Research Topics
| Michael R MulveySummaryAffiliation: Public Health Agency of Canada Country: Canada Publications
| Collaborators
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Detail Information
Publications
Community-based educational intervention to limit the dissemination of community-associated methicillin-resistant Staphylococcus aureus in Northern Saskatchewan, CanadaGeorge R Golding
Population Health Unit, LaRonge, Saskatchewan, Canada
BMC Public Health 12:15. 2012....- New Delhi metallo-β-lactamase in Klebsiella pneumoniae and Escherichia coli, CanadaMichael R Mulvey
Antimicrobial Resistance and Nosocomial Infections section, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
Emerg Infect Dis 17:103-6. 2011..The NDM-1 gene was found on closely related incompatibility group A/C type plasmids. The occurrence of NDM-1 in North America is a major public health concern... 
Mechanisms of resistance and mobility among multidrug-resistant CTX-M-producing Escherichia coli from Canadian intensive care units: the 1st report of QepA in North AmericaPatricia J Baudry
Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
Diagn Microbiol Infect Dis 63:319-26. 2009..We report the 1st qepA-producing E. coli in North America...
ampC gene expression in promoter mutants of cefoxitin-resistant Escherichia coli clinical isolatesDobryan M Tracz
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada
FEMS Microbiol Lett 270:265-71. 2007..Overall, the data indicate that a combination of ampC promoter mutations and other strain-specific factors combine to contribute to the magnitude of cefoxitin resistance in E. coli...- Prevalence and characterization of extended-spectrum β-lactamase- and AmpC β-lactamase-producing Escherichia coli: results of the CANWARD 2007-2009 studyPatricia J Simner
Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0J9
Diagn Microbiol Infect Dis 69:326-34. 2011..In conclusion, ESBL- and AmpC-producing E. coli are established in Canadian hospitals; and although the prevalence rates of these isolates remain low, they are often MDR and associated with the ST131 clone... - Antimicrobial susceptibility of 3931 organisms isolated from intensive care units in Canada: Canadian National Intensive Care Unit Study, 2005/2006George G Zhanel
Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Diagn Microbiol Infect Dis 62:67-80. 2008..aeruginosa), respectively... - Prevalence of antimicrobial-resistant pathogens in Canadian hospitals: results of the Canadian Ward Surveillance Study (CANWARD 2008)George G Zhanel
Clinical Microbiology, Health Sciences Centre, 820 Sherbrook St, Winnipeg, Manitoba, Canada
Antimicrob Agents Chemother 54:4684-93. 2010..The prevalence of MRSA was 27.0% (of which genotypically 27.6% were CA-MRSA), while ESBL-producing E. coli occurred in 4.9% of isolates. An MDR phenotype was common in P. aeruginosa... - Molecular characterization of cefoxitin-resistant Escherichia coli from Canadian hospitalsMichael R Mulvey
Nosocomial Infections, National Microbiology Laboratory, 1015 Arlington St, Winnipeg, Manitoba R3E 3R2, Canada
Antimicrob Agents Chemother 49:358-65. 2005.... - Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum beta-lactamase involved in an outbreak in long-term-care facilities in Toronto, CanadaDavid A Boyd
Nosocomial Infections, National Microbiology Laboratory, 1015 Arlington St, Winnipeg, Manitoba, Canada
Antimicrob Agents Chemother 48:3758-64. 2004..coli strain isolated in India in 1999, revealed that the plasmids had several features in common, including an R100 backbone and several of the resistance genes, including bla(CTX-M-15), bla(TEM-1), bla(OXA-1), tetA, and aac(6')-Ib... - Characterization of Acinetobacter baumannii and meropenem-resistant Pseudomonas aeruginosa in Canada: results of the CANWARD 2007-2009 studyMelissa McCracken
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada R3E 3R2
Diagn Microbiol Infect Dis 69:335-41. 2011..In summary, MDR A. baumannii are rare in Canada and, conversely, meropenem-resistant P. aeruginosa were mostly MDR; however, there was minimal clonal spread among these nonfermentative bacilli... - Hypervirulent Clostridium difficile strains in hospitalized patients, CanadaMichael R Mulvey
Public Health Agency of Canada, 1015 Arlington St, Winnipeg, Manitoba R3E 3R2, Canada
Emerg Infect Dis 16:678-81. 2010..Incidence of human infections increased from 0.5% in 2004/2005 to 1.6% in 2008... - Molecular characterization of moxifloxacin resistance from Canadian Clostridium difficile clinical isolatesAndrew Walkty
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada R3E3R2
