Gary P Kobinger

Summary

Affiliation: Public Health Agency of Canada
Country: Canada

Publications

  1. pmc A porcine adenovirus with low human seroprevalence is a promising alternative vaccine vector to human adenovirus 5 in an H5N1 virus disease model
    Ami Patel
    National Microbiology Laboratory, Public Health Agency of Canada, Canadian Science Centre for Human and Animal Health, Winnipeg, Canada
    PLoS ONE 5:e15301. 2010
  2. pmc Nasal delivery of an adenovirus-based vaccine bypasses pre-existing immunity to the vaccine carrier and improves the immune response in mice
    Maria A Croyle
    Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA
    PLoS ONE 3:e3548. 2008
  3. doi request reprint Replication, pathogenicity, shedding, and transmission of Zaire ebolavirus in pigs
    Gary P Kobinger
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada
    J Infect Dis 204:200-8. 2011
  4. doi request reprint Assessment of the efficacy of commercially available and candidate vaccines against a pandemic H1N1 2009 virus
    Gary P Kobinger
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    J Infect Dis 201:1000-6. 2010
  5. doi request reprint mAbs and Ad-vectored IFN-α therapy rescue Ebola-infected nonhuman primates when administered after the detection of viremia and symptoms
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Sci Transl Med 5:207ra143. 2013
  6. doi request reprint Co-administration of certain DNA vaccine combinations expressing different H5N1 influenza virus antigens can be beneficial or detrimental to immune protection
    Ami Patel
    National Microbiology Laboratory, Public Health Agency of Canada, Canadian Science Centre for Human and Animal Health, Winnipeg, MB, Canada
    Vaccine 30:626-36. 2012
  7. ncbi request reprint Mucosal delivery of adenovirus-based vaccine protects against Ebola virus infection in mice
    Ami Patel
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Canada
    J Infect Dis 196:S413-20. 2007
  8. pmc Enhanced protection against Ebola virus mediated by an improved adenovirus-based vaccine
    Jason S Richardson
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS ONE 4:e5308. 2009
  9. ncbi request reprint Adenovirus-based vaccine prevents pneumonia in ferrets challenged with the SARS coronavirus and stimulates robust immune responses in macaques
    Gary P Kobinger
    Special Pathogens Program, National Microbiology Laboratory, Health Canada, Canadian Science Centre for Human and Animal Health, Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    Vaccine 25:5220-31. 2007
  10. pmc Adenovirus vectors expressing hantavirus proteins protect hamsters against lethal challenge with andes virus
    David Safronetz
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Virol 83:7285-95. 2009

