Richard J Beninger

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. ncbi request reprint The role of signaling molecules in reward-related incentive learning
    Richard J Beninger
    Departments of Psychology and Psychiatry, Queen s University, Kingston ON K7L 3N6, Canada
    Neurotox Res 6:91-104. 2004
  2. ncbi request reprint cAMP-dependent protein kinase and reward-related learning: intra-accumbens Rp-cAMPS blocks amphetamine-produced place conditioning in rats
    Richard J Beninger
    Department of Psychology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Psychopharmacology (Berl) 170:23-32. 2003
  3. ncbi request reprint Typical and atypical antipsychotic medications differentially affect two nondeclarative memory tasks in schizophrenic patients: a double dissociation
    Richard J Beninger
    Department of Psychology, Queen s University, K7L 3N6, Kingston, ON, Canada
    Schizophr Res 61:281-92. 2003
  4. ncbi request reprint Differential effects of calcineurin inhibition and protein kinase A activation on nucleus accumbens amphetamine-produced conditioned place preference in rats
    Todor V Gerdjikov
    Department of Psychology, Queen s University, Kingston, ON K7L 3N6, Canada
    Eur J Neurosci 22:697-705. 2005
  5. ncbi request reprint Nucleus accumbens PKA inhibition blocks acquisition but enhances expression of amphetamine-produced conditioned activity in rats
    Todor V Gerdjikov
    Department of Psychology, Queen s University, Kingston, ON, Canada
    Psychopharmacology (Berl) 190:65-72. 2007
  6. doi request reprint Subchronic phencyclidine in rats: alterations in locomotor activity, maze performance, and GABA(A) receptor binding
    Richard J Beninger
    Centre for Neuroscience Studies, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Behav Pharmacol 21:1-10. 2010
  7. doi request reprint Reduced expression of haloperidol conditioned catalepsy in rats by the dopamine D3 receptor antagonists nafadotride and NGB 2904
    Tomek J Banasikowski
    Center Neurosci Studies, Department Psychology, Queen s University, Kingston, ON, Canada K7L 3 N6
    Eur Neuropsychopharmacol 22:761-8. 2012
  8. doi request reprint Subchronic MK-801 behavioural deficits in rats: partial reversal by the novel nitrate GT 1061
    Richard J Beninger
    Department of Psychology, Queen s University, Kingston ON, Canada K7L 3N6
    Pharmacol Biochem Behav 91:495-502. 2009
  9. doi request reprint Subchronic MK-801 treatment and post-weaning social isolation in rats: differential effects on locomotor activity and hippocampal long-term potentiation
    Donovan M Ashby
    Department of Psychology, Queen s University, Kingston, Ontario, K7L 3N6, Canada
    Behav Brain Res 212:64-70. 2010
  10. pmc Place preference induced by nucleus accumbens amphetamine is impaired by local blockade of Group II metabotropic glutamate receptors in rats
    Todor V Gerdjikov
    Department of Psychology, Queen s University, Kingston, ON K7L 3N6, Canada
    BMC Neurosci 7:43. 2006

Collaborators

Detail Information

Publications46

  1. ncbi request reprint The role of signaling molecules in reward-related incentive learning
    Richard J Beninger
    Departments of Psychology and Psychiatry, Queen s University, Kingston ON K7L 3N6, Canada
    Neurotox Res 6:91-104. 2004
    ..Results support a model of DA-Glu synaptic interactions that form the basis of incentive learning...
  2. ncbi request reprint cAMP-dependent protein kinase and reward-related learning: intra-accumbens Rp-cAMPS blocks amphetamine-produced place conditioning in rats
    Richard J Beninger
    Department of Psychology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Psychopharmacology (Berl) 170:23-32. 2003
    ..Dopamine may produce reward-related learning by activating D(1)-like receptors in the nucleus accumbens (NAc) and stimulating the formation of cyclic adenosine monophosphate (cAMP) and the activation of cAMP-dependent protein kinase (PKA)...
  3. ncbi request reprint Typical and atypical antipsychotic medications differentially affect two nondeclarative memory tasks in schizophrenic patients: a double dissociation
    Richard J Beninger
    Department of Psychology, Queen s University, K7L 3N6, Kingston, ON, Canada
    Schizophr Res 61:281-92. 2003
    ..Results suggest that typical and atypical antipsychotics differentially affect nondeclarative memory mediated by different brain regions...