Diagn Microbiol Infect Dis 66:419-24. 2010..Moderate-level moxifloxacin resistance was associated with a single substitution in GyrA. High-level moxifloxacin resistance was associated with this GyrA substitution plus at least 1 other substitution in GyrA or GyrB... - Comparison of community-associated and health care-associated methicillin-resistant Staphylococcus aureus in Canada: results of the CANWARD 2007-2009 studyKimberly A Nichol
Department of Clinical Microbiology, Health Sciences Centre Diagnostic Services of Manitoba, Winnipeg, Manitoba R3A 1R9, Canada
Diagn Microbiol Infect Dis 69:320-5. 2011..No MRSA resistance occurred with linezolid, daptomycin, or tigecycline. In conclusion, CA-MRSA genotypes represented 25.2% of all MRSA and continue to increase in prevalence in Canadian hospitals... - Molecular characterization of Enterococcus faecalis N06-0364 with low-level vancomycin resistance harboring a novel D-Ala-D-Ser gene cluster, vanLDavid A Boyd
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
Antimicrob Agents Chemother 52:2667-72. 2008..The vanL gene cluster was similar in organization to the vanC operon, but the VanT serine racemase was encoded by two separate genes, vanTm(L) (membrane binding) and vanTr(L) (racemase)... - Multidrug-resistant North American pulsotype 2 Clostridium difficile was the predominant toxigenic hospital-acquired strain in the province of Manitoba, Canada, in 2006-2007James A Karlowsky
Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada 24
J Med Microbiol 61:693-700. 2012..2 vs 9.1%) in Manitoba in 2006-2007, and these isolates demonstrated high levels of clonality and multidrug resistance, and were associated with hospital acquisition... - VanG-type vancomycin-resistant Enterococcus faecalis strains isolated in CanadaDavid A Boyd
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba
Antimicrob Agents Chemother 50:2217-21. 2006..faecalis BM4518. E. faecalis N03-0233 (vancomycin MIC, 16 microg/ml) was found to harbor a novel vanG operon, vanG2, on an element in a different chromosomal location than the vanG-harboring elements in G1-0247 and BM4518... - Comparative genomics of Canadian epidemic lineages of methicillin-resistant Staphylococcus aureusSara Christianson
National Microbiology Laboratory, Winnipeg, Manitoba R3E 3R2, Canada
J Clin Microbiol 45:1904-11. 2007.... - Livestock-associated methicillin-resistant Staphylococcus aureus sequence type 398 in humans, CanadaGeorge R Golding
National Microbiology Laboratory, Winnipeg, Manitoba, Canada
Emerg Infect Dis 16:587-94. 2010..Although prevalence of livestock-associated MRSA seems to be low for the general population in Canada, recent emergence of infections resulting from this strain is of public health concern... - Ambler class A extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. in Canadian hospitalsMichael R Mulvey
Nosocomial Infections, National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba
Antimicrob Agents Chemother 48:1204-14. 2004..In addition, examples of identical or closely related plasmids that were identified at geographically distinct sites across Canada are given. However, there was considerable diversity with respect to plasmid types observed... - Comparison of antimicrobial resistance profiles among extended-spectrum-beta-lactamase-producing and acquired AmpC beta-lactamase-producing Escherichia coli isolates from Canadian intensive care unitsPatricia J Baudry
Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, R3A 1R9, Manitoba, Canada
Antimicrob Agents Chemother 52:1846-9. 2008..ESBL-producing E. coli isolates were more likely to be gentamicin resistant (P < 0.03), fluoroquinolone resistant (P < 0.0001), and multidrug resistant (P < 0.0001) than AmpC-producing E. coli isolates... - Characterization of Escherichia coli urinary tract infection isolates in remote northern Saskatchewan communities: the Northern Antibiotic Resistance PartnershipGeorge R Golding
National Microbiology Laboratory, Winnipeg, Manitoba, Canada
Diagn Microbiol Infect Dis 74:242-7. 2012..Results from this study emphasize the importance of continued surveillance of remote northern communities in order to optimize the efficacy of empiric UTI treatment... - High rates of Staphylococcus aureus USA400 infection, Northern CanadaGeorge R Golding
National Microbiology Laboratory, Winnipeg, Manitoba, Canada
Emerg Infect Dis 17:722-5. 2011..2%) were caused by USA400 strains. Although USA400 prevalence has diminished in the United States, this strain is continuing to predominate throughout many northern communities in Canada... - Salmonella genomic island 1 (SGI1), variant SGI1-I, and new variant SGI1-O in proteus mirabilis clinical and food isolates from ChinaDavid A Boyd