Collaborators

Detail Information

Publications35

  1. pmc A porcine adenovirus with low human seroprevalence is a promising alternative vaccine vector to human adenovirus 5 in an H5N1 virus disease model
    Ami Patel
    National Microbiology Laboratory, Public Health Agency of Canada, Canadian Science Centre for Human and Animal Health, Winnipeg, Canada
    PLoS ONE 5:e15301. 2010
    ..Overall, PAV3-based vector is capable of mediating swift, strong immune responses and offer a promising alternative to AdHu5...
  2. pmc Nasal delivery of an adenovirus-based vaccine bypasses pre-existing immunity to the vaccine carrier and improves the immune response in mice
    Maria A Croyle
    Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA
    PLoS ONE 3:e3548. 2008
    ....
  3. doi request reprint Replication, pathogenicity, shedding, and transmission of Zaire ebolavirus in pigs
    Gary P Kobinger
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada
    J Infect Dis 204:200-8. 2011
    ..See the editorial commentary by Bausch, on pages 179-81.)..
  4. doi request reprint Assessment of the efficacy of commercially available and candidate vaccines against a pandemic H1N1 2009 virus
    Gary P Kobinger
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    J Infect Dis 201:1000-6. 2010
    ..The emergence and global spread of the pandemic H1N1 2009 influenza virus have raised questions regarding the protective effect of available seasonal vaccines and the efficacy of a newly produced matched vaccine...
  5. doi request reprint mAbs and Ad-vectored IFN-α therapy rescue Ebola-infected nonhuman primates when administered after the detection of viremia and symptoms
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Sci Transl Med 5:207ra143. 2013
    ..This study describes conditions capable of saving 100% of EBOV-infected NHPs when initiated after the presence of detectable viremia along with symptoms. ..
  6. doi request reprint Co-administration of certain DNA vaccine combinations expressing different H5N1 influenza virus antigens can be beneficial or detrimental to immune protection
    Ami Patel
    National Microbiology Laboratory, Public Health Agency of Canada, Canadian Science Centre for Human and Animal Health, Winnipeg, MB, Canada
    Vaccine 30:626-36. 2012
    ..Overall, the data suggest that co-administering certain H5N1 antigens offer better or comparable protection to HA alone, however, combining extra antigens may be unnecessary and lead to unfavourable immune responses...
  7. ncbi request reprint Mucosal delivery of adenovirus-based vaccine protects against Ebola virus infection in mice
    Ami Patel
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Canada
    J Infect Dis 196:S413-20. 2007
    ....
  8. pmc Enhanced protection against Ebola virus mediated by an improved adenovirus-based vaccine
    Jason S Richardson
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS ONE 4:e5308. 2009
    ..The immune response elicited by this improved expression cassette vector (Ad-CAGoptZGP) and its ability to afford protection against lethal ZEBOV challenge in mice was compared to the standard Ad-CMVZGP vector...
  9. ncbi request reprint Adenovirus-based vaccine prevents pneumonia in ferrets challenged with the SARS coronavirus and stimulates robust immune responses in macaques
    Gary P Kobinger
    Special Pathogens Program, National Microbiology Laboratory, Health Canada, Canadian Science Centre for Human and Animal Health, Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    Vaccine 25:5220-31. 2007
    ..These data indicate that a heterologous adenovirus-based prime-boost vaccine strategy could safely stimulate strong immunity that may be needed for complete protection against SARS-CoV infection...
  10. pmc Adenovirus vectors expressing hantavirus proteins protect hamsters against lethal challenge with andes virus
    David Safronetz
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Virol 83:7285-95. 2009
    ..These observations set the stage for a more detailed characterization of the types of immunity required to protect humans from hantavirus infections...
  11. doi request reprint Impact of systemic or mucosal immunity to adenovirus on Ad-based Ebola virus vaccine efficacy in guinea pigs
    Jason S Richardson
    Special Pathogens Department, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
    J Infect Dis 204:S1032-42. 2011
    ....
  12. doi request reprint Evaluation of conserved and variable influenza antigens for immunization against different isolates of H5N1 viruses
    Ami Patel
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada
    Vaccine 27:3083-9. 2009
    ..This study emphasizes the need to evaluate the relationship between both arms of the adaptive immune responses in regards to protective efficacy against influenza virus...
  13. pmc Sustained protection against Ebola virus infection following treatment of infected nonhuman primates with ZMAb
    Xiangguo Qiu
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Sci Rep 3:3365. 2013
    ..The data indicate that a robust immune response was generated during the successful treatment of EBOV-infected NHPs with EBOV, which resulted in sustained protection against a second lethal exposure. ..
  14. pmc Monoclonal antibodies combined with adenovirus-vectored interferon significantly extend the treatment window in Ebola virus-infected guinea pigs
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    J Virol 87:7754-7. 2013
    ..p.i.) provided 100% survival, a significant improvement over survival with either treatment alone. The administration of DEF201 within 2 d.p.i. permits later MAb use, with protective efficacy observed up to 8 d.p.i...
  15. pmc Immune parameters correlate with protection against ebola virus infection in rodents and nonhuman primates
    Gary Wong
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Sci Transl Med 4:158ra146. 2012
    ..These results highlight the relevance of total ZGP-specific IgG levels as a meaningful correlate of protection against ZEBOV exposure...
  16. doi request reprint Immunization with vesicular stomatitis virus vaccine expressing the Ebola glycoprotein provides sustained long-term protection in rodents
    Gary Wong
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB, R3E 3R2 Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada
    Vaccine 32:5722-9. 2014
    ..These studies confirm that vaccination with VSVΔG/EBOVGP is able to confer long-term protection against Ebola infection in mice and guinea pigs, and support follow-up studies in non-human primates. ..
  17. pmc Ebola virus transmission in guinea pigs
    Gary Wong
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada
    J Virol 89:1314-23. 2015
    ....