  4. ncbi request reprint Differential effects of calcineurin inhibition and protein kinase A activation on nucleus accumbens amphetamine-produced conditioned place preference in rats
    Todor V Gerdjikov
    Department of Psychology, Queen s University, Kingston, ON K7L 3N6, Canada
    Eur J Neurosci 22:697-705. 2005
    ..Results suggest that CN acts as a negative regulator in the establishment of NAc amphetamine-produced CPP, a form of reward-related learning...
  5. ncbi request reprint Nucleus accumbens PKA inhibition blocks acquisition but enhances expression of amphetamine-produced conditioned activity in rats
    Todor V Gerdjikov
    Department of Psychology, Queen s University, Kingston, ON, Canada
    Psychopharmacology (Berl) 190:65-72. 2007
    ....
  6. doi request reprint Subchronic phencyclidine in rats: alterations in locomotor activity, maze performance, and GABA(A) receptor binding
    Richard J Beninger
    Centre for Neuroscience Studies, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Behav Pharmacol 21:1-10. 2010
    ..The observed changes in GABAA receptors in the rat brain are consistent with the notion that alterations in GABAergic receptor function contribute to the behavioral and cognitive impairments associated with repeated exposure to PCP...
  7. doi request reprint Reduced expression of haloperidol conditioned catalepsy in rats by the dopamine D3 receptor antagonists nafadotride and NGB 2904
    Tomek J Banasikowski
    Center Neurosci Studies, Department Psychology, Queen s University, Kingston, ON, Canada K7L 3 N6
    Eur Neuropsychopharmacol 22:761-8. 2012
    ..5 mg/kg) significantly attenuate conditioned catalepsy in rats when given in test but not when given during sensitization. Results implicate DA D3 receptors in regulating the expression of conditioned catalepsy...
  8. doi request reprint Subchronic MK-801 behavioural deficits in rats: partial reversal by the novel nitrate GT 1061
    Richard J Beninger
    Department of Psychology, Queen s University, Kingston ON, Canada K7L 3N6
    Pharmacol Biochem Behav 91:495-502. 2009
    ..These ameliorative effects of GT 1061 may be linked to the activation of NO- and GABA-dependent signaling and suggests a new direction for treating cognitive dysfunction in schizophrenia...
  9. doi request reprint Subchronic MK-801 treatment and post-weaning social isolation in rats: differential effects on locomotor activity and hippocampal long-term potentiation
    Donovan M Ashby
    Department of Psychology, Queen s University, Kingston, Ontario, K7L 3N6, Canada
    Behav Brain Res 212:64-70. 2010
    ....
  10. pmc Place preference induced by nucleus accumbens amphetamine is impaired by local blockade of Group II metabotropic glutamate receptors in rats
    Todor V Gerdjikov
    Department of Psychology, Queen s University, Kingston, ON K7L 3N6, Canada
    BMC Neurosci 7:43. 2006
    ..In previous studies, NAc basal and amphetamine-produced DA transmission was altered by Group II mGluR agents. We tested whether NAc amphetamine CPP depends on Group II mGluR transmission...
  11. doi request reprint Probabilistic classification and gambling in patients with schizophrenia receiving medication: comparison of risperidone, olanzapine, clozapine and typical antipsychotics
    James I Wasserman
    Department of Psychology, Queen s University, 62 Arch St, Kingston, ON K7L 3N6, Canada
    Psychopharmacology (Berl) 222:173-83. 2012
    ....
  12. ncbi request reprint Place preference induced by nucleus accumbens amphetamine is impaired by antagonists of ERK or p38 MAP kinases in rats
    Todor V Gerdjikov
    Department of Psychology, Queen s University, Kingston, ON, Canada
    Behav Neurosci 118:740-50. 2004
    ..Results suggest that ERK and p38, but not JNK, MAPKs may be necessary for the establishment of NAc amphetamine-produced CPP and may also mediate other forms of reward-related learning dependent on NAc...
  13. doi request reprint The antidepressant phenelzine enhances memory in the double Y-maze and increases GABA levels in the hippocampus and frontal cortex of rats
    Sarah M Simpson
    School of Undergraduate Medicine, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Pharmacol Biochem Behav 102:109-17. 2012
    ..It was concluded that PLZ does not specifically augment memory in SI or subchronic MK-801-treated rats...
