Research Topics
| R J BeningerSummaryAffiliation: Queen's University Country: Canada Publications
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Publications
Subchronic MK-801 behavioural deficits in rats: partial reversal by the novel nitrate GT 1061Richard J Beninger
Department of Psychology, Queen s University, Kingston ON, Canada K7L 3N6
Pharmacol Biochem Behav 91:495-502. 2009..These ameliorative effects of GT 1061 may be linked to the activation of NO- and GABA-dependent signaling and suggests a new direction for treating cognitive dysfunction in schizophrenia...- Subchronic phencyclidine in rats: alterations in locomotor activity, maze performance, and GABA(A) receptor bindingRichard J Beninger
Centre for Neuroscience Studies, Queen s University, Kingston, Ontario K7L 3N6, Canada
Behav Pharmacol 21:1-10. 2010..The observed changes in GABAA receptors in the rat brain are consistent with the notion that alterations in GABAergic receptor function contribute to the behavioral and cognitive impairments associated with repeated exposure to PCP... - Neonatal ventral hippocampal lesions in male and female rats: effects on water maze, locomotor activity, plus-maze and prefrontal cortical GABA and glutamate release in adulthoodRichard J Beninger
Department of Psychology, Queen s University, 62 Arch Street, Kingston, ON K7L 3N6, Canada
Behav Brain Res 202:198-209. 2009..Findings support the notion that behavioural abnormalities in post-pubertal male and female nVHL rats are associated with decreases in PFC neurotransmitter release... - Dopaminergic mechanism of reward-related incentive learning: focus on the dopamine D(3) receptorR J Beninger
Department of Psychology, and Centre for Neuroscience Studies, Queen s University, Kingston ON, K7L 3N6 Canada
Neurotox Res 14:57-70. 2008..Perhaps Drd3 participates in the molecular mechanisms underlying the role of dopamine and of dopamine receptor subtypes in reward-related incentive learning... - Regional differences in the action of antipsychotic drugs: implications for cognitive effects in schizophrenic patientsRichard J Beninger
Department of Psychology, Queen s University, 62 Arch St, Kingston, ON, K7L 3N6, Canada
Neurotox Res 18:229-43. 2010..These findings suggest that some of the cognitive deficits seen in schizophrenic patients may be related to the medications that are used to treat them... 
Differential effects of calcineurin inhibition and protein kinase A activation on nucleus accumbens amphetamine-produced conditioned place preference in ratsTodor V Gerdjikov
Department of Psychology, Queen's University, Kingston, ON K7L 3N6, Canada
Eur J Neurosci 22:697-705. 2005..Results suggest that CN acts as a negative regulator in the establishment of NAc amphetamine-produced CPP, a form of reward-related learning...- Nucleus accumbens PKA inhibition blocks acquisition but enhances expression of amphetamine-produced conditioned activity in ratsTodor V Gerdjikov
Department of Psychology, Queen s University, Kingston, ON, Canada
Psychopharmacology (Berl) 190:65-72. 2007.... - Place preference induced by nucleus accumbens amphetamine is impaired by antagonists of ERK or p38 MAP kinases in ratsTodor V Gerdjikov
Department of Psychology, Queen's University, Kingston, ON, Canada
Behav Neurosci 118:740-50. 2004..Results suggest that ERK and p38, but not JNK, MAPKs may be necessary for the establishment of NAc amphetamine-produced CPP and may also mediate other forms of reward-related learning dependent on NAc... - The effects of amphetamine and raclopride on food transport: possible relation to defensive behavior in ratsH C Dringenberg
Department of Psychology, Queen s University, Kingston, Ontario, Canada
