Brian M Bennett

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. ncbi request reprint Nitrates and NO release: contemporary aspects in biological and medicinal chemistry
    Gregory R J Thatcher
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612 7231, USA
    Free Radic Biol Med 37:1122-43. 2004
  2. ncbi request reprint NO chimeras as therapeutic agents in Alzheimer's disease
    Gregory R J Thatcher
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S Wood St, Chicago, IL 60612 7231, USA
    Curr Alzheimer Res 3:237-45. 2006
  3. ncbi request reprint Cognitive deficits in rats after forebrain cholinergic depletion are reversed by a novel NO mimetic nitrate ester
    Brian M Bennett
    Department of Pharmacology and Toxicology, Queen s University, Kingston, ON, Canada
    Neuropsychopharmacology 32:505-13. 2007
  4. doi request reprint Role of microsomal glutathione transferase 1 in the mechanism-based biotransformation of glyceryl trinitrate in LLC-PK1 cells
    Yanbin Ji
    Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen s University, Kingston, Ontario, Canada
    Biochem Pharmacol 77:1702-8. 2009
  5. ncbi request reprint Nitration of tyrosine 92 mediates the activation of rat microsomal glutathione s-transferase by peroxynitrite
    Yanbin Ji
    Department of Pharmacology and Toxicology, Department of Physiology, Faculty of Health Sciences, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 281:1986-91. 2006
  6. ncbi request reprint Role of mitochondrial aldehyde dehydrogenase in nitrate tolerance
    Jon DiFabio
    Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen s University, Kingston, ON, Canada K7L 3N6
    Mol Pharmacol 64:1109-16. 2003
  7. pmc Compartmentation and compartment-specific regulation of PDE5 by protein kinase G allows selective cGMP-mediated regulation of platelet functions
    Lindsay S Wilson
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, ON, Canada K7L 3N6
    Proc Natl Acad Sci U S A 105:13650-5. 2008
  8. ncbi request reprint Chemosensitization of cancer in vitro and in vivo by nitric oxide signaling
    Lisa J Frederiksen
    Department of Anatomy, Queen s University, Kingston, Ontario, Canada
    Clin Cancer Res 13:2199-206. 2007
  9. ncbi request reprint Biotransformation of glyceryl trinitrate by rat hepatic microsomal glutathione S-transferase 1
    Yanbin Ji
    Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Pharmacol Exp Ther 318:1050-6. 2006
  10. ncbi request reprint Inhibition of phosphodiesterase 5 selectively reverses nitrate tolerance in the venous circulation
    Jeffery D MacPherson
    Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen s University, Kingston, ON, Canada
    J Pharmacol Exp Ther 317:188-95. 2006

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Nitrates and NO release: contemporary aspects in biological and medicinal chemistry
    Gregory R J Thatcher
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612 7231, USA
    Free Radic Biol Med 37:1122-43. 2004
    ..Aspects of the therapeutic and biological activity of nitrates are reviewed in the context of the chemistry of nitrates and the elusive efficient 3e- reduction required to generate NO...
  2. ncbi request reprint NO chimeras as therapeutic agents in Alzheimer's disease
    Gregory R J Thatcher
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S Wood St, Chicago, IL 60612 7231, USA
    Curr Alzheimer Res 3:237-45. 2006
    ..NO chimeras and hybrid nitrates hold promise as therapeutics for AD with multiple sites of action...
  3. ncbi request reprint Cognitive deficits in rats after forebrain cholinergic depletion are reversed by a novel NO mimetic nitrate ester
    Brian M Bennett
    Department of Pharmacology and Toxicology, Queen s University, Kingston, ON, Canada
    Neuropsychopharmacology 32:505-13. 2007
    ..This approach may be superior to that of current drugs that attempt only to salvage the residual function of damaged cholinergic neurons...
  4. doi request reprint Role of microsomal glutathione transferase 1 in the mechanism-based biotransformation of glyceryl trinitrate in LLC-PK1 cells
    Yanbin Ji
    Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen s University, Kingston, Ontario, Canada
    Biochem Pharmacol 77:1702-8. 2009
    ..We conclude that although MGST1 mediates the biotransformation of GTN in intact cells, this biotransformation does not contribute to the formation of activators of sGC...