  18. pmc A single sublingual dose of an adenovirus-based vaccine protects against lethal Ebola challenge in mice and guinea pigs
    Jin Huk Choi
    Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, United States
    Mol Pharm 9:156-67. 2012
    ..SL immunization also reduced systemic anti-Ad5 T and B cell responses in naive mice and those with PEI, suggesting that secondary immunizations could be highly effective for both populations...
  19. pmc Airway delivery of an adenovirus-based Ebola virus vaccine bypasses existing immunity to homologous adenovirus in nonhuman primates
    Jason S Richardson
    Special Pathogens Department, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    J Virol 87:3668-77. 2013
    ....
  20. ncbi request reprint Recent advances in Ebolavirus vaccine development
    Jason S Richardson
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada
    Hum Vaccin 6:439-49. 2010
    ..Post-exposure protection is particularly important in outbreak and biodefense settings, as well as clinical and laboratory settings in the case of accidental exposure...
  21. pmc Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp
    Xiangguo Qiu
    National Laboratory for Zoonotic Diseases and Special Pathogens, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Nature 514:47-53. 2014
    ..ZMapp exceeds the efficacy of any other therapeutics described so far, and results warrant further development of this cocktail for clinical use. ..
  22. ncbi request reprint Human immunodeficiency viral vector pseudotyped with the spike envelope of severe acute respiratory syndrome coronavirus transduces human airway epithelial cells and dendritic cells
    Gary P Kobinger
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada R3E 3R2
    Hum Gene Ther 18:413-22. 2007
    ..Spike-pseudotyped HIV-based vector is a novel lung-directed gene transfer vehicle that holds promise for the treatment of genetic lung diseases such as cystic fibrosis or alpha(1)-antitrypsin deficiency...
  23. doi request reprint Intranasal immunization with an adenovirus vaccine protects guinea pigs from Ebola virus transmission by infected animals
    Gary Wong
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada
    Antiviral Res 116:17-9. 2015
    ..Prior vaccination resulted in robust levels of EBOV-specific antibodies and conferred complete protection in gps. These results support the use of vaccines to prevent EBOV transmission between hosts. ..
  24. pmc Stimulation of Ebola virus production from persistent infection through activation of the Ras/MAPK pathway
    James E Strong
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada R3E 3R2
    Proc Natl Acad Sci U S A 105:17982-7. 2008
    ....
  25. pmc PEGylation of a vesicular stomatitis virus G pseudotyped lentivirus vector prevents inactivation in serum
    Maria A Croyle
    Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin Austin, Texas 78712, USA
    J Virol 78:912-21. 2004
    ....
  26. pmc Pentamers not found in the universal proteome can enhance antigen specific immune responses and adjuvant vaccines
    Ami Patel
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
    PLoS ONE 7:e43802. 2012
    ..Overall, the data suggest that rare or non-existent oligopeptides can be developed as immunomodulators and supports the further evaluation of some 5-mer peptides as potential vaccine adjuvants...
  27. pmc Establishment and characterization of a lethal mouse model for the Angola strain of Marburg virus
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    J Virol 88:12703-14. 2014
    ..This model provides an important tool to screen candidate vaccines and therapeutics against MARV infections...
  28. pmc The multiple roles of sGP in Ebola pathogenesis
    Marc Antoine de La Vega
    1 Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    Viral Immunol 28:3-9. 2015
    ..This review summarizes the multiple roles that sGP may play during infection and highlights the implications for the future design of vaccines and treatments...
  29. doi request reprint Post-exposure therapy of filovirus infections
    Gary Wong
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada
    Trends Microbiol 22:456-63. 2014
    ....
  30. pmc Novel adeno-associated viruses derived from pig tissues transduce most major organs in mice
    Alexander Bello
    1 Public Health Agency of Canada, National Microbiology Laboratory, Special Pathogens Program, Winnipeg, Canada 2 University of Manitoba, Department of Medical Microbiology
    Sci Rep 4:6644. 2014
    ..Porcine tissues are antigenically similar to human tissues and by inference, porcine AAVs may provide fresh tools to contribute to the development of gene therapy-based solutions to human diseases. ..
  31. doi request reprint Characterization of host immune responses in Ebola virus infections
    Gary Wong
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street Winnipeg, MB, R3E 3R2 Canada
    Expert Rev Clin Immunol 10:781-90. 2014
    ..This review summarizes the host immune response to Ebola infection, and highlights the short- and long-term immune responses crucial for protection, which holds implications for the design of future vaccines and therapeutics...
  32. doi request reprint Immune evasion in ebolavirus infections
    Jonathan Audet
    1 Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    Viral Immunol 28:10-8. 2015
    ..While our understanding of the interactions between the human and viral proteins increases, details of those interactions in other hosts remain largely unclear and represent a gap in our knowledge...
  33. pmc Backs against the wall: novel and existing strategies used during the 2014-2015 Ebola virus outbreak
    Gary Wong
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    Clin Microbiol Rev 28:593-601. 2015
    ..This review aims to summarize the candidates currently under consideration for postexposure use in infected patients during the largest EBOV outbreak in history. ..
  34. ncbi request reprint Chimpanzee adenovirus vaccine protects against Zaire Ebola virus
    Gary P Kobinger
    Special Pathogens Program, National Microbiology Laboratory, Health Canada, Canadian Science Centre for Human and Animal Health, University of Manitoba, Winnipeg, Canada
    Virology 346:394-401. 2006
    ..These results validate further development of Chimpanzee-based vaccine and highlight the impact of pre-existing immunity to the vaccine carrier...
  35. doi request reprint Successful treatment of ebola virus-infected cynomolgus macaques with monoclonal antibodies
    Xiangguo Qiu
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Sci Transl Med 4:138ra81. 2012
    ..These data highlight the important role of antibodies to control EBOV replication in vivo, and support the use of mAbs against a severe filovirus infection...