 Promoter Regions
    Mario Muredda
    Queen s University Cancer Research Institute, Botterell Hall Room A315C, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Mol Pharmacol 64:1259-69. 2003
    ..Finally, we show that the tumor suppressor protein p53 can repress the human and rodent promoters by a mechanism that is independent of the Sp1 elements...
  43. ncbi request reprint Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1)
    Elaine M Leslie
    Department of Pharmacology and Toxicology, Kingston, Ontario, Canada
    Drug Metab Dispos 31:11-5. 2003
    ..Our results suggest that flavonoids stimulate MRP1-mediated GSH transport by increasing the apparent affinity of the transporter for GSH but provide no evidence that a cotransport mechanism is involved...
  44. ncbi request reprint GSH-dependent photolabeling of multidrug resistance protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain
    Qingcheng Mao
    Cancer Research Laboratories and Department of Pathology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 277:28690-9. 2002
    ..Finally, vanadate-induced trapping of ADP inhibited [125I]LY475776 labeling, suggesting that ATP hydrolysis causes a conformational change in MRP1 that reduces the affinity of the protein for this inhibitor...
  45. ncbi request reprint Transport of glutathione and glutathione conjugates by MRP1
    Susan P C Cole
    Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Trends Pharmacol Sci 27:438-46. 2006
    ..Site-directed mutagenesis studies and biophysical analyses have provided important insights into the structural determinants of MRP1 that influence GSH and GSH conjugate binding and transport...
  46. ncbi request reprint Determinants of the substrate specificity of multidrug resistance protein 1: role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17
    Da Wei Zhang
    Cancer Research Laboratories and Department of Pathology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 277:20934-41. 2002
    ..Together with our previous results, these findings suggest that residues with side chain hydrogen bonding potential, clustered in the cytoplasmic half of TM17, participate in the formation of a substrate binding site...
  47. ncbi request reprint A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance
    Silke Conrad
    Food Chemistry and Environmental Toxicology, University of Kaiserslautern, Kaiserslautern, Germany
    Pharmacogenetics 12:321-30. 2002
    ....
  48. ncbi request reprint Molecular modeling correctly predicts the functional importance of Phe594 in transmembrane helix 11 of the multidrug resistance protein, MRP1 (ABCC1)
    Jeff D Campbell
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    J Biol Chem 279:463-8. 2004
    ....
  49. ncbi request reprint Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1)
    Kenichi Nunoya
    Department of Xenobiotic and Disposition, Minase Research Institute, Ono Pharmaceutical Co, Ltd, Osaka, Japan
    Drug Metab Dispos 31:1016-26. 2003
    ..Our studies also suggest that although rMRP1 and mMRP1 are 95% identical in primary structure, their substrate specificities may be influenced by amino acids that are not conserved between the two rodent proteins...
  50. ncbi request reprint Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
    Elaine M Leslie
    Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Toxicol Appl Pharmacol 204:216-37. 2005
    ..Species variations in substrate specificity and tissue distribution of these transporters are also addressed since these properties have implications for in vivo models of toxicity used for drug discovery and development...