Xiangguo Qiu

Summary

Affiliation: Public Health Agency of Canada
Country: Canada

Publications

  1. ncbi request reprint Establishment and characterization of a lethal mouse model for the Angola strain of Marburg virus
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    J Virol 88:12703-14. 2014
  2. pmc Ebola GP-specific monoclonal antibodies protect mice and guinea pigs from lethal Ebola virus infection
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS Negl Trop Dis 6:e1575. 2012
  3. ncbi request reprint Characterization of Zaire ebolavirus glycoprotein-specific monoclonal antibodies
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    Clin Immunol 141:218-27. 2011
  4. ncbi request reprint mAbs and Ad-vectored IFN-α therapy rescue Ebola-infected nonhuman primates when administered after the detection of viremia and symptoms
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Sci Transl Med 5:207ra143. 2013
  5. pmc Sustained protection against Ebola virus infection following treatment of infected nonhuman primates with ZMAb
    Xiangguo Qiu
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Sci Rep 3:3365. 2013
  6. ncbi request reprint Immunization with vesicular stomatitis virus vaccine expressing the Ebola glycoprotein provides sustained long-term protection in rodents
    Gary Wong
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB, R3E 3R2 Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada
    Vaccine 32:5722-9. 2014
  7. ncbi request reprint Ebola virus transmission in Guinea pigs
    Gary Wong
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada
    J Virol 89:1314-23. 2015
  8. ncbi request reprint Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp
    Xiangguo Qiu
    National Laboratory for Zoonotic Diseases and Special Pathogens, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Nature 514:47-53. 2014
  9. pmc Monoclonal antibodies combined with adenovirus-vectored interferon significantly extend the treatment window in Ebola virus-infected guinea pigs
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    J Virol 87:7754-7. 2013
  10. pmc Mucosal immunization of cynomolgus macaques with the VSVDeltaG/ZEBOVGP vaccine stimulates strong ebola GP-specific immune responses
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS ONE 4:e5547. 2009

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Establishment and characterization of a lethal mouse model for the Angola strain of Marburg virus
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    J Virol 88:12703-14. 2014
    ..This model provides an important tool to screen candidate vaccines and therapeutics against MARV infections...
  2. pmc Ebola GP-specific monoclonal antibodies protect mice and guinea pigs from lethal Ebola virus infection
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS Negl Trop Dis 6:e1575. 2012
    ..These results indicate that MAbs particularly when used as an oligoclonal set are a potential therapeutic for post-exposure treatment of EBOV infection...
  3. ncbi request reprint Characterization of Zaire ebolavirus glycoprotein-specific monoclonal antibodies
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    Clin Immunol 141:218-27. 2011
    ..All 8 MAb improved survival rates by 33%-100% against a high dose lethal challenge with mouse-adapted ZEBOV. This work has important implications for further development of vaccines and immunotherapies for ZEBOV infection...
  4. ncbi request reprint mAbs and Ad-vectored IFN-α therapy rescue Ebola-infected nonhuman primates when administered after the detection of viremia and symptoms
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Sci Transl Med 5:207ra143. 2013
    ..This study describes conditions capable of saving 100% of EBOV-infected NHPs when initiated after the presence of detectable viremia along with symptoms. ..
  5. pmc Sustained protection against Ebola virus infection following treatment of infected nonhuman primates with ZMAb
    Xiangguo Qiu
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Sci Rep 3:3365. 2013
    ..The data indicate that a robust immune response was generated during the successful treatment of EBOV-infected NHPs with EBOV, which resulted in sustained protection against a second lethal exposure. ..
  6. ncbi request reprint Immunization with vesicular stomatitis virus vaccine expressing the Ebola glycoprotein provides sustained long-term protection in rodents
    Gary Wong
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB, R3E 3R2 Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada
    Vaccine 32:5722-9. 2014
    ..These studies confirm that vaccination with VSVΔG/EBOVGP is able to confer long-term protection against Ebola infection in mice and guinea pigs, and support follow-up studies in non-human primates. ..
  7. ncbi request reprint Ebola virus transmission in Guinea pigs
    Gary Wong
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada
    J Virol 89:1314-23. 2015
    ....
  8. ncbi request reprint Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp
    Xiangguo Qiu
    National Laboratory for Zoonotic Diseases and Special Pathogens, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Nature 514:47-53. 2014
    ..ZMapp exceeds the efficacy of any other therapeutics described so far, and results warrant further development of this cocktail for clinical use. ..
  9. pmc Monoclonal antibodies combined with adenovirus-vectored interferon significantly extend the treatment window in Ebola virus-infected guinea pigs
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    J Virol 87:7754-7. 2013
    ..p.i.) provided 100% survival, a significant improvement over survival with either treatment alone. The administration of DEF201 within 2 d.p.i. permits later MAb use, with protective efficacy observed up to 8 d.p.i...
  10. pmc Mucosal immunization of cynomolgus macaques with the VSVDeltaG/ZEBOVGP vaccine stimulates strong ebola GP-specific immune responses
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS ONE 4:e5547. 2009
    ..Zaire ebolavirus (ZEBOV) produces a lethal viral hemorrhagic fever in humans and non-human primates...
  11. ncbi request reprint Successful treatment of ebola virus-infected cynomolgus macaques with monoclonal antibodies
    Xiangguo Qiu
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Sci Transl Med 4:138ra81. 2012
    ..These data highlight the important role of antibodies to control EBOV replication in vivo, and support the use of mAbs against a severe filovirus infection...
  12. pmc Immune parameters correlate with protection against ebola virus infection in rodents and nonhuman primates
    Gary Wong
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Sci Transl Med 4:158ra146. 2012
    ..These results highlight the relevance of total ZGP-specific IgG levels as a meaningful correlate of protection against ZEBOV exposure...
  13. ncbi request reprint Molecular characterization of the monoclonal antibodies composing ZMAb: a protective cocktail against Ebola virus
    Jonathan Audet
    Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada, R3E 0J9
    Sci Rep 4:6881. 2014
    ....
  14. ncbi request reprint Post-exposure therapy of filovirus infections
    Gary Wong
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada
    Trends Microbiol 22:456-63. 2014
    ....
  15. ncbi request reprint The Multiple Roles of sGP in Ebola Pathogenesis
    Marc Antoine de La Vega
    1 Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    Viral Immunol 28:3-9. 2015
    ..This review summarizes the multiple roles that sGP may play during infection and highlights the implications for the future design of vaccines and treatments. ..
  16. ncbi request reprint Characterization of host immune responses in Ebola virus infections
    Gary Wong
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street Winnipeg, MB, R3E 3R2 Canada
    Expert Rev Clin Immunol 10:781-90. 2014
    ..This review summarizes the host immune response to Ebola infection, and highlights the short- and long-term immune responses crucial for protection, which holds implications for the design of future vaccines and therapeutics...