Matthew W Gilmour

Summary

Affiliation: Public Health Agency of Canada
Country: Canada

Publications

  1. pmc Multilocus sequence typing of Escherichia coli O26:H11 isolates carrying stx in canada does not identify genetic diversity
    Matthew W Gilmour
    Emerging Bacterial Pathogens Program, National Microbiology Laboratory, Winnipeg, Manitoba, Canada
    J Clin Microbiol 43:5319-23. 2005
  2. pmc Genetic characterization of clinical and agri-food isolates of multi drug resistant Salmonella enterica serovar Heidelberg from Canada
    Ashleigh K Andrysiak
    Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada
    BMC Microbiol 8:89. 2008
  3. pmc Molecular typing of a Legionella pneumophila outbreak in Ontario, Canada
    Matthew W Gilmour
    National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada
    J Med Microbiol 56:336-41. 2007
  4. pmc Use of the espZ gene encoded in the locus of enterocyte effacement for molecular typing of shiga toxin-producing Escherichia coli
    Matthew W Gilmour
    National Microbiology Laboratory, 1015 Arlington Street, Winnipeg, Manitoba, Canada
    J Clin Microbiol 44:449-58. 2006
  5. pmc Sequence-based typing of genetic targets encoded outside of the O-antigen gene cluster is indicative of Shiga toxin-producing Escherichia coli serogroup lineages
    Matthew W Gilmour
    National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada
    J Med Microbiol 56:620-8. 2007
  6. pmc High-throughput genome sequencing of two Listeria monocytogenes clinical isolates during a large foodborne outbreak
    Matthew W Gilmour
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada
    BMC Genomics 11:120. 2010
  7. ncbi request reprint Rapid detection of Vibrio species using liquid microsphere arrays and real-time PCR targeting the ftsZ locus
    Dobryan M Tracz
    National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada
    J Med Microbiol 56:56-65. 2007
  8. pmc Limited genetic diversity in Salmonella enterica serovar Enteritidis PT13
    Adam B Olson
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada
    BMC Microbiol 7:87. 2007
  9. pmc A comparison of Shiga-toxin 2 bacteriophage from classical enterohemorrhagic Escherichia coli serotypes and the German E. coli O104:H4 outbreak strain
    Chad R Laing
    Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Lethbridge, Alberta, Canada
    PLoS ONE 7:e37362. 2012
  10. pmc Isolation and genetic characterization of a coinfection of non-O157 Shiga toxin-producing Escherichia coli
    Matthew W Gilmour
    National Microbiology Laboratory, Winnipeg, Manitoba, Canada
    J Clin Microbiol 45:3771-3. 2007