Behav Pharmacol 11:447-54. 2000..The food-carrying test provides a rich, ethologically valid paradigm to assess the effects of psychoactive drugs on species-specific, defensive behaviors in rodents... - Double dissociation of the effects of haloperidol and the dopamine D3 receptor antagonist ABT-127 on acquisition vs. expression of cocaine-conditioned activity in ratsT J Banasikowski
Department of Psychology, Queen s University, 62 Arch St, Kingston ON, Canada K7L 3N6
J Pharmacol Exp Ther 335:506-15. 2010..Results suggest that D2 receptors are more critically involved in acquisition than initial expression and D3 receptors are more critically involved in expression than acquisition of conditioned activity based on cocaine... - Subchronic MK-801 treatment and post-weaning social isolation in rats: differential effects on locomotor activity and hippocampal long-term potentiationDonovan M Ashby
Department of Psychology, Queen s University, Kingston, Ontario, K7L 3N6, Canada
Behav Brain Res 212:64-70. 2010.... - Increased GABAergic activity in the region of the pedunculopontine and deep mesencephalic reticular nuclei reduces REM sleep and impairs learning in ratsS M Fogel
Centre for Neuroscience Studies, Queen s University, Canada
Behav Neurosci 124:79-86. 2010..Normal GABAergic transmission in the PPN/DpMe may be necessary for REM to occur and for the consolidation of incentive learning... - Conditioned locomotion in rats following amphetamine infusion into the nucleus accumbens: blockade by coincident inhibition of protein kinase AM A Sutton
Department of Psychology, Queen s University, Kingston, Ontario, Canada
Behav Pharmacol 11:365-76. 2000..These results demonstrate that the activation of PKA plays a critical role in the process by which properties of drugs become associated with environmental stimuli... - Cortical muscarinic receptor function following quinolinic acid-induced lesion of the nucleus basalis magnocellularisB J Scarth
Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
Exp Neurol 103:158-64. 1989..These results suggest that muscarinic receptors linked to phosphatidylinositol metabolism in the cortex are localized on intrinsic cortical neurons and not on afferent terminals from basal forebrain cholinergic neurons... - Dopamine D1-like receptors and reward-related incentive learningR J Beninger
Department of Psychology, Queen s University, Kingston, Canada
Neurosci Biobehav Rev 22:335-45. 1998..Thus, when reward-related incentive learning takes place, it may be the action of DA acting at D1-like receptors that leads to plastic changes in the striatum that form the substrate of that learning... - Dopamine and incentive learning: a framework for considering antipsychotic medication effectsRichard J Beninger
Departments of Psychology and Psychiatry, Queen s University, Kingston ON K7L3N6, Canada
Neurotox Res 10:199-209. 2006..It remains the task of researchers and clinicians to sort out the symptoms associated with the endogenous illness from possible iatrogenic symptoms resulting from the antipsychotic medications used to treat schizophrenia... - Intra-accumbens protein kinase C inhibitor NPC 15437 blocks amphetamine-produced conditioned place preference in ratsHarinder Aujla
Department of Psychology, Queen s University, Kingstone, Ont, Canada
Behav Brain Res 147:41-8. 2003..Results implicate PKC in the NAc in reward-related learning. More work is needed to elucidate the signaling pathways involved in this type of learning... - Intra-BLA or intra-NAc infusions of the dopamine D3 receptor partial agonist, BP 897, block intra-NAc amphetamine conditioned activityHarinder Aujla
Department of Psychology, Queen s University, Kingston, Ontario, Canada
Behav Neurosci 118:1324-30. 2004..Results indicate that the ability of BP 897 to attenuate the expression of conditioned activity is mediated in part by the NAc and BLA... 