  14. ncbi request reprint Intra-BLA or intra-NAc infusions of the dopamine D3 receptor partial agonist, BP 897, block intra-NAc amphetamine conditioned activity
    Harinder Aujla
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    Behav Neurosci 118:1324-30. 2004
    ..Results indicate that the ability of BP 897 to attenuate the expression of conditioned activity is mediated in part by the NAc and BLA...
  15. doi request reprint Post-weaning social isolation and subchronic NMDA glutamate receptor blockade: effects on locomotor activity and GABA signaling in the rat suggest independent mechanisms
    Andrea J Hickey
    Centre for Neuroscience Studies, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Pharmacol Biochem Behav 101:231-8. 2012
    ..Results suggest that SI and subchronic MK-801 may act through independent mechanisms...
  16. ncbi request reprint Dimenhydrinate produces a conditioned place preference in rats
    Alison G Halpert
    Department of Psychology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Pharmacol Biochem Behav 75:173-9. 2003
    ..Future investigations into the neurotransmitter systems modulating this effect are awaited...
  17. ncbi request reprint Intra-accumbens protein kinase C inhibitor NPC 15437 blocks amphetamine-produced conditioned place preference in rats
    Harinder Aujla
    Department of Psychology, Queen s University, Kingstone, Ont, Canada
    Behav Brain Res 147:41-8. 2003
    ..Results implicate PKC in the NAc in reward-related learning. More work is needed to elucidate the signaling pathways involved in this type of learning...
  18. pmc Increased drinking following social isolation rearing: implications for polydipsia associated with schizophrenia
    Emily R Hawken
    Centre for Neuroscience Studies, Queen s University, Kingston, Canada
    PLoS ONE 8:e56105. 2013
    ..The addition of subchronic MK-801 treatment did not significantly augment the amount of water consumed. These findings suggest a predisposition to polydipsia is a schizophrenia-like behavioral effect of post-weaning social isolation...
  19. doi request reprint Neonatal ventral hippocampal lesions in male and female rats: effects on water maze, locomotor activity, plus-maze and prefrontal cortical GABA and glutamate release in adulthood
    Richard J Beninger
    Department of Psychology, Queen s University, 62 Arch Street, Kingston, ON K7L 3N6, Canada
    Behav Brain Res 202:198-209. 2009
    ..Findings support the notion that behavioural abnormalities in post-pubertal male and female nVHL rats are associated with decreases in PFC neurotransmitter release...
  20. doi request reprint Differential effects of dopamine and AMPA receptor antagonists on the expression of conditioned avoidance responding in rats
    Gregory A Boivin
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    Behav Neurosci 122:377-84. 2008
    ..Results are consistent with a role for AMPA receptors in maintaining the expression of learning...
  21. doi request reprint Haloperidol conditioned catalepsy in rats: a possible role for D1-like receptors
    Tomek J Banasikowski
    Center for Neuroscience Studies, Kingston, ON, Canada
    Int J Neuropsychopharmacol 15:1525-34. 2012
    ..Conditioned catalepsy requires functional D1-like receptors during sensitization sessions but not during test sessions...
  22. doi request reprint Evidence for 2-stage models of sleep and memory: learning-dependent changes in spindles and theta in rats
    Stuart M Fogel
    Centre for Neuroscience Studies, Queen s University, Kingston, Ontario, Canada
    Brain Res Bull 79:445-51. 2009
    ..Perhaps first theta increases to organize and consolidate material via hippocampal-neocortical dialogue, followed by subsequent refinement in the cortex by spindles during SWS...
  23. doi request reprint Amphetamine-induced enhancement of responding for conditioned reward in rats: interactions with repeated testing
    Todor V Gerdjikov
    Department of Psychology, Queen s University, Kingston, ON, K7L 3N6, Canada
    Psychopharmacology (Berl) 214:891-9. 2011
    ..The mesolimbic dopamine system underlies the ability of reward-related stimuli to control operant behavior. Previous work has shown that amphetamine potentiates operant responding for conditioned rewards (CRs)...
  24. doi request reprint Regional differences in the action of antipsychotic drugs: implications for cognitive effects in schizophrenic patients
    Richard J Beninger
    Department of Psychology, Queen s University, 62 Arch St, Kingston, ON, K7L 3N6, Canada
    Neurotox Res 18:229-43. 2010
    ..These findings suggest that some of the cognitive deficits seen in schizophrenic patients may be related to the medications that are used to treat them...