National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Canada R3E 3R2
Antimicrob Agents Chemother 52:340-4. 2008..Sequencing showed that SGI1 and variants were integrated at the 3' end of the chromosomal thdF gene as previously described for Salmonella strains... - Comparison of CMY-2 plasmids isolated from human, animal, and environmental Escherichia coli and Salmonella spp. from CanadaLaura F Mataseje
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada R3E 3R2
Diagn Microbiol Infect Dis 67:387-91. 2010..Genetically similar CMY-2 plasmids isolated from either E. coli or Salmonella from human, animal, and environmental sources are widely distributed across Canada and cluster into replicon types I1, A/C, and K/B and an unidentified group... - The effect of the Salmonella genomic island 1 on in vitro global gene expression in Salmonella enterica serovar Typhimurium LT2George R Golding
National Microbiology Laboratory, 1015 Arlington Ave, Winnipeg, Manitoba, Canada, R3E 3R2
Microbes Infect 9:21-7. 2007..This is the first report examining gene expression within the SGI1, as well as its potential effect on global gene expression, and sets the foundation for future studies involving the effect of SGI1 in other Salmonella spp... - Increase in ampC promoter strength due to mutations and deletion of the attenuator in a clinical isolate of cefoxitin-resistant Escherichia coli as determined by RT-PCRDobryan M Tracz
National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington St, Winnipeg, Manitoba, Canada, R3E 3R2
J Antimicrob Chemother 55:768-72. 2005..To characterize the mechanism of cefoxitin resistance in clinical isolate Escherichia coli N99-0001... - Identification of a progenitor of the CTX-M-9 group of extended-spectrum beta-lactamases from Kluyvera georgiana isolated in GuyanaAdam B Olson
University of Manitoba, Winnipeg, Canada
Antimicrob Agents Chemother 49:2112-5. 2005..KLUY-1 exhibited 100% amino acid identity with the extended-spectrum beta-lactamase CTX-M-14. We also show that a 2.7-kb Kluyvera chromosomal region exhibits 99% nucleotide identity to a portion of In60 that includes bla(CTX-M-9)... - whole-genome sequence of livestock-associated st398 methicillin-resistant staphylococcus aureus Isolated from Humans in CanadaGeorge R Golding
National Microbiology Laboratory, Winnipeg, Manitoba, Canada
J Bacteriol 194:6627-8. 2012.... - Antimicrobial susceptibility of Pseudomonas aeruginosa isolates obtained from patients in Canadian intensive care units as part of the Canadian National Intensive Care Unit studyAndrew Walkty
Department of Medicine, Health Sciences Centre, Winnipeg, MB, Canada
Diagn Microbiol Infect Dis 61:217-21. 2008..Fifty isolates (11.9%) were resistant to antimicrobials from > or =3 classes. Ninety-six percent of multidrug-resistant (MDR) isolates remained fully susceptible to colistin (polymyxin E)... - Emergence of multidrug-resistant Salmonella Paratyphi B dT+, CanadaMichael R Mulvey
Health Canada, Winnipeg, Manitoba
Emerg Infect Dis 10:1307-10. 2004..Most of these strains harbor Salmonella genomic island 1 (SGI1). Further studies are needed to determine factors contributing to the observed emergence of this multidrug-resistant strain... - Characterization of a Salmonella enterica serovar Agona strain harbouring a class 1 integron containing novel OXA-type beta-lactamase (blaOXA-53) and 6'-N-aminoglycoside acetyltransferase genes [aac(6')-I30]Michael R Mulvey
Bacterial and Enteric Diseases Program, National Microbiology Laboratory, Health Canada, 1015 Arlington St, Winnipeg, Manitoba, Canada, R3E 3R2
J Antimicrob Chemother 54:354-9. 2004..To characterize by molecular methods a multidrug-resistant Salmonella enterica serovar Agona (S. enterica Agona) isolated from a hospitalized patient in Rio de Janeiro, Brazil... - Characterization of methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci and extended-spectrum beta-lactamase-producing Escherichia coli in intensive care units in Canada: Results of the Canadian National Intensive Care Unit (CAN-George G Zhanel
Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba
Can J Infect Dis Med Microbiol 19:243-9. 2008..Methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and vancomycin-resistant enterococci (VRE) are important hospital pathogens in Canada and worldwide... - Truncation in the tcdC region of the Clostridium difficile PathLoc of clinical isolates does not predict increased biological activity of Toxin B or Toxin ARuth Murray