Collaborators

Detail Information

Publications26

  1. pmc Multilocus sequence typing of Escherichia coli O26:H11 isolates carrying stx in canada does not identify genetic diversity
    Matthew W Gilmour
    Emerging Bacterial Pathogens Program, National Microbiology Laboratory, Winnipeg, Manitoba, Canada
    J Clin Microbiol 43:5319-23. 2005
    ....
  2. pmc Genetic characterization of clinical and agri-food isolates of multi drug resistant Salmonella enterica serovar Heidelberg from Canada
    Ashleigh K Andrysiak
    Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada
    BMC Microbiol 8:89. 2008
    ..Heidelberg in chicken agri-food sources and the simultaneous increase of MDR S. Heidelberg in human clinical samples...
  3. pmc Molecular typing of a Legionella pneumophila outbreak in Ontario, Canada
    Matthew W Gilmour
    National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada
    J Med Microbiol 56:336-41. 2007
    ..These molecular typing methods confirmed the outbreak source as a contaminated air conditioning cooling tower...
  4. pmc Use of the espZ gene encoded in the locus of enterocyte effacement for molecular typing of shiga toxin-producing Escherichia coli
    Matthew W Gilmour
    National Microbiology Laboratory, 1015 Arlington Street, Winnipeg, Manitoba, Canada
    J Clin Microbiol 44:449-58. 2006
    ..The study focused on the characterization of three clinically significant seropathotypes of LEE-positive STEC, and we have used the observed genetic variation at a pathogen-specific locus for detection and subtyping of STEC...
  5. pmc Sequence-based typing of genetic targets encoded outside of the O-antigen gene cluster is indicative of Shiga toxin-producing Escherichia coli serogroup lineages
    Matthew W Gilmour
    National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada
    J Med Microbiol 56:620-8. 2007
    ....
  6. pmc High-throughput genome sequencing of two Listeria monocytogenes clinical isolates during a large foodborne outbreak
    Matthew W Gilmour
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada
    BMC Genomics 11:120. 2010
    ..monocytogenes isolates was used to rapidly provide the genome sequence of the primary outbreak strain and to investigate the extent of genetic diversity associated with a change of a single restriction enzyme fragment during PFGE...
  7. ncbi request reprint Rapid detection of Vibrio species using liquid microsphere arrays and real-time PCR targeting the ftsZ locus
    Dobryan M Tracz
    National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada
    J Med Microbiol 56:56-65. 2007
    ..cholerae, V. parahaemolyticus and V. vulnificus. These assays permitted the identification of a presumptive V. parahaemolyticus isolate as Vibrio alginolyticus, which was verified using additional molecular characterization...
  8. pmc Limited genetic diversity in Salmonella enterica serovar Enteritidis PT13
    Adam B Olson
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada
    BMC Microbiol 7:87. 2007
    ..Enteritidis PT13...
  9. pmc A comparison of Shiga-toxin 2 bacteriophage from classical enterohemorrhagic Escherichia coli serotypes and the German E. coli O104:H4 outbreak strain
    Chad R Laing
    Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Lethbridge, Alberta, Canada
    PLoS ONE 7:e37362. 2012
    ..Further studies are required to determine whether the elevated Stx2-production levels are due to bacteriophage or E. coli O104:H4 host related factors...
  10. pmc Isolation and genetic characterization of a coinfection of non-O157 Shiga toxin-producing Escherichia coli
    Matthew W Gilmour
    National Microbiology Laboratory, Winnipeg, Manitoba, Canada
    J Clin Microbiol 45:3771-3. 2007
    ..However, both STEC serotypes are known to cause serious disease, and the significant repertoire of virulence determinants in both strains made it impossible to determine their individual contributions to the clinical symptoms...
  11. pmc Genetic determinants and polymorphisms specific for human-adapted serovars of Salmonella enterica that cause enteric fever
    Dobryan M Tracz
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    J Clin Microbiol 44:2007-18. 2006
    ..These determinants provided phylogenetic data on the genetic relatedness of serovars Typhi, Paratyphi A, and Sendai; and the protocols developed might allow the rapid identification of these Salmonella serovars that cause enteric fever...
  12. pmc Effects of the Campylobacter jejuni CJIE1 prophage homologs on adherence and invasion in culture, patient symptoms, and source of infection
    Clifford G Clark
    National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba, R3E 3R2, Canada
    BMC Microbiol 12:269. 2012
    ..jejuni isolates with and without these prophages with patients' symptoms, with source, and with clonal lineages within the C. jejuni population...
  13. pmc Comparative genomics of Vibrio cholerae from Haiti, Asia, and Africa
    Aleisha R Reimer
    Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    Emerg Infect Dis 17:2113-21. 2011
    ..However, because no identical genetic match was found among sequenced contemporary isolates, a definitive genetic origin for the outbreak in Haiti remains speculative...
  14. doi request reprint Isolation and detection of Shiga toxin-producing Escherichia coli in clinical stool samples using conventional and molecular methods
    Matthew W Gilmour
    National Microbiology Laboratory, Winnipeg, MN, Canada
    J Med Microbiol 58:905-11. 2009
    ..This toolbox of molecular methods provided robust detection capabilities for STEC in clinical stool samples, including co-infection of multiple serogroups...
  15. doi request reprint Serotype distribution of invasive Streptococcus pneumoniae in Canada during the introduction of the 13-valent pneumococcal conjugate vaccine, 2010
