Genomes and Genes
Affiliation: Queen's University
- Fission yeast rad12+ regulates cell cycle checkpoint control and is homologous to the Bloom's syndrome disease geneS Davey
Department of Oncology, Queen s University, Kingston, Ontario, Canada
Mol Cell Biol 18:2721-8. 1998..The physical chromosome segregation defects seen in rad12 null cells combined with the checkpoint regulation defect seen in the rad12+ overproducer implicate rad12+ as a key coupler of chromosomal integrity with cell cycle progression...
- The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1R P St Onge
Cancer Research Laboratories, Queen s University, Kingston, Ontario K7L 3N6, Canada
Mol Biol Cell 10:1985-95. 1999..Finally, we show that hRAD9 is a nuclear protein, indicating that in this signal transduction pathway, hRAD9 is physically proximal to the upstream (DNA damage) signal rather than to the downstream, cytoplasmic, cell cycle machinery...
- DNA damage-dependent and -independent phosphorylation of the hRad9 checkpoint proteinR P St Onge
Cancer Research Laboratories and the Departments of Pathology, Biochemistry, and Oncology, Queen s University, Kingston, Ontario K7L 3N6, Canada
J Biol Chem 276:41898-905. 2001..Unlike the IR-induced phosphorylation at serine 272, this event is dependent on serine 277 and threonine 292, two C-terminal (S/T)P sites in hRad9...
- HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control geneC M Udell
Cancer Research Laboratories, Department of Oncology and Department of Pathology, Queen s University, Kingston K7L 3N6, Canada
Nucleic Acids Res 26:3971-6. 1998..The ability of HRAD1 to partially complement yeast rad1 mutants suggests that this gene is required for G2checkpoint control in human cells...