Place preference induced by nucleus accumbens amphetamine is impaired by local blockade of Group II metabotropic glutamate receptors in ratsTodor V Gerdjikov
Department of Psychology, Queen s University, Kingston, ON K7L 3N6, Canada
BMC Neurosci 7:43. 2006..In previous studies, NAc basal and amphetamine-produced DA transmission was altered by Group II mGluR agents. We tested whether NAc amphetamine CPP depends on Group II mGluR transmission...- The role of signaling molecules in reward-related incentive learningRichard J Beninger
Departments of Psychology and Psychiatry, Queen s University, Kingston ON K7L 3N6, Canada
Neurotox Res 6:91-104. 2004..Results support a model of DA-Glu synaptic interactions that form the basis of incentive learning... - cAMP-dependent protein kinase and reward-related learning: intra-accumbens Rp-cAMPS blocks amphetamine-produced place conditioning in ratsRichard J Beninger
Department of Psychology, Queen s University, Kingston, Ontario, Canada K7L 3N6
Psychopharmacology (Berl) 170:23-32. 2003..Dopamine may produce reward-related learning by activating D(1)-like receptors in the nucleus accumbens (NAc) and stimulating the formation of cyclic adenosine monophosphate (cAMP) and the activation of cAMP-dependent protein kinase (PKA)... - Typical and atypical antipsychotic medications differentially affect two nondeclarative memory tasks in schizophrenic patients: a double dissociationRichard J Beninger
Department of Psychology, Queen s University, K7L 3N6, Kingston, ON, Canada
Schizophr Res 61:281-92. 2003..Results suggest that typical and atypical antipsychotics differentially affect nondeclarative memory mediated by different brain regions... - Kynurenic acid protects against the neurochemical and behavioral effects of unilateral quinolinic acid injections into the nucleus basalis of ratsB A Wirsching
Department of Psychology, Queen s University, Kingston, Ontario, Canada
Behav Neurosci 103:90-7. 1989..Results confirm that KYN antagonizes the neurotoxic and mnemonic effects of QUIN alone and suggest that the memory deficits induced by nbm lesions cannot be solely attributed to changes in feeding or locomotor activity... - Hippocampal-prefrontocortical circuits: PKA inhibition in the prefrontal cortex impairs delayed nonmatching in the radial maze in ratsH Aujla
Department of Psychology, Queen's University, Kingston, Ontario, Canada
Behav Neurosci 115:1204-11. 2001..0, microg/0.5 microl) selectively impaired delayed nonmatching-to-position. Results suggest that activation of the cAMP-PKA pathway by dopamine acting at D1-like receptors in the frontal cortex is necessary for working memory... - Differential effects of dopamine and AMPA receptor antagonists on the expression of conditioned avoidance responding in ratsGregory A Boivin
Department of Psychology, Queen s University, Kingston, Ontario, Canada
Behav Neurosci 122:377-84. 2008..Results are consistent with a role for AMPA receptors in maintaining the expression of learning... - Schizophrenic patients treated with clozapine or olanzapine perform better on theory of mind tasks than those treated with risperidone or typical antipsychotic medicationsIoulia Savina
Department of Psychology, Queen s University, Kingston ON, Canada, K7L 3N6
Schizophr Res 94:128-38. 2007..We concluded that ToM performance of schizophrenic patients is influenced by the antipsychotic they are taking. Our results suggest that olanzapine or clozapine but not typicals or risperidone may improve or protect ToM ability... - Water maze versus radial maze: differential performance of rats in a spatial delayed match-to-position task and response to scopolamineBrandi K Ormerod
Department of Psychology, Queen s University, Kingston, Canada K7L 3N6
Behav Brain Res 128:139-52. 2002..8 mg/kg dose impaired performance. The pattern of results may reflect different natural tendencies of rats to alternate (win-shift) versus not alternate (win-stay) in dry land versus swim tasks... - Post-training intra-striatal scopolamine or flupenthixol impairs radial maze learning in ratsGlenn Legault
Department of Psychology, Queen s University, Kingston, Ont, Canada K7L 3N6
Behav Brain Res 170:148-55. 2006..Trans-flupenthixol produced less impairment than cis-flupenthixol. Results suggest that ACh and DA receptors in the dorsal striatum during hours 0-4 following training play a role in habit learning... - Pimozide, like extinction, devalues stimuli associated with sucrose takingL D Johnston
Department of Psychology, Queen's University, K7L 3N6, Kingston, Ontario, Canada
Pharmacol Biochem Behav 68:583-90. 2001..Pimozide injections in the home cage had no effect. These data support the idea that DA mediates the conditioned reinforcing properties provided by access to the taking link of the chain... - Prepulse inhibition following lesions of the inferior colliculus: prepulse intensity functionsL Li
