R D Andrew

Summary

Affiliation: Queen's University
Country: Canada

Publications

  1. ncbi Potential sources of intrinsic optical signals imaged in live brain slices
    R D Andrew
    Queen s University, Kingston, Ontario, K7L 3N6, Canada
    Methods 18:185-96, 179. 1999
  2. ncbi Physiological evidence that pyramidal neurons lack functional water channels
    R David Andrew
    Department of Anatomy and Cell Biology and Centre for Neuroscience Studies, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Cereb Cortex 17:787-802. 2007
  3. ncbi Imaging anoxic depolarization during ischemia-like conditions in the mouse hemi-brain slice
    I Joshi
    Department of Anatomy and Cell Biology, Queen's University, Kingston, Ontario K7L 3N6, Canada
    J Neurophysiol 85:414-24. 2001
  4. ncbi Anoxic depolarization mediates acute damage independent of glutamate in neocortical brain slices
    C R Jarvis
    Department of Anatomy and Cell Biology, Queen's University, Kingston, Ontario, Canada K7L 3N6
    Cereb Cortex 11:249-59. 2001
  5. ncbi Magnetic resonance imaging of neuronal and glial swelling as an indicator of function in cerebral tissue slices
    P W Stroman
    Centre for Neuroscience Studies, Queen s University, Kingston, Ontario, Canada
    Magn Reson Med 59:700-6. 2008
  6. ncbi Whole isolated neocortical and hippocampal preparations and their use in imaging studies
    Melissa L Davies
    Department of Anatomy and Cell Biology and The Centre for Neuroscience Studies, Queen s University, Kingston, Ont, Canada
    J Neurosci Methods 166:203-16. 2007
  7. ncbi Structural abnormalities in neurons are sufficient to explain the clinical disease and fatal outcome of experimental rabies in yellow fluorescent protein-expressing transgenic mice
    Courtney A Scott
    Health Sciences Centre, GF543, 820 Sherbrook Street, Winnipeg, Manitoba, Canada
    J Virol 82:513-21. 2008

Collaborators

Detail Information

Publications7

  1. ncbi Potential sources of intrinsic optical signals imaged in live brain slices
    R D Andrew
    Queen s University, Kingston, Ontario, K7L 3N6, Canada
    Methods 18:185-96, 179. 1999
    ..5) While hyperosmotic conditions reduce LT by causing cells to shrink, excitotoxic conditions reduce LT by causing dendritic beading. This conformational change increases light scattering even as the tissue continues to swell...
  2. ncbi Physiological evidence that pyramidal neurons lack functional water channels
    R David Andrew
    Department of Anatomy and Cell Biology and Centre for Neuroscience Studies, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Cereb Cortex 17:787-802. 2007
    ..However, these same neurons then swell dramatically upon oxygen/glucose deprivation or [K+]0 elevation, so prolonged depolarization (as during stroke or seizure) apparently swells neurons by opening nonaquaporin channels to water...
  3. ncbi Imaging anoxic depolarization during ischemia-like conditions in the mouse hemi-brain slice
    I Joshi
    Department of Anatomy and Cell Biology, Queen's University, Kingston, Ontario K7L 3N6, Canada
    J Neurophysiol 85:414-24. 2001
    ..Glutamate receptor antagonists neither block the AD in the ischemic core nor, we propose, block recurrent PID arising close to the core...
  4. ncbi Anoxic depolarization mediates acute damage independent of glutamate in neocortical brain slices
    C R Jarvis
    Department of Anatomy and Cell Biology, Queen's University, Kingston, Ontario, Canada K7L 3N6
    Cereb Cortex 11:249-59. 2001
    ..Using this slice model, therapeutically tolerable drugs that block the AD and SD can be investigated...
  5. ncbi Magnetic resonance imaging of neuronal and glial swelling as an indicator of function in cerebral tissue slices
    P W Stroman
    Centre for Neuroscience Studies, Queen s University, Kingston, Ontario, Canada
    Magn Reson Med 59:700-6. 2008
    ..These observations demonstrate the biophysical basis of the fMRI contrast mechanism that has been termed "signal enhancement by extravascular water protons," or SEEP...
  6. ncbi Whole isolated neocortical and hippocampal preparations and their use in imaging studies
    Melissa L Davies
    Department of Anatomy and Cell Biology and The Centre for Neuroscience Studies, Queen s University, Kingston, Ont, Canada
    J Neurosci Methods 166:203-16. 2007
    ..Moreover the neurons undergo swelling with accompanying dendritic beading following AD induced by simulated ischemia, similar to cortical damage described in vivo...
  7. ncbi Structural abnormalities in neurons are sufficient to explain the clinical disease and fatal outcome of experimental rabies in yellow fluorescent protein-expressing transgenic mice
    Courtney A Scott
    Health Sciences Centre, GF543, 820 Sherbrook Street, Winnipeg, Manitoba, Canada
    J Virol 82:513-21. 2008
    ..We conclude that the observed structural changes are sufficient to explain the severe clinical disease with a fatal outcome in this experimental model of rabies...