  25. ncbi request reprint Role of dopamine D3 receptors in the expression of conditioned fear in rats
    Shelley N Swain
    Department of Psychology, 62 Arch St, Queen s University, Kingston ON, Canada K7L 3N6
    Eur J Pharmacol 579:167-76. 2008
    ..Thus, BP 897 and SB-277011A dose-dependently attenuated the expression but not the acquisition of conditioned fear. These findings suggest that BP 897 and SB-277011A reduce the control of responding by aversively conditioned stimuli...
  26. ncbi request reprint Schizophrenic patients treated with clozapine or olanzapine perform better on theory of mind tasks than those treated with risperidone or typical antipsychotic medications
    Ioulia Savina
    Department of Psychology, Queen s University, Kingston ON, Canada, K7L 3N6
    Schizophr Res 94:128-38. 2007
    ..We concluded that ToM performance of schizophrenic patients is influenced by the antipsychotic they are taking. Our results suggest that olanzapine or clozapine but not typicals or risperidone may improve or protect ToM ability...
  27. ncbi request reprint Dopamine and incentive learning: a framework for considering antipsychotic medication effects
    Richard J Beninger
    Departments of Psychology and Psychiatry, Queen s University, Kingston ON K7L3N6, Canada
    Neurotox Res 10:199-209. 2006
    ..It remains the task of researchers and clinicians to sort out the symptoms associated with the endogenous illness from possible iatrogenic symptoms resulting from the antipsychotic medications used to treat schizophrenia...
  28. doi request reprint Dissociable effects of ultralow-dose naltrexone on tolerance to the antinociceptive and cataleptic effects of morphine
    Katharine J Tuerke
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    Behav Pharmacol 22:558-63. 2011
    ....
  29. doi request reprint Increased schedule-induced polydipsia in the rat following subchronic treatment with MK-801
    Emily R Hawken
    Centre for Neuroscience Studies, Queen s University, Kingston, ON K7L 3N6, Canada
    Schizophr Res 125:93-8. 2011
    ..In comparison with saline-treated control animals, subchronic MK-801 treatment significantly increased SIP. These findings suggest an animal model of polydipsia associated with schizophrenia in humans...
  30. doi request reprint Different types of avoidance behavior in rats produce dissociable post-training changes in sleep
    Stuart M Fogel
    Centre for Neuroscience Studies, Queen s University, Kingston, ON, Canada, K7L 3N6
    Physiol Behav 102:170-4. 2011
    ..Training-dependent changes in post-acquisition sleep may reflect distinct processes involved in the consolidation of these different memory traces...
  31. doi request reprint Amphetamine stimulates Wnt3 increases in rat nucleus accumbens
    R John Macleod
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Neuroreport 23:846-50. 2012
    ..Our data support the hypothesis that proximate Wnt signalling is rapidly activated by amphetamine in the adult rat nucleus accumbens...
  32. ncbi request reprint People newly in love are more responsive to positive feedback
    Cassandra L Brown
    Department of Psychology, Queen s University, Kingston, ON, Canada
    Psychol Rep 110:753-63. 2012
    ..This suggests that people who are newly in love show a bias toward responding to positive feedback, which may reflect a general bias towards reward-seeking...
  33. doi request reprint Comparison of nafadotride, CNQX, and haloperidol on acquisition versus expression of amphetamine-conditioned place preference in rats
    Tomek J Banasikowski
    Centre for Neuroscience Studies, Queen s University, Kingston, Ontario, Canada
    Behav Pharmacol 23:89-97. 2012
    ..The results suggest that AMPA/kainate and DA D3 receptors are more strongly involved in the expression of amphetamine CPP and D2 receptors are more strongly involved in the acquisition of amphetamine CPP...
  34. ncbi request reprint A dopamine D3 receptor partial agonist blocks the expression of conditioned activity
    Harinder Aujla
    Department of Psychology, Queen s University, Kingston, ON, Canada
    Neuroreport 13:173-6. 2002
    ....
  35. ncbi request reprint Water maze versus radial maze: differential performance of rats in a spatial delayed match-to-position task and response to scopolamine
    Brandi K Ormerod
    Department of Psychology, Queen s University, Kingston, Canada K7L 3N6
    Behav Brain Res 128:139-52. 2002
    ..8 mg/kg dose impaired performance. The pattern of results may reflect different natural tendencies of rats to alternate (win-shift) versus not alternate (win-stay) in dry land versus swim tasks...