Department of Psychology, Queen s University, Kingston, Ontario, Canada
Physiol Behav 65:133-9. 1998..These data suggest that the IC is an important structure in the neural circuit mediating acoustic PPI... - Biphasic effects of 7-OH-DPAT on the acquisition of responding for conditioned reward in ratsM A Sutton
Department of Psychology, Queen's University, K7L 3N6, Kingston, ON, Canada
Pharmacol Biochem Behav 69:195-200. 2001..50 mg/kg neither impaired nor enhanced CR lever responding. The biphasic profile of 7-OH-DPAT may arise through differential actions at D3 vs. D2 receptors or presynaptic vs. postsynaptic DA receptors at low and high doses, respectively... - A dopamine D3 receptor partial agonist blocks the expression of conditioned activityHarinder Aujla
Department of Psychology, Queen's University, Kingston, ON, Canada
Neuroreport 13:173-6. 2002.... - Paradoxical effects of the opioid antagonist naltrexone on morphine analgesia, tolerance, and reward in ratsKelly J Powell
Department of Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada
J Pharmacol Exp Ther 300:588-96. 2002..0 mg/kg) extended the duration of the morphine-induced conditioned place preference. These effects of naltrexone on morphine-induced reward may have implications for chronic treatment with agonist-antagonist combinations... - Evidence for 2-stage models of sleep and memory: learning-dependent changes in spindles and theta in ratsStuart M Fogel
Centre for Neuroscience Studies, Queen s University, Kingston, Ontario, Canada
Brain Res Bull 79:445-51. 2009..Perhaps first theta increases to organize and consolidate material via hippocampal-neocortical dialogue, followed by subsequent refinement in the cortex by spindles during SWS... - Effects of Parkinson disease on two putative nondeclarative learning tasks: probabilistic classification and gamblingJames G Perretta
Department of Psychology, Queen's University, Kingston, Ontario, Canada
Cogn Behav Neurol 18:185-92. 2005..The current finding that IGT performance was impaired in early PD implies ventromedial prefrontal cortical dysfunction early in the disease... - Dimenhydrinate produces a conditioned place preference in ratsAlison G Halpert
Department of Psychology, Queen's University, Kingston, Ontario, Canada K7L 3N6
Pharmacol Biochem Behav 75:173-9. 2003..Future investigations into the neurotransmitter systems modulating this effect are awaited... - Role of dopamine D3 receptors in the expression of conditioned fear in ratsShelley N Swain
Department of Psychology, 62 Arch St, Queen s University, Kingston ON, Canada K7L 3N6
Eur J Pharmacol 579:167-76. 2008..Thus, BP 897 and SB-277011A dose-dependently attenuated the expression but not the acquisition of conditioned fear. These findings suggest that BP 897 and SB-277011A reduce the control of responding by aversively conditioned stimuli... - Too much of a good thing? Elevated baseline sleep spindles predict poor avoidance performance in ratsS M Fogel
Centre for Neuroscience Studies, Queen s University, Kingston, Ontario, Canada
Brain Res 1319:112-7. 2010..Results suggest that while spindles may be involved in memory consolidation, in some cases, high levels of spindles prior to training may be maladaptive... - The dopamine D(3) receptor-preferring partial agonist BP 897 dose-dependently attenuates the expression of amphetamine-conditioned place preference in ratsH Aujla
Department of Psychology, Queen's University, Kingston K7L 3N6, Canada
Behav Pharmacol 16:181-6. 2005..5 mg/kg) during the test blocked the amphetamine-CPP. There was no evidence that BP 897 produced a conditioned aversion. Results supported the hypothesis that BP 897 would block expression, but not acquisition, of amphetamine-CPP... - Mechanisms and abuse liability of the anti-histamine dimenhydrinateAlison G Halpert
Department of Psychology, Queen's University, Kingston, Ont, Canada K7L 3N6
Neurosci Biobehav Rev 26:61-7. 2002..Further support comes from reports of acute and chronic abuse of DMH by humans. Collectively, results confirm the abuse liability of DMH... - Scopolamine during the paradoxical sleep window impairs radial arm maze learning in ratsGlenn Legault
Department of Psychology, Queen's University, Kingston, ON, Canada K7L 3N6
Pharmacol Biochem Behav 79:715-21. 2004..Results suggest that REM sleep and intact ACh neurotransmission are required during the PSW for rats to learn the radial maze task... - Post-weaning social isolation increases activity in a novel environment but decreases defensive burying and subchronic MK-801 enhances the activity but not the burying effect in ratsSarah M Simpson
Department of Psychology, Queen s University, Kingston, Ontario, Canada
Pharmacol Biochem Behav 95:72-9. 2010..The behavioral abnormalities of SI rats may be a manifestation of GABAergic dysfunction that has recently become evident in schizophrenia...