  5. ncbi request reprint Nitration of tyrosine 92 mediates the activation of rat microsomal glutathione s-transferase by peroxynitrite
    Yanbin Ji
    Department of Pharmacology and Toxicology, Department of Physiology, Faculty of Health Sciences, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 281:1986-91. 2006
    ....
  6. ncbi request reprint Role of mitochondrial aldehyde dehydrogenase in nitrate tolerance
    Jon DiFabio
    Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen s University, Kingston, ON, Canada K7L 3N6
    Mol Pharmacol 64:1109-16. 2003
    ....
  7. pmc Compartmentation and compartment-specific regulation of PDE5 by protein kinase G allows selective cGMP-mediated regulation of platelet functions
    Lindsay S Wilson
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, ON, Canada K7L 3N6
    Proc Natl Acad Sci U S A 105:13650-5. 2008
    ..We submit that our findings may define a molecular mechanism by which PDE5 inhibition can differentially impact selected cellular functions of platelets, and perhaps of other cell types...
  8. ncbi request reprint Chemosensitization of cancer in vitro and in vivo by nitric oxide signaling
    Lisa J Frederiksen
    Department of Anatomy, Queen s University, Kingston, Ontario, Canada
    Clin Cancer Res 13:2199-206. 2007
    ..Here, we determined whether chemosensitization by NO mimetics requires cGMP-dependent signaling and whether low concentrations of NO mimetics can chemosensitize tumors in vivo...
  9. ncbi request reprint Biotransformation of glyceryl trinitrate by rat hepatic microsomal glutathione S-transferase 1
    Yanbin Ji
    Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Pharmacol Exp Ther 318:1050-6. 2006
    ....
  10. ncbi request reprint Inhibition of phosphodiesterase 5 selectively reverses nitrate tolerance in the venous circulation
    Jeffery D MacPherson
    Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen s University, Kingston, ON, Canada
    J Pharmacol Exp Ther 317:188-95. 2006
    ..These results suggest that increased PDE5 activity in the venous circulation contributes to the altered hemodynamic response to GTN following chronic GTN exposure...
  11. ncbi request reprint Effect of in vivo nitrate tolerance on hypersensitivity to NO donors after NO-synthase blockade
    Jodan D Ratz
    Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen s University, Kingston, ON K7L 3N6, Canada
    Can J Physiol Pharmacol 80:1106-18. 2002
    ....
  12. ncbi request reprint Neuroprotection against ischemic brain injury conferred by a novel nitrate ester
    James N Reynolds
    Department of Pharmacology and Toxicology, Queen s University, Kingston, ON, Canada
    Bioorg Med Chem Lett 12:2863-6. 2002
    ..A novel nitrate showed relatively weak systemic effects, but in the middle cerebral artery occlusion rat model of focal ischemia, reduced the cerebral infarct by 60-70% when administered 4 h after the onset of ischemia...
  13. ncbi request reprint Steady-state maternal and fetal plasma concentrations of glyceryl trinitrate (GTN) in the preterm sheep
    Mark A Bustard
    Department of Pharmacology and Toxicology, Botterell Hall, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Can J Physiol Pharmacol 81:884-9. 2003
    ..18. The FA [GTN] (<5 nM) indicates that the fetus cleared essentially all GTN in the UV, and the maternal and fetal heart rate and mean arterial pressure appear to be independent of maternal GTN infusion...
  14. ncbi request reprint Activation of microsomal glutathione s-transferase by peroxynitrite
    Yanbin Ji
    Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen s University, Kingston, Ontario, Canada
    Mol Pharmacol 63:136-46. 2003
    ....
  15. ncbi request reprint Novel nitrates as NO mimetics directed at Alzheimer's disease
    Gregory R J Thatcher
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S Wood St Chicago, IL 60612 7231, USA
    J Alzheimers Dis 6:S75-84. 2004
    ....