  36. doi request reprint Reinforcer devaluation by extinction depends on the food restriction protocol
    Tyson W Baker
    Department of Psychology, Queen s University, 62 Arch Street, Kingston, ON K7L 3N6, Canada
    Behav Processes 90:124-9. 2012
    ....
  37. doi request reprint Post-weaning social isolation increases activity in a novel environment but decreases defensive burying and subchronic MK-801 enhances the activity but not the burying effect in rats
    Sarah M Simpson
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    Pharmacol Biochem Behav 95:72-9. 2010
    ..The behavioral abnormalities of SI rats may be a manifestation of GABAergic dysfunction that has recently become evident in schizophrenia...
  38. ncbi request reprint Mechanisms and abuse liability of the anti-histamine dimenhydrinate
    Alison G Halpert
    Department of Psychology, Queen s University, Kingston, Ont, Canada K7L 3N6
    Neurosci Biobehav Rev 26:61-7. 2002
    ..Further support comes from reports of acute and chronic abuse of DMH by humans. Collectively, results confirm the abuse liability of DMH...
  39. ncbi request reprint Effects of Parkinson disease on two putative nondeclarative learning tasks: probabilistic classification and gambling
    James G Perretta
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    Cogn Behav Neurol 18:185-92. 2005
    ..To assess performance on two nondeclarative (implicit) memory tasks of Parkinson disease (PD) patients without dementia in the earlier or later stages of the disease (Hoehn and Yahr Scale scores of 1-2.5 or 3-4, respectively)...
  40. ncbi request reprint Paradoxical effects of the opioid antagonist naltrexone on morphine analgesia, tolerance, and reward in rats
    Kelly J Powell
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
    J Pharmacol Exp Ther 300:588-96. 2002
    ..0 mg/kg) extended the duration of the morphine-induced conditioned place preference. These effects of naltrexone on morphine-induced reward may have implications for chronic treatment with agonist-antagonist combinations...
  41. ncbi request reprint Post-training intra-striatal scopolamine or flupenthixol impairs radial maze learning in rats
    Glenn Legault
    Department of Psychology, Queen s University, Kingston, Ont, Canada K7L 3N6
    Behav Brain Res 170:148-55. 2006
    ..Trans-flupenthixol produced less impairment than cis-flupenthixol. Results suggest that ACh and DA receptors in the dorsal striatum during hours 0-4 following training play a role in habit learning...
  42. ncbi request reprint Scopolamine during the paradoxical sleep window impairs radial arm maze learning in rats
    Glenn Legault
    Department of Psychology, Queen s University, Kingston, ON, Canada K7L 3N6
    Pharmacol Biochem Behav 79:715-21. 2004
    ..Results suggest that REM sleep and intact ACh neurotransmission are required during the PSW for rats to learn the radial maze task...
  43. ncbi request reprint Comorbidity of substance abuse with other psychiatric disorders
    Tomas Palomo
    Servicio Psiquiatrico, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain
    Neurotox Res 12:17-27. 2007
    ..Further studies are needed to fully characterize the neurocircuits and transmitters involved in various psychiatric disorders and their possible common elements in comorbid drug abuse...
  44. ncbi request reprint Treatment consideration and manifest complexity in comorbid neuropsychiatric disorders
    Tomas Palomo
    Psychiatry Service, 12 de Octubre, University Hospital, Madrid 28041, Spain
    Neurotox Res 12:43-60. 2007
    ..These observations suggest a need to re-evaluate established diagnostic criteria and disorder definitions, focusing instead on symptoms and symptom-profiles...
  45. ncbi request reprint Comorbidity implications in brain disease: neuronal substrates of symptom profiles
    Tomas Palomo
    Psychiatry Service, 12 de Octubre, University Hospital, Madrid 28041, Spain
    Neurotox Res 12:1-15. 2007
    ....
  46. ncbi request reprint Werner J. Schmidt (1950-2007). Pushing the boundary of neuroscience: a true academician and a complete gentleman
    Trevor Archer
    University of Goteborg, Department of Psychology, Goteborg, Sweden
    Neurotox Res 12:i-iv. 2007