    Walter H B Demczuk
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada
    Can J Microbiol 58:1008-17. 2012
    ..Continued monitoring of invasive pneumococcal serotypes in Canada is important to identify epidemiological trends and assess the impact of the newly introduced PCV13 vaccine on public health...
  16. ncbi request reprint Phylogenetic relationships of Campylobacter jejuni based on porA sequences
    Clifford G Clark
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB
    Can J Microbiol 53:27-38. 2007
    ..Different MOMP sequence groups may have different biological or antigenic properties, which in turn may be associated with survival in different environments, host adaptation, or virulence...
  17. doi request reprint Evaluation of MALDI-TOF mass spectroscopy methods for determination of Escherichia coli pathotypes
    Clifford G Clark
    Enteric Diseases Program, Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB R3E 3R2 Canada Electronic address
    J Microbiol Methods 94:180-91. 2013
    ..coli isolates from all pathotypes to the species level and, furthermore, that the Bruker extraction and MALDI-TOF MS with the evaluation criteria developed in this work was effective for differentiating most pathotypes. ..
  18. doi request reprint Baseline epidemiology of Streptococcus pneumoniae serotypes in Canada prior to the introduction of the 13-valent pneumococcal vaccine
    Heather J Adam
    Clinical Microbiology, Health Sciences Centre, Diagnostic Services of Manitoba, Winnipeg, Manitoba, Canada
    Microb Drug Resist 18:176-82. 2012
    ..5% of MDR-S. pneumoniae were covered by PCV-13. Accordingly, PCV-13 will provide coverage against a significant proportion of circulating S. pneumoniae strains in Canada, including the critical antimicrobial-resistant strains...
  19. pmc Vibrio cholerae in Traveler from Haiti to Canada
    Matthew W Gilmour
    Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    Emerg Infect Dis 17:1124-5. 2011
    ..In these instances, illness was related to travel to Haiti or consumption of contaminated water on the island of Hispaniola (which is shared by Haiti and Dominican Republic)...
  20. ncbi request reprint The complete nucleotide sequence of the resistance plasmid R478: defining the backbone components of incompatibility group H conjugative plasmids through comparative genomics
    Matthew W Gilmour
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alta, Canada T6G 2R3
    Plasmid 52:182-202. 2004
    ..The similarity to a diverse set of bacterial sequences highlights the ability of horizontally transferable DNA elements to acquire and disseminate genetic traits through the bacterial gene pool...
  21. ncbi request reprint Interaction between the co-inherited TraG coupling protein and the TraJ membrane-associated protein of the H-plasmid conjugative DNA transfer system resembles chromosomal DNA translocases
    James E Gunton
    Department of Medical Microbiology and Immunology, 1 63 Medical Sciences Building, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Microbiology 153:428-41. 2007
    ..It is proposed that TraJ is a functional part of the IncH-type coupling protein complex required for translocation of DNA through the cytoplasmic membrane...
  22. ncbi request reprint Interaction between the IncHI1 plasmid R27 coupling protein and type IV secretion system: TraG associates with the coiled-coil mating pair formation protein TrhB
    Matthew W Gilmour
    Department of Medical Microbiology, 1 28 Medical Sciences Building, University of Alberta, Edmonton, Canada T6G 2R3
    Mol Microbiol 49:105-16. 2003
    ..These data support a model in which the coupling protein interacts with an Mpf component to target the transferring DNA strand held by the relaxosome to the transmembrane Mpf complex...
  23. pmc Functional and mutational analysis of conjugative transfer region 2 (Tra2) from the IncHI1 plasmid R27
    Trevor D Lawley
    Department of Biological Sciences, University of Alberta, Edmonton, Canada T6G 2R3
    J Bacteriol 185:581-91. 2003
    ..Furthermore, the Mpf/type IV secretion systems encoded by IncH and IncF transfer systems are distinct from that of the IncP transfer system. The phenotypic and ecological significance of these observations is discussed...
  24. ncbi request reprint Subcellular localization and functional domains of the coupling protein, TraG, from IncHI1 plasmid R27
    James E Gunton
    Department of Medical Microbiology and Immunology, 1 63 Medical Sciences Building, University of Alberta, Edmonton, Alberta, Canada T6G 2R3
    Microbiology 151:3549-61. 2005
    ..These results allow the definition of domains within TraG that are involved in conjugative transfer, and determination of the cellular location of the R27 coupling protein...
  25. pmc A subassembly of R27-encoded transfer proteins is dependent on TrhC nucleoside triphosphate-binding motifs for function but not formation
    Matthew W Gilmour
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2R3, Canada
    J Bacteriol 186:1606-13. 2004
    ..These results indicate that TrhC requires intact NTP-binding motifs to function during conjugative transfer but that these motifs are not essential for the assembly of TrhC into a complex with other transfer proteins...
  26. pmc Functional and mutational analysis of conjugative transfer region 1 (Tra1) from the IncHI1 plasmid R27
    Trevor D Lawley
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2R3
    J Bacteriol 184:2173-80. 2002
    ..This analysis indicates that the Mpf components of R27 share a common lineage with those of the IncF transfer system, whereas the relaxase of R27 is ancestrally related to that of the IncP transfer system...