St Boniface Research Centre, Winnipeg, MB, Canada
BMC Infect Dis 9:103. 2009..To assess the role of hyper-production of Toxins A and B in clinical isolates of Clostridium difficile, two NAP1-related and five NAP1 non-related strains were compared... - Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006George G Zhanel
Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Antimicrob Agents Chemother 52:1430-7. 2008..aeruginosa, H. influenzae, Enterococcus spp., S. pneumoniae, and K. pneumoniae are the most common isolates recovered from clinical specimens in Canadian ICUs. A MDR phenotype is common for P. aeruginosa isolates in Canadian ICUs... - Successful treatment of ctx-m ESBL producing Escherichia coli relapsing pyelonephritis with long term pivmecillinamLindsay E Nicolle
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
Scand J Infect Dis 39:748-9. 2007..coli who was cured with a prolonged course of pivmecillinam. This suggests pivmecillinam may be effective treatment for selected patients with pyelonephritis with these organisms... - Staphylococcus aureus harbouring Enterotoxin A as a possible risk factor for multiple sclerosis exacerbationsMichael R Mulvey
National Microbiology Laboratory, Antimicrobial Resistance and Nosocomial Infections, Winnipeg, Canada
Mult Scler 17:397-403. 2011..Objective: This study examined the association between individuals with multiple sclerosis (MS) and colonization with S. aureus harbouring superantigens... - Enterococcus gallinarum N04-0414 harbors a VanD-type vancomycin resistance operon and does not contain a D-alanine:D-alanine 2 (ddl2) geneDavid A Boyd
National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington St, Winnipeg, Manitoba, Canada R3E 3R2
Antimicrob Agents Chemother 50:1067-70. 2006..The D-Ala:D-Ala ligase 2 gene (ddl2) was not present in the strain, though it is found downstream of the vanS gene from the vanC operon in E. gallinarum ATCC 49573 and 19 other E. gallinarum strains tested... - The genetics of Salmonella genomic island 1Michael R Mulvey
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
Microbes Infect 8:1915-22. 2006..Drug-resistant variants of SGI1 have been identified in numerous serotypes. Strains harboring SGI1 may be more virulent and have a tendency to rapidly disseminate... - Enterococcus faecium N03-0072 carries a new VanD-type vancomycin resistance determinant: characterization of the VanD5 operonDavid A Boyd
Nosocomial Infections, National Microbiology Laboratory, Health Canada, 1015 Arlington Street, Winnipeg, Manitoba, Canada
J Antimicrob Chemother 54:680-3. 2004..A set of universal primers was designed in order to identify all current vanD variants by PCR. CONCLUSIONS: E. faecium N03-0072 carries a new VanD-type operon, designated VanD5... - Community-associated methicillin-resistant Staphylococcus aureus, CanadaMichael R Mulvey
National Microbiology Laboratory, Winnipeg, Manitoba, Canada
Emerg Infect Dis 11:844-50. 2005..Over 50% of both clonal groups displayed high-level resistance to mupirocin. This is the first report of the USA400 strain harboring the lukF-PV and lukS-PV toxin genes in Canada... - Serratia marcescens outbreak in a neonatal intensive care unit related to the exit port of an oscillatorTracy M Macdonald
Department of Infection Prevention and Control Services, IWK Health Center, Halifax, Canada
Pediatr Crit Care Med 12:e282-6. 2011..To interrupt transmission of Serratia marcescens colonization in a neonatal intensive care unit and determine the source of ongoing transmission... - Characterization of variant Salmonella genomic island 1 multidrug resistance regions from serovars Typhimurium DT104 and AgonaDavid Boyd
National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba, Canada R3E 3R2
Antimicrob Agents Chemother 46:1714-22. 2002..We hypothesize that the MDR of SGI1 is subject to recombinational events that lead to the various resistance phenotypes in the Salmonella strains in which it is found... - A preliminary guideline for the assignment of methicillin-resistant Staphylococcus aureus to a Canadian pulsed-field gel electrophoresis epidemic type using spa typingGeorge R Golding
National Microbiology Laboratory, Winnipeg, Manitoba
Can J Infect Dis Med Microbiol 19:273-81. 2008.... - Characterization of the first extended-spectrum beta-lactamase-producing Salmonella isolate identified in CanadaMichael R Mulvey
Nosocomial Infections, National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba, Canada
J Clin Microbiol 41:460-2. 2003..The ESBL gene was located on a 70-kb transferable plasmid which also carried tetracycline and trimethoprim resistance elements...